TWI750600B - Fluid measurement device and fabrication method thereof - Google Patents

Abstract

A fluid measurement device including a first elastic layer, a second elastic layer, a third elastic layer, and a vessel is provided. The second elastic layer is located between the first elastic layer and the third elastic layer, and the vessel is located in the third elastic layer. The first elastic layer, the second elastic layer and the third elastic layer are made of organosilicon compound, first dye, and scattering material. Concentrations of the first dye and the scattering material in the first elastic layer, the second elastic layer, and the third elastic layer are different. Volume of third elastic layer is larger than that of the second elastic layer and the first elastic layer. A fabrication method is also provided.

Description

Fluid measuring element and method of making the same

The present invention relates to a measuring element and a manufacturing method thereof, in particular to a fluid measuring element and a manufacturing method thereof.

In the existing medical detection technology, there are many instruments mainly for measuring the cardiovascular system in the living body. Among the values that can be measured by the existing detection instruments, the blood oxygen concentration that can monitor the proportion of oxygen-enriched blood and hypoxic blood in the living body is one of the important physiological values. Therefore, the blood oxygen concentration machine has always been developed in this field. One of the main technologies.

In order to develop and produce a blood oxygen concentration machine with better performance and higher precision, it is still necessary to directly draw blood samples from the human body for measurement during the test. In order to be able to measure blood with different blood oxygen concentrations, it is also necessary to collect the blood of patients with low blood oxygen for a long time, which requires a lot of time and labor costs. Therefore, how to more effectively enable the blood oxygen concentration machine to obtain signals corresponding to blood with different blood oxygen concentrations is still one of the main problems to be solved in the art.

The fluid measuring element of the embodiments of the present invention can simulate and measure the physical properties of tissues and the flow of bodily fluids in a living body.

The fluid measuring element of the embodiment of the present invention includes a first elastic layer, a second elastic layer, a third elastic layer, and at least a flow channel. The second elastic layer is disposed on the third elastic layer. The first elastic layer is disposed on the second elastic layer, and the second elastic layer is located between the first elastic layer and the third elastic layer. The flow channel is disposed in the third elastic layer, and a mixed fluid flows in the flow channel. The first elastic layer, the second elastic layer and the third elastic layer are formed of an organic silicon compound, a first dye and a scattering material. The first dye in the first elastic layer, the second elastic layer and the third elastic layer respectively has a first dye concentration, a second dye concentration and a third dye concentration different from each other. The scattering materials in the first elastic layer, the second elastic layer and the third elastic layer respectively have a first material concentration, a second material concentration and a third material concentration which are different from each other. The volume of the third elastic layer is larger than the volumes of the second elastic layer and the first elastic layer.

In an embodiment of the present invention, the sidewalls of the first elastic layer, the second elastic layer and the third elastic layer are aligned with each other.

In an embodiment of the present invention, the inner diameter of the flow channel is in the range of 2 mm to 16 mm.

In an embodiment of the present invention, the above-mentioned first elastic layer, second elastic layer and third elastic layer are stacked along a first direction. The first elastic layer has a measurement surface whose normal vector is parallel to the first direction. In the first direction, The first elastic layer has a first height, the second elastic layer has a second height, and a first depth is spaced between the third elastic layer and the measuring surface. The first height is less than the second height, and the first depth falls within a range of 2 mm to 24 mm.

In an embodiment of the present invention, the ratio of the first height to the second height is in the range of 0.51 to 1.06, and the first depth is in the range of 13 mm to 15 mm.

In an embodiment of the present invention, the ratio of the first height to the second height is in the range of 0.26 to 0.47, and the first depth is in the range of 14 mm to 24 mm.

In an embodiment of the present invention, the ratio of the first height to the second height is in the range of 0.2 to 1.5, and the first depth is in the range of 6 mm to 10 mm.

In an embodiment of the present invention, the ratio of the first height to the second height is in the range of 0.38 to 1.58, and the first depth is in the range of 2 mm to 2.5 mm.

