TW202116362A - Solution with high antimicrobial ability and lubricating effect - Google Patents

Abstract

This present disclosure relates to a solution with high antimicrobial ability and lubricating effect, which is composed of an antimicrobial ingredient and a lubricating ingredient, wherein the concentration of the antimicrobial ingredient ranged from 1-3000 ppm. In the case that the concentration of the antimicrobial ingredient is at least 1 ppm, if the solution contacts the target for at least 300 seconds, the solution can kill more than 90% of the microorganisms. In the case that the concentration of the antimicrobial ingredient is at least 10 ppm, if the solution contacts the target for at least 10 seconds, the solution can kill more than 90% of the microorganisms.

Description

Solution with high antimicrobial ability and lubricating effect

The present invention relates to a solution with high antimicrobial ability and lubricating effect, especially an antimicrobial ingredient with a concentration of at least 1 ppm /10 ppm, which can kill more than 90 seconds when contacting a target for at least 300 seconds/10 seconds. % Of microorganisms is a solution with high antimicrobial ability and lubricating effect.

In the contact lens market, how to effectively disinfect the lenses and maintain the lubricity of the lenses are two important issues. In the past, the lubricating ingredients added in contact lens solutions mainly used polyols, glycosaminoglycans, cellulose mixed ethers, sodium carboxymethyl cellulose, carboxymethyl cellulose (CMC), and hydroxypropyl methyl Cellulose (hydroxypropyl methylcellulose, HPMC), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), propylene glycol, glycerin, hyaluronic acid, ethyl lactate or oily substances, etc. When the lubricating component exists alone, it is more susceptible to microbial contamination due to the lack of antimicrobial components, which may cause the user's eyes to be infected. However, most of the lubricating ingredients are difficult to be compatible with the sterilizing ingredients. When the lubricating ingredients and the sterilizing ingredients are mixed at the same time, a common problem is that the sterilizing ingredients are interfered by the lubricating ingredients, resulting in a decrease in the sterilizing effect.

Furthermore, in addition to the degree of disinfection of contact lenses, users also value safety and antimicrobial efficiency. One of the disinfectant solutions for contact lenses has an antimicrobial component of benzalkonium chloride (BAC). Although benzalkonium chloride has antimicrobial effects, it is toxic and irritating. If the user uses it for a long time, it will easily cause corneal damage and disease. One of the disinfectant solutions for contact lenses has an antimicrobial component of polyhexamethylene biguanide (PHMB). The toxicity of polyhexamethylene biguanide is low. However, if it is desired to have a sufficient killing effect in a short time, its concentration needs to be at least 500 ppm, and there is a problem of easy residue. One of the disinfectant solutions for contact lenses has an antimicrobial component of hydrogen peroxide. During the antimicrobial process, it takes 4-8 hours for this disinfectant to completely convert hydrogen peroxide into oxygen and water through platinum. Avoid unconverted hydrogen peroxide from causing irritation to human eyes. Other types of contact lens disinfectants such as povidone-iodine (PVP-I) and chlorhexidine, the concentration of the two needs to be at least 250, 1000 ppm to have sufficient ability to kill microorganisms However, if the concentration of antimicrobial ingredients cannot be effectively reduced, it may cause adverse effects on users.

Therefore, in order to overcome the shortcomings of the prior art, through the specific ratio of antimicrobial components and lubricating components, the embodiment of the present invention provides a solution with high antimicrobial ability and lubricating effect, and at least one of the solutions after the solution contacts the target After a certain period of time, the solution can kill more than 90% of microorganisms.

Based on at least one of the foregoing objectives, the solution provided by the present invention has high antimicrobial ability and lubricating effect. The solution includes an antimicrobial component and a lubricating component, wherein the concentration of the antimicrobial component is 1-3000ppm, and the antimicrobial ability of the solution is: when the concentration of the antimicrobial component is at least 1ppm, the solution is in contact with the target for at least 300 seconds , Can kill more than 90% of microorganisms; or when the concentration of antimicrobial ingredients is at least 10ppm, the solution can kill more than 90% of microorganisms when the solution is in contact with the target for at least 10 seconds.

Optionally, the microorganisms are bacteria, fungi or viruses.

Optionally, the concentration of the lubricating component is 0.01-30 milligrams per milliliter (mg/ml).

Based on at least one of the foregoing objectives, the solution provided by the present invention is composed of chlorine dioxide and lubricating components, and has high antimicrobial ability and lubricating effect. The concentration of chlorine dioxide is 1-3000 ppm, and the concentration of the lubricating components is The concentration is 0.01-30 mg/ml.

Optionally, the lubricating component includes at least one of polyols, salts of polyols, glycosaminoglycans, salts of glycosaminoglycans, cellulose mixed ethers, and salts of cellulose mixed ethers.

Optionally, when the lubricating component is a polyol and/or its salt, the concentration of the polyol and/or its salt is 0.4-30 mg/ml; when the lubricating component is a glycosaminoglycan And/or its salts, the concentration of glycosaminoglycan and its salts is 0.01-5 mg/ml; and when the lubricating component is cellulose mixed ether and/or its salts, the fiber The concentration of the mixed ether and its salts is 0.24-10 mg/ml.

Optionally, when the lubricating component is a polyol and/or its salt, the concentration of the polyol and/or its salt is 10-30 mg/ml; when the lubricating component is a glycosaminoglycan In the case of and/or its salts, the concentration of glycosaminoglycan and/or its salts is 0.05-5 mg/ml; and when the lubricating component is cellulose mixed ether and/or its salts , The concentration of cellulose mixed ether and/or its salts is 1.2-10 mg/ml.

Optionally, any one of the foregoing solutions, wherein the polyhydric alcohol is glycerin, propylene glycol, caprylyl glycol, ethylhexyl glycerol, hexylene glycol, xylitol, polyethylene glycol, polypropylene glycol or pentane glycol.

Optionally, any one of the foregoing solutions, wherein the glycosaminoglycan is hyaluronic acid (Hyaluronic Acid, HA), chondroitin sulfate (Chondroitin Sulfate, CS), dermatan sulfate (Dermatan Sulfate, DS), keratan sulfate (Keratan Sulfate), sulfate, KS), Heparan sulfate (HS) or Heparin (HP).

Optionally, any one of the foregoing solutions, wherein the cellulose mixed ether is methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose, or hydroxyethyl cellulose.

In short, the solution provided by the embodiment of the present invention has both high-efficiency antimicrobial ability and lubricating effect. The concentration of the antimicrobial component of the solution is low, so when it is used in biomedical materials (for example, contact lenses), the degree of harm to the user is also very low. Moreover, the solution can kill more than 90% of microorganisms in a short time, and has the advantage of high antimicrobial efficiency. The double-effect one-in-one effect of the solution has advantages for various markets in need (for example, maintenance liquid for contact lenses, lubricating liquid for sterile machines, etc.).

In order to make the above and other objects, features and advantages of the present invention more comprehensible, detailed descriptions are made as follows in conjunction with the accompanying drawings.

In order to fully understand the purpose, features and effects of the present invention, the following specific embodiments are used in conjunction with the accompanying drawings to give a detailed description of the present invention. The description is as follows.

The embodiment of the present invention provides a solution with high antimicrobial ability and lubricating effect, which includes an antimicrobial component and a lubricating component. The antimicrobial component of the solution is selected from chlorine dioxide. When the concentration of the antimicrobial component is at least 1 ppm, the solution can kill more than 90% of the microorganisms after 300 seconds of contact with the target; or when the concentration of the antimicrobial component is at least At 10 ppm, the solution can kill more than 90% of microorganisms after 10 seconds of contact with the target. Please note here that although the aforementioned antimicrobial component is selected from chlorine dioxide, the present invention does not limit the antimicrobial component, and other antimicrobial components with the aforementioned antimicrobial ability can also be used.

The antimicrobial component "chlorine dioxide" of the solution of the present invention has the characteristics of a strong oxidant, and its principle for antimicrobial use is to break the bond of the amino acid of the microorganism and lose its activity, so that the microorganism will eventually die due to inability to metabolize. Chlorine dioxide is listed by the World Health Organization (WHO) as a safe and efficient disinfectant of A1 level. Even a small amount of it is not easy to harm the human body even if it is swallowed. Furthermore, chlorine dioxide has the characteristic of decomposition when exposed to light, that is, when the chlorine dioxide is exposed to light, it will automatically decompose into oxygen and chloride ions that are harmless to the human body over time. Therefore, it can be used for longer time to cause harm The lower the degree. Please refer to Table 1 for the decomposition situation of chlorine dioxide . Table 1 shows the concentration trend table of 1 ppm chlorine dioxide aqueous solution under xenon lamp irradiation. The xenon lamp system is used to simulate the exposure of sunlight, and the model of the xenon lamp is YS03 sold by UHAO. The model of the chlorine dioxide concentration detection instrument is DT1B sold by Photometer. As shown in Table 1 , when the chlorine dioxide aqueous solution is irradiated with the xenon lamp for a longer time, the detected chlorine dioxide concentration is lower, and when the chlorine dioxide aqueous solution is irradiated with the xenon lamp for 120 minutes, the chlorine dioxide concentration can be The concentration dropped to the lowest detection limit of the detection instrument (less than 0.02 ppm).

