TW200917962A - Pyrazole compounds for controlling invertebrate pests - Google Patents

Abstract

The present invention relates to novel pyrazole compounds of the formulae I and II, to their salts and their N-oxides which can be used for combating or controlling invertebrate pests, in particular arthropod pests. The invention also relates to a method for controlling invertebrate pests by using these compounds. The present invention also relates to seed and to an agricultural and veterinary composition comprising said compounds. wherein A is a pyrazole radical of the formulae A1, A2 or A3 ♯ denotes the binding site to the remainder of formulae I or II; X1 is S, O or NR1a; X2 is OR2a, NR2bR2c, S(O)mR2d; X3 is a lone pair or oxygen; R1, R2 and R3 are, inter alia, hydrogen, and wherein R41, R42, R43, R51, R52, R53, R61, R62, R63, are as defined in claim 1.

Description

200917962 IX. INSTRUCTIONS: [Technical field to which the invention pertains] One invention relates to a novel n-sitting compound which can be used to resist or control invertebrate pests, particularly arthropod pests. The invention also relates to a method of controlling an invertebrate pest by using such compounds. The invention is also directed to seeds and agricultural and veterinary compositions comprising compounds such as 6H. [Prior Art] ..., spinal insects and especially arthropods and nematodes can destroy growing and harvested crops and invade wooden houses and commercial buildings, resulting in significant economic losses in food supply and property. Although a large number of insecticides are known, since target pests are resistant to such agents, there is a continuing need for new agents that are resistant to arthropod pests such as insects, spiders, and nematodes. Accordingly, it is an object of the present invention to provide compounds which exhibit excellent insecticidal activity and which exhibit a broad spectrum of activity against a number of different invertebrate pests, especially against difficult to control insects, spiders and nematodes. WO 2 003/106427 describes N-aryl decylamines of pyrazole carboxylic acids in which the pyrazole I ring has a 2-pyridyl group at the ortho position of the formamide group. The compounds mentioned therein can be used to combat invertebrate pests. WO 2004/046129 describes benzamidine compounds substituted with 2-(1-arylpyrazol-5-yl)carbonylamino groups, which are mentioned for their use against invertebrate pests.曰 Patent No. 2007-77106 describes N-aryl decylamine of 1-(3-hydropyridin-2-yl)-pyrazole-5-carboxylic acid, which is mentioned as being useful for combating invertebrate pests. 133661.doc 200917962 Chinese Patent No. 92?8 rtm ti ^ - No. described as an agrochemical bactericide and a true halogen agent for aromatic and heterozygous μ夂 [Summary] w than bitten formazan . The purpose of this is to provide and have 彳I _ _ &&& amp, have excellent aphid activity (especially insecticidal activity, and for many different I ridges & ..., vertebrate pests (especially for difficult Controlled insects, arachnids, and nematodes) exhibit broad-spectrum activity of compounds. It has been found that these purposes can be obtained from the following formula I and π compounds and their salts (especially 其. their primordial or veterinary In a first aspect, the invention relates to a method of controlling an invertebrate pest, the method comprising treating with an insecticidally effective amount of a compound of the formula (4)! pyrazole compound or a salt thereof or an N·oxide Pests, their food supply, their habitat or their breeding grounds, or plants, seeds, soils, areas, materials or environments in which they grow or grow pests, or materials, plants, seeds, soils that are intended to be protected from pest infestation or infestation , surface or space:

Α Al, A2 or A3 pyrazolyl

A1 A2

133661.doc 200917962 # indicates a binding site to the rest of formula I or II; X1 is s, Q or NR_la; X is OR2a, NR2bR2c, s(0)mR2d; X3 isphaned electron pair or oxygen; R1 is hydrogen , CN, (:]-(: 〇-alkyl, CVCw haloalkyl, C3_Ci〇, cycloalkyl, C3-C10-dentocycloalkyl, C3-C10-cycloalkylmethyl, c3-c10- Halogenated cycloalkylmethyl, C2_Cl (r alkenyl, c2_Cl〇_haloalkenyl, C2-C10-alkynyl, c3_c10-haloalkynyl, Cl-C4-extension-CN, 〇Ra, Cl_c4 - Stretching base_0Ra, c(Y)Rb, Ci_c4_alkylene-C(Y)Rb, C(Y)0Re, Cl_C4_alkylene group _c(Y)〇RC, S(〇)2Rd, NReRf , C1-C4-alkylene-NReRf, c(Y)NRgRh, CrC4-alkylene-C(Y)NRgRh, S(0)mNReRf, C(Y)NRiNReRf, phenyl, heteroaryl, phenyl -cvcvalkyl and heteroaryl_Cl_c4_, wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents Rx; Hydrogen, halogen, Cl_C4_alkyl, C--C4-haloalkyl, (:,-(:4-3⁄4 oxy, (VC4-haloalkoxy, Cl_c4_alkylthio, Ci_c4_haloalkylthio, CrC4- Alkyl Sulfhydryl, Ci_c4_haloalkylsulfinylene, q-C4-alkylsulfonyl, Ci_c4_haloalkylsulfonyl, c3-c6-cycloalkyl, C3-C6-iS cycloalkyl, C2_C4_ Dilute, c2_C4-haloalkenyl, C2-C4-alkynyl or Ci_c4_alkoxy; R3 is hydrogen, halogen, G-cu-alkyl, Ci_C4_haloalkyl, Ci_C4_alkoxy' CVC4 -haloalkoxy, Ci_c4_alkylthio, Ci_c4_halogen 133661.doc •9· 200917962 Sulphur-based, Cl-pyrene-based sulphate, Ci_C4_ 齿代院基亚罐醯基, c, 々烧基Xanthyl group, tooth-based alkyl group, acid group,

C3-c6-rings, c3_c6· _cycloalkyl, Q々 dilute, G ca alkenyl, C 2 —C 4 —block or Ci® alkoxy _Ci 々 基 ; ; ; ; ; ; ; ; ; ;

R 41 f R51 , R42 and R43 are selected from the group consisting of hydrogen, dentate, (3), nickname, phenyl group, ring group, c3m group methyl group, C2_Ci〇-alkenyl group, C2_ci. Block basis, the aliphatic or cyclic moiety of the last six groups described above may be unsubstituted, partially or completely "or may have 2 or 3 identical or different substituents V, 0Ra, SRa, c (Y) Rb, c (7) 〇 rc, S (9) #, NReRf, C (Y) NRgRh, stupid, phenyl _c 丨 基本 basic oxy-CVCV, 5-membered heteroaryl and heterocyclic The heterocyclic group and the aromatic ring of the last 5 groups may be unsubstituted or may have the same or different substituents Rx; a group of free radicals: hydrogen, halogen, (3), N〇2, C , °_院基, ring-form, c5-c10-ring dilute, c3_Cl.-cycloalkylmethyl, c2-Cl.-dilute, C2々.. alkynyl, wherein the last six one groups The aliphatic or cyclic moiety may be unsubstituted, may be partially moieved, or may have 1, 2 or 3 identical or different substituents.

Ry, 〇Ra, SRa, c(7)Rb, c(7)〇Re, s(9)2Rd, NReRf, C(Y) earn Rh, phenyl, phenyl, phenoxy 133661.doc •10- 200917962

R 52

a C4·alkyl group, a 5-membered heteroaryl group and a heterocyclic-cvc4-alkyl group, wherein the heterocyclic group and the aromatic ring of the last five groups described above may be unsubstituted or may have 1, 2, 3, 4 Or 5 identical or different substituents RX; • R53 is selected from the group consisting of hydrogen, dentate, cn, n〇2, CrC]. - alkyl, C3-Cl. - cycloalkyl, C5_C丨. - cycloalkenyl, c10-cycloalkylmethyl, C2_Cl. , base, c2_Ci. Alkynyl, wherein the aliphatic or cyclic moiety of the last six of the above groups may be unsubstituted, partially or fully dentated or may have 1, 2 or 3 identical or different substituents, 〇Ra, SRa, c(Y)Rb, c(7)〇RC, s(〇)2Rd, NReRf, c(7)NR£Rh, heterocyclic group, phenyl group, phenyl-Cl-c4-alkyl group, phenoxy-CrC4-alkyl group and heterocyclic ring _Ci_c4_alkyl wherein the heterocyclic group and the aromatic ring of the last five groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents rX; R63 is selected from the group consisting of Groups: hydrogen, N〇2, mouth <1〇-alkyl, C3-C1()-cycloalkyl, C5_Cl()-cycloalkenyl, CA. a cycloalkylmethyl group, a C2_C10-alkenyl group, a C2_C10-alkynyl group, wherein the aliphatic or cyclic moiety of the last six groups described above may be unsubstituted, partially or fully toothed or may have 1, 2 or 3 identical or different substituents Ry, ORa, SRa, C(Y)Rb, c(7)〇RC, s(〇)2Rd, NReRf, C(Y)NRgR, S(0)mNReRf, (^(Y^R' NReRf, heterocyclyl, phenyl, phenylalkyl, phenoxy*_C|_C4_alkyl and heterocyclic _C!-(V alkyl' wherein the last 5 groups of the heterocyclic group and the aromatic ring It may be unsubstituted or may have 丨, 2, 3, 4 or 5 identical or different substituents Rx; I33661.doc 200917962 R is selected from the group consisting of hydrogen, N〇2, Ci_c] 〇_alkyl , ^ c "cycloalkyl 'c" Cl.-cycloalkenyl, C3_Ci〇•cycloalkylmethyl, C2-C〗 〇-fluorenyl, C2_Cl〇_ fast radical, wherein the last _ group of aliphatic Or the cyclic moiety may be unsubstituted, may be partially or completely functionalized or may have 1, 2 or 3 identical or different substituents Ry, 〇Ra, SRa, C(Y)Rb, c(7)〇Re, s(〇 2Rd, NReRf, c(7) dish^, S(0)mNReRf, C(Y)NRiNReRf, phenyl, stupid CIA alkyl, benzene a — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — , 4 or 5 identical or different substituents Rx; Y system or S;

Rla is selected from the group consisting of hydrogen, CVGo-alkyl, CrCV haloalkyl, C3_C|〇-cycloalkyl, c3-Cl0-cycloalkylmethyl, c3_Ci0_halocycloalkyl, c2_c10-alkenyl, C2-C10 -i alkenyl, c2-c10-alkynyl, Cl_Cl〇-alkoxy-C1-C4-alkyl, 〇Ra, phenyl, heteroaryl, phenyl_cnc4_alkyl and heteroaryl-CfC: a 4-alkyl group, wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 substituents independently of each other selected from the group consisting of: _, cyanide Base, nitro, q-C4-alkyl, cvcv haloalkyl, cvcv alkoxy and Ci-C4-haloalkoxy; R2a is selected from the group consisting of CrCV alkyl, C--C4-haloalkyl, C3-C6 -cycloalkyl, C3-CV-cycloalkyl, c2_c4-alkenyl, c2-C4-_alkenyl, c2-c4-alkynyl, Cl_c4_alkoxy_Cl_c4-alkyl, phenyl, hetero芳133661.doc 12 200917962, phenyl-C^-C4-alkyl and heteroaryl_c _c4_alkyl, wherein the aromatic ring of the last four groups described above may be unsubstituted or may have an antimony, 2. 3, 4 or 5 substituents independently selected from the group consisting of halogen, cyano, nitro, Cl_C4_alkyl, C i_C4_haloalkyl, CVC4·alkoxy and (^-(:4-haloalkoxy; R2b, R2e are independently selected from hydrogen, Ci_C4_alkyl, Ci_c4_haloalkyl, C3-C6' alkyl, C3 -C6-halogenated cycloalkyl, c2-C4-thinyl, c2-c4-_alkenyl, c2-C4-blockyl, Cl_c4_alkoxy-Ci_c4_alkyl, C,-C4-alkylcarbonyl , Ci_c4_haloalkylcarbonyl, Ci_c4_alkylsulfonyl, C^C4-haloalkylsulfonyl, phenyl, phenylcarbonyl, phenylsulfonyl, heteroaryl, heteroarylcarbonyl, heteroarylsulfonate An anthracene, a styryl-CrC4-alkyl and a heteroaryl-Cl_c4-alkyl group, wherein the aromatic ring of the last 8 groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 each other Substituents independently selected from the group consisting of halogen, cyano, nitro, Cl_C4_alkyl, Ci_c4_ _alkyl, C-C4-alkoxy, and (^-(:4-haloalkoxy) Or R and R together with the nitrogen atom to which they are bonded form a 5- or 6-membered saturated or unsaturated heterocyclic ring' which may have another hetero atom selected from the group consisting of ruthenium, 5 and N as a ring member atom and wherein the heterocyclic ring may be Unsubstituted or can have 1, 2, 3, 4 or 5 separate from each other a substituent selected from the group consisting of halogen, cyano, nitro, CVCV alkyl, (VCV haloalkyl, Cl_Cr alkoxy, and haloalkoxy; R2d is selected from CVCV alkyl, CVCV haloalkyl, C3-C6-cycloalkyl, C3-c6- _cycloalkyl, C2_C4-alkenyl, C2_C4_haloalkenyl, 133661.doc -13- 200917962 c2 C4-blockyl, Cl_c4 Oxylenyl, phenyl, heteroaryl, phenyl-CrC4-alkyl and heteroaryl-Ci_C4_alkyl, wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2 , 3, 4 or 5 substituents independently of each other selected from the group consisting of halogen, cyano, nitro, Ci_c4_Hyun, Ci_c4_ _ 院, C^CV alkoxy and Cl_c4_haloalkoxy R, R, Rc are independently of each other selected from the group consisting of hydrogen, Ci_C4_alkyl, haloalkyl, c3-c6-cycloalkyl, c3_C6_cycloalkylmethyl, C3_C6_halocycloalkyl, C2-C4- Dilute, c2-c4-halogenated, C2-C4-fast, C|-C4-homolyl_Cl_c4-homo, phenyl, heteroaryl, phenyl-Ci_C4_alkyl and hetero Aryl-c"C4_alkyl, wherein the aromatic ring of the last four groups mentioned above is Unsubstituted or may have an anthracene, 2, 3, 4 or 5 substituents independently of each other selected from the group consisting of dentate, cyanonitro 'C1-C4-hospital, C!-C4-_ Derivatives, C1-C4-alkoxy and C^-Cr haloalkoxy;

Rd is selected from the group consisting of CrCV alkyl, CrCV haloalkyl, c3-c6-ring, C3-C6-cycloalkylindolyl, c3-c6-halocycloalkyl, c2-c4-diyl,

CrCc dentate, C2_C4-fast, C1-C4-homolyl-c]c, phenyl, heteroaryl, phenyl-CrCr alkyl and heteroaryl _c"

a Cc alkyl group, wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 substituents independently of each other selected from the group consisting of the following & , nitrate, base, c丨々, tiger base, cvc4-haloalkyl, CVC4-alkoxy and (^-(: 4-_ alkoxy; 1 133661.doc -14- 200917962

Re, Rf are independently of each other selected from the group consisting of hydrogen, Ci_c4_alkyl, C _C4_ _alkyl, q-cv cycloalkyl, C3_C0_cycloalkylmethyl, C3_C6_dental cycloalkyl, C2-C4- Dilute, c2-C4-equivalent alkenyl, c2_c4_block, CVC4-alkoxy; bake, Ci_C44 yl, C1_C4_haloalkylcarbonyl, Cl-C4_alkylsulfonyl, Ci_c4__ Alkenyl h group, phenyl, phenylcarbonyl, phenylsulfonyl, heteroaryl, heteroaryl, heteroaryl fluorenyl, phenyl Ace and heteroaryl-C^-C4- An alkyl group, wherein the aromatic ring in the last eight groups described above may be unsubstituted or may have i, 2, 3, 4 or 5 substituents independently of each other selected from the group consisting of dentate, cyano , nitro, cvc4-alkyl, Cl_c4_haloalkyl, Ci_c4ioxy and haloalkoxy; or

Rm% together with the nitrogen atom to which they are bonded form a 5- or 6-membered saturated or unsaturated heterocyclic ring which may have another hetero atom selected from fluorene as a ring member atom and wherein the heterocyclic ring may be unsubstituted or may have丨, 2, 3, * or 5 substituents independently of each other selected from the group consisting of halogen, cyano, decyl, Cl-C4-alkyl, Led alkyl, ^C4_houseoxy and (^-〇: 4-halogenated alkoxy; ..., the core is independently selected from the group consisting of hydrogen^-alkyl group, cyclyl, c3-c6-cycloalkyl, c3-c6_ii cycloalkyl, C2_C4 _ dilute, c2-c4-periodic, C2_C4_block, Ci_c4_morphyloxyalkyl, phenyl, heteroaryl, phenyl-Ci_C4_alkyl and heteroaryl... wide Cc alkyl, The aromatic ring of the above four last groups may be taken or may have 1, 2, 3, 4 or 5 independently of each other selected from the following 133661.doc •15- 200917962 halogen 'cyano, nitro The Ci_C4_alkane Cl-cv alkoxy group and the <^-0:4-haloalkoxy group are selected from the group consisting of: gas, Ci 々 院, d々 (4), (4)-ring, and C3_C6. Methyl, cycloalkyl, CVCV alkenyl, c2_C4 • by alkenyl, C2_C41 a compound, a cvcv-oxyl-cvc4-alkyl group, a phenyl group and a phenyl-alkyl group, wherein the benzene ring in the last two groups may be unsubstituted or may be V, have 1 2 3 4 or 5 independent of each other. a substituent selected from the group consisting of a cyano group, a cyano group, a nitro group, a Ci_C4 group, a (V oxiranyl group, a cvcv alkoxy group, and a koji alkoxy group); Group: halogen, cyano, nitro, Ci_c4_alkyl, CVC4-haloalkyl, C|_C4_alkoxy, Ci_c4_haloalkoxy, thio, Ci_c4_haloalkylthio, Ci_c4_alkyl sulfhydryl , CrC4-haloalkylsulfinyl, Cl_c4_alkylsulfonate, a substituent group of the group, CVCV haloalkyl; R (

Rx Brewing, Ci-CV^alkylsulfonyl, Cl-C4-alkylcarbonyl, CV cv haloalkylcarbonyl, c3_c6_cycloalkyl' c3_c6_halocycloalkyl, C2-C4-ene a group, a C2-C4-_alkenyl group, a C2-C4-alkynyl group, and a C,-C4-alkoxy group-C--C4-based group;

Ry is independently selected from the group consisting of CrCc alkyl, CrCcii alkyl, C-C4-alkoxy, Ci-C4. halo-oxyloxy, C1-C4-thiol, Ci-C4-halogen Base, CVC4-alkyl sulphide, cvCri 代基基基醯, CVC4-垸基醯 base, C1-C4-haloalkyl thiol, C3-C6-cycloalkyl, C3- C6-halocyclohexyl, CrCr dilute, 13366l.doc -16- 200917962 c2-c4-haloalkenyl, ^^2-c4-alkynyl, Ci_C4_alkoxy-Ci_C4_ alkyl and CVC^- Alkylcarbonyl. In the second aspect of the ancient t, the present invention provides a method for controlling an invertebrate pest, and the effective amount of the formula (1) is called 嗤 compound or its salt or secret substance or the right δ is small. , 3~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Or plants in their breeding grounds, in pots, or in plants that grow or grow pests, plant propagation materials (such as seeds), in soil, areas, materials, or environments, or to prevent pests from invading or invading (ι Λ a material, a plant, a plant propagation material (such as a seed), a soil, a surface or a space. In a third aspect, the invention provides a method for infesting and protecting a plant from which an invertebrate pest infests The method comprises the use of a compound of formula I or II or an agriculturally acceptable salt or physiochemical seed thereof.

The seed of the invention comprises at least one of the formula 1 or II and/or an agriculturally acceptable salt or an antioxidant thereof. Providing a method of treating or protecting an animal against parasite infestation or sensation of wood - comprising an effective amount of an animal and a parasiticidal compound of formula I or II as defined above or a veterinary acceptable salt thereof Or N_oxidation (four) touch. Contacting an animal with a compound 1 or hydrazine, a salt thereof or a veterinary composition of the invention means administering or administering it to an animal. So far, it has not been elaborated! Other compounds and their salts, but the compound of formula I, which has the following conditions, has a formula of Α2, Χι system 〇, Rl, r2, r3, r42 and ^ are each of the wind' and R53 is 2-phenylidene, 2_经5_fylphenyl, 2_carbyl-I33661.doc 200917962 5-ethylphenyl, 2-hydroxy-5-indolyl, 2-hydroxy-45-dimethylphenyl, 2-hydroxy- 3,4-Dimethylphenyl or 2-hydroxyl-3,5-dimethylphenyl, -A has the formula A3, X1 is hydrazine, and r2, r3, r43 and r63 are each hydrogen, and R53 is benzene. Base, 4-fluorophenyl, 4-methoxyphenyl, 4-bromophenyl, 4-chlorophenyl, 4-nonylphenyl, 4-ethoxyphenyl, 2,4-dimethyl Phenyl, 2-hydroxyphenyl, 2-hydroxy-5-methylphenyl, 2-hydroxy-% ethylphenyl, 2-hydroxy-5-indolyl, 2-hydroxy- 4,5-dimethyl Phenylphenyl, 2-hydroxy-3,4-dimethylphenyl or 2-hydroxy-3,5-dimethylphenyl, _X Ο, R'R and R3 are each gas and octagonal W benzene Methyl(mono)-nitropyrazol-5-yl, 丨-methylpyrazole-5, 丨_methyl_4_apyrazol-5-yl, 1-ethyl-4-bromopyrazole-3 -yl, i_ethyl_3_mercaptopyrazole-4-yl, 1-methyl-3-trifluoromethylpyrazole-4-yl, 丨_phenyl_5_phenyl Merylaminopyrazol-4-yl, 1-(4-phenylphenyl)-3-phenylaminocarbonyl-5-methylpyrazole-4-yl, 1-phenyl-5-[(4-indole) Phenyl)carbonyl]aminopyrazole-4-yl, 4-iodopyrazol-3-yl, 1-methylpyrazol-3-yl, 5-a-1-1-methylpyrazole-3-yl, 5 -Nitrobazole _3_ group, ι·(4_chlorophenyl)_5_trifluoromethyl 11 azole -4-yl, 1-phenyl _3_ porphin-2-yl " ratio &quot Sodium-4-yl, 1-phenyl-3,5-dimethylpyrazol-4-yl, 4-bromo-5-nitropyrazol-3-yl or 5-cyclopropyl-indole-( Ig,ι_dioxotetrahydrothiophene-3-yl)-!H-pyrazol-3-yl; and the following compounds are excluded: -1-(4-chlorobenzyl)-5-trifluoromethyl-ratio.曱-4-曱酸吼σ定-3-ylguanamine, 133661.doc -18- 200917962 -丨-phenyl-3-thiophene-2-yl-1H-pyrazole-4-furoic acid pyridine-3- Baseline amine, 3'5-methyl-1-phenyl-s--4-carboxylic acid bite-3-ylamine. Thus, the present invention also encompasses novel pyrazole compounds of the formulae I and II and salts thereof, in particular agriculturally or veterinary acceptable salts thereof, and their cerium-oxides. Another object of the invention is an agricultural composition comprising at least one novel Formula I or II as defined above. ratio. The compound and/or its agriculturally acceptable salt or cerium-oxide and at least one liquid or solid carrier are employed. Another object of the invention is a veterinary composition comprising at least one novel pyrazole compound of the formula I or II as defined above and/or a veterinary acceptable salt or cerium-oxide thereof and at least one veterinary Acceptable liquid or solid carrier. The invention further relates to plant propagation material, such as seeds, comprising at least one compound of formula I or II as defined herein. The invention further relates to the use of a compound of formula 1 or U as defined herein for controlling an invertebrate pest. [Examples] In the compound of formula I or II, it is in the eight or. Substituents on the pyridyl ring may contain one or more chiral centers. In this case, the terminal substituents, the formula may exist in different enantiomeric or diastereomeric forms. In the case of the formula, the 'compounds' may also be present in the cis- or trans-isomer form with reference to the N=c axis. The present invention relates to each possible stereoisomer of the formula 丨 or ^ compound, ie, With respect to mono-enantiomers or diastereomers and mixtures thereof. The compounds of formula I or II may be amorphous or may exist - or a plurality of different crystalline states 133661.doc -19- 200917962 (polymorph), It may have different macroscopic properties such as stability or exhibit different biological properties such as activity. The present invention includes a mixture of amorphous and crystalline or π compounds, compounds ^ or II, and a mixture of crystals, and Crystalline or crystalline salt. The salt of formula I or hydrazine compound is preferably an agriculturally and veterinary acceptable salt. It can be formed by conventional methods, for example, if the compound of formula I has a basic B group b The compound is formed by reacting the acid with the anion, or by reacting a compound of formula I or hydrazine with a suitable base. The agriculturally acceptable salts of compounds I and II specifically cover the salts of such cations or their acids. Acid plus The salt's respective cations and anions have no adverse effect on the insecticidal action of the compound I or II. Therefore, it is suitable for the specific cation and the ancient metal test (sodium and oblique preferred) ion soil test metal (about, magnesium and strontium are preferred). An ion, a transition metal (manganese, copper, zinc, and iron) ion, and an ammonium ion, which may have one to four C1 alkyl substituents and/or a phenyl or benzyl substituent, if desired. Isopropylammonium, tetramethylammonium tetrabutylammonium, triterpene basal acid is preferred) and scaly ions, sparse ions (three ((VCV filament) is preferred) and cerium oxide ions (three (C) -C4·alkyl) ruthenium oxide is preferred. The anion of the acid addition salt is mainly chloride ion, desert ion, gas ion, hydrogen sulfate ion, sulfate ion H hydrogen ion, acid hydrogen ion, phosphoric acid Root ion, nitrate ion, hydrogencarbonate ion, carbonate ion, hexafluoride ion, hexahydrate acid ion, benzoate ion and CrC4-alkanoic acid (preferably citrate, acetate, An anion of a two acid salt and a butyrate) which can be made by formula (4) Formed by reacting with an acid of the corresponding anion 133661.doc -20- 200917962 (preferably hydrochloric acid, hydrobromic acid, sulfuric acid, acid or nitric acid). Veterinarily acceptable salts of the compound of formula (I) are especially encompassed by the industry. Salts or acid addition salts of such cations which are known or accepted for the formation of veterinary salts. Suitable acid addition salts (for example formed from compounds of formula I or II containing a basic nitrogen atom such as an amine group) Including salts with inorganic acids, such as hydrochlorides, sulfates, phosphates, and nitrates; and salts of organic acids, such as acetic acid, maleic acid (eg, maleate or dibasic acid salt) a salt of dimaleic acid, fumaric acid (such as a monobasic acid salt or a dibasic acid salt of fumaric acid), difumaric acid, decane sulfenic acid, methanesulfonic acid, and succinic acid. The term oxide" includes any compound of the formula' having, in addition to the pyridinium nitrogen having a portion of χ3, having at least one disordered atom oxidized to the cerium oxide moiety. Covering insects, spiders and nematodes

Or plant propagation material at the time of transplantation or here. Prophylactic treatment of plant protection compounds previously may be used herein. The term "invertebrate pests" encompasses animal populations that invade plants thereby causing damage and ectoparasites, which can invade Knots I3366I.doc -21 200917962 The term "cultivating plants" as used herein, includes plants that have been altered by propagation, mutagenesis or genetic engineering. Genetically modified plants are plants whose genetic material has been altered by the use of recombinant DNA techniques which are not obtainable by cross-breeding, mutation or natural recombination in the natural environment. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant in order to modify certain characteristics of the plant. Such genetic modifications also include, but are not limited to, proteins implemented by, for example, glycosylation or polymer addition (eg, prenylation, acetamylation or farnesylation or PEG moieties) - or polypeptide) dry-to-translational modification of the polymer (eg as disclosed in the literature below: Biotechn〇1

Prog. July 7/8, 2001; 17(4): 72〇-8., Pr〇tein (iv) Des Sel· 2004 6 A; l7(l): 57-66, Nat, Pr〇t〇C.2007; 2(5) :1225- 35., Curr. 〇pin. Chem. Biol. October 2006; 10(5): 487_91 Epub August 28, 2006 Bio, Biomaterials. March 2001; 22(5)· 405-17, BioconjugChem. January-February 2005; 16(1): 113-21). The term "cultivated plants" as used herein also includes plants which have been rendered tolerant to the application of a particular class of herbicides by conventional methods of breeding or genetic engineering. The herbicides are, for example, hydroxy-phenylpyruvate Oxygenase (HPPD) inhibitor, acetaminolate synthase (alS) inhibitor, for example, urinary urea (see, for example, U.S. Patent No. 6,222,100, WO 01/82685,

WO 00/26390, WO 97/41218, WO 98/02526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/14357, WO 03/13225, WO 03/14356, WO 04/16073) Or imidazoline _ (see, for example, U.S. Patent No. 6,222,100, WO 01/82685, WO 00/26390, WO 97/41218, WO 98/02526, WO 98/02527, 133661.doc • 22· 200917962

WO 04/106529, WO 05/20673, WO 03/14357, WO 03/13225, WO 03/143 56, WO 04/16073); enol c-oxalic acid-3-phosphate synthase (Epsps) inhibitor For example, glyphosate (see, for example, WO 92/00377); glutamine-synthase (GS) inhibitors, such as glufosinate (see, for example, European Patent EP-A- 0242236, EP-A-242246) or oxynil herbicide. The tolerance of several cultivated plants to herbicides has been conferred by conventional breeding (mutagenization) methods such as Clearfield® Brassica (Can〇la) to imidalin (eg, imazamox) Tolerance. Genetic engineering methods have been used to confer tolerance to herbicides (eg, soybean, cotton, corn, sugar beet, and canola) to herbicides (eg, glyphosate and glufosinate), some of which are commercially available under the trade name RoundupReady® ( Glyphosate) and LibertyLink® (glyphosate) are commercially available. The term "cultivated plants" as used herein additionally includes plants which are capable of synthesizing the following products by using recombinant DN a technology: one or more insecticidal proteins, in particular from the bacterium Bacillus, specifically from Bacillus thuringiensis Of (bacillus thuringiensis), such as a-endotoxin, such as CrylA (b), CrylA (c), CrylF, CryIF (a2), CryllA (b),

CrylllA, CrylllB (bl) or Cry9c; plant insecticidal protein (VIp), such as VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins of bacterial nematodes such as Photorhabdus or Xenorhabdus ); toxins produced by animals, such as scorpion toxins, your spider toxins, wasp toxins, or other insect-specific neurotoxins; toxins produced by fungi such as Streptomycete toxins, plant lectins, 133661.doc •23 - 200917962 such as phloem or barley lectin; lectin; $ white enzyme inhibitor, such as trypsin inhibitor, serine protease inhibitor, statin (_'), semi-proline protease inhibitor or papaya Protease inhibitor; ribosome inactivating protein (RIP), such as urinary toxin, corn _RIp, abrin, loofah, saporin or lycopene (bry〇din); steroid metabolism enzymes, for example 3-hydroxysteroid oxidase, ecdysone_1〇1>_glycosyl-transferase, cholesterol oxidase, sputum hormone inhibitor or Hmg-CoA-reductase; ion channel blocker' such as steel or clever Agents harness lag; juvenile hormone can be an enzyme, diuretic hormone receptors (heiic〇kinin receptor); stilbene synthase, bibenzylyl synthase, chitinases or glucanases. In the context of the present invention, such insecticidal proteins or toxins are also to be expressly understood to be protoxins, hybrid proteins, truncated proteins or other modified proteins. Hybrid proteins are characterized by a new combination of protein domains (see, for example, w〇 〇2/〇157〇1). Other examples of such toxins or genetically modified plants capable of synthesizing such toxins are disclosed, for example, in

European Patent No. EP-A 374 753, WO 93/007278, WO

95/34656, European Patent No. EP_A 427 529, European Patent No. Ep_A 45 1 878, WO 03/01 881 0 and WO 03/052073. Methods of producing such genetically modified plants are generally known to those skilled in the art and are described, for example, in the above publication. The plants contained in genetically modified plants can protect plants that produce such proteins against pests from certain arthropod insect taxa, especially against aphids (coleoptera, flies (Diptera) )), and butterflies and moths (Lepidoptera) and target plant parasitic nematodes (Nematoda). 13366 丨.doc -24- 200917962 Also includes the use of recombinant DNA technology

As used herein, the term "cultivating plants synthesize one or more LV & i to Phytophthora infestans derived from the wild potato (Solanum buib〇castanum) resistance gene) or lysozyme (for example, can synthesize A cultivar of horse mash that has an enhanced resistance to a bacterium such as Erwinia amyi_ra. The method of producing such a modified plant is generally known to those skilled in the art and is described in (for example) in the publication mentioned above. The term, cultivated plant, as used herein, additionally includes a plant which, by means of recombinant DNA technology, can synthesize one or more proteins to increase the productivity of such plants (eg biomass production, grain yield, meal content, Oil content or protein content), tolerance to drought, salinity or other growth limiting environmental factors, or tolerance to pests and fungal, bacterial or viral pathogens. The term "cultivating plants" as used herein additionally includes plants which, by using recombinant DNA techniques, contain altered amounts of inclusions or new inclusions to specifically modify human or animal nutrition, for example, to produce long chains that promote health. Oil crops of omega-3 fatty acids or unsaturated omega-9 fatty acids (eg Nexera® canola). The term "cultivating plants" as used herein, additionally includes plants which, by using recombinant DNA techniques, contain altered amounts of contained or new contents 133661.doc -25-200917962 to specifically improve the production of raw materials, for example A potato (eg, Amflora® potato) that produces an increased amount of branched powder. The statement 'is the organic part mentioned in Li Yiyi _ and the term halogen phase-- is the collective name of each group member listed earlier. The prefix 匕/^ indicates in each case the number of possible carbon atoms in the group. The term dentate in each case means fluorine 'bromo, gas or iodine, especially chaotic, gas or desert. And the alkyl moiety used in the alkoxyalkyl, alkylamino, dialkylamino, alkylcarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl groups" The alkyl group means, in each case, a straight-chain or branched alkyl group having from 1 to 1 carbon atoms, often having from 1 to 6 carbon atoms, preferably from 1 to 4 carbon atoms. Examples of alkyl groups are methyl, ethyl, n-propyl, isopropyl, n-butyl, 2-butyl, isobutyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methyl Butyl, 3-nonylbutyl, 2,2-dimercaptopropyl, 1-ethylpropyl, n-hexyl, hydrazine, dimethyl propyl, hydrazine, 2 dimethyl propyl hydrazine Pentyl, 2-mercaptopentyl, 3-methylpentyl, 4-methylpentyl, I1. dimethylbutyl, 1,2-dimethylbutyl, 1,3-didecyl Butyl, 2,2-dimercaptobutyl, 2,3-dimethylbutyl, 3,3-didecylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1, hydrazine , 2-trimethylpropyl, hydrazine, 2,2-trimethylpropyl, 1-ethyl-1-mercaptopropyl, 1-ethyl-2-methylpropyl, n-heptyl, ^ Methylhexyl, 2-methylhexyl, 3-methylhexyl, 4-mercaptohexyl, 5-methylhexyl, 1-ethylpentyl, 2-ethylpentyl, 3-ethylindenyl, hydrazine _propylpentyl, n-octyl, 丨-mercaptooctyl, 2-fluorenylheptyl, 丨_ethylhexyl, 2-ethylhexyl, 12-dimethylhexyl, propylpentyl and 2 Kee 133661.doc -26- 200917962 base. The term "haloalkyl" as used herein and in the alkylene moiety of haloalkylthio and haloalkylsulfonyl, in each case denotes a straight or branched alkyl group, which typically has from 1 to 10 One carbon atom, often having from 丨 to 6 carbon atoms, and wherein the hydrogen atom of this group is partially or completely replaced by a dentate atom. The haloalkyl moiety is preferably selected from the group consisting of C]-C4__alkyl, more preferably from C2 halo, especially from C i -C: 2-fluoroalkyl, such as fluoromethyl, difluoromethyl 'Trifluoromethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, heptafluoroisopropyl and And so on. The term "alkoxy" as used herein, in each case, denotes a straight or branched alkyl group which is bonded via an oxygen atom and which typically has from one to one carbon atom, often from 1 to 6 carbons. The atom preferably has from 丨 to 4 carbon atoms. Examples of alkoxy groups are methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, 2-butoxy, isobutoxy, tert-butoxy, pentyloxy, "Gytyloxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, bethylpropoxy, hexyloxy, u-dimethylpropoxy With dimethylpropoxy, 1-methylpentyloxy, 2-methylpentyloxy, 3-methylpentyloxy, 4-methylpentyloxy, u•dimethylbutoxy, Dimethylbutoxy 1,3 methylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxyethyl Butoxy, 2-ethylbutoxy, U,2-trimethylpropoxy, Hi trimethylpropoxy, bethyl + methylpropoxy, 1-ethyl 2 -methylpropoxy Base n-heptyloxy, benzyl hexyloxy, 2-methylhexyloxy, 3-methylhexyloxy, phenethyl hexyloxy, 5· 133661.doc -27- 200917962 hexyloxy, 1 -ethylpentyloxy, 2-ethylpentyloxy, 3-ethylpentyloxy' 1-propylpentyloxy, n-octyloxy, 1-decyloctyloxy, 2-methylheptyloxy I-ethylhexyl, 2-ethylhexyl Group, iota, 2- dimethyl-hexyloxy group, 1-propyl and 2-propyl-pentyloxy group, pentyloxy group. The term "the alkoxy group" as used herein, in each case, denotes a straight-chain or branched alkoxy group having from 10 to 10 carbon atoms, often having from 丨 to 6 carbon atoms, preferably having丨 to 4 carbon atoms, and wherein the hydrogen atom of this group is partially or completely replaced by a hydroxyl atom, especially by a gas atom. Preferably, the oxy moiety of the dentate includes a Cl 々 代 代 ethoxy group, especially a Ci_C2 _ gas, such as fluoromethoxy, dimethoxy, trimethoxy, _ gas ethoxy, 2 · fluoroethoxy, 2, 2 • difluoroethoxy, such as .trifluoroethoxy, fluoroethoxy, 2, 2, 2 _ _ ethoxy, 2 , 2· 2 gas ^ • gas ethyl lactyl, 2, 2, 2-trisethoxy, pentafluoroethoxy and the like. The term "cycloalkyl" used in the 3 C!0 cycloalkyl-methyl cycloalkyl moiety means, in each case, a mono- or bicyclic cycloaliphatic group, usually W C atoms or 3 Up to 6. Atoms such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptin, % octyl, bicyclo [2.1.1] hexamethylene, monoheptyl, bicyclo [2.2 · Πheptyl, and bicyclo [2.2.2] octyl 2 and "cyclohexyl-methyl" in the southern ring of the ring-based part of the 6-hydroxy-alkyl group, in each group, It is generally and ancient, and the white under the moon indicates that the mono- or bicyclic ring aliphatics have a total of 3 to 1 。. An atom or 3 to 6 C atoms, at least one of the deniers (eg, !, 2, 3, 〇r ding /, Τ main _ substitution. Examples are... A: replaced by (d) 'especially by chaotic % propyl, 1, 2 -, 2,2- and 2,3-two 13366I.doc •28- 200917962 gas king propyl, 122 two preparation τ class τιο $ ,, difluoro% propyl, 2,2,3,3-tetrafluoro Cyclopropyl, 1- and -: 3⁄4 propyl, hydrazine, 2_, 2, 2_ and 2,3_di-cyclopropyl propyl", 2, trichlorocyclocarbonate 22, 223, 2, 3, 3~ Tetrachlorocyclopropyl, 1-, 2- and 3-Dencyclopentyl, 1,2_, 2j2 2'3_ '3'3_, 3,4·, 2,5·II Icyclopentyl, 1~, 2_ and 3-cyclopentyl, 1,2-, 2,2-, 2 3u , , 3,3_, 3,4-, 2,5-dichlorocyclopentyl and the like. The term '' is used herein. "Thinyl" means, in each case, a monounsaturated hydrocarbon group typically having 2 to 10 (eg 2, 3, 4, 5 a ^ , , 6, 7, or 8) C atoms, such as ethylene, dilute Propyl (2-propylene small base), propylene small base, 2-propylene -2-yl, methallyl (2-methylpropenene + base), butyl butyl group, 3 · Dingzhi-Buji, 2-pentene+yl, 3_戍稀·卜基, 4_戊妇-卜基, 卜 methylbut-2- -1·基, 2_r, 1 & 2 ethylpropan-2-ene_ι_yl, and the like. The term "fried" is used herein to mean "large beta", and in the case of the parent species, it usually has 2 to 1 0 (eg 2, 3, 4, 5, ft, 7 hoppers, or 8) monounsaturated hydrocarbon groups of C atoms, such as ethynyl, propargyl (2-propyne-1-yl), 1 -propyn-1-yl, 1-mercaptopropan-2-yn-1-yl), 2-butyne-indenyl, 3_a),yn-1-yl, I.pentyne-i, 3-pentyne-1 -yl, 4-pentyne-1 yl, i _methyl 丞 i T T-but-2-yn-1-yl, 1-ethylpropan-2-cyclo-1-yl and And the like. The term "(:丨-匕-alkane rp 4 milyl-Cl~c4-alkyl, referred to as c _c4_alkyl', wherein one carbon atom has an upper r ^β Indole alkoxy. Examples are ch2- och3, ch2-oc2h5, n-propoxymethyl, cH2 〇cH(cH3)2, n-butoxymethyl, (1-methylpropoxy)methyl , (2_methylpropoxy)methyl, CH2-〇C(CH3)3, 2-(methoxy)ethyl, 2-(ethoxy)ethyl, 2 (n-propoxy)ethyl , 2·(1•methylethoxy)ethyl, 2_(n-butoxy)ethyl I33661.doc -2 9- 200917962, 2-(1-methylpropoxy)ethyl, 2-(2-methylpropoxy)ethyl, 2 (1,1-dimethylethoxy)ethyl, 2_( Methoxy)propyl, 2-(ethoxy)propyl, 2-(n-propoxy)propyl, 2-(1-methylethoxy)propyl, 2-(n-butoxy)propyl, 2-(1-methylpropoxy)propyl, 2-(2-methylpropoxy)propyl, 2-(1,1-dimethylethoxy)propyl, 3-(methoxy) Propyl, 3-(ethoxy)propyl, 3-(n-propoxy)propyl, 3-(1-decylethoxy)propyl, % r \ (n-butoxy)propyl, 3- (1-mercaptopropoxy)propyl, 3-(2-methylpropoxy)propyl, 3·(1,^methylethoxy)propyl, 2-(methoxy)butyl, 2-(Ethoxy)butyl, 2-(n-propoxy)butyl, 2-(1-decylethoxy)butyl, 2-(n-butoxy)butyl, 2-(1-methyl) Propoxy)butyl, 2·(2_^'methylpropoxy)butyl, 2-(1,1-didecylethoxy)butyl, 3(methoxy)butyl, 3 -(ethoxy)butyl, 3-(n-propoxy)butyl, 3-(1-decylethoxy)butyl, 3-(n-butoxy)butyl, 3-(1•methyl C Oxy)butyl, % (2-mercaptopropoxy)butyl, 3-(anthracene-diylethoxy)butyl, 4-(methoxy)butyl, 4-(ethoxy) Butyl, 4-(n-propoxy)butyl, methylethyloxy)butyl, 4-(n-butoxy)butyl, benzyl, 4-(2-mercaptopropoxy)butyl, 4 -(1,1_ and so on. 4-(Bypropylpropoxy)butyldinylethoxy)butyl and the term "alkylthio" (alkylthio:alkyl_s_) as used herein means straight-chain or branched-chain saturated alkane A group having from 1 to 1 carbon atoms, preferably having from 丄 to ^ carbon atoms (=C -C4-alkylthio) (as described above), which is bonded via a sulfur atom. The term "haloalkylthio" as used herein, refers to an alkylthio group as defined above, wherein the hydrogen atom is partially or partially replaced by gas, gas, indifference and/or substitution. 133661.doc -30- 200917962 The term "alkyl" is used herein. Sulfhydryl" (alkyl thiopurinyl: Ci_C6_alkyl-S(0)-) means a straight or branched saturated alkyl group (as described above) having from 1 to 10 carbon atoms, It preferably has from 1 to 4 carbon atoms (=C|-C4_alkyl hydrazone) and is bonded via a sulfur atom of a sulfinyl group at any position in the alkyl group. The term "haloalkyl" is used herein. Sulfoinyl" refers to the above alkylsulfinyl group in which the hydrogen atom is partially or completely substituted with fluorine, gas, bromine and/or iodine. The term "alkylsulfonyl," (alkyl s(=0)2_), as used herein, refers to a straight or branched saturated alkyl group having from 10 to 10 carbon atoms, preferably from 4 to 4 carbon atoms. a carbon atom hq-C4-alkylsulfonyl) (as described above) which is bonded at any position in the alkyl group via a sulfur atom of a sulfonyl group. The term "haloalkylsulfonyl" Refers to the above alkylsulfonyl group, wherein the hydrogen atom is partially or completely substituted by fluorine, chlorine, indifference and/or angstrom. V. The term "heterocyclyl" generally includes a 5-, 6-, 7- or 8-membered monoheterocyclic group. And 8 to 10 membered bicyclic heterocyclic groups, mono- and: ring groups may be saturated, unsaturated or aromatic (=heteroaryl). Mono- and bicyclic heterocyclic groups usually contain], 2 3 or 4 heteroatoms selected from N, oxime and 8 as ring members. The term "heteroaryl" includes a monocyclic 5- or 6-membered heteroaromatic group containing 1: ':3 or 4 Heteroatoms from N, 〇 and 8 serve as ring members. Examples of the beixiangfang group include pyridyl (ie, 2, %, or 4-pyridine^, broadly based (ie, 2-, 4 or 5, kibazine, 哒 (ie 3- Qin) a thiol group (ie, 2 or a sylylene group), a sulphonyl group (ie, 2 or 3+ groups). 5 um. Sit, different (four) base (ie 3 - _ or 5 _ ^ base), (4) base (ie 2 · 133661 .doc 200917962, 3- or 5_ (four) base), iso-salt base (ie 3...4_ Or 5_iso. Sesinyl)"Bizozolyl (ie 1-, 3-, 4- or 5-anthracene. Sodium), Sodium sulphate (ie Bu 2_, Heart or 5 mercapto), 喔二嗤 base (such as 孓 or ^^ (4) noise two Junji ^ or / 〇, 2, 3_ ° 恶二° sit) base, 3_ or 5_(1,2,4-° dioxin) base, 2- or 5 - (1,3,4·thiadi. sit) base), thiophene (for example, 2_ or 5_(1,3,4_ 唆 唆) base, 5-(1,2,3-嗟) (2) base, 3_ or 5_(1,2,4_thiadisyl), three examples (four)... grab or buy ^^^^^^^^^^^^^^^^^^ Siwaji (9) This or scratching the term "heteroaryl" also includes 8 to 1 member of the bicyclic heteroaromatic group q package 31, 2 or 3 A hetero atom selected from Ν'〇Β as a ring member, /5 or 6-shell heteroaromatic ring with a benzene ring or with a 5 or 6-membered heteroaromatic group.: Ben: or with 5 or 6 members The heteroaromatic group is slightly combined with the 5_ class and "this Kaifu Nanji, Ben Kai sing sing... 嗓 嗓 1 azole 2 open! Wow, stupid and terrible base, benzo y. Stupid (4): soil, this oxazinyl, 啥琳基, iso- 啥 基 ... 吟 ... ... ... ... ... 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 ' 诸如 人 人 及 及 及 及 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合 合Examples of the unsaturated heterocyclic ring include a saturated or unsaturated non-aromatic heterocyclic ring 'e.g., π, sirhas, w, fluorenyl, π, oxazolidine, imidazolinyl, 0, hydrogenfuranyl, -H. , tetrakisyl, sulphur-based di-amyl, U3_dioxolanyl, m-cyclohexane, di-oxygen, thiophene, thiophene, sulphate, porphyrin, isoxazole嗾I ^ ° sit on the base, ° plug. sit on the base, different scent Olivin塞 σ σ 定 133661.doc -32- 200917962 Isothiazolidinyl, thioxanthene, hexahydropyridyl, hexahydropyrazinyl, pyranyl, dihydropyranyl, tetrahydropyran And hydrazine, 4-dioxoalkyl, thiopyranyl, dihydrothiopyranyl, tetrahydrothiopyranyl, morpholinyl, thiazinyl and the like. Also contains 1 or 2 carbonyl groups as ring members. Examples of the ring include pyrrolidin-2-indenyl, pyrrolidine-2,5-dione, mezolidine-2-keto, cherazazole-2-one, oroxazolidine-2-yl and And so on. The terms "phenyl-cvc4) and "phenoxy-Ci_C4_alkyl" mean phenyl or phenoxy, respectively, via Cl_C4_alkyl (especially fluorenyl (=heteroarylmethyl)) Bonded to the rest of the molecule, examples include a benzyl group, anthranilyl, 2-phenethyl, 2-phenoxyethyl, etc. The term "heterocycle-CVCV alkyl" ", heteroaryl_ Ci_C4_alkyl group" respectively refers to a hetero- or heteroaryl group as defined above, which is bonded to the molecule via a Ci_Cc alkyl group (especially methyl (hetero = heterocyclylmethyl or heteroarylmethyl)) The rest. The levy is also about the compound of formula I or II. Moonlight

The comments made by the preferred embodiments of the compositions of the invention are individually effective and - preferably - effective when combined with one another. The preferred embodiment of the invention relates to a method and application of the formula Ιπ to a salivation compound, a salt thereof, a group emulsion thereof, and the like. Among the compounds of the formula, X1 in the formula I is preferably a compound of oxygen, sulfur or a part of N_Rla. Particularly preferred are those compounds of formula I wherein χ1 is oxygen. In which X is the NR type! Among the compounds, specific examples relate to the compound, wherein Ria^c /, u is a q-cv alkyl group, C]_C6_haloalkylcycloalkyl, C3-C6-ring-burning manicure, its r^6 6 garment Substrate, CyCV halocycloalkyl, CyCpene J3366l.doc •33- 200917962 base c2 (:6-Southern rare base, C2_C6_ block, Ci_C4_alkoxy_Ci_C6j phenyl, heteroaryl a phenyl group, a phenyl-C, a C4 alkyl group, and a heteroaryl group _Cl_C4-alkyl group, wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 Substituents independently selected from the group consisting of: a phytase, a cyano group, a nitro group, a G-CV alkyl group, a Cl_C4_dentate alkyl group, a C-C4 alkoxy group, and a GC: 4-haloalkoxy group; Or a partial 〇Ra. Specifically, σ, R is a C-C6-alkyl group, a c3-C6-cycloalkylindenyl group, a C3_C6-alkenyl C3_C6-alkynyl group, a C^CV alkoxy group-CVC4-alkyl group or Part 〇Ra, wherein R is as defined above and in particular is selected from Ci_C6_alkyl, CV% alkylmethyl, C3_C0-alkenyl, C3_C6-alkynyl and Ci_C4_alkoxy_C1-C4 a compound of the formula I, preferably a compound thereof, wherein R1 is hydrogen, CN CVCw-alkyl, C jC^o-halogenated, c2-C10-dilutyl, C2_Ci-haloalkenyl, c2-C10-alkynyl, C^-CV alkoxy-c^-Cw alkyl, c]- C4-alkylene-CN, 0Ra, C(Y)Rb, c(Y)〇Rc^s(〇)2Rd. More preferred are compounds of formula i, wherein R is hydrogen, Ci_Ci〇_alkyl, Ci_Ci 〇_haloalkyl, C2-C10-alkenyl, c2_Cl0_haloalkenyl, c2_Ci〇-alkynyl, q-C4-alkoxy-C^Cm-alkyl or CVC4·alkylene-CN, specifically Hydrogen, (VC3-alkyl or Cl_C4_alkylene-CN, especially hydrogen, decyl or ethyl. Another embodiment of the invention relates to a pyrazole compound of the formula ii, a salt thereof, an N-oxide thereof and And the method and application of the compound. In the formula, the preferred formula X2 is 0Rh or a compound thereof. Among the compounds, R2a is preferably Cl_C6_alkyl, C3-C6• Alkenyl, C3_C6_block 133661.doc -34- 200917962, CVCV cycloalkylmethyl or Cl_C4_alkoxy-10-yl. Further examples relate to compounds of formula I wherein χ2 carries NR2bp2c L 2b ” K. In these examples, 'R and Re are preferably selected independently of each other from the group L. _C6-alkyl, C3-C6. cycloalkylmethyl Or Cl 々 alkoxy H (tetra) and R 2e together with the milk atom to which they are bonded form a saturated nitrogen 5- or 6-membered heterocyclic ring of a bonded nitrogen, which may comprise

Another hetero atom selected from ruthenium, S and N, such as NR2bR2c S, 1 - π ratio, each α-based group, 1 - hexa-n-n ratio π-base, 1 - hexahydro-π ratio π-methyl group, heart 4 is + / Phyrinol or 4-thiomorpholinyl. R2 in the methods, uses and compounds of the invention are selected from the group consisting of hydrogen, methyl, difluoroindolyl-IImethoxy and trifluoromethoxy compounds in the methods and applications of the invention and in the compounds R3 It is selected from the group consisting of hydrogen, methyl, and difluoroindolyl. It is a trimethoxymethyl group, a methoxy group, a method, and an application thereof. Preferred are compounds, methods and uses of the formulas I and II of difluoroindolyl, methoxy, f-fluoromethoxy and difluoromethoxy. In particular, at least one of the groups R2 or R3 of the formulae I and II is hydrogen. An excellent embodiment of the invention relates to Formula I and indole compounds and salts thereof, wherein both Scale 2 and R3 are hydrogen.

Another preferred embodiment of the present invention relates to a ruthenium compound and a ruthenium compound thereof, and a ruthenium-oxide thereof, wherein R2 is hydrogen and R3 is selected from the group consisting of hydrogen, methyl, difluoromethyl, trifluoromethyl, fluorene Oxy, difluoromethoxy and trifluoromethoxy. Another preferred embodiment of the invention is related to the formula! And a hydrazine compound and a salt thereof, wherein R3 is a gas and the R-line is selected from the group consisting of hydrogen, methyl, difluorodecyl, trifluoromethyl, methoxy, difluoromethoxy and trifluoromethoxy. Preferred embodiments of the invention are directed to a pyrazole compound of formula I and II, a salt thereof, an N-oxide thereof, and methods and uses thereof, wherein a is a group Ai. 133661 .doc -35- 200917962 It is preferred that the compound of formula 1 is wherein X1, R丨, R2 and R3 are as defined above and in particular have a preferred meaning. In the pyrazole compounds of the formula 1 and 11 in the A group A1, R4] and R5 are more independently selected from the group consisting of hydrogen, halogen, CN, Cl-Cl〇-alkyl, c3_Ci〇_cycloalkyl, C2_Ciq_alkenyl and Ci_Ciq_alkynyl, wherein the aliphatic or cyclic moiety of the last four groups described above may be unsubstituted, partially or fully halogenated or may have 1 or 2 identical or different substituents Ry. Specifically, R4 and R51 are independently selected from the group consisting of hydrogen, _, CN, Ci_c4_alkyl, c丨_C4-white alkyl C3-C6_cycloalkyl and C3_C6_halocycloalkyl More preferably, it is selected from the group consisting of hydrogen, halogen, CN, CH3, CH2F, CHF2, and cf3. Preferably, at least one or both of the groups R4 & R51 are hydrogen. Specifically, 'R41 or R51 is selected from the group consisting of _, CN, Ci_Ci 〇 烧, C3_Ci. a cycloalkyl group, C2_c1 (r alkenyl and C2_Ci〇-alkynyl, wherein the aliphatic or cyclic moiety of the last four groups described above may be unsubstituted, partially or fully halogenated or may have 1 or 2 of the same Or a different substituent Ry, while the other group or the other hydrogen or halogen in rS1, especially hydrogen. More preferably, R4 1 or R5 ! is selected from the group consisting of halogen, CN, c--c4-alkyl, c- C4-haloalkyl, c3-c6-cycloalkyl and c3-c6-halocycloalkyl' and most preferably selected from the group consisting of halogen, CN, Ch3, CH2F, CHF2 and CF3 'simultaneous groups R41 or R51 Further, one is hydrogen. In the formula I and I] of the group A1, the ratio of r6 1 is preferably selected from the group consisting of Cl_Cl〇_alkyl, Cl-C. _haloalkyl, C3-C10-cycloalkyl, (1:3-(310-_-cycloalkyl, c3-C10-cycloalkyl), C3-Ci〇-halocycloalkyl, C2 -C10-alkenyl, c2-cl0_ _ baking base, C1-C4-Hyun-oxy-C^-Cw alkyl, phenyl, benzyl, phenyloxy- fluorenyl, 133661.doc -36- 200917962 5- or 6-shell heteroaryl, 5- or 6-membered heteroarylmethyl, wherein the (hetero)aromatic ring in the last five of the above groups is Substituted or may have 1, 2, 3, 4 or 5 identical or different substituents RX, as defined above and preferably selected from the group consisting of a pectin, c, a c4-alkyl, C]_C4_ Alkyl, Ci_C4_alkoxy, ci<-halogenated 6 oxy, (VC4-alkylsulfonyl and Cl_C4_haloalkylsulfonyl. More preferably c-C4·alkyl or C] _C4_haloalkyl, especially methyl 'ethyl, n-propyl, isopropyl, difluoromethyl, trifluoromethyl, 2-fluoroclay, fluoroethyl and 2,2,2-diethyl Also preferred are those of the A group A1! and „compounds, wherein RSI is as defined herein and wherein R is selected from phenyl, benzyl and 5- or 6-membered heteroaryl, especially 吼Pyridyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl isoxazole, isothiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, triazole a 1,2,4-triazolyl or tetrazolyl group in which the aromatic moiety of the phenyl, benzyl and 5- or 6-membered heteroaryl groups is unsubstituted or may have 1, 2 or 3 identical or Different substituents Rx, as defined above and preferably selected from the group consisting of halogen, G-CV leuco, CVCV halogenated alkyl, CrCV Group, burn group, acyl continued CVCV alkyl, halo and C ^ -CU- burning performance acyl group Suitable examples of the group A1-based group of the following formula:. Al a, Al b,

Al.c, Al.d, Al.e, Al.f, Al.g, Al.h, Al.i, Al.k,

Al.l, Al.m, A1.n, A1_0, Αι·ρ, A1 q, A1 r, M s,

Al.t, Al.u, Al.v, Al.w, Al.x, Aly& A1 z, wherein R6i is as defined in one of the columns of Table A1 (group Ai.al_A1 a81 to ai.z1_ Al.z81) : 133661.doc -37- 200917962

A1.d A1.e

, N A1

m A

n 1 A

NIR 9 T- A #l

CH

, N 61

NI6R

CH p A1

,N

q 61 NIR A F Hc

,N

NIR c A1

c 2 H

(c H(

s A1 u A1

Kb'/Ryz l H 2 ch3 3 ch2ch3 4 ch2ch2ch3 5 CH(CH3)2 6 ch2cf3 I3366l.doc -38- 200917962 R6I/R52 7 C(CH3)3 8 C6H5 9 4-Cl-C6H4 10 4-F-C6H4 11 2,4-Cl2-C6H3 12 4-(CH30)-C6H4 13 2-0 ratio. Stationary 14 5 ·Gas-2-° ratio σ定基15 ch2-c6h5 16 4-(OCF3)-C6H4 17 4-(SCF3)-C6H4 18 4-(OCHF2)-C6H4 19 4-(CF(CF3)2) -C6H4 20 4-(S02CH3)-C6H4 21 2,6-Cl-4-CF3-C6H2 22 3-A-5-trifluoro-indolyl acridine-2-yl 23 3-pyridyl 24 4-bite 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 2·Base 30 4-mercaptothiazol-2-yl 31 4-phenylthiazol-2-yl 32 5-triazolyl 33 3-decyl-triazol-5-yl 34 4-chlorobenzyl 35 4- Nitro-1-pyrazolyl-indenyl 36 2-imidazolyl 37 4-° m. Sit-base 38 5-mi-α sitting base 39 2-° 咕 base 40 4-° evil. Sitting base 41 5-α evil '• sitting base 42 3-iso.恶 ° sita 43 4-isoxazolyl 44 5-isoxazolyl 45 3-methylisoxazole-5-yl 46 5-nonylisoxazole-3-yl 47 3-° ratio 吐 133661 .doc -39- 200917962 R6i/R52 48 [1,3,4]thiadiazole-2-yl 49 5-tetrazole 50 4-N02-C6H4 51 4-CF3-C6H4 52 2,4-F2- C6H3 53 3,5-Cl2-C6H3 54 3,4-Cl2-C6H3 55 4-C(CH3)3-C6H4 56 3-Cl-C6H4 57 3-F-C6H4 58 2-F-C6H4 59 2-CF3- C6H4 60 2-CH30-C6H4 61 3-CH30-C6H4 62 3-Cl-4-F-C6H3 63 3-N02-C6H4 64 2-CH3-C6H4 65 3-CH3-C6H4 66 4-CH3-C6H4 67 2- phenyl-C6H4 68 3-phenyl-C6H4 69 2-F-4-Cl-C6H3 70 2,4,6-Cl3-C6H2 71 2,3,4-Cl3-C6H2 72 2,6-F2-C6H3 73 Ch2f 74 chf2 75 cf3 76 ch2chf2 77 ch2ci 78 chci2 79 CC13 80 CH2CHC12 81 ch2cci3 Here and in the following table, C6H5 represents phenyl, CH2-C6H5 represents benzyl, 4-C1-C6H4 represents 4-phenyl, 4- F-C6H4 represents 4-fluorophenyl, 4-(CH30)-C6H4 represents 4-methoxyphenyl, 2,4-Cl2-C6H3 represents 2,4-diphenyl, 4-(CF(CF3) 2) -C6H4 represents 4-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)phenyl, 4-(OCF3)-C6H4 represents 4-(trifluorodecyloxy) Phenyl, 4-(SC F3)- 133661.doc -40· 200917962 C#4 represents 4_(trifluoromethylthio)phenyl, 4-(OCHF2)-C6H4 represents 4-(difluorodecyloxy)phenyl, 4-(S02CH3 )-C6H4 represents 4_(fluorenylsulfonyl)phenyl] 2,6-Cl-4-CF3-C6H2 represents 2,6-dichloro-4-(trifluoromethyl)phenyl, 4-NO2-C6H4 The table is not 4-nitrophenyl, 4-CF3-C6H4 represents 4-(trimethylsulfonyl)phenyl, 2,4-F2-C6H3 represents 2,4-difluorophenyl, 3,5-Cl2-C6H3 Represents 3,5-diphenylphenyl, 3,4-Cl2-C6H3 represents 3,4-dichlorophenyl, 4-C(CH3)3-C6H4 represents 4-tert-butylphenyl, 3-Cl- C6H4 represents 3-gas phenyl, 3-F-C6H4 represents 3-fluorophenyl, 2-F-C6H4 represents 2-fluorophenyl, 2-CF3-C6H4 represents 2-(trifluoromethyl)phenyl, 2 -CH30-C6H4 represents 2-decyloxyphenyl, 3-CH30-C6H4 represents 3-decyloxyphenyl, 3-Cl-4-F-C6H3 represents 3-vapor-4-fluorophenyl, 3-N02 -C6H4 represents 3-nitrophenyl, 2-CH3-C6H4 represents 2-fluorenylphenyl, 3-CH3-C6H4 represents 3-tolyl, 4-CH3-C#4 represents 4-fluorenylphenyl, 2-phenyl The group -C6H4 represents a biphenyl-2-yl group, the 3-phenyl group _ GH4 represents a phenyl group 3-yl group, and the 2-F-4-Cl-C6H3 represents a 2-fluoro-4-phenyl group, 2, 4, 6 -Cl3-C6H2 represents 2,3,4-trichlorophenyl, 2,3,4-C l3-C6H2 represents 2,3,4-trisylphenyl, and 2,6-F2-C6H3 represents 2,6-difluorophenyl. Another embodiment of the present invention relates to a pyrazole compound of the formula I and II, a salt thereof, and a method and use of the same, wherein the A group A2. Preferred among them are the compounds of the formula I wherein X1, R1, R2 and R3 are as defined above and in particular have a preferred meaning. In the pyrazole compounds of the formula I and II in which the A group A2 is selected, R42 is preferably selected from the group consisting of hydrogen, halogen, CN, CrCV alkyl, CVC4-haloalkyl, ΓC1〇-cyclodyl, C3_ClQ-halogen. Ring-based and phenyl, which may be unsubstituted <1, may have 1, 2, 3, 4 or 5 identical or different substituents Rx, as defined above in 133661.doc • 41 · 200917962 and preferred Is selected from the group consisting of halogen, C _C4_alkyl, Ci_c4_self alkyl, CVC4-alkoxy, alkoxy, 〇1_〇4_alkylsulfonyl, and Cl-C4·haloalkyl sulfonate醯基. Specifically, R42 is selected from the group consisting of hydrogen, halogen, CN, Cl_c4-alkyl, Ci_c4_-alkyl, c3_C6_cycloalkyl, and CVCV halocycloalkyl, and more preferably selected from the group consisting of hydrogen, halogen, cN, CH3, CH2F, CHF2 and CF3. In the pyrazole compounds of the formula I and II in which the A group A2 is present, R52 is preferably selected from the group consisting of hydrogen, halogen, Ci_Ci〇-alkyl, C丨_C丨 haloalkyl, C3_C10- Cycloalkyl, C3-C10-halocycloalkyl, C3-C10-cyclohexylmethyl, C3_C10-halocycloalkylmethyl, c2_Ci〇-alkenyl, substituted dilute, CrCV alkoxy_Cl_Cl0 - alkyl, phenyl, benzyl, phenoxy-indenyl, 5- or 6-membered heteroaryl, 5- or 6-membered heteroaryl fluorenyl, wherein the (hetero) aroma of the last five of the above groups The ethnic ring may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents RX, as defined above and preferably selected from the group consisting of halogen, (VCV alkyl, CVC4-haloalkyl, Ci_C4_alkoxy, eve: 4-haloalkoxy, Ci_C4_alkylsulfonyl, and c _C4_haloalkylsulfonyl. R52 is more preferably selected from the group consisting of hydrogen, halogen, CN, CVC!--Alkyl, Cl_C haloalkyl^3-L10-% alkyl, c3-c10-halocycloalkyl, c3_Ci〇-cycloalkylmethyl, cycloalkylmethyl, C2_c10-alkenyl , C2~c10-i alkenyl and C _C4_alkoxyalkyl. R52 is better Halogen, Ci_C4_alkyl or haloalkyl, especially decyl, ethyl, n-propyl, isopropyl, difluorodecyl, trifluoromethyl and 2,2,2-trifluoroethyl. Also preferred Is a compound of formula I and II wherein a group A2, wherein R42 and R62 are as defined in the present invention, and wherein R52 is selected from the group consisting of phenyl, benzyl and 5- or 6 in 133661.doc-42-200917962 Heteroaryl, especially acridinyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, 1,2,4-thiadiazolyl, 1,3,4- Thiadiazolyl, 12,3-triazolyl, 1,2,4-triazolyl or tetrazolyl, wherein the aromatic moiety of the stupid, benzyl and 5- or 6-membered heteroaryl is unsubstituted Or may have 丨, 2 or 3 identical or different substituents Rx, as defined above and preferably selected from the group consisting of _, C, _C4_alkyl, (VCV haloalkyl, C^CV alkoxy, Cl_c4 a haloalkoxy group, a CrC4-alkylsulfonyl group, and a Cl_c4_haloalkylsulfonyl group. In the formula I and the π» ratio of the group A group, R62 is preferably selected from the group consisting of Group: CVCio-alkyl, C丨_Cl〇_haloalkyl' C3-c10-cycloalkyl , c3-c10-i cycloalkyl, C3_Ci〇_cycloalkylmethyl, c3-c10-halocycloalkylindenyl, c2_Ci"alkenyl, c2_Ci〇_haloalkenyl, C1-C4-alkane An oxyalkyl group, a benzyl group, a benzyl group and a phenoxymethyl group, wherein the aromatic ring of the last three groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents RX, which is as defined above and more preferably selected from the group consisting of halogen, q-cv alkyl, cvc4-haloalkyl, CVO alkoxy, Gc:4-haloalkoxy, Ci_C4-alkylsulfonyl, and Ci_C4 _ halogenated base. R62 is more preferably Ci_C4_alkyl or Ci_C4_haloalkyl, especially methyl, ethyl, n-propyl, isopropyl, difluorodecyl, trifluoromethyl and 2,2,2-difluoroethyl. Examples of suitable groups A2 are those of the formula: A2.aa, A2.ab, A2.ac, A2.ad, A2.ae, A2.af, A2.ag, A2.ah, A2.ai, A2 .ak, A2.al, A2.am, A2.an and A2.ao, where R52 is as defined in one of the tables in Table A1 (group A2.aal-A2.aa81 to A2.aol-A2.ao81): 133661 .doc -43 - 200917962

R 52

R 52

CH3 R 52 ch2f r 52 chf2 r 52

CF 3 , N, # , N' # IM, plant NHHHHH A2.aa A2.ab A2.ac A2.ad A2.ae , # , 52 52 52 A2.ao A2.ai A2.am A2.an Suitable group Other examples of A2 are groups of the formula: A2.ba, A2.bb, A2.be, A2.bd, A2.be, A2.bf, A2.bg, A2.bh, A2.bi, A2.bk , A2.bl, A2.bm, A2.bn and A2.bo, where R52 is as defined in the column A1 (group A2.bal-A2.ba81 to A2.bol-A2.bo81):

# A2.af

Cl R,#

Br,#

I R #

CN N, , # A2.ag A2.ah R5\ CH2CH3 R5\ (CH2)2CH3 r\ N, , # N, '# N, A2.ai CH(CH3)2 , # A2.ak

H

R 52 N, I ch3 A2.ba

# 、52 ch2f r N I ch3 A2.be '# 52

N, # I ch3 A2.bd

# A2.be

A2.bf

A2.bh A2_bi A2_bk 133661.doc -44 - 200917962

CH 3

CH 3

CH 3 A2.bl A2.bm A2.bn A2.bo . Other examples of suitable groups A2 are those of the formula: A2.ca, A2.cb, A2.cc, A2.cd, A2.ce, A2.cf, A2.cg, A2.ch, A2.ci, A2.ck, A2.cl, A2.cm, A2.cn and A2.co, wherein R52 is as defined in one of the columns of Table A1 (group A2.cal-A2.ca81 to A2.col-A2.co8 1) : 52

R # A2.ca Ν' N I CHF. CH, '#

A2.cc A2.cd A2.ce 2 A2.cb

A2.cg A2.ch A2.ci A2.ck A2.cf

, 52 CHF2 A2.cm N,

N I CHF A2.cn ch(ch3)2 #

Other examples of suitable groups A2 are those of the formula: A2.da, A2.db, A2.dc, A2.dd, A2.de, A2.df, A2.dg, A2.dh, A2.di, A2.dk, A2.dl, A2.dm, A2.dn and A2.do, where R52 is 133661.doc -45- 200917962 as defined in one of the tables A1 (group A2_dal-A2.da81 to A2.dol· A2.do81):

52 ch2ch3 r 52 (CH2)2CH3 R 52

A2.d

I CF3 A2.dk

R N, N I CF, '# Ν' A2.dl 'N I cf3 A2.dm '# N,, N I cf3 A2.dn '# (ch(ch3)2 r

A2.d〇 v.. Another embodiment of the present invention relates to a method and application of a compound such as a compound of the formula I and II °, a salt thereof, and the like, wherein the group A is A3. Among them, preferred are the compounds of the formula I, wherein X1, R, R2 and R3 are as defined above and have a preferred meaning. In the pyrazole compounds of the formula I and II wherein the group A is A, R43 is preferably selected from the group consisting of hydrogen, halogen, CN, (VCV alkyl, CVCV haloalkyl, c C10-if < alkyl, C3-C1G-halogen Cycloalkyl and phenyl, which may be unsubstituted, may have 1, 2, 3, 4 or 5 identical or different substituents RX, as defined herein and preferably selected from halogen, Ci_C4-alkane. Base, Ci_Cp halide 133661 .doc -46 · 200917962 Alkyl Cl-C4_alkoxy, CVC4.haloalkoxy, Cl_C4_alkylsulfonyl and C1-C4_haloalkylsulfonyl" Specifically, R43 It is selected from the group consisting of hydrogen, a nutrient CN, a Ci-CV alkyl group, a CVC4-complex alkyl group, a c3-C6-cycloalkyl group, and a C3_CV halocycloalkyl group, and is preferably selected from the group consisting of hydrogen, halogen, cH3, CH2F. , CHF2 and cf3.

In the pyrazole compound of the formula A3, R53 is preferably free from the group consisting of hydrogen, _, c, -c] 0-alkyl, c]-c丨〇-haloalkyl, C3-C1G-cycloalkyl, cycloalkyl, C3_CiQ-cycloalkylmethyl, c3-c "cycloalkylmethyl, c2_Ci.-alkenyl, c2_c].__ alkenyl, Ci-CV alkoxy-CVCw alkyl, phenyl, benzyl, phenoxy-methyl, 5- or 6-membered heteroaryl, 5- or 6-membered heteroarylmethyl, wherein the last five of the above groups The (hetero)aromatic ring may be unsubstituted or may have 1, 2, 4 or 5 identical or different substituents RX, as defined above and preferably selected from halogen, Ci-CV alkyl, CVCU a haloalkyl group, a Ci_c4_alkoxy group, a CVC4-comonyloxy group, a Cl_c4_institutional group, and a Ci_c4_dentate alkylsulfonyl group. R53 is more preferably selected from the group consisting of hydrogen' Halogen, CN, (:!-(:!〇-alkyl, CVCw haloalkyl, c^3-Lio-alkyl, C3-C10-ii cycloalkyl, C3-C丨〇-cycloalkyl Based on L3-C10-halogenated

Cycloalkylmethyl, C2-C10-alkenyl, C2_C10-haloalkenyl and C _C4_alkoxy-Ci-Ci fluorenyl. R is better gas, halogen ' 戍 c C halogenated alkyl', especially methyl, ethyl, n-propyl, fluorene, difluoroindenyl, diterpenoid or 2,2,2 - Two defeated ethyl. Also preferred are compounds of the formulae I and II wherein R.sup.43 and R.sup.6 are as defined above, and wherein R.sup.5 is selected from the group consisting of phenyl, benzyl and 5- or 6-membered. Aryl, aryl, 133661.doc •47- 200917962 pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, 1,2,4-thiadiazolyl ,: i, 3,4-thiadiazolyl, trioxazolyl, 1,2,4-triazolyl or tetrazolyl, of which phenyl, benzyl and 5- or 6-membered heteroaryl The aromatic moiety is unsubstituted or may have fluorene, 2 or 3 identical or different substituents R, as defined above and preferably selected from the group consisting of halogen, alkyl, CrCV dentate alkyl, Cl_C4_alkoxy , Ci_C4__alkoxy, G-C4.alkylsulfonyl, and Ci_C4_haloalkylsulfonyl. In the formula I, the group A and the π. In the azole compound, R63 is preferably selected from the group consisting of hydrogen, Ci_Ci〇-alkyl, Ci_Ci〇_dentylalkyl, c3-c10-cycloalkyl, cycloalkyl, C3_c "cycloalkane" Methyl, c3-Cl "complex cycloalkyl", C2_Ci〇. dilute, C2_Ci "alkenyl, CVCr alkoxy-cVC" 烷基-alkyl, phenyl, benzyl, phenoxy- a methyl, 5- or 6-membered heteroaryl, 5- or 6-membered heteroarylmethyl group, wherein the (hetero)aromatic ring in the last of the above groups may be unsubstituted or may have hydrazine, 2, 3 , 4 or 5 identical or different substituents RX, as defined above and preferably selected from the group consisting of halogen, CVC4-hospital, Ci_C4_haloalkyl, Ci_C4_alkoxy,

Ci c4 i is an alkoxy group, a decyl group, and a Ci_C4_haloalkylsulfonyl group. R53 is more preferably C|_C4_alkyl or Ci_C4_haloalkyl, especially methyl, ethyl, n-propyl, isopropyl, difluoromethyl, trifluoromethyl and 2,2,2-trifluoroethyl base. Also preferred are those in which the a group a2 is a compound wherein R and R 3 are as defined herein and wherein R53 is selected from phenyl, benzyl and 5- or 6-membered heteroaryl. 'Especially bite base. Specific thiol, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, 1,2,4-thiadithio, sylylene, 1,2,3-tri. Sitting base, 1, 2, 4-three. Sodium or 133661.doc •48· 200917962 Azolyl, wherein the aromatic moiety of the phenyl, benzyl and 5- or 6-membered heteroaryl is unsubstituted or may have 1, 2 or 3 identical or different substituents Rx, which is as defined above and preferably selected from the group consisting of halogen, q-C4-alkyl, C^-CU-haloalkyl, CVC4-alkoxy, CVC4-haloalkoxy, cvc4-nonylsulfonyl And haloalkylsulfonyl. Among the formula I and the IID of the A group A3, it is preferred that R5 or R63 is hydrogen, CN, (^-(^-alkyl or CrCV halogenated alkyl (especially hydrogen, CN, And CH3, CH2F, CHF2 or CF3), wherein R53 may also be halogen, and the other group of R53, R03 is selected from the group consisting of alkyl, eve, haloalkyl, C3-C10-cycloalkane , c3-c10- |g substituted ring, c3-Ci〇-cycloalkylmethyl, C3-C10- _cycloalkylmethyl, C2-C10-alkenyl, C2-C10-i , CVCV, oxy-C, -c10-alkyl, phenyl, benzyl, phenoxy-indenyl, 5- or 6-membered heteroaryl, 5- or 6-membered heteroarylmethyl, wherein The (hetero)aromatic ring in the last 5 groups may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents Rx ', as defined above and especially selected from halogen, C] C4 alkyl, CVC 4-haloalkyl, q-CV alkoxy, (VCV haloalkoxy, C1-C4-alkyl fluorenyl, and c^CV haloalkyl fluorenyl. Specifically R63 hydrogen , CN, Cl-C4-alkyl or alkyl, especially hydrazine, CN, CH3, CH2F, CHF2 or CF3, and R53 is selected from c, C:4·alkyl, C--C4_haloalkyl' especially methyl, ethyl, n-propyl, isopropyl, difluoromethyl, trifluoromethyl and 2,2,2-trifluoroethyl , phenyl, benzyl and 5- or 6-membered heteroaryl 'especially pyridyl, pyrazolyl, y. succinyl, 嗔" succinyl, thiazolyl, isoxazolyl, isothiazolyl, anthracene, 2 , 4_thiadiazolyl, 133661 .doc -49- 200917962 1,3,4-thiadiazolyl, iota, 2,3-triazolyl, 1,2,4-triazolyl or tetrazolyl, Wherein the aromatic moiety of the phenyl, benzyl and 5- or 6-membered heteroaryl is unsubstituted or has 1, 2 or 3 identical or different substituents rx, as defined above and preferably Selected from halogen, Ci-CU-alkyl, halogenated alkyl, cvcv alkoxy, cvc4-haloalkoxy, cvc4-alkylsulfonyl, and C-C4-haloalkylsulfonyl, or R53 Hydrogen, halogen, CN, CVC4-alkyl or cvc4-haloalkyl, especially hydrogen, CN, CH3, CH2F, CHF2 or CF3, and R63 is selected from C|-C4_alkyl, Ci-C: 4-haloalkane, especially Sulfhydryl, ethyl, n-propyl, isopropyl, difluorodecyl, trifluoromethyl and 2,2,2-trifluoroethyl, phenyl, And 5- or 6-membered heteroaryl 'especially. Than base, oxime, imidin, um. succinyl, thiazolyl, isoxazolyl, isothiazolyl, 1,2,4 thiadipine Azolyl ' 1,3,4-thiadiazolyl, anthracene, 2,3-triazolyl, oxime triazole or tetrazolyl, wherein phenyl, benzyl and 5- or 6-membered heteroaryl The aromatic moiety in the unsubstituted or may have 1, 2 or 3 identical or different substituents rx, as defined above and preferably selected from the group consisting of halogen, C丨-C4·alkyl, c- C4-_alkylene, Ci-CV alkoxy, CVC4-haloalkoxy, c]-c4-alkylsulfonylhalocarboyl. Examples of suitable groups A3 are those of the formula: A3.aa, A3.ab, A3.ac, A3.ad, A3.ae, A3 af, A3 ag, A3 ah, A3 y, eight 341^, eight 3.31, eight 3.3111, eight 3′′ 11 and eight 3′′〇, of which 1^63 is as defined in one of the tables in Table 8 (Group 8 3.&&1-in 3]81 to 3,3〇 1-in 3.3〇81): 133661.doc •50- 200917962

3 6 N-R

A3.aa A3.ab A3.ac A3.ad A3.ae CH3CH2 # CH3(CH2)2 # (CH3)2CH # # NC #

3 6 NIR

, N

NIR

'N

'N

3,6 NIR

VAX

3 6 NIR

'N

N A3.ak

3 6 NIR A3.af A3.ag A3.ah A3_ai # cl #

Br # # WR63

, N

3 • 6 NIR

3 6 NIR

Wide NI63R A3.al A3.am A3.an A3.ao. Table A3: W 1 H 2 ch3 3 ch2ch3 4 ch2ch2ch3 5 ch(ch3)2 6 ch2cf3 7 C(CH3)3 8 c6h5 9 4-Cl-C6H4 10 4-F-C6H4 11 2,4-Cl2-C6H3 12 4 -(CH30)-C6H4 13 2-0 ratio mutated 14 5-gas-2·β specific thiol group 15 ch2-c6h5 16 4-(〇CF3)-C6H4 17 4-(SCF3)-C6H4 18 4-(OCHF2 )-C6H4 19 4-(CF(CF3)2)-C6H4 20 4-(S02CH3)-C6H4 133661.doc -51 - 200917962 21 2,6-Cl-4-CF3-C6H2 22 3·rat-5-two Gas-methyl 0 is more than 嗔-2-yl 23 3-pyridyl 24 4-0 ratio ° 25 2-嗔α-based 26 4,5-dimethyl-thiazol-2-yl 27 bucket-嗟 base 28 5-thiazolyl 29 4-trifluoromethyl-thiazol-2-yl 30 4-mercaptothiazol-2-yl 31 4-phenylthiazol-2-yl 32 5-triazolyl 33 3-fluorenyl- Triazol-5-yl 34 4-sulfobenzyl 35 4-nitro-1-. Bizozolyl-fluorenyl 36 2-imidazolyl 37 4-° Mickey 38 5-flavor. Sit-base 39 2-° oxazepine 40 4-. Oxypyrazine 41 Sitrate 42 3-Isooxazolyl 43 4-isoxyl group 44 5-isor. Sitrate 45 3-mercaptoisoxazole-5-yl 46 5-mercaptooxazol-3-yl 47 3-0 σ sylylene 48 [1,3,4]thiadiazol-2-yl 49 5-four° sitting base 50 4-N02-C6H4 51 4-CF3-C6H4 52 2,4-F2-C6H3 53 3,5-Cl2-C6H3 54 3,4-Cl2-C6H3 55 4-C(CH3)3 -C0H4 56 3-Cl-C6H4 57 3-F-C6H4 58 2-F-C6H4 59 2-CF3-C6H4 60 2-CH30-C6H4 61 3-CH30-C6H4 133661.doc -52- 200917962 R53/Rw 62 3_Cl -4-F-C6H3 63 3-N〇2-C6H4 64 2-CH3-C6H4 65 3-CH3-QH4 66 4-CH3-C6H4 67 2-Phenyl-C6H4 68 3-Phenyl-C6H4 69 2-F -4-Cl-C6H3 70 2,4,6-Cl3-C6H2 71 2,3,4-Cl3-C6H2 72 2,6-F2-C6H3 73 ch2f 74 chf2 75 cf3 76 ch2chf2 77 ch2ci 78 CHC12 79 CC13 80 CH2CHC12 81 CH2CC13 Other examples of suitable groups A3 are those of the formula: A3.ba, A3.bb, A3.bc, A3.bd, A3.be, A3.bf, A3.bg, A3.bh, eight3.1 ^, 八三上1<;, eight 3.1) 1, eight 3.1)] 11, eight 3.1) 11 and eight 3.1) 〇, of which 1163 is as defined in one of the tables A3 (group A3.bal-A3.ba81 To A3.bol-A3.bo81): c OH # cl

, N

3 *6 NIR a

, N #

c 0 H F

3 6 NIR a

, N #

c H

3 >6 NIR Λ - a # c o

3 6 NIR a

'N #

3 6 NIR A3.bb A3.be A3.be A3.ba

CH3(CH2)2 # (CH3)2CH A3.bf

Cl

,N

N 63 R A3.bg

Cl·

3 6 NIR

A3.bd #, N

c N A3.bh A3.bi A3.bk a n/i63r # 133661.doc -53 200917962

# A3.bo / Other examples of suitable groups A3 are groups of the formula: A3.ca, A3.cb, A3.cc, A3.cd, A3.ce, A3.cf, A3.cg, A3.ch , A3.ci, A3.ck, A3.cl, A3.cm, A3.cn and A3.co, wherein R53 is as defined in one of Table A3, 歹ij (group A3.cal-A3.ca81 to A3. col-A3.co81):

#

CH, CH. # CHJCH丄 # (CH丄CH

A3.cf A3, eg A3.eh

/N

#

R

H A3, cl

A3.cm

A3.cn

R53^^ /NRNH A3, co Other examples of suitable groups A3 are groups of the formula: A3.da, A3.db, A3.de, A3.dd, A3.de, A3.df, A3.dg, A3.dh, 八三.以,八三.(11^,八三.(1卜八3.4111,八三,(111 and 八3, £1〇) The rule 53 is as defined in one of the tables in Table A3. Mission A3.dal-A3.da81 to A3.dol- 133661.doc -54- 200917962 A3.do81):

A3.da

# FH2C # F2HC, R 53

./N N I ch3 A3.dc

R 5:

, N, NT I ch3 A3.dd

#

CH3CH2 # CH3(CH2)? # (CH3)2CH.N

R 53

N I CH3 A3.df R N I ch3 A3.dg

R 53

# N I CH,

A3.di

# NC

# A3.dh

Other examples of suitable groups A3 are those of the formula: A3.ea, A3.eb, A3.ec, A3.ed, A3.ee, A3.ef, A3.eg, A3.eh, A3.ei, A3.ek, A3.el, A3.em, A3.en and A3.eo, wherein R53 is as defined in one of the tables A3 (group A3.eal-A3.ea81 to A3.eol-A3.eo81):

A3.ea A3.eb

A3.ec

A3.ed A3.ee 133661.doc -55- 200917962 ch3ch2 # CH3(CH2)2 # (CH3)2CH,

R 53

./N N I CHF.

R N I

2 A3.ef CHF2 A3.eg R N I chf2 A3.eh #

A3.ei A3.ek

A3.el A3.em A3.en A3.eo. Further examples of suitable groups A3 are those of the formula: A3.fa, A3.fb, A3.fc, A3.fd, A3.fe, A3.ff, A3.fg, A3.fh, A3.fi, A3.fk, A3.fl, A3.fm, A3.fn and A3.fo, wherein R53 is as defined in one of the columns of Table A3 (group A3.fal-A3.fa81 to A3.fol-A3.fo81):

# η r.

# FHX

# F.HC

# F,C

# A3.fa A3.fb A3.fc A3.fd CH3CH2 # CH3(CH2)2 # (CH3)2CHs #

R53^^ χΝ R N I

〇f3 A3.ff

A3.fl r53^^ R N Icf3 A3.fg # #

A3.fm

R 5;

N I cf3 A3.fh

A3.fi A3.fe # NC #

#

#

A3.fo 133661.doc -56- 200917962 In addition, x3 is preferably a lone pair. The formula of the oxime system is also called the N-oxide of the compound I or II. In addition, the variables Y, Ra, RC, Rd, Re, Rf, Rg, R, R and Ry preferably have one of the following meanings independently of each other: Y system;

Ra, Rb, and Re are each independently selected from the group consisting of hydrogen, Ci_C4_alkyl and Ci_C4_dentate; R is selected from C-C4-alkyl and CVC4-haloalkyl; R, R are independently selected from hydrogen, Ci_C4_alkyl, or R and R together with the nitrogen atom to which they are bonded form a 5- or 6-membered saturated heterocyclic ring, which may have another hetero atom selected from 0, as a ring member atom, such as a terpene bite -1 _ cap, hydrazine and hydrazine /, pyridin-1-yl, morpholin-4-yl, hexahydropyrazine-1-yl or 4-methylhexahydropyrazine 丨-yl;

Rg Rx R 'R1 are independently selected from hydrogen and Ci_C4_alkyl;

Ry is selected from the group consisting of halogen, cyano, nitro, Cl-C4-^, CVC4-i alkyl, Ci_c4_alkoxy, c] heart-haloalkoxy, q-C4-alkane The sulfonyl group and the oxime 1 < 4__alkylsulfonyl group; are selected from the group consisting of Cl_C4_alkoxy, C3-C0-cycloalkyl and phenyl. An excellent embodiment of the present invention relates to a compound of the formula Hb and a salt thereof, wherein χ1#〇 and X are orphaned electron pairs. These compounds are also referred to hereinafter as compound la. 0 广 a人(la) R1 R2 In the formula "中的变化^心尺^ is as defined in this article ^ in the formula 133661.doc -57- 200917962 "Chemical & towel is preferred by their compounds, of which a The group a is, for example, a group selected from pyrazolyl Al.alA1.z81. Preferred among the compounds of formula Ia are those compounds wherein at least one of the groups R1, R2 and R3, at least two of the preferred groups R, R2 and r3, and more preferably all groups r1, have R3 A preferred meaning. A preferred embodiment is a compound of the formula la and a salt thereof, wherein A is a group A1 as defined herein, especially a group A1 wherein R4!, Rsi and r6i have the preferred meanings, especially the formula A1a to Barium z pyrazolyl 'for example, a group selected from pyrazolyl A1, allA1 281; R-hydrogen, ci_c4-alkyl or CVCV alkoxy-CVCV alkyl, most preferably hydrogen, decyl or ethyl R2 is selected from the group consisting of hydrogen, decyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy and trifluoromethoxy; and R3 is selected from hydrogen, methyl, difluoromethyl And trifluoromethyl, methoxy, difluoromethoxy and trifluoromethoxy; and preferably wherein one or both of the group ... and the ruler 3 are hydrogen. Examples of the compounds of this preferred embodiment are the compounds listed in Tables 丨 to 75 below. Table 1 : Compounds of the formula 1a and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.al to Al.a81. Table 2: Compounds of the formula 1a and salts thereof, wherein R1 is methyl, R2 and R3 are gas and wherein A is selected from the group Al.a^A1.a8i. Table 3: Compounds of the formula 1a and salts thereof, wherein R1 is ethyl, r2&r3 is hydrogen and wherein A is selected from the group Ai.ai to Al.a81. 133661.doc -58- 200917962 Table 4: Table 5: Table 6: Table 7: Table 8: Table 9: Table 10: Table 11: Table 12: Table 13: Table 14: Table 15: Compounds of formula la and their salts, Wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.bl to Al.b81. And a salt thereof, wherein R is a fluorenyl group, R2 and R3 are hydrogen and wherein A is selected from the group consisting of Al. bl to Al.b81. A compound of the formula la and a salt thereof, wherein the ethyl group, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.bl to Al.b81. A compound of the formula la and a salt thereof, wherein R!, 尺 2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.cl to Al.c81. And a salt thereof, wherein Ri is a fluorenyl group, and ampule 3 is hydrogen and wherein A is selected from the group consisting of the groups Al.cl to A1.C81. A compound of the formula la and a salt thereof, wherein Ri is an ethyl group, the rule 2 and the ruler 3 are a gas and wherein the A group is selected from the group ai.ci to Ai.cgl. A compound of the formula la and a salt thereof, wherein Ri, R2 & R3 are hydrogen and wherein a is selected from the group consisting of the groups Al.dl to Al.dSl. A compound of the formula la and a salt thereof wherein Ri is a methyl group, and a ruthenium 3 is hydrogen and wherein A is selected from the group consisting of the groups Al.dl to Al.d81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, "and the ruler 3 is hydrogen and wherein A is selected from the group consisting of the groups Al. dl to Al.d81. The compound of the formula la and its salt, wherein R, R2 & R3 are Hydrogen and wherein a is selected from the group consisting of the groups Al.el to Al.e81. The compound of the formula la and the salt thereof, wherein R is a fluorenyl group, the ruler 2 and the gas are selected and wherein the A group is selected from the group Al.el to Al. E81. A compound of the formula la and a salt thereof, wherein Ri is ethyl, R2 & R3 is a gas and wherein A is selected from the group consisting of Al.el to Al.e81. 133661.doc -59- 200917962 Table 16: Compounds of formula h and a salt thereof, wherein R1, 尺2 and 尺3 are hydrogen and wherein a is selected from the group A1. f 1 to a 1. f 8 1. Table 17. Compounds of the formula 1a and salts thereof, wherein R1 is a fluorenyl group, r2 And R3 is hydrogen and wherein A is selected from the group consisting of the groups Al.fl to Al.fSl. Table 18: Compounds of the formula 1a and salts thereof, wherein R1 is ethyl, R2& R3 is hydrogen and wherein A is selected from the group A1 .f^A1.f81. Table 19: Compounds of the formula & and their salts, wherein Ri, ... and 3 are hydrogen and wherein a is selected from the group A1.gl to A1.g81. Table 20: Compounds of formula h and a salt thereof, wherein Ri is a sulfhydryl group, "and the ruler 3 is hydrogen and wherein the A group is selected from the group VIII 1. § 1 to 八 1 s 81. Table 21: Compounds of the formula h and their salts, in which Ri is ethyl, the rule 2 and the rule 3 are hydrogen and wherein the A is from the group Ai.gi to Ai.ggi. Table 22: Compounds of the formula 1a and salts thereof, wherein r, R2 & R3 are hydrogen and wherein a is selected from the group A1.hi to A1.h8. Table 23: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, "and the rule 3 is hydrogen and wherein A is selected from the group consisting of the groups Al.hl to Al.h81. Table 24: Compounds of the formula la and salts thereof, wherein Ri Is an ethyl group, the ruler 2 and the ruler 3 are chlorine and wherein the A group is selected from the group of Al.hl to Al.h81. Table 25: a compound of the formula la and a salt thereof, wherein Ri, R2 & R3 are hydrogen and wherein a is selected From the group Al.il to Al.i81. Table 26: Compounds of the formula la and salts thereof, wherein R! is a fluorenyl group, the sizing elements 2 and R3 are hydrogen and wherein the A group is selected from the group consisting of the groups Al.il to Al.i81. Table 27: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is a gas and wherein A is selected from the group consisting of the groups Al.il to Al.i81. 133661.doc 60· 200917962 Table 28: Compounds of the formula h and a salt thereof, wherein Ri, "and the ruler 3 are hydrogen and wherein a is selected from the group consisting of the groups Al.kl to Al.k81. Table 29: Compounds of the formula la and salts thereof, wherein the Ri-based fluorenyl group, and the calilem 3 are hydrogen and wherein the A group is selected from the group consisting of the groups Al.kl to Al.k81. Table 30: Compounds of the formula la and salts thereof, wherein Ri is ethyl, the rule 2 and the rule 3 are hydrogen and wherein A is selected from the group consisting of the groups Al.kl to Al.k81. Table 31: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group consisting of the groups Al.ll to A1.181. Table 32: Compounds of the formula la and salts thereof, wherein R is methyl, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.ll to A1.181. Table 33: Compounds of the formula la and salts thereof, wherein the ruthenium is an ethyl group, R2 and R3 are hydrogen and wherein the A group is selected from the group A1.U to A1.181. Table 34: Compounds of the formula la and salts thereof wherein r1, R2 and R3 are hydrogen and wherein A is selected from the group A1.ml to A1.m81. Table 35: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, the sizing elements 2 and R3 are a gas and wherein the A group is selected from the group consisting of the groups Al.ml to Al.m81. Table 36: Compounds of the formula la and salts thereof, wherein R1 is ethyl, the quaternary 2 and R3 are chloro and wherein A is selected from the group consisting of the groups Al.ml to Al.m81. Table 37: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.nl to Al.n81. Table 38: Compounds of the formula la and their salts, in which R1 is a fluorenyl group,! And R3 is nitrogen and wherein A is selected from the group consisting of the groups Al.nl to Al.n81. Table 39: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2 and R3 are nitrogen and wherein A is selected from the group consisting of the groups Al.nl to Al.n81. 133661.doc -61 · 200917962 Table 40: Compounds of the formula la and salts thereof, wherein R1, R2 and r3 are hydrogen and wherein A is selected from the group consisting of the groups Al.ol to AI.08I. Table 41: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, the sizing elements 2 and R3 are hydrogen and wherein the A group is selected from the group consisting of the groups Al.ol to A1.081. Table 42: Compounds of the formula la and salts thereof, wherein R1 is ethyl, r2 and R3 are chloro and wherein A is selected from the group consisting of the groups Al.ol to A1.081. Table 43: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A1.pi to A1.p81. Table 44: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.pl to Al.p81. Table 45: Compounds of the formula la and salts thereof, wherein R1 is ethyl, "and R3 is hydrogen and wherein A is selected from the group consisting of the groups Al.pl to Al.p81. Table 46: Compounds of the formula la and their salts" wherein Ri, And R3 are hydrogen and wherein a is selected from the group consisting of the groups Al.ql to Al.q81. Table 47: Compounds of the formula 1a and salts thereof, wherein R1 is methyl, Han 2 and R 3 are hydrogen and wherein A is selected from The group Al.ql to Al.q81. 'Table 48: A compound of the formula 1a and a salt thereof, wherein R1 is ethyl, r2&r3 is hydrogen and wherein A is selected from the group A1.q^A1 q81. Table 49: And a salt thereof, wherein R, R2 and R3 are hydrogen and wherein a is selected from the group A1.rl to A1.r81. Table 50: Compounds of the formula ia and salts thereof, wherein Ri is a thiol group, ... R3 is hydrogen and wherein A is selected from the group consisting of the groups Al.rl to Al.r81. Table 51: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group Al. Rl to Al, r 81. 133661.doc -62- 200917962 Table 52: Compounds of the formula la and salts thereof, wherein Ri, Ruler 2 and R3 are hydrogen and wherein a is selected from the group A1.s 1 to A1.s8 1 . Table 53: Compounds of the formula la and salts thereof, wherein R is a fluorenyl group, R2 and R3 are hydrogen and wherein A is selected from the group a1s1 to ai .s 81. Table 54: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group ai.si to ai.s8i. Table 55: Compounds of the formula la and salts thereof, Wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A1.tl to A1.t8 1. Table 56: a compound of the formula la and a salt thereof, wherein the Ri is a sulfhydryl group, the ruler 2 and the ruler 3 are hydrogen and wherein A is selected from the group consisting of the groups Al.tl to Al.t81. Table 57: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group consisting of Al.tl to Al.t81 Table 58: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein A is selected from the group A1 · u 1 to A1. u 8 1. Table 59: Compounds of the formula la and salts thereof, wherein曱 base, 尺 2 and 尺 3 are 氲 and wherein A is selected from the group consisting of Al.ul to A1.U81. Table 60: Compounds of formula la and salts thereof, wherein Ri is ethyl, "and ruler 3 is hydrogen and wherein A is selected from the group consisting of Al.ul to Al.u81. Table 61: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.vl to Al.v81. Table 62 Compounds of the formula ia and salts thereof, wherein R1 is a fluorenyl group, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.vl to Al.v81. Table 63: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group consisting of the groups Al.vl to Al.v81. 133661.doc -63- 200917962 Table 64: Table 65: Table 66: Table 67: Table 68: Table 69: Table 70: Table 71: Table 72: Table 73: Table 74: Table 75: Compounds of the formula la and their salts, Wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group consisting of the groups Al.wl to A1.W81. And a salt thereof, wherein R1 is a fluorenyl group, R2 and R3 are nitrogen and wherein A is selected from the group consisting of the groups Al.wl to Al.w81. And a salt thereof, wherein R1 is ethyl, R2 and R3 are nitrogen and wherein A is selected from the group consisting of Al.wl to Al.w81. A compound of the formula la and a salt thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A1.xl to A1.x81. A compound of the formula la and a salt thereof, wherein R1 is a fluorenyl group, the quaternary 2 and R3 are nitrogen and wherein the A group is selected from the group consisting of the groups Al.xl to A1.X81. And a salt thereof, wherein R1 is ethyl, & 2 and R3 are chloro and wherein A is selected from the group consisting of the groups Al.xl to A1.X81. A compound of the formula la and a salt thereof, wherein Ri, the ruler 2 and the R3 are hydrogen and wherein a is selected from the group A1.yl to A1.y81. A compound of the formula la and a salt thereof, wherein Ri is a methyl group, R2 & R3 is a gas and wherein A is selected from the group consisting of the groups Al.yl to Al.y81. A compound of the formula la and a salt thereof, wherein the ethyl group, the rule 2 and the ruler 3 are a gas and wherein the A group is selected from the group consisting of the groups Al.yl to Al.y81. A compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group consisting of the groups Al.zl to Al.z81. A compound of the formula 1a and a salt thereof, wherein R1 is methyl, R2 and R3 are hydrogen and wherein A is selected from the group αι·ζι to ai.z81. And a salt thereof, wherein R! is ethyl, and 3 is a gas and wherein A is selected from the group Ai.zi to Ai.zgi. 133661.doc -64- 200917962 Another preferred embodiment relates to a compound of formula 13 and a re-sleeping, group A as defined herein, which is a group A2 having the preferred meanings: In particular, the oxime group of the formula - to A2.d〇, for example, a group selected from the group consisting of carbazolyl groups wA2.aa81 to A2.dol-A2.do81;

R1 is hydrogen, CVC4.alkyl or CVCV alkoxy is preferably hydrogen, fluorenyl or ethyl; R2 is selected from the group consisting of hydrogen, fluorenyl, _-murine methyl, tris, difluoromethoxy and trifluoro a methoxy group; and R3 is selected from the group consisting of hydrogen, methyl, -difluoromethyl, tris, difluoromethoxy, and trifluoromethane; one of J fluoromethyl, methoxyl R2, and R3 or Both are hydrogen. Examples of compounds of this preferred embodiment are the compounds listed in Tables 76 to 23 above: Formula h compounds and salts thereof wherein Ri, R2 & R3 are hydrogen and wherein a is selected from the group A2. Aal to A2.aa8 1. Table 77: A compound of the formula la and a salt thereof, wherein R1 is a methyl group, R2 and R3 are a gas, and wherein A is selected from the group A2.aal to A2.aa81. Table 78: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2&R3 is a gas and wherein A is selected from the group A2.aal to A2.aa81.

Table 79: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Abl to A2. Ab81. Table 80: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, R2 and R3 are a gas and wherein A is selected from the group A2. Abl to A2. Ab81. 133661. Doc-65- 200917962 Table 81: Compounds of the formula la and salts thereof, wherein Ri is ethyl and 3 is gas and wherein A is selected from the group A2. Abl to A2. Ab81. Table 82: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein a is selected from the group A2. Acl to A2. Ac81. Table 83: Compounds of the formula la and salts thereof, wherein R1 is methyl, R2&R3 is hydrogen and wherein A is selected from the group A2. Acl to A2. Ac81. Table 84: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2&R3 is a gas and wherein A is selected from the group A2. Acl to A2. Ac81. Table 85: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein A is selected from the group A2, adl to A2. Ad81. Table 86: Compounds of the formula la and salts thereof, wherein R1 is methyl, and amphibious 3 is gas and wherein A is selected from the group A2. Adl to A2. Ad81. Table 87: Compounds of the formula la and salts thereof, wherein R1 is ethyl, 1^2 and R3 are gaseous and wherein A is selected from the group A2. Adl to A2. Ad81. Table 88: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Ael to A2. Ae81. Table 89: Compounds of the formula la and salts thereof, wherein R1 is methyl, R2 and R3 are gaseous and wherein A is selected from the group A2. Ael to A2. Ae81. Table 90: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2 and R3 are gaseous and wherein A is selected from the group A2. Ael to A2. Ae81. Table 91: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Afl to A2. Af81. Table 92: Compounds of the formula la and salts thereof, wherein R1 is methyl, R2 and R3 are gaseous and wherein A is selected from the group A2. Afl to A2. Af81. I33661. Doc-66- 200917962 Table 93: Compounds of the formula la and salts thereof, wherein W is ethyl, sizing 2 and R3 are gaseous and wherein A is selected from the group A2. Afl to A2. Af81. Table 94: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Agl to A2. Ag81. Table 95: Compounds of the formula la and salts thereof, wherein R1 is methyl, R2 and R3 are gaseous and wherein A is selected from the group A2. Agl to A2. Ag81. Table 96: Compounds of the formula la and salts thereof, wherein R1 is ethyl and 3 is gas and wherein A is selected from the group A2. Ahl to A2. Ah81. Table 97: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Ail to A2. Ai81. Table 98: Compounds of the formula la and salts thereof, wherein R1 is a methyl group, and a genus 3 is a gas and wherein the A is selected from the group A2. Ail to A2. Ai81. Table 99: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2&R3 is a gas and wherein the A is far from the group A2. Ail to A2. Ai81. Table 100: Compounds of the formula la and salts thereof, wherein R1, R2 & R3 are hydrogen and wherein A is selected from the group A2. Akl to A2. Ak81. Table 101: Compounds of the formula la and salts thereof, wherein R is a fluorenyl group, and a sulphate is a hydrogen group and wherein the A group is selected from the group A2. Akl to A2. Ak81. Table 102: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2&R3 is hydrogen and wherein A is selected from the group A2. Akl to A2. Ak81. Table 103: Compounds of the formula la and salts thereof, wherein Ri, ... and 3 are hydrogen and wherein A is selected from the group A2. All to A2. Al81. Table 104: Compounds of the formula la and salts thereof, wherein ... are methyl, R2 and R3 are hydrogen and wherein A is selected from the group A2. All to A2. Al81. 133661. Doc-67- 200917962 Table 105: Compounds of the formula la and salts thereof, wherein R1 is ethyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A2. All to A2. Al81. Table 106: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Aml to A2. Am81. Table 107: Compounds of the formula la and salts thereof, wherein R1 is methyl, r2 and R3 are gaseous and wherein A is selected from the group A2. Aml to A2. Am81. Table 1 08: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2 and R3 are gaseous and wherein A is selected from the group A2. Aml to A2. Am81. Table 109: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Anl to A2. An81 〇 Table 110: Compounds of the formula la and salts thereof, wherein R1 is methyl, R2 and R3 are hydrogen and wherein A is selected from the group A2. Anl to A2. An81. Table 1 : a compound of the formula la and a salt thereof, wherein R1 is an ethyl group, R2 and r3 are a gas and wherein A is selected from the group A2. Anl to A2. An81 〇 Table 112: a compound of the formula la and a salt thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Aol to A2. Ao81. Table 11 3: a compound of the formula la and a salt thereof, wherein R1 is a methyl group, R2 and R3 are hydrogen and wherein A is selected from the group A2. Aol to A2. Ao81. Table 114: Compounds of the formula la and salts thereof, wherein R1 is ethyl, ft 2 and R3 are gaseous and wherein A is selected from the group A2. Aol to A2. Ao81. Table U 5 : a compound of the formula la and a salt thereof, wherein r1, R2 and R3 are hydrogen and wherein a is selected from the group A2. Bal to A2. Ba81. Table 116: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is gaseous and wherein A is selected from the group A2. Bal to A2. Ba81. 133661. Doc-68- 200917962 Table 1 17: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A2. Bal to A2. Ba81. Table 118: Compounds of the formula la and salts thereof, wherein r1 '2 and R3 are hydrogen and wherein A is selected from the group A2. Bbl to A2. Bb81. Table 119: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 and R3 are hydrogen and wherein A is selected from the group A2. Bbl to A2. Bb81. Table 120: Compounds of the formula la and salts thereof, wherein r1 is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group A2. Bbl to A2. Bb81. Table 121: Compounds of the formula la and salts thereof, wherein ri, ulmen 2 and R3 are hydrogen and wherein a is selected from the group A2. Bcl to A2. Bc81. Table 122: Compounds of the formula la and salts thereof, wherein Ri is methyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A2. Bcl to A2. Bc81. Table 123: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A2. Bcl to A2. Bc81. Table 124: Compounds of the formula la and salts thereof, wherein ri, R2 and R3 are hydrogen and wherein A is selected from the group A2. Bdl to A2. Bd81. Table 125: Compounds of the formula la and salts thereof, wherein r1 is methyl, r2 and R3 are nitrogen and wherein A is selected from the group A2. Bdl to A2. Bd81. Table 126: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group A2. Bdl to A2. Bd81. Table 127: Compounds of the formula la and salts thereof, wherein r', R2 and R3 are hydrogen and wherein A is selected from the group A2. Bel to A2. Be81. Table 128: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, R2 and R3 are hydrogen and wherein A is selected from the group A2. Bel to A2. Be81. 133661. Doc-69- 200917962 Table 129: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A2. Bel to A2. Be81. Table 130: Compounds of the formula la and salts thereof, wherein Ri, Ruler 2 and Rule 3 are hydrogen and wherein a is selected from the group A2. Bfl to A2. Bf81. Table 131: Compounds of the formula la and salts thereof, wherein R is methyl, the quaternary 2 and R3 are hydrogen and wherein the A is selected from the group A2. Bfl to A2. Bf81. Table 132: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A2. Bfl to A2. Bf81. Table 133: Compounds of the formula la and salts thereof, wherein Ri, ... and 3 are hydrogen and wherein A is selected from the group A2. Bgl to A2. Bg81. Table 134: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, the sizing elements 2 and R3 are hydrogen and wherein the A group is selected from the group A2. Bgi to A2. Bg81. Table 135: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and sizing 3 are hydrogen and wherein A is selected from the group A2. Bhl to A2. Bh8 1. Table 136: Compounds of the formula la and salts thereof, wherein Ri, Ruler 2 and Rule 3 are hydrogen and wherein A is selected from the group A2. Bil to A2. Bi81. Table 137: Compounds of the formula la and salts thereof, wherein are fluorenyl, R2 & R3 are hydrogen and wherein A is selected from the group A2. Bil to A2. Bi81. Table 138: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group A2. Bil to A2. Bi81. Table 139: Compounds of the formula la and salts thereof, wherein R, R2 & R3 are hydrogen and wherein a is selected from the group A2. Bkl to A2. Bk81. Table 140: Compounds of the formula la and salts thereof, wherein Ri is methyl, and amp 3 is hydrogen and wherein A is selected from the group A2. Bkl to A2. Bk81. 133661 . Doc-70- 200917962 Table 14 1 : Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2 and r3 are gas and wherein A is selected from the group A2. Bkl to A2. Bk81. Table 142: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Bll to A2. Bl81. Table 143: Compounds of the formula la and salts thereof, wherein R1 is a methyl group, and a genus 3 is a gas and wherein the A is selected from the group A2. Bll to A2. M81. Table 144: Compounds of the formula la and salts thereof, wherein are ethyl, R2 & R3 gas and wherein A is selected from the group A2. M1 to A2. Bl81. Table 145: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Bml to A2. Bm81. Table 146: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, R2 and R3 are a gas and wherein A is selected from the group A2. Bml to A2, bm81. Table 147: Compounds of the formula la and salts thereof, wherein R1 is ethyl, r2 and R3 are gaseous and wherein A is selected from the group A2. Bml to A2. Bm81. Table 148: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A2, bnl to A2. Bn81. Table 149: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, R2 and R3 are chloro and wherein A is selected from the group A2. Bnl to A2. Bn81. Table 150: Compounds of the formula la and salts thereof, wherein r is ethyl, R2 & R3 is gaseous and wherein A is selected from the group A2. Bnl to A2. Bn81. Table 151: Compounds of the formula la and salts thereof, wherein r], r2&r3 are hydrogen and wherein A is selected from the group A2. Bol to A2. Bo81. Table 152: Compounds of the formula la and salts thereof, wherein R1 is methyl, R2 and R3 are gaseous and wherein A is selected from the group A2. Bol to A2. Bo81. 133661. Doc 200917962 Table 153: Table 154: Table 155: Table 156: Table 157: Table 158: Table 159: Table 160: Table 161: Table 162: Table 163: Table 164: Compounds of the formula la and salts thereof, wherein are ethyl, R2 and R3 are gas and wherein A is selected from the group A2. Bol to A2. Bo81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A2. Cal to A2. Ca81. a compound of the formula la and a salt thereof, wherein Ri is a methyl group, R2&R3 is a gas and wherein A is selected from the group A2. Cal to A2. Ca81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, and a Han 3 gas and wherein the A group is selected from the group A2. Cal to A2. Ca81. a compound of the formula la and a salt thereof, wherein Ri, ... and 3 are hydrogen and wherein a is selected from the group A2. Cbl to A2. Cb81. a compound of the formula la and a salt thereof, wherein Ri is a fluorenyl group, and a calilem 3 is hydrogen and wherein A is derived from the group A2. Cb 1 to A2. Cb8 1. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, and a calilem 3 gas and wherein the A group is selected from the group A2. Cbl to A2. Cb81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A2. Ccl to A2. Cc81. a compound of the formula la and a salt thereof, wherein Ri is a fluorenyl group, R2 & R3 is hydrogen and wherein A is selected from the group A2. Cc 1 to A2. Cc81. a compound of the formula la and a salt thereof, wherein R is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A2. Ccl to A2. Cc81. A compound of the formula 1a and a salt thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Cdl to A2. Cd81. a compound of the formula la and a salt thereof, wherein Ri is a methyl group, R2&R3 is a gas and wherein A is selected from the group A2. Cdl to A2. Cd81. 133661. Doc-72- 200917962 Table 165: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and sizing 3 are hydrogen and wherein A is selected from the group A2. Cdl to A2. Cd81. Table 166: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A2. Cel to A2. Ce81. Table 167: Compounds of the formula la and salts thereof, wherein Ri is methyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A2. Cel to A2. Ce81. Table 168: Compounds of the formula la and salts thereof, wherein Ri is ethyl, "and the rule 3 is chlorine and wherein the A is selected from the group A2. Cel to A2. Ce81. Table 169: Compounds of the formula la and salts thereof, wherein Ri, ... and 3 are hydrogen and wherein A is selected from the group A2. Cfl to A2. Cf81. Table 170: Compounds of the formula la and salts thereof, wherein Ri is methyl, ... and 3 is hydrogen and wherein A is selected from the group A2. Cfl to A2. Cf81. Table 171: Compounds of the formula la and salts thereof, wherein Ri is ethyl, ... and Han 3 gas and wherein A is selected from the group A2. Cfl to A2. Cf81. Table 172: Compounds of the formula la and salts thereof, wherein Ri, Ruler 2 and Rule 3 are hydrogen and wherein a is selected from the group A2. Cgl to A2. Cg81. Table 173: Compounds of the formula la and salts thereof, wherein Ri is a sulfhydryl group, a ft 2 and a Han 3 nitrogen and wherein the A is selected from the group A2. Cgl to A2. Cg81. Table 174: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and R3 are chlorine and wherein A is selected from the group A2. Chl to A2. Ch81. Table 175: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A2, cil to A2. Ci81. Table 176: Compounds of the formula la and salts thereof, wherein Ri is methyl, ft 2 and R3 are nitrogen and wherein A is selected from the group A2. Cil to A2. Ci81. 133661. Doc-73- 200917962 Table 177: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A2. Cil to A2. Ci81. Table 178: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein a is selected from the group A2. Ckl to A2. Ck81. Table 179: Compounds of the formula la and salts thereof, wherein R1 is methyl, R2&R3 is hydrogen and wherein A is selected from the group A2. Ckl to A2. Ck81. Table 180: Compounds of the formula la and salts thereof, wherein R1 is ethyl, ft 2 and R3 are gaseous and wherein A is selected from the group A2. Ckl to A2. Ck81. Table 181: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Cll to A2. Cl81. Table 182: Compounds of the formula la and salts thereof wherein R! is a fluorenyl group, a sizing element 2 and an R3 group are chlorine and wherein the A group is selected from the group A2. Cll to A2. C181. Table 183: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2&R3 is a gas and wherein A is selected from the group A2. Cll to A2. C181. Table 184: a compound of the formula la and a salt thereof wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A2. Cml to A2. Cm81. Table 185: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, R2 and R3 are a gas and wherein the A group is selected from the group A2. Cml to A2. Cm81. Table 186: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2 and R3 are gaseous and wherein A is selected from the group A2. Cml to A2. Cm81. Table 187: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein a is selected from the group A2. Cnl to A2. En81. Table 1 8 8 : a compound of the formula la and a salt thereof, wherein Ri is a methyl group, R 2 and R 3 are a gas and wherein A is selected from the group A 2 . Cnl to A2. Cn81. 133661. Doc •74- 200917962 Table 189: Compounds of formula la and their salts' wherein r1 is ethyl, Han 2 and R 3 are gases and wherein A is selected from group A2. Cnl to A2. Cn81. Table 190: Compounds of the formula la and salts thereof, wherein r, r2 and R3 are hydrogen and wherein a is selected from the group A2. Col to A2. Co81. Table 191: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, R2&R3 is a gas and wherein A is selected from the group A2. Col to A2. Co81. Table 192: Compounds of the formula la and salts thereof, wherein Ri is ethyl and 3 is gas and wherein A is selected from the group A2. Co 1 to A2. Co8 1. Table 193: Compounds of the formula la and salts thereof, wherein Ri, Ruler 2 and R3 are hydrogen and wherein a is selected from the group A2. Dal to A2. Da81. Table 194: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A2. Dal to A2. Da81. Table 195: Compounds of the formula la and salts thereof, wherein R] is ethyl, R2&R3 is a gas and wherein A is selected from the group A2. Dal to A2. Da81. Table 196: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein A is selected from the group A2. Dbl to A2. Db81. Table 197: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, R2 and R3 are hydrogen and wherein A is selected from the group A2. Dbl to A2. Db81. Table 198: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A2 to A2. Db81. Table 199: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein A is selected from the group A2. Dcl to A2. Dc81. Table 200: Compounds of the formula la and salts thereof, wherein Ri is methyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A2. Dcl to A2. Dc81. 133661. Doc-75- 200917962 Table 201: Table 202: Table 203: Table 204: Table 205: Table 206: Table 207: Table 208: Table 209 · Table 210: Table 211: Table 212: Compounds of Formula la and their salts R1 is ethyl, 尺 2 and R3 are chlorine and wherein A is selected from the group A2. Dcl to A2. Dc81. a compound of the formula la and a salt thereof wherein R, R2 and R3 are hydrogen and wherein A is selected from the group A2. Ddl to A2. Dd81. a compound of the formula la and a salt thereof, wherein R is a methyl group, and a calilem 3 is ammonia and wherein the A group is selected from the group A2. Ddl to A2. Dd81. a compound of the formula la and a salt thereof, wherein r is ethyl, R2 & R3 is a gas and wherein A is selected from the group A2. Ddl to A2. Dd81. a compound of the formula la and a salt thereof, wherein r1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Del to A2. De81. a compound of the formula la and a salt thereof, wherein the methyl group, and the calilem 3 are hydrogen and wherein the A group is selected from the group A2. Del to A2. De81. a compound of the formula la and a salt thereof, wherein Ri is ethyl, and 3 is chlorine and wherein A is selected from the group A2. Del to A2. De81. a compound of the formula la and a salt thereof, wherein Ri, R2 & R3 are hydrogen and wherein A is selected from the group A2. Dfl to A2. Df81. a compound of the formula la and a salt thereof, wherein Ri is a fluorenyl group, a sizing element 2 and a sizing element 3 are hydrogen and wherein the A group is selected from the group A2. Dfl to A2. Df81. a compound of the formula la and a salt thereof, wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A2. Dfl to A2. Df81. a compound of the formula la and a salt thereof, wherein R 2 and R 3 are hydrogen and wherein A is selected from the group A 2 . Dgl to A2. Dg81. A compound of the formula 1a and a salt thereof, wherein R is a fluorenyl group, R2 and R3 are hydrogen and wherein A is selected from the group A2. Dgl to A2. Dg81. 133661. Doc-76- 200917962 Table 213: Compounds of the formula la and salts thereof, wherein R] is ethyl, R2&R3 is gaseous and wherein A is selected from the group A2. Dhl to A2. Dh81. Table 214: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are a gas and wherein a is selected from the group A2. Dil to A2. Di81. Table 215: Compounds of the formula la and salts thereof, wherein Ri is methyl 'R2& R3 is hydrogen and wherein A is selected from the group A2. Dil to A2. Di81. Table 216: Compounds of the formula la and salts thereof, wherein Ri is ethyl and 3 is gas and wherein A is selected from the group A2. Dil to A2. Di81. Table 217: Compounds of the formula 1a and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A2. Dkl to A2. Dk81. Table 218: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A2. Dkl to A2. Dk81. Table 219: Compounds of the formula la and salts thereof, wherein Ri is an ethyl group, and a genus 3 is a gas and wherein the A group is selected from the group A2. Dkl to A2. Dk81. Table 220: a compound of the formula la and a salt thereof, wherein Ri, the ruler 2 and the ruler 3 are hydrogen and wherein a is selected from the group A2. Dll to A2. Dl81. Table 221: Compounds of the formula 13 and salts thereof, wherein 111 is methyl, 112 and 113 are hydrogen and wherein A is selected from the group A2. Dll to A2. Dl81. Table 222: Compounds of the formula la and salts thereof, wherein Ri is ethyl, and Han 3 is hydrogen and wherein A is selected from the group A2. Dll to A2. Dl81. Table 223: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A2. Dml to A2. Dm81. Table 224: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A2. Dml to A2. Dm81. 133661. Doc -77- 200917962 Table 225 Table 226 Table 227 Table 228 ('Table 229 Table 230 Table 231 Another A \ R1 R2 R3 : a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, R 2 & R 3 is hydrogen and wherein A Is selected from the group A2. Dml to A2. Dm81. And a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A2. Dnl to A2. Dn81. A compound of the formula la and a salt thereof, wherein Ri is methyl, and 3 is hydrogen and wherein A is selected from the group VIII (1111 to VIII). (11181. A compound of the formula la and a salt thereof, wherein Ri is ethyl, R2& R3 is hydrogen and wherein A is selected from the group A2. Dnl to A2. Dn81. a compound of the formula la and a salt thereof, wherein Ri, R2 & R3 are hydrogen and wherein a is selected from the group A2. Dol to A2. Do81. A compound of the formula la and a salt thereof, wherein Ri is a fluorenyl group, "and a dentate 3 is hydrogen and wherein the A is selected from the group A2. Dol to A2. Do81. And a salt thereof, wherein R is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group A2. Dol to A2, do81. A preferred embodiment is a compound of the formula la and a salt thereof, wherein the group A3' as defined herein is especially a group A3 wherein r43, r53 and R63 have the preferred meanings, especially the formula VIII3(10) to A3. Pyrazolyl of do, for example selected from pyrazolyl A3 aal_A3旳81 to A3. dol-A3. a group of do81; hydrogen, C丨-CV alkyl or Cl_C4_alkoxy·CpC2·alkyl, most preferably hydrogen, methyl or ethyl; selected from hydrogen, methyl, difluoromethyl, Trifluoromethyl, decyloxy, di-haloxycarbonyl and trifluoromethoxy; and is selected from the group consisting of hydrogen, methyl, difluoromethyl, trifluoromethyl, methoxy 133661. Doc-78- 200917962, difluoromethoxy and trifluoromethoxy; and wherein one or both of the groups... and R3 are hydrogen. Examples of the compounds of this preferred embodiment are the compounds listed in Table 2 below; 32 to 477. Table 232: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A3. Aal to A3. Aa81. Table 233: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Aal to A3. Aa81. Table 234: Compounds of the formula la and salts thereof, wherein R is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group A3. Aal to A3. Aa81. Table 235: Compounds of the formula la and salts thereof, wherein R!, R2 and R3 are hydrogen and wherein a is selected from the group A3. Abl to A3. Ab81. Table 236: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, and the genus 3 is hydrogen and wherein the A group is selected from the group A3, abl to A3. Ab81. Table 237: Compounds of the formula la and salts thereof, wherein Ri is ethyl, and 3 is hydrogen and wherein A is selected from the group A3. Abl to A3. Ab81. Table 238: Compounds of the formula la and salts thereof, wherein R2 and R3 are hydrogen and wherein a is selected from the group A3. Acl to A3. Ac81. Table 239: Compounds of the formula la and salts thereof, wherein Ri is methyl, and amp 3 is hydrogen and wherein A is selected from the group A3. Acl to A3. Ac81. Table 240: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group A3. Acl to A3. Ac81. Table 241: Compounds of the formula la and salts thereof, wherein Ri, and Caliper 3 are hydrogen and wherein a is selected from the group A3, adl to A3. Ad81. 133661. Doc •79- 200917962 Table 242: Compounds of the formula la and their salts, in which Ri is methyl, Han 2 and R 3 are hydrogen and wherein A is selected from the group A3. Adl to A3. Ad81. Table 243: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 and R3 are chlorine and wherein A is selected from the group A3. Adl to A3. Ad81. Table 244: Compounds of the formula la and salts thereof, wherein ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Ael to A3. Ae8 1. Table 245: Compounds of the formula la and salts thereof, wherein Ri is methyl, and R3 is hydrogen and wherein A is selected from the group A3. Ael to A3. Ae81. Table 246: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and sizing 3 are hydrogen and wherein A is selected from the group A3. Ael to A3. Ae81. Table 247: Compounds of the formula la and salts thereof, wherein ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Afl to A3. Af81. Table 248: Compounds of the formula la and salts thereof, wherein Ri is methyl, ... and Han 3 hydrogen and wherein A is selected from the group A3. Ai l to A3. Af81. Table 249: Compounds of the formula la and salts thereof, wherein Ri is ethyl, ft 2 and Han 3 hydrogen and wherein A is selected from the group A3. Afl to A3. Af81. Table 250: a compound of the formula la and a salt thereof, wherein Ri, the ruler 2 and the rule 3 are hydrogen and wherein a is selected from the group A3. Agl to A3. Ag81. Table 251: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, ... and a Han 3 series hydrogen and wherein the A group is remote from the group A3. Agl to A3. Ag81. Table 252: Compounds of the formula la and salts thereof, wherein R1 is ethyl, ... and Han 3 hydrogen and wherein A is selected from the group A3. Agl to A3. Ag81. Table 253: Compounds of the formula la and salts thereof, wherein Ri, Ruler 2 and Rule 3 are hydrogen and wherein a is selected from the group A3. Ahl to A3. Ah81. 133661. Doc -80- 200917962 Table 254: Table 255: Table 256: Table 257: Table 258: Table 259: Table 260: Table 261: Table 262: Table 263: Table 264: Table 265: Formula la compounds and salts thereof, wherein Rl Is a methyl group, R2 and R3 are hydrogen and wherein A is selected from the group A3. Ahl to A3. Ah81. a compound of the formula la and a salt thereof, wherein is an ethyl group, R2 and R3 are hydrogen and wherein A is selected from the group A3. Ahl to A3. Ah81. A compound of the formula 1a and a salt thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group VIII. & 丨 1 to 八 3 meaning 81. a compound of the formula la and a salt thereof, wherein Ri is a sulfhydryl group, a ruthenium 2 and a Han 3 gas, and wherein the A is distant from the group A3. Ail to A3. Ai81. a compound of the formula la and a salt thereof, wherein R] is an ethyl group, R2 and R3 are a gas and wherein the A group is selected from the group consisting of a group A3, ail to A3. Ai81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A3. Akl to A3. Ak81. a compound of the formula la and a salt thereof, wherein Ri is a methyl group, the rule 2 and the rule 3 are hydrogen and wherein the A is selected from the group A3. Akl to A3. Ak81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, and a genus 3 is hydrogen and wherein the A group is selected from the group A3. Akl to A3. Ak81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A3. All to A3. Al81. a compound of the formula la and a salt thereof, wherein Ri is a fluorenyl group, the quaternary 2 and the R 3 are hydrogen and wherein the A is selected from the group A3. All to A3. Al81. a compound of the formula la and a salt thereof wherein R is an ethyl group, a Han 2 and an R 3 are hydrogen and wherein the A group is selected from the group A3. All to A3. Al81. a compound of the formula la and a salt thereof, wherein R1, 尺2 and R3 are hydrogen and wherein A is selected from the group VIII. Strong 1111 to 8 3. 311181. I33661. Doc-81 - 200917962 Table 266: Table 267: Table 268: Table 269: Table 270: Table 271: Table 272: Table, 273: Table 274: Table 275: Table 276: Table 277: Compounds of the formula la and their salts, wherein Rl is a methyl group, and a Han 3 gas and wherein the A is selected from the group A3. Aml to A3. Am81. The compound of the formula la and its salt' are in the form of an ethyl group, and a genus of the genus 3 and wherein the group A is selected from the group A3. Am 1 to A3, am8 1. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Anl to A3. An81. a compound of the formula la and a salt thereof, wherein R1 is a fluorenyl group, and a sulphate 3 system gas and wherein the A group is selected from the group A3. Anl to A3. An81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, a ruthenium 2 and a R3 system gas, and wherein the A group is selected from the group A3. Anl to A3. An81. a compound of the formula la and a salt thereof, wherein R, ... and 3 are hydrogen and wherein a is selected from the group A3. Aol to A3. Ao81. a compound of the formula la and a salt thereof, wherein ... is a methyl group, a dentine 2 and a genus 3 is hydrogen and wherein the A is distant from the group A^. Aol to A3. Ao81. a compound of the formula la and a salt thereof, wherein R, "and R3 are hydrogen and wherein a is selected from the group A3. Bal to A3. Ba81. a compound of the formula la and a salt thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Bal to A3. Ba81. A compound of the formula la and a salt thereof wherein Ri is an ethyl group, R2 and R3 are hydrogen and wherein A is selected from the group A3. Bal to A3. Ba81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A3. Bbl to A3. Bb81. a compound of the formula la and a salt thereof, wherein Ri is a methyl group, and a striate 3 is hydrogen and wherein the A is selected from the group A3. Bbl to A3. Bb81. 133661. Doc-82- 200917962 Table 278: Table 279: Table 280: Table 281: Table 282: Table 283: Table 284: Table 285: Table 286: Table 287: Table 288: Table 289: Compounds of the formula la and their salts, wherein Ri Is an ethyl group, and a genus 3 gas and wherein A is selected from the group A3. Bbl to A3. Bb81. a compound of the formula la and a salt thereof, wherein r1, r2 and R3 are hydrogen and wherein A is selected from the group A3. Bcl to A3. Bc81. a compound of the formula la and a salt thereof, wherein Ri is a methyl group, and a calilem 3 is a gas and wherein the A is selected from the group A3. Bcl to A3. Bc81. a compound of the formula la and a salt thereof, wherein is an ethyl group, and a Han 3 gas and wherein the A group is selected from the group A3. Bci to A3. Bc81. a compound of the formula la and a salt thereof wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Bdl to A3. Bd81. And a salt thereof, wherein Ri is a methyl group, R2 and R3 are a gas and wherein A is selected from the group A3. Bdl to A3. Bd81. a compound of the formula la and a salt thereof, wherein is an ethyl group, R2&R3 is a gas and wherein A is selected from the group A3. Bdl to A3. Bd81. a compound of the formula la and a salt thereof, wherein Ri, and the rule 3 are hydrogen and wherein a is selected from the group A3. Bel to A3. Be81. And a salt thereof, wherein Ri is a fluorenyl group, R2 and R3 are a gas and wherein A is selected from the group A3. Bel to A3. Be81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, R2 and R3 are a gas and wherein A is selected from the group A3. Bel to A3. Be81. a compound of the formula la and a salt thereof, wherein R, 2 and R3 are hydrogen and wherein a is selected from the group A3. Bfl to A3. Bf81. A compound of the formula 1a and a salt thereof wherein R1 is a methyl group, R2 and R3 are a gas and wherein A is selected from the group A3. Bfl to A3. Bf81. 133661. Doc-83- 200917962 Table 290: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A3. Bfl to A3. Bf81. Table 291: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein A is selected from the group A3. Bgl to A3. Bg81. Table 292: Compounds of the formula la and salts thereof, wherein R is methyl, and R3 is a gas wherein A is selected from the group A3. Bgl to A3. Bg81. Table 293: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is a gas and wherein A is selected from the group A3. Bgl to A3. Bg81. Table 294: Compounds of the formula la and salts thereof, wherein R1, Ruler 2 and Ruler 3 are hydrogen and wherein A is selected from the group A3. Bhl to A3. Bh81. Table 295: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, a sizing element 2 and an R3 group are chlorine and wherein the A group is selected from the group A3. Bhl to A3. Bh81. Table 296: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2 and R3 are gaseous and wherein A is selected from the group A3. Bhl to A3. Bh81. Table 297: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein A is selected from the group A3. Bil to A3. Bi81. Table 298: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, a sizing element 2 and an R3 system gas, and wherein the A group is selected from the group A3. Bil to A3. Bi81. Table 299: Compounds of the formula la and salts thereof, wherein R1 is ethyl, r2 and R3 are gaseous and wherein A is selected from the group A3. Bil to A3. M81. Table 300: Compounds of the formula la and salts thereof, wherein R1, R2 and r3 are hydrogen and wherein A is selected from the group A3. Bkl to A3. Bk81. Table 3 0 1 : a compound of the formula la and a salt thereof, wherein R1 is a methyl group, r2 and R3 are a gas and wherein A is selected from the group A3. Bkl to A3. Bk81. 133661. Doc-84 - 200917962 Table 302: Compounds of the formula la and salts thereof, wherein R1 is ethyl, ... and Han 3 hydrogen, and wherein A is selected from the group A3. Bkl to A3. Bk81. Table 303. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Bll to A3. Bl81. Table 304: Compounds of the formula la and salts thereof, wherein ... are methyl, R2 and R3 are hydrogen and wherein A is selected from the group A3. M1 to A3. Bl81. Table 305: Compounds of the formula la and salts thereof, wherein Ri is ethyl, and 3 is hydrogen and wherein A is selected from the group A3. M1 to A3. Bl81. Table 306: a compound of the formula la and a salt thereof, wherein the rule 2 and the rule 3 are hydrogen and wherein a is selected from the group A3. Bml to A3. Bm81. Table 307: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Bml to A3. Bm81. Table 308: Compounds of the formula la and salts thereof, wherein N is an ethyl group, "and a dentate 3 is hydrogen and wherein the A is selected from the group A3. Bml to A3. Bm81. Table 309: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein a is selected from the group A3. Bnl to A3. Bn81. Table 310: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, R2 and R3 are hydrogen and wherein A is selected from the group A3 bnl to A3, bn81. Table 311: Compounds of the formula la and salts thereof, wherein Ri is ethyl, and 3 is hydrogen and wherein A is selected from the group A3. Bnl to A3. Bn81. Table 312: Compounds of the formula la and salts thereof wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Bol to A3. Bo81. TABLE 3 1 3 : Compounds of the formula la and salts thereof, wherein are methyl, R 2 and R 3 are gases and wherein A is selected from the group A 3 . Bol to A3. Bo81. 133661. Doc * 85 - 200917962 Table 314: Compounds of the formula la and salts thereof, wherein R and 3 are hydrogen and wherein A is selected from the group A3. Cal to A3. Ca81. Table 315: Compounds of the formula la and salts thereof, wherein R1 is methyl, and ampendix 3 is gas and wherein A is selected from the group A3. Cal to A3. Ca81. Table 316: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2&R3 is a gas and wherein A is selected from the group A3. Cal to A3. Ca81. Table 317: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein A is selected from the group A3. Cbl to A3. Cb81. Table 318: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, and R3 is a gas wherein A is selected from the group A3. Cbl to A3. Cb81. Table 319: Compounds of the formula la and salts thereof, wherein R1 is ethyl, sizing 2 and R3 are gaseous and wherein A is selected from the group A3. Cbl to A3. Cb81. Table 320: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein A is selected from the group A3. Ccl to A3. Cc81. Table 321 : Compounds of the formula la and salts thereof, wherein Ri is methyl, R 2 and R 3 are gaseous and wherein A is selected from the group A3. Ccl to A3. Cc81. Table 322: Compounds of the formula la and their salts, of which! ^ is ethyl, and R3 is a gas and wherein A is selected from the group A3. Ccl to A3. Cc81. Table 323: Compounds of the formula la and salts thereof, wherein ri, 尺 2 and 尺3 are hydrogen and wherein a is selected from the group A3. Cdl to A3. Cd8 1. Table 324: Compounds of the formula la and salts thereof, wherein Ri is methyl, ft 2 and R3 are gaseous and wherein A is selected from the group A3. Cdl to A3. Cd81. Table 325: Compounds of the formula la and salts thereof wherein ri is ethyl, r2 and r3 are gases and wherein A is selected from the group A3. Cdl to A3. Cd81. 133661. Doc-86 - 200917962 Table 326: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein a is selected from the group VIII 3^1 to VIII. 〇681. Table 327: Compounds of the formula la and salts thereof, wherein the ruthenium is a fluorenyl group, the sizing 2 and the sizing 3 are hydrogen and wherein the A is selected from the group A3. Cel to A3. Ce81. Table 328: Compounds of the formula la and salts thereof, wherein R is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Cei to A3. Ce81. Table 329: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein A is selected from the group A3. Cfl to A3. Cf81. Table 330: Compounds of the formula la and salts thereof, wherein Ri is methyl, and 3 is hydrogen and wherein A is selected from the group A3. Cfl to A3. Cf81. Table 331: Compounds of the formula la and salts thereof, wherein Ri is ethyl, and 3 is hydrogen and wherein A is selected from the group A3. Cfl to A3. Cf81. Table 332: Compounds of the formula la and salts thereof, wherein Ri, Ruler 2 and Rule 3 are hydrogen and wherein A is selected from the group A3. Cgl to A3. Cg8 1. Table 333: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, the ft 2 and the ft 3 are hydrogen and wherein the A is selected from the group A3 cgl to A3. Cg81. Table 334: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and sizing 3 are hydrogen and wherein A is selected from the group A3. Cgl to A3. Cg81. Table 335: Compounds of the formula la and salts thereof, wherein r|, R2 and R3 are hydrogen and wherein A is selected from the group A3. Chl to A3. Ch81. Table 336: Compounds of the formula la and salts thereof, wherein R! is methyl, ft. 2 and amp. 3 are hydrogen and wherein A is selected from the group A3. Chi to A3. Ch81. Table 337: Compounds of the formula la and salts thereof, wherein Ri is ethyl' and the ampere 3 is hydrogen and wherein A is selected from the group A3. Chi to A3. Ch81. 133661. Doc-87· 200917962 Table 338: Compounds of the formula la and salts thereof, wherein R, R2 and R3 are hydrogen and wherein a is selected from the group A3. Cil to A3. Ci81. Table 339: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, ... and a Han 3 gas, and wherein the A group is selected from the group A3. Cil to A3. Ci81 〇 Table 340: a compound of the formula la and a salt thereof, wherein R is an ethyl group, and a genus 3 is hydrogen and wherein the A group is selected from the group A3. Cil to A3. Ci81. Table 341: Compounds of the formula la and salts thereof, wherein R!, R2 and R3 are hydrogen and wherein a is selected from the group A3. Ckl to A3, ck81. Table 342: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, ... and a Han 3 series hydrogen and wherein the A group is selected from the group A3. Ckl to A3. Ck81. Table 343: Compounds of the formula la and salts thereof, wherein R is ethyl, ... and Han 3 gas and wherein A is selected from the group A3. Ckl to A3. Ck81. Table 344: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Cll to A3. C181. Table 345: a compound of the formula la and a salt thereof wherein r1 is a fluorenyl group, R2 and R3 are a gas and wherein A is selected from the group A3. Cll to A3. C181. Table 346: a compound of the formula la and a salt thereof wherein Ri is an ethyl group, the rule 2 and R3 are hydrogen and wherein A is selected from the group A3. Cli to A3. C181. Table 347: Compounds of the formula ia and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Cml to A3. Cm81. Table 348: Compounds of the formula la and salts thereof, wherein R is methyl, and 2 and R3 are hydrogen and wherein A is selected from the group A3. Cml to A3. Cm81. Table 349: Compounds of the formula Ia and salts thereof, wherein Ri is ethyl, sizing 2 and R3 are hydrogen and wherein A is selected from the group A3. Cml to A3. Cm81 〇 133661. Doc-88- 200917962 Table 350: Compounds of the formula la and salts thereof, wherein R1, R2& R3 are hydrogen and wherein a is selected from the group A3. Cnl to A3. Cn81. Table 351: Compounds of the formula la and salts thereof, wherein R1 is methyl, ... and Han 3 is hydrogen and wherein A is selected from the group A3. Cnl to A3. Cn81. Table 352: Compounds of the formula la and salts thereof, wherein R1 is ethyl, "and ... is hydrogen and wherein A is selected from the group A3 cnl to A3. Cn81. Table 353: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A3_co1 to A3. Co8 1. Table 354: Compounds of the formula la and salts thereof, wherein R1 is fluorenyl, R2 and R3 are hydrogen and wherein A is selected from the group A3. Col to A3. Co81 〇 Table 355: a compound of the formula la and a salt thereof, wherein Ri' R2 and R3 are hydrogen and wherein A is selected from the group A3. Dal to A3. Da81. Table 3 56: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 and R3 are hydrogen and wherein A is selected from the group A3. Dal to A3. Da81. Table 3 57: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Dal to A3. Da81. Table 358: Compounds of the formula la and salts thereof, wherein R1, Ruler 2 and R3 are hydrogen and wherein A is selected from the group A3. Dbl to A3. Db81. Table 3 59: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, R2 and R3 are a gas and wherein A is selected from the group A3. Dbl to A3. Db81. Table 360: Compounds of the formula la and salts thereof, wherein R1 is ethyl, sizing 2 and R3 are gaseous and wherein A is selected from the group A3. Dbl to A3. Db81. Table 361: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A3. Dc 1 to A3. Dc8 1. 133661. Doc •89· 200917962 Table 362: Compounds of the formula la and salts thereof, wherein Ri is methyl, R 2 and R 3 are hydrogen and wherein A is selected from the group A3. Del to A3. Dc81. Table 363: Compounds of the formula la and salts thereof, wherein R! is ethyl, R2&R3 is hydrogen and wherein A is selected from the group A3. Dcl to A3. Dc81. Table 364: Compounds of the formula la and salts thereof, wherein Ri, Ruler 2 and R3 are hydrogen and wherein A is selected from the group A3. Ddl to A3. Dd81. Table 365: Compounds of the formula la and salts thereof wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Ddl to A3. Dd81. Table 366: a compound of the formula la and a salt thereof, wherein R! is an ethyl group, and a calilem 3 is hydrogen and wherein A is selected from the group A3. Ddl to A3. Dd81. Table 367: Compounds of the formula la and salts thereof, wherein R2&R3 is hydrogen and wherein A is selected from the group A3. Del to A3. De81. Table 3: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Del to A3. De81. Table 69: Compounds of the formula la and salts thereof, wherein R! is an ethyl group, and a genus 3 is a gas and wherein the A group is selected from the group A3. Del to A3. De81. Table 3 70: a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A3. Dfl to A3. Df81. Table 371: Compounds of the formula la and salts thereof, wherein R1 is methyl, sizing 2 and sizing 3 and wherein A is selected from the group A3. Dfl to A3. Df81. Table 3 72: a compound of the formula la and a salt thereof, wherein R1 is an ethyl group, a ruthenium 2 and a R3 system gas, and wherein the A group is selected from the group A3. Dfl to A3. Df81. Table 373: Compounds of the formula la and salts thereof wherein R1, R2 and R3 are hydrogen and wherein a is selected from the group A3. Dgl to A3. Dg81. 133661. Doc-90- 200917962 Table 3 74: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Dgl to A3. Dg81. Table 375: Compounds of the formula la and salts thereof, wherein R1 is ethyl, "and Han 3 hydrogen" and wherein A is selected from the group A3. Dgl to A3. Dg81. Table 376: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Dhl to A3. Dh81. Table 3 77: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Dhl to A3. Dh81. Table 378: Compounds of the formula la and salts thereof, wherein Ri is ethyl, and 3 is chlorine and wherein A is selected from the group A3. Dhl to A3. Dh81. Table 379: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein a is selected from the group A3. Dil to A3. Di81. Table 3 80: Compounds of the formula la and salts thereof, wherein r/ is methyl, R2& R3 is hydrogen and wherein A is selected from the group A3. Dil to A3. Di81. Table 381: Compounds of the formula la and salts thereof, wherein Ri is ethyl and 3 is gas and wherein A is selected from the group A3. Dil to A3. Di81. Table 382: Compounds of the formula la and salts thereof, wherein r1, R2& R3 are hydrogen and wherein A is selected from the group A3. Dkl to A3. Dk81. Table 383: Compounds of the formula la and salts thereof, wherein rJ is a fluorenyl group, R2& R3 is a chloro group and wherein A is selected from the group A3. Dkl to A3. Dk81. Table 3 84: Compounds of the formula la and salts thereof, wherein are ethyl, sizing 2 and R3, and wherein A is selected from the group A3. Dk 1 to A3. Dk8 1. Table 385: Compounds of the formula la and salts thereof wherein R1, Rule 2 and R3 are hydrogen and wherein A is selected from the group A3. Dll to A3. Dl81. 133661. Doc-91 - 200917962 Table 3 86: Compounds of the formula la and salts thereof, wherein ... is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Dll to A3. Dl81. Table 387: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2&R3 is a gas and wherein A is selected from the group A3. Dll to A3, dl81. Table 388: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Dml to A3. Dm8 1. Table 389: Compounds of the formula la and their salts, of which! ^ is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Dm 1 to A3. Dm81. Table 390: a compound of the formula la and a salt thereof, wherein ... is an ethyl group, a ft 2 and a genus 3 hydrogen, and wherein the A is selected from the group A3. Dml to A3. Dm81. Table 391: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Dnl to A3. Dn81. Table 392: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 & R3 is hydrogen and wherein A is selected from the group A3 dnl to A3. Dn81. Table 393: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is nitrogen and wherein A is selected from the group A3. Dnl to A3. Dn81. Table 394: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Dol to A3. Do81. Table 395: Compounds of the formula la and salts thereof, wherein are: fluorenyl, ... and Han 3 hydrogen and wherein the A is selected from the group A3. Dol to A3. Do81. Table 396: Compounds of the formula la and salts thereof, wherein Ri, R2AR3 are hydrogen and wherein a is selected from the group A3, eal to A3. Ea81. Table 397. Compounds of the formula la and salts thereof, wherein r1 is methyl, r2 and r3 are hydrogen and wherein A is selected from the group A3. Eal to A3. Ea81. 133661. Doc-92- 200917962 Table 3 98: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Eal to A3. Ea81. Table 399: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Ebl to A3. Eb81. Table 400: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, R2&R3 is hydrogen and wherein A is selected from the group A3. Ebl to A3. Eb81. Table 401: Compounds of the formula la and salts thereof, wherein Ri is an ethyl group, and the ampere 3 is hydrogen and wherein the A group is selected from the group A3. Ebl to A3. Eb81. Table 402: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein a is selected from the group A3. Ecl to A3. Ec81. Table 403: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, the sizing elements 2 and 3 are hydrogen and wherein the A group is selected from the group A3. Eel to A3. Ec81. Table 404: Compounds of the formula la and salts thereof wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Eel to A3. Ec81. Table 405: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein a is selected from the group A3. Edl to A3. Ed81. Table 406: Compounds of the formula la and salts thereof, wherein Ri is methyl, R2 and R3 are gaseous and wherein A is selected from the group A3. Edl to A3. Ed81. Table 407: Compounds of the formula la and salts thereof wherein Ri is ethyl, R2 & R3 is a gas and wherein A is selected from the group A3. Edl to A3. Ed81. Table 408: Compounds of the formula la and salts thereof, wherein ri, R2 & R3 are hydrogen and wherein A is selected from the group VIII. 661 to 8 3. 6681. Table 409: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, R2 and R3 are a gas and wherein A is selected from the group A3. Eel to A3. Ee81. 133661. Doc-93- 200917962 Table 410: Table 411: Table 412: Table 413: Table 414: Table 415: Table 416: Table 417: Table 418: Table 419: Table 420: Table 421: Compounds of the formula la and their salts, wherein Ri Is an ethyl group, R2 and R3 are hydrogen and wherein A is selected from the group A3. Eel to A3. