TWI761233B - Bioinformatics measurement system - Google Patents

Abstract

A bioinformatics measurement system includes at least one measurement device and a host. The measurement device is configured for measurement a bioinformatics of an individual. The host establishes a wireless communication connection with the measurement device to receive the bioinformatics measured by the measurement device. The host selectively switches to a pairing mode or a beacon mode according to the number of connections of the measurement device to establish the wireless communication connection so that the above-mentioned bioinformatics measurement system can be adapted to different application scenarios. A method for correcting bioinformatics is also disclosed, which can predict future bioinformatics according to a slope change of the bioinformatics, and make the predicted bioinformatics close to the current bioinformatics.

Description

Bioinformatics Measurement System

The present invention relates to a measurement system and a calibration method, in particular to a biological information measurement system and a biological information calibration method.

The conventional way to obtain biological information (such as blood sugar) is to have a medical staff puncture a needle to draw blood or a user to pierce the skin to obtain a small amount of blood and then perform chemical analysis. Such a measurement method is only the biological information obtained at a single time point. If the measurement is intensive, it will not only cause inconvenience to the operator, but also make the subject feel more pain, thereby causing a feeling of rejection or reducing the number of measurements.

In order to overcome the above problems, a bio-information sensing patch has been developed, which can be attached to the skin of the living body, and can reduce the subject's pain and obtain tissue fluid with low-invasive puncture, so that it can be continuously and continuously for a long time. to obtain the biological information of the subject. Generally speaking, the bio-information sensing patch needs to send the bio-information back to a host so that the user can read the measurement result. However, in different application scenarios, such as individuals or care institutions, the bio-information sensing patch needs to establish a connection with the host in a specific way, which leads to limitations and inconveniences in application.

In addition to measuring real-time bio-information such as electrocardiogram (ECG) or electroencephalogram (EEG), bio-information sensing patches can also measure delayed bio-information such as blood sugar from sweat or tissue fluid. Since the biological information measured by the biological information sensing patch is delayed for a period of time, how to make the biological information measured by the biological information sensing patch close to the current biological information is an important issue.

In view of this, proposing a bio-information sensing patch to overcome the above-mentioned shortcomings is an extremely urgent goal at present.

The present invention provides a biological information measurement system, which can be selectively switched to a pairing mode or a beacon mode according to the number of connections of the measurement device, so that the biological information measurement system of the present invention can be applied to different application scenarios .

A biological information measurement system according to an embodiment of the present invention includes at least one measurement device and a host. The measuring device is used for measuring a biological information of an individual. The host and the measuring device establish a wireless communication connection to receive the biological information measured by the measuring device, wherein the host selectively switches to a pairing mode or a beacon mode and at least one according to the number of connections of the measuring device The measuring device establishes a wireless communication connection, and the host and the measuring device generate a first key according to the device address of at least one of the host and the measuring device, and encrypt the wireless communication connection with the first key.

The following detailed description will be given in conjunction with the accompanying drawings through specific embodiments, so as to make it easier to understand the purpose, technical content, characteristics and effects of the present invention.

10, 10a, 10b, 10c: measuring device

11: Measuring components

12: Storage unit

13: Operation unit

14: Wireless communication components

20: Host

21: Display components

22: Storage unit

23: Operation unit

24: Wireless communication components

30: Server

31: Storage unit

32: Machine Learning Operation Unit

33: Communication components

40: Internet

k1~k4: slope

R1, R2, R3: biological information signal

r1~r5: biological information

S31~S38: encryption steps

S41~S44: Calibration steps

S71~S74: Calibration steps

S81~S83: Calibration steps

T1, T2, T3: transmission interval

t0~t5: time point

Ts: time synchronization signal

△t1~△t4: Time interval

FIG. 1 is a schematic diagram showing a biological information measurement system according to an embodiment of the present invention.

FIG. 2 is a schematic diagram showing the communication sequence of the biological information measurement system in the beacon mode according to an embodiment of the present invention.

FIG. 3 is a schematic diagram showing the encrypted connection steps of the biological information measurement system according to an embodiment of the present invention.

FIG. 4 is a flow chart showing a biological information calibration method according to an embodiment of the present invention.

FIG. 5 is a schematic diagram showing changes in biological information measured by the measuring device.

FIG. 6 is a schematic diagram showing a biological information measurement system according to another embodiment of the present invention.

FIG. 7 is a schematic diagram illustrating a method for calibrating biological information on a server side according to an embodiment of the present invention.

FIG. 8 is a schematic diagram illustrating a method for calibrating biological information on the host side according to an embodiment of the present invention.

The various embodiments of the present invention will be described in detail below, with the accompanying drawings as examples. In addition to these detailed descriptions, the present invention can also be widely implemented in other embodiments, and any easy substitutions, modifications, and equivalent changes of any of the embodiments are included within the scope of the present invention, and the scope of the patent application is allow. In the description of the specification, numerous specific details are provided in order to provide the reader with a more complete understanding of the present invention; however, the present invention may be practiced without some or all of the specific details. Also, well-known steps or elements have not been described in detail to avoid unnecessarily limiting the invention. The same or similar elements in the drawings will be represented by the same or similar symbols. It should be noted that the drawings are for illustrative purposes only, and do not represent the actual size or number of components, and some details may not be fully drawn for the sake of simplicity in the drawings.

Referring to FIG. 1 , a biological information measurement system according to an embodiment of the present invention includes at least a measurement device 10 and a host 20 . The measuring device 10 is used for measuring a biological information of an individual, such as at least one of blood glucose level and blood ketone level, but not limited thereto. For example, the measurement device 10 may include a bio-information sensing patch, or other implantable bio-information sensing elements. The host 20 establishes a wireless communication connection with the measuring device 10 to receive the biological information measured by the measuring device 10 .

The measuring device 10 includes a measuring element 11 , a storage unit 12 , an arithmetic unit 13 and a wireless communication element 14 . The measuring element 11 is configured correspondingly according to the biological information of the target to be measured. For example, the measuring element 11 may be a microneedle coated with a suitable reaction reagent. The arithmetic unit 13 processes the biological information measured by the measuring element 11 and stores it in the storage unit 12 and/or transmits it back to the host 20 via the wireless communication element 14 .

The host 20 includes a display element 21 , a storage unit 22 , an operation unit 23 and a wireless communication element 24 . The host 20 receives the biological information measured by the measuring device 10 through the wireless communication element 24 , and is processed by the computing unit 23 and stored in the storage unit 22 and/or displayed on the display element 21 for the user to read the information of the measuring device 10 . Measured biological information. For example, the host 20 is a computer, such as a desktop computer or a notebook computer, or a mobile internet device, such as a smart phone, a tablet computer, etc., and can also be dedicated or non-dedicated for matching measurement The medical device of device 10.

In one embodiment, the host 20 can selectively switch to a pairing mode or a beacon mode to establish a wireless communication connection with the measurement device 10 according to the number of connections of the measurement device 10 . For example, when a single measurement device 10 establishes a wireless communication connection with the host 20 , the pairing mode can be used to pair with the measurement device 10 . The connection in pairing mode can be realized by using the existing communication protocol. For example, the measurement device 10 can establish a wireless communication connection with the host 20 according to the Bluetooth protocol, the Zigbee protocol, the Thread protocol or the IEEE 802.11ah protocol (eg, the Sub-1GHz protocol).

When a plurality of measurement devices 10, 10a, 10b establish wireless communication connections with the host 20, the host 20 switches to the beacon mode to communicate with the measurement devices 10, 10a, 10b. In an embodiment, please refer to FIG. 2 , after the host 20 periodically sends a time synchronization signal Ts, it waits to receive the measured biological information sequentially returned by the plurality of measuring devices 10 , 10 a and 10 b . For example, the host 20 may divide a plurality of transmission intervals T1, T2, T3 between any two time synchronization signals Ts, and write the number of transmission intervals in the time synchronization signal Ts. After receiving the time synchronization signal Ts, the measurement devices 10, 10a, and 10b can select corresponding transmission intervals T1, T2, and T3 to return the biological information according to the time synchronization signal Ts. As shown in FIG. 2 , the measurement device 10 returns the biological information signal R1 in the transmission interval T1; the measurement device 10a returns the biological information signal in the transmission interval T2 R2; the measuring device 10b returns the biological information signal R3 in the transmission interval T3. It can be understood that the number of transmission intervals T1, T2, and T3 must be equal to or greater than the number of wireless communication connections established between the measuring devices 10, 10a, 10b and the host 20 to avoid communication collisions, that is, different amounts. The detection device 10, 10a or 10b returns the biological information in the same transmission interval T1, T2 or T3.

In one embodiment, the measurement devices 10, 10a, and 10b can select corresponding transmission intervals T1, T2, and T3 according to their own device addresses. For example, the measurement devices 10, 10a, and 10b can take the remainder of dividing their own device address by the number of transmission intervals as the transmission interval of the returned biological information. If different measurement devices 10, 10a, 10b select the same transmission interval for communication, that is, when a communication collision occurs, one of the measurement devices 10, 10a, 10b can add one to the remainder in sequence to avoid communication collisions. situation.

In one embodiment, for the security of data transmission, the wireless communication connection between the measuring device 10 and the host 20 may be an encrypted communication connection, and the encryption method may be applicable to the pairing mode or the beacon mode. Please refer to FIG. 3 to illustrate the steps of establishing an encrypted wireless communication connection between the measurement device 10 and the host 20 . First, the measurement device 10 requests the host 20 to establish a wireless communication connection ( S31 ), and the host 20 responds to the connection request of the measurement device 10 ( S32 ). Next, the measuring device 10 and the host 20 each generate a first key (S33). For example, the measuring device 10 and the host 20 can generate the first key according to the device address of the measuring device 10, but not limited thereto, the measuring device 10 and the host 20 can also generate the first key according to the device address of the host 10 or the host 10 and the device address of the measuring device 10 to generate a first key. After the first key is generated, the measuring device 10 and the host 20 can use the first key to encrypt and decrypt the data transmitted by the wireless communication connection ( S34 ). Preferably, the measuring device 10 and the host 20 can exchange a second key under the wireless communication connection encrypted with the first key (S35). For example, the host 20 can generate the second key and transmit it to the measuring device 10, or vice versa, then the measuring device 10 and the host 20 can use the second key to encrypt the data transmitted by the wireless communication connection and Decryption (S36), for example, the host 20 transmits a time synchronization signal (S37) to And the measuring device 10 returns the biological information (S38). In one embodiment, the host 20 or the measurement device 10 may request the measurement device 10 to update the second key periodically or irregularly, so as to improve the security of data transmission.

Since the target measured by the measuring device 10 may include the measurement of blood glucose level and/or blood ketone level from sweat or tissue fluid, etc., there may be a delay phenomenon. In order to make the biological information measured by the measurement device 10 close to the current biological information, it is necessary to calibrate the biological information measured by the measurement device 10 . Please refer to FIG. 4 to illustrate a method for correcting biological information according to an embodiment of the present invention. First, an electronic device obtains a plurality of biological information of a previous time interval and a current time interval of an individual (S41), such as delayed biological information. Next, the measuring device calculates the slope of the biological information for each time interval (S42). Please refer to FIG. 5 together. For example, the measuring device measures the biological information r0, r1 and r2 at the time points t0, t1 and t2, respectively, and then calculates the slope of the biological information corresponding to the time intervals Δt1 and Δt2. k1, k2.

Next, the measuring device predicts a predicted slope of the biological information in the next time interval based on the change in the slope of the biological information ( S43 ). For example, when the absolute value of the slope (such as k2) of the current time interval (such as Δt2) is greater than the absolute value of the slope (such as k1) of the previous time interval (such as Δt1), it means that the change of biological information gradually slows down. The uptrend changes to a steep uptrend, as shown in Figure 5, or from a slow downtrend to a steep downtrend. At this time, the predicted slope k3 may be the slope (k2) of the current time interval (Δt2) multiplied by a predetermined value. On the contrary, when the absolute value of the slope of the current time interval is smaller than the absolute value of the slope of the previous time interval, it means that the change of the biological information changes from a steep upward trend to a slow upward trend, or from a steep downward trend to a slow downward trend. At this time, the predicted slope may be the slope of the current time interval divided by a predetermined value. Alternatively, when the slope of the current time interval is equal to the slope of the previous time interval, the slope of the predicted next time interval is the slope of the current time interval. It can be understood that the preset value can be adjusted according to the size of the time interval, the measured target biological information or other background factors, and can also be dynamically adjusted according to the ratio between the slopes of the plurality of time intervals. Finally, the measuring device can calculate the biological information after the next time interval according to the predicted slope (S44). For example, the predicted slope of the next time interval (eg, Δt3) is k3, therefore, according to the measured time point t2 The biological information r2 and the predicted slope k3 can predict the biological information r3 at the time point t3 after the next time interval Δt3.

值時，可判斷所量測到的生物訊息即將反轉，例如從上升趨勢改變為下降趨勢，或是從下降趨勢改變為上升趨勢，因此，預測斜率可為目前時間間隔之斜率之負值。請再參照圖5，舉例而言，量測裝置於時間點t4、t5量測到生物訊息r4、r5，並計算出時間間隔△t4之斜率k4。由於斜率k4之絕對值|k4|小於一

值，因此，下一時間間隔之預測斜率可為斜率k4之負值，亦即方向相反。 When the absolute value of the slope of the current time interval is less than one

When the value is , it can be determined that the measured biological information is about to reverse, such as changing from an upward trend to a downward trend, or from a downward trend to an upward trend. Therefore, the predicted slope can be a negative value of the slope of the current time interval. Referring to FIG. 5 again, for example, the measuring device measures the biological information r4 and r5 at time points t4 and t5, and calculates the slope k4 of the time interval Δt4. Since the absolute value |k4| of the slope k4 is less than one

Therefore, the predicted slope for the next time interval may be the negative value of the slope k4, ie in the opposite direction.

The biological information correction method of the present invention can be realized without high computing power (such as matrix operation), therefore, the measurement device with limited computing power and memory can realize the biological information correction method of the present invention, but not limited to this . Referring to FIG. 6 , in an embodiment, the biological information measurement system of the present invention may include a measurement device 10 , a host 20 and a server 30 disposed in the cloud. The host 20 and the server 30 can also implement the biological information correction method of the present invention. For example, the measurement device 10 can send the biological information back to the host 20 via the wireless communication connection, so the host 20 can also implement the biological information calibration method of the present invention. Alternatively, the host 20 can establish a connection with the server 30 via a mobile communication network or via a wired or wireless network interface via the Internet 40, and transmit the biological information measured by the measuring device 10 to the server 30, The server 30 can implement the biological information correction method of the present invention and return the prediction result to the host 20 for the user to read the prediction result.

In the aforementioned embodiment, the measurement device 10 transmits the measured biological information to the server 30 via the host 20, but is not limited thereto. In an embodiment, please refer to FIG. 6 again, the measurement device 10c can directly establish a network communication connection with the server 30 via a Low Power Wide Area Network (LPWAN) for back transmission. The biological information measured by the measuring device 10c. For example, the low-power wide area network can be LoRa, Sigfox or NB-IoT, which has the characteristics of small amount of data transmission, long transmission distance and power saving, and thus is suitable for the measurement device of the present invention.

In one embodiment, the server 30 can further predict and correct the biological information measured by the measuring device. Please refer to FIG. 6 and FIG. 7 together. In one embodiment, the server 30 includes a storage unit 31 , a machine learning operation unit 32 and a communication element 33 . The communication element 33 can be a wired or wireless network interface connected to the Internet 40 to receive the biological information measured by the measuring device 10c. First, the server 10 stores the received biological information of a plurality of different individuals in the storage unit 31 as a historical biological information (S71). Next, the machine learning operation unit 32 establishes a calibration model through machine learning (S72). For example, the calibration model is based on machine learning modeling of recurrent neural network (RNN). Next, the server 30 trains the calibration model based on the stored historical biological information of a plurality of different individuals (S73). Finally, the server 30 predicts the biological information of the specific individual in the next time interval by using the trained calibration model and a plurality of biological information of the specific individual, and transmits the biological information to the host 20 for the user to read.

In one embodiment, the server 30 can provide the calibration model to the host 20 for the host 20 to further predict and correct the biological information measured by the measuring device. For example, referring to FIG. 8 , the host can store a plurality of biological information of a single individual as an individual historical biological information ( S81 ). Next, the calibration model established by the server 30 is trained with the stored individual historical biological information (S82). Finally, the host uses the trained calibration model and a plurality of biological information of the specific individual to predict the biological information of the specific individual in the next time interval ( S83 ), and displays it on the display element.

In view of the above, the biological information measurement system of the present invention can selectively switch between the pairing mode and the beacon mode according to the number of connections of the measurement devices, so that the biological information measurement system of the present invention can be applied to different application scenarios . In addition, the biological information correction method of the present invention can predict the biological information of the next time interval according to the change of the slope of the biological information, so that the predicted biological information is close to the current biological information, and the biological information correction method of the present invention can compare with the computing power. Low measurement device to achieve.

The above-mentioned embodiments are only to illustrate the technical ideas and characteristics of the present invention, and the purpose is to enable those skilled in the art to understand the content of the present invention and implement them accordingly, and should not be limited by these The patent scope of the present invention, that is, all equivalent changes or modifications made according to the spirit disclosed in the present invention, should still be covered within the patent scope of the present invention.

10, 10a, 10b: measuring device

11: Measuring components

12: Storage unit

13: Operation unit

14: Wireless communication components

20: Host

21: Display components

22: Storage unit

23: Operation unit

24: Wireless communication components

Claims (8)

A biological information measurement system, comprising: at least one measurement device for measuring a biological information of an individual; and a host for establishing a wireless communication connection with the measurement device to receive the measurement device The measured biological information, wherein the host selectively switches to a pairing mode or a beacon mode according to the number of connections of the measuring device to establish the wireless communication connection with the at least one measuring device, and the host and the measuring device generates a first key according to the device address of at least one of the host and the measuring device, and encrypts the wireless communication connection with the first key. The biological information measurement system of claim 1, wherein the wireless communication connection conforms to the Bluetooth protocol, the Zigbee protocol, the Thread protocol or the IEEE 802.11ah protocol. The biological information measurement system according to claim 1, wherein when the host and a plurality of the measurement devices establish the wireless communication connection in the beacon mode, they periodically send a time synchronization signal and then wait to receive the plurality of measurements The biological information returned by the measuring device in sequence. The biological information measurement system of claim 3, wherein the host divides a plurality of transmission intervals between the time synchronization signals, and writes the number of the transmission intervals in the time synchronization signal. The biological information measurement system of claim 4, wherein the number of the transmission intervals is equal to or greater than the number of connections of the measurement device establishing the wireless communication connection with the host, and each measurement device selects The biological information returned by the corresponding transmission interval. The biological information measurement system according to claim 1, wherein the host is a computer, a mobile Internet device, or a medical device. The biological information measurement system according to claim 1, wherein the biological information includes at least one of a blood glucose value and a blood ketone value. The biological information measurement system of claim 1, wherein the host and the measurement device exchange a second key with the wireless communication connection encrypted with the first key, and encrypt with the second key The wireless communication connection is used to transmit the biometric information, wherein the second key is updated regularly or irregularly.

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