table 1 Xenon lamp irradiation time (min) Chlorine dioxide concentration (ppm) 0 1.01 5 0.745 10 0.56 15 0.385 30 0.09 60 0.025 120 Below detection limit 180 Below detection limit

Furthermore, the method for introducing chlorine dioxide into the solution of the present invention adopts a one-step system, that is, directly adding chlorine dioxide into the solution in the form of tablets, aqueous solutions or other forms. One-step system has the advantages of high convenience and safety, and it is used to replace the traditional two-step system (input sodium chlorite and hydrochloric acid to react to produce chlorine dioxide) possible risks and hazards (for example, Produce carcinogenic by-products such as haloalkanes, chloramines and bromates). Chlorine dioxide exists in a gaseous state in the solution, so it is easy to escape from the solution to the air. The advantage of the traditional Two-step system is that it can reduce the high loss rate of chlorine dioxide caused by the easy and rapid escape to the air. However, Since the solution of the present invention can achieve the effect of killing microorganisms in a short period of time (for example, 300 seconds), a more convenient and safe One-step system can be used without worrying about the problem of rapid escape of chlorine dioxide.

Next, the conditions and effects of the solution with high antimicrobial ability and lubricating effect will be further explained through examples. First, please refer to Table 2 to know the anti-microbial effect of the solution containing only chlorine dioxide. Table 2 is the correspondence table of the concentration of chlorine dioxide and the time to kill the microorganisms. As shown in Table 2 , the antimicrobial component in the solution is chlorine dioxide, and it has an antimicrobial effect when the concentration of chlorine dioxide is 1-3000 ppm. Examples 1 and 2 both use chlorine dioxide with a concentration of 1 ppm, and perform the antimicrobial test at 600/300 seconds respectively, and Examples 3-5 use chlorine dioxide with a concentration of 3/10/3000 ppm respectively. Chlorine dioxide is tested for killing microorganisms at 60/10/10 seconds respectively. The microorganisms are, for example, but not limited to bacteria, fungi or viruses. From the results of Examples 1-5, it can be seen that the conditions of Examples 1-5 can effectively kill microorganisms. The comparison results of Examples 1 and 2 show that the chlorine dioxide solution with a concentration of 1 ppm only takes 300 seconds to have a qualified antimicrobial effect, and the results of Examples 4 and 5 show that the chlorine dioxide solution with a concentration of 10 ppm The solution only takes 10 seconds to have a qualified anti-microbial effect. The higher the concentration of chlorine dioxide, the shorter the time it takes to kill microorganisms, that is, the added concentration of chlorine dioxide and the effect of killing microorganisms. Directly proportional. In the embodiments of the present invention, a qualified microbicide effect is defined as being capable of killing more than 90% of microbes. In the embodiment of the present invention, the microorganisms used as the test objects are bacteria and fungi. In addition, 2 ppm of chlorine dioxide can kill 93.7% of viruses within 120 seconds, and the conditions fall within the range of preferred embodiments 2 and 4. Therefore, the solution of the present invention can be used to kill microorganisms such as bacteria, fungi or viruses.

table 2 Example Time to kill microorganisms (seconds) Chlorine dioxide concentration (ppm) The result of killing microorganisms 1 600 1 qualified 2 300 1 qualified 3 60 3 qualified 4 10 10 qualified 5 10 3000 qualified

Next, please continue to refer to the following examples to know the conditions and effects when the solution includes both antimicrobial ingredients and lubricating ingredients. The lubricating component of the solution of the present invention can be polyhydric alcohols, polyhydric alcohol salts, glycosaminoglycans, glycosaminoglycan salts, cellulose mixed ethers or salts of cellulose mixed ethers, where the polyhydric alcohols are, for example, but Not limited to glycerin, propylene glycol, caprylyl glycol, ethylhexyl glycerol, hexylene glycol, xylitol, polyethylene glycol, polypropylene glycol or pentane glycol, glycosaminoglycans such as but not limited to hyaluronic acid (Hyaluronic Acid, HA), Chondroitin Sulfate (CS), Dermatan Sulfate (DS), Keratan sulfate (KS), Heparan sulfate (HS) or Heparin (Heparin, HP), and cellulose mixed ethers such as but not limited to methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose or hydroxyethyl cellulose.

Table 3 is a test table for the compatibility of lubricating components with chlorine dioxide. In Example 6, polyol is used as the lubricating component and propylene glycol is selected. In Example 7, polyol is used as the lubricating component and glycerin is selected. In Example 8, glycosaminoglycan was used as the lubricating component and hyaluronic acid (ie, hyaluronic acid) was selected, and in Example 9, cellulose mixed ether was used as the lubricating component and hydroxypropyl methyl fiber was selected. Vegetarian. As shown in Table 3 , in Examples 6-9, when the concentration of chlorine dioxide is 1 ppm, the concentration of the lubricating components in Examples 6-9 is 30 mg/ml (mg/ml) of propylene glycol. ); glycerol 30 mg/ml; hyaluronic acid 5 mg/ml; hydroxypropyl methyl cellulose 10 mg/ml, the results of Examples 6-9 all show that it has a qualified antimicrobial effect. The results of Examples 6-9 show that the specific combination of antimicrobial components and lubricating components of the solutions provided by the present invention can maintain the antimicrobial effect, and only a low concentration of antimicrobial components can be used to achieve the effect.

table 3 Example Lubricating composition Lubricating component concentration (Mg/ml) Chlorine dioxide concentration (ppm) Antimicrobial result 6 Propylene Glycol 30 1 qualified 7 glycerin 30 1 qualified 8 Hyaluronic acid 5 1 qualified 9 Hydroxypropylmethylcellulose 10 1 qualified

When the antimicrobial ingredient is mixed with the lubricating ingredient to form a solution, the concentration of the lubricating ingredient is not unlimited. When the lubricating component is added to a certain concentration, the viscosity of the solution will rise rapidly and will cause its coefficient of friction (COF) to rise. The friction coefficient is related to the friction between the two surfaces. The smaller the friction coefficient of the solution, the higher the user's comfort when using the solution, that is, the smaller the friction coefficient, the better. On the contrary, when the friction coefficient of the solution increases, the user's comfort in use will decrease and inconvenience. Examples 6-9 also tested the changes in the friction coefficient of each group of solutions under the conditions of their lubricating components and their concentration conditions, and used the model CETR UMT-2 lubricating fluid sold by Bruker in the test. The coefficient is the control group, and the friction coefficient of the control group is 0.0184. Please refer to Figures 1 to 4. Figure 1 is a graph showing the relationship between propylene glycol concentration and friction coefficient in Example 6 of the present invention, Figure 2 is a graph showing the relationship between glycerin concentration and friction coefficient in Example 7 of the present invention, and Figure 3 is Example 8 of the present invention The relationship between the concentration of hyaluronic acid and the coefficient of friction, and FIG. 4 is the relationship between the concentration of hydroxypropyl methylcellulose and the coefficient of friction of Example 9 of the present invention. Please refer to the results of Examples 6-9 and FIGS. 1 to 4 to understand the relationship between the concentration of the lubricating component and the friction coefficient of the solution under different conditions and its lubricating effect.

The conditions of Example 6 are compared to Table 3. The test results are shown in Figure 1. When the antimicrobial component "chlorine dioxide" is 1 ppm, the lubricating component "propylene glycol" has a concentration of 0.4-30 mg/ml , The friction coefficient of the solution is less than the friction coefficient of the control group 0.0184, so the results under the conditions of Example 6 show that when the lubricating component in the solution is polyol and/or its salt, the concentration is 0.4-30 mg/ml The polyol "Propylene Glycol" can form a solution with antimicrobial ability and lubricating effect with chlorine dioxide. As shown in Figure 1, as the concentration of propylene glycol increases from 0.4 mg/ml to 20 mg/ml, the friction coefficient of the solution reaches the lowest value of 0.0019. When the concentration of propylene glycol increases upward, the friction coefficient of the solution increases upward. In Example 6, when the concentration of the lubricating component in the solution is between 0.4-30 mg/ml, the solution has a good lubricating effect. When the concentration of the lubricating component is between 10-30 mg/ml, the solution has a better lubricating effect. .

The conditions of Example 7 are compared to Table 3. The test results are shown in Figure 2. When the antimicrobial component "chlorine dioxide" is 1 ppm, the lubricating component "glycerin" has a concentration of 0.4-30 mg/ml , The friction coefficient of the solution is less than the friction coefficient of the control group 0.0184, so the results under the conditions of Example 7 show that when the lubricating component in the solution is polyol and/or its salt, the concentration is 0.4-30 mg/ml The polyol "glycerin" can form a solution with antimicrobial ability and lubricating effect with chlorine dioxide. The results in Figure 2 show that as the concentration of glycerol increases from 0.4 mg/ml to 25 mg/ml, the friction coefficient of the solution reaches the lowest value of 0.0037. When the concentration of glycerin increases upward, the friction coefficient of the solution increases upward. In Example 7, when the concentration of the lubricating component in the solution is between 0.4-30 mg/ml, the solution has a good lubricating effect. When the concentration of the lubricating component is between 10-30 mg/ml, the solution has a better lubricating effect. .

The conditions of Example 8 are compared to Table 3. The test results are shown in Figure 3. When the antimicrobial component "chlorine dioxide" is 1 ppm, the lubricating component "Hyaluronic acid" has a concentration of 0.01-5 mg/ml The friction coefficient of is less than the friction coefficient of the control group 0.0184, so the results under the conditions of Example 8 show that when the lubricating component in the solution is glycosaminoglycan and/or its salt, the concentration is 0.01-5 mg/ml The glycosaminoglycan "Hyaluronic acid" can form a solution with antimicrobial ability and lubricating effect with chlorine dioxide. As shown in Figure 3, as the concentration of hyaluronic acid increased from 0.01 mg/ml to 1 mg/ml, the friction coefficient of the solution reached the lowest value of 0.0033. When the concentration of hyaluronic acid increases upwards, the friction coefficient of the solution increases upwards. In Example 8, when the concentration of the lubricating component in the solution is between 0.01-5 mg/ml, the solution has a good lubricating effect. When the concentration of the lubricating component is between 0.05-5 mg/ml, the solution has a better lubricating effect. .

The conditions of Example 9 are compared to Table 3. The test results are shown in Figure 4. When the antimicrobial component "chlorine dioxide" is 1 ppm, the lubricating component "hydroxypropyl methylcellulose" has a concentration of 0.24 The friction coefficient at -10 mg/ml is less than the friction coefficient of the control group 0.0184. Therefore, the results under the conditions of Example 9 show that when the lubricating component in the solution is cellulose mixed ether and/or its salt, the concentration is 0.24-10 mg/ml of cellulose mixed ether "Hydroxypropyl Methylcellulose" can form a solution with antimicrobial power and lubricating effect with chlorine dioxide. As shown in Figure 4, as the concentration of hydroxypropyl methylcellulose increases from 0.24 mg/ml to 5 mg/ml, the friction coefficient of the solution reaches the minimum value of 0.0020. When the concentration of hydroxypropyl methyl cellulose increases upwards, the friction coefficient of the solution increases upwards. In Example 9, when the concentration of the lubricating component in the solution is between 0.24-10 mg/ml, the solution has a good lubricating effect, and when the concentration of the lubricating component is between 0.24-10 mg/ml, the solution has a better lubricating effect .

According to the results of Examples 6-9, the solution provided by the present invention has both antimicrobial components and lubricating components, wherein the lubricating components are not limited to polyols and/or their salts, glycosaminoglycans and/or their salts Or cellulose mixed ether and/or its salt, and the solution of the present invention does not limit its use, for example, it can be used in contact lens maintenance solution or as a lubricating solution for sterile machines. In the embodiment of the present invention, since different types of lubricating components have different molecular sizes, they have different suitable addition concentrations. For example, lubricating ingredients with smaller molecules such as polyols and/or their salts can have a higher added concentration, and lubricating ingredients with larger molecules such as glycosaminoglycans and/or their salts or mixed ethers such as cellulose. And/or its salts have a lower concentration.

In summary, compared with the prior art, the technical effects of the solution with high antimicrobial ability and lubricating effect described in the embodiments of the present invention are described as follows.

In the prior art, it is difficult to combine the disinfection components of the contact lens solution with the lubricating solution. The reason is that the antimicrobial components and the lubricating components are difficult to be compatible, and the two will even cancel each other's effects, resulting in antimicrobial and lubricating The effect is discounted. In contrast, the solution with high antimicrobial ability and lubricating effect described in the embodiments of the present invention can include both antimicrobial ingredients and lubricating ingredients, and only needs a low concentration of antimicrobial ingredients to be effective. It is effective in multiple industries (such as contact lenses). , Mechanical appliances) are sufficiently competitive.

The present invention has been disclosed in preferred embodiments above, but those skilled in the art should understand that the above-mentioned embodiments are only used to describe the present invention and should not be construed as limiting the scope of the present invention. It should be noted that all changes and substitutions equivalent to the foregoing embodiments should be included in the scope of the present invention.

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Figure 1 is a graph showing the relationship between the concentration of propylene glycol and the coefficient of friction in Example 6 of the present invention.

Figure 2 is a graph showing the relationship between the glycerin concentration and the friction coefficient in Example 7 of the present invention.

Figure 3 is a graph showing the relationship between hyaluronic acid concentration and friction coefficient in Example 8 of the present invention.

Figure 4 is a graph showing the relationship between the concentration of hydroxypropyl methylcellulose and the coefficient of friction in Example 9 of the present invention.

Claims (10)

A solution with high antimicrobial ability and lubricating effect, comprising an antimicrobial component and a lubricating component, wherein the concentration of the antimicrobial component is 1-3000ppm, and the antimicrobial ability of the solution is: When the concentration of the antimicrobial component is at least 1 ppm, the solution can kill more than 90% of microorganisms when it contacts a target for at least 300 seconds; or when the concentration of the antimicrobial component is at least 10 ppm, the solution is exposed to a target. At least 10 seconds of the target, it can kill more than 90% of the microorganisms. The solution according to claim 1, wherein the microorganism is a bacterium, a fungus or a virus. The solution according to claim 1, wherein the concentration of the lubricating component is 0.01-30 milligrams per milliliter (mg/ml). A solution with high antimicrobial ability and lubricating effect composed of chlorine dioxide and lubricating components, wherein the concentration of the chlorine dioxide is 1-3000 ppm, and the concentration of the lubricating component is 0.01-30 mg/ml. The solution according to claim 3, wherein the lubricating component includes: polyols, salts of polyols, glycosaminoglycans, salts of glycosaminoglycans, cellulose mixed ethers, and salts of cellulose mixed ethers At least one of the classes. The solution according to claim 4, wherein when the lubricating component is a polyhydric alcohol and/or its salt, the concentration of the polyhydric alcohol and/or its salt is 0.4-30 mg/ml; When the ingredient is glycosaminoglycan and/or its salts, the concentration of the glycosaminoglycan and its salts is 0.01 to 5 mg/ml; and where the lubricating ingredient is cellulose mixed ether and/or its salts In the case of cellulose, the concentration of the cellulose mixed ether and its salts is 0.24-10 mg/ml. The solution according to claim 5, wherein when the lubricating component is a polyhydric alcohol and/or its salt, the concentration of the polyhydric alcohol and/or its salt is 10-30 mg/ml; In the case of glycosaminoglycan and/or its salt, the concentration of the glycosaminoglycan and/or its salt is 0.05-5 mg/ml; and when the lubricating component is cellulose mixed ether and/or its salt In the case of cellulose, the concentration of the cellulose mixed ether and/or its salts is 1.2-10 mg/ml. The solution according to one of claims 5 to 7, wherein the polyol is glycerin, propylene glycol, octanediol, ethylhexylglycerol, hexylene glycol, xylitol, polyethylene glycol, polypropylene glycol or Pentylene glycol. The solution according to one of claims 5 to 7, wherein the glycosaminoglycan is hyaluronic acid (HA), chondroitin sulfate (Chondroitin Sulfate, CS), dermatan sulfate (Dermatan Sulfate, DS), Keratan sulfate (KS), Heparan sulfate (HS) or Heparin (HP). The solution according to one of claims 5 to 7, wherein the cellulose mixed ether is methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose or Hydroxyethyl cellulose.

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