In an embodiment of the present invention, the above-mentioned mixed fluid includes a second dye and a third dye. For light in a first wavelength band, the maximum difference between the absorption rate of the second dye and the absorption rate of the third dye is 1.9 to 2.5 times; for light in a second wavelength band, the absorption rate of the second dye is 1.9 to 2.5 times. The maximum difference between the absorbance of the second dye and the absorbance of the third dye is 0.5 to 0.8 times; the absorbance of the second dye is the same as the absorbance of the third dye for light with first-order absorption wavelengths. The wavelength of the first waveband is smaller than the wavelength of the second waveband, and the isoabsorption wavelength is located between the first waveband and the second waveband.

In an embodiment of the present invention, the above-mentioned first band includes a range in wavelengths in the range of 730 nm to 785 nm. The second band includes wavelengths falling within the range of 810 nm to 880 nm.

In an embodiment of the present invention, the above-mentioned scattering material includes titanium dioxide.

In an embodiment of the present invention, the above-mentioned light-absorbing dye is substantially black.

In an embodiment of the present invention, the above-mentioned fluid measuring element further includes a delivery syringe connected to the third elastic layer, the front end of the delivery syringe is located in the flow channel, the center of the flow channel extends along an axis, and The center of the front end of the delivery syringe is substantially aligned with the axis, and the delivery syringe is used to accommodate and inject the mixed fluid into the flow channel.

In an embodiment of the present invention, the above-mentioned organosilicon compounds in the first elastic layer, the second elastic layer and the third elastic layer respectively have a first compound concentration, a second compound concentration and a third compound concentration different from each other. Compound concentration. The Young's coefficient of the first elastic layer is in the range of 4.75KPa to 2.4MPa; the Young's coefficient of the second elastic layer 120 is in the range of 4KPa to 20KPa; the Young's coefficient of the third elastic layer 130 is in the range of 2KPa to 12KPa Scope.

In an embodiment of the present invention, the above-mentioned fluid measuring element further includes a light-transmitting elastic layer disposed on one side of the third elastic layer. The flow channel passes through the transparent elastic layer, and the second elastic layer and the first elastic layer are sequentially arranged above the transparent elastic layer.

The manufacturing method of the fluid measuring element according to the embodiment of the present invention includes: mixing an organosilicon compound, a curing agent and a first dye into a first mixture; adding scattering material to the first mixture and mixing into a second mixture; placing the second mixture in a first mold, and the first mold has a column, and the column exceeds the height of the second mixture; performing the steps on the first mold and the second mixture air extraction; heating and baking the first mold and the second mixture to form a third elastic layer in the first mold; mixing the organosilicon compound, the curing agent and the first dye into a third mixture; adding the scattering material to the third mixing the mixture into a fourth mixture; placing the fourth mixture into the second mold; evacuation of the second mold and the fourth mixture; heating and baking the second mold and the fourth mixture to form a second elasticity in the second mold layer; mixing organosilicon compound, curing agent and first dye into fifth mixture; adding scattering material to fifth mixture and mixing into sixth mixture; placing sixth mixture into third mold; The mixture is evacuated; the third mold and the sixth mixture are heated and baked to form a first elastic layer in the third mold; and the second elastic layer and the first elastic layer are sequentially arranged on the third elastic layer.

In an embodiment of the present invention, after forming the third elastic layer, the above-mentioned manufacturing method further includes: placing the mixture of the organosilicon compound and the curing agent on the first elastic layer; and heating and baking to form the light-transmitting elastic layer.

It can be seen from the above that the fluid measuring element of the embodiment of the present invention has the first elastic layer, the second elastic layer and the third elastic layer with the flow channel, which can simulate the optical properties of each layer of tissue under the skin in the living body. The mixed fluid can also be simulated as blood for the detection device to measure.

d1: first direction

h1: first height

h2: second height

k1: first depth

r1: inner diameter

s1: axis

S101: Steps

S102: Steps

S103: Steps

S104: Steps

S105: Steps

S106: Steps

S107: Steps

S108: Steps

S109: Steps

S110: Steps

S111: Steps

S112: Steps

S113: Steps

S114: Steps

S115: Steps

S116: Steps

2-2: Cut the noodle line

50: blood oxygen concentration machine

100: Fluid measuring element

100A: Fluid measuring element

110: First elastic layer

110sw: Sidewall

111: Measuring Surface

120: Second elastic layer

120sw: Sidewall

130: Third elastic layer

131: Translucent elastic layer

130sw: Sidewall

140: runner

150: mixed fluid

160: Conveying Syringe

161: Front End

162: Drain line

Figure 1 is a three-dimensional schematic diagram of a fluid measuring element in an embodiment of the present invention; Figure 2 is another cross-sectional schematic diagram of a fluid measuring element according to an embodiment of the present invention; Figure 3 is according to the secant line in Figure 1 2-2 is a schematic cross-sectional view; FIG. 4 is a schematic perspective view of a fluid measuring element in another embodiment of the present invention; and FIG. 5 is a schematic flowchart of a manufacturing method for manufacturing a fluid measuring element in an embodiment of the present invention. .

The fluid measuring element proposed in the embodiment of the present invention can be applied in blood oxygen concentration machine or ultrasonic image measurement, but the present invention is not limited thereto.

FIG. 1 is a schematic perspective view of a fluid measuring element in an embodiment of the present invention. Referring to FIG. 1 , in this embodiment, the fluid measuring element 100 includes a first elastic layer 110 , a second elastic layer 120 , a third elastic layer 130 and at least a flow channel 140 .

The second elastic layer 120 is disposed on the third elastic layer 130 . The first elastic layer 110 is disposed on the second elastic layer 120 , and the second elastic layer 120 is located between the first elastic layer 110 and the third elastic layer 130 .

The flow channel 140 is disposed on the third elastic layer 130 . The first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 are formed of an organic silicon compound, a first dye and a scattering material.

For example, the organosilicon compound of this embodiment may include polydimethylsiloxane (PDMS); the first dye may be a black dye, which may include India Ink; the scattering material may include titanium dioxide (titanium dioxide, TiO ₂ ), but the present invention is not limited thereto.

Referring to FIG. 1 , in this embodiment, the first dye has a first dye concentration in the first elastic layer 110 . The first dye has a second dye concentration in the second elastic layer 120 . The first dye has a third dye concentration in the third elastic layer 130 . The first dye concentration, the second dye concentration, and the third dye concentration are different from each other.

Specifically, in this embodiment, the first dye has a good absorptivity for light whose wavelength is in an absorption band. For example, the absorption band may include light with a wavelength of 730 nm to 850 nm, and the first dye has a relatively high and similar absorption rate for light with a wavelength within this range.

The scattering material has a first material concentration in the first elastic layer 110 . The scattering material has a second material concentration in the second elastic layer 120 . The scattering material has a third material concentration in the third elastic layer 130 . The first material concentration, the second material concentration, and the third material concentration are different from each other.

Specifically, in the present embodiment, the scattering materials may each serve as a scattering source of light in the first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 . For example, the scattering material may have a relatively high and similar scattering coefficient for light with wavelengths ranging from 730 nm to 900 nm.

In this embodiment, the volume of the third elastic layer 130 is larger than the volumes of the second elastic layer 120 and the first elastic layer 110 . For example, in this embodiment, the volume of the third elastic layer 130 is, for example, 160 cubic centimeters, The volume of the second elastic layer 120 is, for example, 25 cubic centimeters, and the volume of the first elastic layer 110 is, for example, 25 cubic centimeters. The volume of the third elastic layer 130 is larger than that of the second elastic layer 120 , and the volume of the third elastic layer 130 is also larger than that of the first elastic layer 110 .

Therefore, the first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 can be sequentially simulated as the skin layer, the fat layer and the muscle layer of the living body. The organosilicon compounds in the first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 can make these layers each have elasticity similar to the skin layer, the fat layer and the muscle layer.

The first dye in the first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 can adjust the light absorption effect of these layers. The scattering materials in the first elastic layer 110, the second elastic layer 120, and the third elastic layer 130 can adjust the light scattering effect of these layers. Therefore, the fluid measuring element 100 can simulate the physical and optical properties of the skin layer, the fat layer and the muscle layer of the living body by the first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 .

For example, in the fluid measuring device 100 of this embodiment, the concentration of the first dye is greater than the concentration of the third dye, and the concentration of the third dye is greater than the concentration of the second dye. On the other hand, the first material concentration is greater than the second material concentration, and the second material concentration is greater than the third material concentration. Therefore, the first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 of the fluid measuring element 100 can simulate the optical properties of the skin layer, the fat layer and the muscle layer of the living body.

For another example, in an embodiment of the present invention, the first elastic layer The normalized absorption coefficient of 110 for light with wavelengths falling from 730 nm to 880 nm may fall within the range of 0.4 to 0.5, and the normalized reduction scattering coefficient may fall within the range of 5 to 9; the second elastic layer 120 may fall within the range of 5 to 9 for wavelengths. The normalized absorption coefficient of light at 730 nm to 880 nm may be less than 0.02, and the normalized reduced scattering coefficient may fall within the range of 3 to 6; The normalized absorption coefficient of light may fall in the range of 0.05 to 0.062, and the normalized reduced scattering coefficient may fall in the range of 1 to 2.

The concentration of the first material of the first elastic layer 110 is 0.31 mg per ml; the concentration of the second material of the second elastic layer 120 is 0.16 mg per ml; the concentration of the third material of the third elastic layer 130 is 0.1 mg per ml, but The present invention is not limited to this. In some embodiments of the invention, the first material concentration may fall in the range of 0.3 to 2.72 milligrams per milliliter; the second material concentration may fall in the range of 0.15 to 1.62 milligrams per milliliter; the third material concentration may fall in the range of 0.15 to 1.62 milligrams per milliliter 0.08 to 0.42 mg range to provide proper scattering.

On the other hand, in the above embodiment, the ratio of the first dye concentration, the second dye concentration and the third dye concentration can be substantially 40.9:2:5.7, but the present invention is not limited thereto. In other embodiments, the first dye concentration, the second dye concentration and the third dye concentration can be adjusted according to the absorption rate of the dye itself.

Since the normalized absorption coefficient and normalized reduced scattering coefficient of the light can be close to the optical properties of, for example, Caucasian skin, the fluid measuring element 100 of this embodiment has the first elastic layer 110 and the second elastic layer 120 And the third elastic layer 130 can provide a good simulation effect. It should be noted that the above-mentioned normalized absorption coefficient is a ^{normalized value of 4.6 cm −1} , and the normalized reduced scattering coefficient is ^{a normalized value of 4.6 cm −1} as a reference value.

FIG. 2 is a schematic cross-sectional view of the fluid measuring element 100 according to an embodiment of the present invention. Please refer to FIG. 2. In this embodiment, the flow channel 140 is formed in the third elastic layer 130, and the flow channel 140 passes through the third elastic layer. Layer 130. The flow channel 140 in the third elastic layer 130 of the fluid measuring element 100 is suitable for allowing the mixed fluid 150 to flow. Therefore, the fluid measuring element 100 of this embodiment can also simulate the flow of blood by mixing the fluid 150 .

For example, when a blood oximeter 50 is disposed on the measuring surface 111 of the first elastic layer 110 of the fluid measuring element 100, the flow channel 140 can be simulated as being located under the skin layer and the fat layer of the living body, The blood vessels in the muscle layer further provide a good simulated environment for the blood oxygen concentration machine 50 to measure. In other embodiments, the measurement surface 111 can also be used for measurement by an ultrasonic probe, but the invention is not limited thereto.

Further, the organosilicon compounds in the first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 respectively have a first compound concentration, a second compound concentration and a third compound concentration different from each other, and Each of the first elastic layer 110, the second elastic layer 120 and the third elastic layer 130 further contains a curing agent.

The third compound concentration is different from the second compound concentration, and the second elastic layer 120 and the third elastic layer 130 can change their respective Young's coefficients by adjusting the respective second compound concentration and third compound concentration. Example In other words, the Young's coefficient of the third elastic layer 130 in this embodiment is smaller than the Young's coefficient of the second elastic layer 120 . Similarly, the second compound concentration is different from the first compound concentration. By adjusting the first compound concentration and the second compound concentration, the Young's coefficient of the second elastic layer 120 can be made smaller than the Young's coefficient of the first elastic layer 110 . Therefore, the first elastic layer 110, the second elastic layer 120 and the third elastic layer 130 can simulate the skin layer, the fat layer and the muscle layer, but the present invention is not limited thereto.

In some embodiments of the present invention, the Young's coefficient of the first elastic layer 110 may fall within the range of 4.75KPa to 2.4MPa, which is suitable for simulating the skin layer; the Young's coefficient of the second elastic layer 120 may fall within the range of 4KPa to 20KPa It is suitable for simulating the fat layer; the Young's coefficient of the third elastic layer 130 can fall in the range of 2KPa to 12KPa, which is suitable for simulating the muscle layer. Those with ordinary knowledge in the technical field of the present invention can adjust the concentration of the first compound, the concentration of the second compound and the concentration of the third compound according to the needs and the race to be simulated, so as to achieve the above-mentioned material properties.

FIG. 3 is a schematic cross-sectional view according to the secant line 2-2 in FIG. 1 . Referring to FIG. 3 , in this embodiment, the first elastic layer 110 , the second elastic layer 120 and the third elastic layer 130 are stacked along the first direction d1 . For example, the first elastic layer 110 has sidewalls 110sw, the second elastic layer 120 has sidewalls 120sw, the third elastic layer 130 has sidewalls 130sw, and the sidewalls 110sw, 120sw, 130sw are aligned with each other. Therefore, when the oximeter 50 measures on the measurement surface 111, the fluid measurement element 100 can provide a good simulation environment.

In this embodiment, the first direction d1 is parallel to the measurement surface 111 the normal vector. In the first direction d1, the first elastic layer 110 has a first height h1, the second elastic layer 120 has a second height h2, and a first depth k1 is spaced between the flow channel 140 and the measuring surface 111.

Specifically, the first height h1 of the first elastic layer 110 is smaller than the second height h2 of the second elastic layer 120 , and the first depth k1 between the flow channel 140 and the measuring surface 111 may fall from 2 mm to 24 mm mm range. Therefore, the flow channel 140 can appropriately simulate the blood vessels under the skin of the living body, and the first elastic layer 110 and the second elastic layer 120 can be respectively simulated as a skin layer and a fat layer.

Meanwhile, the inner diameter r1 of the flow channel 140 may fall within the range of 2 mm to 16 mm. Therefore, the flow channel 140 can simulate the internal jugular vein, femoral artery, dorsal pedis artery or radial artery of a human body.

For example, in an embodiment of the present invention, the ratio of the first height h1 to the second height h2 is in the range of 0.51 to 1.06, and the first depth k1 is in the range of 13 mm to 15 mm, so The fluid measuring element 100 can be modeled as an internal jugular vein.

In another embodiment of the present invention, the ratio of the first height h1 to the second height h2 is in the range of 0.26 to 0.47, and the first depth k1 is in the range of 14 mm to 24 mm, so the fluid measurement Element 100 can be modeled as a femoral artery.

In yet another embodiment of the present invention, the ratio of the first height h1 to the second height h2 is in the range of 0.2 to 1.5, and the first depth k1 is in the range of 6 mm to 10 mm. Therefore, the fluid measurement Element 100 can be modeled as the dorsal foot artery.

In yet another embodiment of the present invention, the ratio of the first height h1 to the second height h2 is in the range of 0.38 to 1.58, and the first depth k1 is in the range of 2 mm to 2.5 mm, so the amount of fluid The measuring element 100 can be modeled as a radial artery.

On the other hand, please refer to FIG. 2 , the mixed fluid 150 of this embodiment may include a second dye and a third dye. For light in a first wavelength band, the maximum difference between the absorption rate of the second dye and the absorption rate of the third dye is 1.9 to 2.5 times; for light in a second wavelength band, the absorption rate of the second dye is 1.9 to 2.5 times. The maximum difference between the absorbance of the second dye and the absorbance of the third dye is 0.5 to 0.8 times; the absorbance of the second dye is the same as the absorbance of the third dye for light with first-order absorption wavelengths. The wavelength of the first waveband is smaller than the wavelength of the second waveband, that is, the wavelength value of the first waveband is smaller than the wavelength value of the second waveband, and the isoabsorption wavelength is located between the first waveband and the second waveband.

Further, the second dye and the third dye are water-soluble dyes.

For example, the above-mentioned first wavelength band includes wavelengths in the range of 730 nm to 785 nm, and the second wavelength band includes wavelengths in the range of 810 nm to 880 nm. Thus, the second dye may simulate the optical properties of non-oxyhemoglobin in the mixed fluid 150 and the third dye may simulate the optical properties of oxygenated heme in the mixed fluid 150 .

Referring to FIG. 2 , in the embodiment of the present invention, the fluid measuring element 100 further includes a delivery syringe 160 , which is connected to the third elastic layer 130 , and the front end 161 of the delivery syringe 160 is located in the flow channel 140 .

The center of the flow channel 140 extends along an axis s1 and conveys the syringe The center of the front end 161 of 160 is substantially aligned with the axis s1. The delivery syringe 160 is used to accommodate and inject the mixed fluid 150 into the flow channel 140 . In other words, the front end 161 of the syringe 160 in this embodiment is inserted into the flow channel 140 , and the syringe 160 and the flow channel 140 are coaxial.

Therefore, the fluid measuring element 100 of the present embodiment can further control the flow rate of the mixed fluid 150 through the delivery syringe 160 , and the user can also simulate the pulse in the flow channel 140 by controlling the delivery syringe 160 . The delivery syringe 160 can be manually controlled or driven by a pump, and the present invention is not limited thereto.

Further, the fluid measuring element 100 may further include a drain line 162 , which is inserted into the other end of the flow channel 140 relative to the front end 161 of the syringe 160 , so that the mixed fluid 150 can enter and exit from the flow channel 140 .

FIG. 4 is a schematic perspective view of a fluid measuring element in another embodiment of the present invention. Referring to FIG. 4 , the fluid measuring element 100A of this embodiment is similar to the above-mentioned fluid measuring element 100 , and includes a first elastic layer 110 , a second elastic layer 120 , a third elastic layer 130 and a flow channel 140 . The only difference is that the fluid measuring element 100A of this embodiment further includes a light-transmitting elastic layer 131 . The transparent elastic layer 131 is disposed on one side of the third elastic layer 130 , and the flow channel 140 passes through the transparent elastic layer 131 . The second elastic layer 120 and the first elastic layer 110 may be disposed above the light-transmitting elastic layer 131 and the third elastic layer 130 in sequence.

Specifically, the light-transmitting elastic layer 131 allows the user to directly observe the flow of the mixed fluid in part of the flow channel 140 . Since the third elastic layer 130 and the transparent elastic layer 131 have elasticity, the transparent elastic layer 131 The user can also observe the shape change of the flow channel 140 when the mixed fluid flows in the flow channel 140 .

FIG. 5 is a schematic flowchart of a manufacturing method for manufacturing a fluid measuring element according to an embodiment of the present invention. The component symbols in FIG. 1 will be used together to assist in the description below. Please refer to FIG. 5. In an embodiment of the present invention, the method for fabricating the above-mentioned fluid measuring element 100 may include: mixing an organosilicon compound, a curing agent And the first dye is mixed into the first mixture (step S101 ); the scattering material is added to the first mixture and mixed into the second mixture (step S102 ); the second mixture is placed in the first mold (step S103 ). The first mold has a cylinder, and the cylinder exceeds the height of the second mixture.

For example, the time to mix the first mixture may fall in the range of 20 minutes to 60 minutes; the time to mix the second mixture may fall in the range of 20 minutes to 60 minutes.

Next, the first mold and the second mixture are evacuated (step S104). For example, the first mold and the second mixture may be evacuated for 120 to 210 minutes.

After air extraction, the first mold and the second mixture are heated and baked to form the first elastic layer 110 (step S105 ). For example, the first mold and the second mixture may be heated and baked for 24 to 48 hours, and the heating temperature may fall within the range of 60 degrees Celsius to 100 degrees Celsius.

Next, the organic compound, the curing agent and the first dye are mixed into a third mixture (step S106 ); the scattering material is added to the third mixture and mixed into a fourth mixture (step S107 ); the fourth mixture is placed in the The second mold (step S108 ); the second mold and the fourth mixture are evacuated (step S109 ); the second mold and the fourth mixture are heated and baked to form the second elastic layer 120 (step S110 ). The mixing time, pumping time, heating temperature and heating time of the above steps are similar to the above steps S101 to S105, and will not be repeated here.

After the second elastic layer 120 is completed, the organic compound, the curing agent and the first dye are mixed into a fifth mixture (step S111 ); the scattering material is added to the fifth mixture and mixed into a sixth mixture (step S112 ); The sixth mixture is placed in the third mold (step S113 ); the third mold and the sixth mixture are pumped (step S114 ); the third mold and the sixth mixture are heated and baked to form the third elastic layer 130 (step S115 ) ). The mixing time, pumping time, heating temperature and heating time of the above steps are similar to the above steps S101 to S105, and will not be repeated here. Next, the second elastic layer 120 is disposed on the third elastic layer 130, and the first elastic layer 110 is disposed on the second elastic layer 120 to form the fluid measuring element 100 (step S116).

In the above step S108 and step S113, after the fourth mixture or the sixth mixture is placed in the second mold or the third mold, respectively, the uncured organosilicon compound can be scraped off, so that the second elastic layer 120 and the first elastic layer 120 can be formed. The elastic layer 110 may have a flat surface.

On the other hand, after step S105 , the mixture of the organosilicon compound and the curing agent can be placed on the first elastic layer 110 , and the above-mentioned transparent elastic layer 131 can be completed by heating and baking (see FIG. 4 ).

To sum up, the manufacturing method of the embodiment of the present invention can provide a A fluid measuring element with good physical properties and optical properties, and the fluid measuring element has a first dye and a scattering material because of the first elastic layer, the second elastic layer and the third elastic layer with the flow channel. It simulates the optical properties of each layer of tissue under the skin in the organism, and also has organic silicon compounds that can simulate the physical properties of each layer of tissue. The mixed fluid in the flow channel can also be simulated as blood for the detection device to measure.

2-2: Cut the noodle line

100: Fluid measuring element

110: First elastic layer

120: Second elastic layer

130: Third elastic layer

140: runner

Claims (10)

A fluid measuring element, comprising: a third elastic layer; a second elastic layer disposed on the third elastic layer; a first elastic layer disposed on the second elastic layer, and the second elastic layer is located between the first elastic layer and the third elastic layer; and At least one flow channel is disposed in the third elastic layer, and a mixed fluid flows in the flow channel, The first elastic layer, the second elastic layer and the third elastic layer are formed of organosilicon compounds, a first dye and a scattering material, and the first dye is in the first elastic layer, The second elastic layer and the third elastic layer respectively have a first dye concentration, a second dye concentration and a third dye concentration different from each other, and the scattering material is in the first elastic layer. The layer, the second elastic layer and the third elastic layer each have a first material concentration, a second material concentration and a third material concentration different from each other, The volume of the third elastic layer is larger than the volumes of the second elastic layer and the first elastic layer. The fluid measuring element of claim 1, wherein the inner diameter of the flow channel falls within a range of 2 mm to 16 mm. The fluid measuring element of claim 1, wherein the The first elastic layer, the second elastic layer and the third elastic layer are stacked along a first direction, and the first elastic layer has a measurement surface whose normal vector is parallel to the first direction, In the first direction, the first elastic layer has a first height, the second elastic layer has a second height, and a first depth is spaced between the flow channel and the measuring surface , and the first height is smaller than the second height, and the first depth falls within the range of 2 mm to 24 mm. The fluid measuring element according to claim 1, wherein the mixed fluid includes a second dye and a third dye, and for light in a first wavelength band, the absorption rate of the second dye and the The maximum difference in the absorption rate of the third dye is 1.9 to 2.5 times; for a second wavelength band, the maximum difference between the absorption rate of the second dye and the absorption rate of the third dye is 0.5 to 0.8 times; for the light with the first absorption wavelength, the absorption rate of the second dye is the same as the absorption rate of the third dye, and the wavelength of the first band is smaller than that of the second dye The wavelength of the wavelength band, the isosbestic wavelength is located between the first wavelength band and the second wavelength band. The fluid measurement element of claim 4, wherein the first wavelength band includes wavelengths falling within a range of 730 nm to 785 nm, and the second wavelength band includes wavelengths falling within a range of 810 nm to 880 nm wavelength. The fluid measuring element of claim 1, wherein the scattering material comprises titanium dioxide, and the light absorbing dye is substantially black. The fluid measuring element according to claim 1, further comprising a delivery syringe connected to the third elastic layer, the front end of the delivery syringe is located in the flow channel, and the center of the flow channel is along the An axis extends, and the center of the front end of the delivery syringe is substantially aligned with the axis, and the delivery syringe is used for accommodating and injecting the mixed fluid into the flow channel. The fluid measuring device according to claim 1, wherein the organosilicon compound has a first compound concentration different from each other in the first elastic layer, the second elastic layer and the third elastic layer. , a second compound concentration and a third compound concentration, and the Young's coefficient of the first elastic layer falls within the range of 4.75KPa to 2.4MPa; the Young's coefficient of the second elastic layer 120 falls within the range of 4KPa to 20KPa range; the Young's coefficient of the third elastic layer 130 falls within the range of 2KPa to 12KPa. The fluid measuring element according to claim 1, further comprising a light-transmitting elastic layer disposed on one side of the third elastic layer, the flow channel passing through the light-transmitting elastic layer, and the second elastic layer The elastic layer and the first elastic layer are sequentially arranged above the transparent elastic layer. A manufacturing method of a fluid measuring element, comprising: mixing the organosilicon compound, the curing agent and the first dye into a first mixture; adding scattering material to the first mixture and mixing into a second mixture; placing the second mixture into a first mold, wherein the first mold has a cylinder that exceeds the height of the second mixture; Evacuate the first mold and the second mixture; heating and baking the first mold and the second mixture to form a third elastic layer in the first mold; mixing the organosilicon compound, the curing agent and the first dye into a third mixture; adding the scattering material to the third mixture and mixing into a fourth mixture; placing the fourth mixture into a second mold; Evacuate the second mold and the fourth mixture; heating and baking the second mold and the fourth mixture to form a second elastic layer in the second mold; mixing the organosilicon compound, the curing agent and the first dye into a fifth mixture; adding the scattering material to the fifth mixture and mixing into a sixth mixture; placing the sixth mixture into a third mold; Evacuate the third mold and the sixth mixture; heating and baking the third mold and the sixth mixture to form a first elastic layer in the third mold; and The second elastic layer and the first elastic layer are sequentially arranged on the third elastic layer.

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