TWI455723B - 納曲酮及安非他酮於治療超重或肥胖病患之用途 - Google Patents

納曲酮及安非他酮於治療超重或肥胖病患之用途 Download PDF

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TWI455723B
TWI455723B TW095143283A TW95143283A TWI455723B TW I455723 B TWI455723 B TW I455723B TW 095143283 A TW095143283 A TW 095143283A TW 95143283 A TW95143283 A TW 95143283A TW I455723 B TWI455723 B TW I455723B
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naltrexone
bupropion
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unit dosage
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TW200803900A (en
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Anthony A Mckinney
Gary Tollefson
Michael A Cowley
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Orexigen Therapeutics Inc
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Claims (6)

  1. 一種納曲酮(naltrexone)及安非他酮(bupropion)之用途，其係用以製備用於治療超重或肥胖病患之藥物，其中該治療包含：在第一治療期間內每日口服投予包含第一量之納曲酮及安非他酮之藥物至該病患，其中該第一治療期間係至少三天，且其中該第一量之納曲酮及安非他酮為每日投予一次；在第二治療期間內每日口服投予包含第二量之納曲酮及安非他酮之藥物至該病患，其中該第二量包含第一量之納曲酮之兩倍量及第一量之安非他酮之兩倍量，其中該第二治療期間係至少四天，且其中該第二量之納曲酮及安非他酮為以兩個相等之每日劑量投予；在第三治療期間內每日口服投予包含第三量之納曲酮及安非他酮之藥物至該病患，其中該第三量包含第一量之納曲酮之三倍量及第一量之安非他酮之三倍量，其中該第三治療期間係至少一週，其中該第三量之納曲酮及安非他酮為以兩個每日劑量投予，一劑量包含每日劑量之2/3，且另一劑量包含每日劑量之1/3；及在第四治療期間內每日口服投予包含第四量之納曲酮及安非他酮之藥物至該病患，其中該第四量包含第一量之納曲酮之四倍量及第一量之安非他酮之四倍量，其中該第四量之納曲酮及安非他酮為以兩個相等之每日劑量投予； 其中納曲酮係持續釋放形式，其中安非他酮係持續釋放形式，且其中該第一量之安非他酮為90mg，且其中該第一量之納曲酮為4mg或5mg至10mg。
  2. 如請求項1之用途，其中該第一量之納曲酮及安非他酮係呈單一單位劑型。
  3. 如請求項1之用途，其中該第一量之納曲酮係呈單一單位劑型且該第一量之安非他酮係呈單一單位劑型。
  4. 如請求項1之用途，其中該第一量之納曲酮及安非他酮係呈單一單位劑型，其中該第二量之納曲酮及安非他酮係呈兩個單一單位劑型，其中該第三量之納曲酮及安非他酮係呈三個單一單位劑型，且其中該第四量之納曲酮及安非他酮係呈四個單一單位劑型。
  5. 如請求項1之用途，其中該第一量之納曲酮為4mg。
  6. 如請求項1之用途，其中該第一量之納曲酮為5mg至10mg。
TW095143283A 2005-11-23 2006-11-22 納曲酮及安非他酮於治療超重或肥胖病患之用途 TWI455723B (zh)

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AR (2) AR057632A1 (zh)
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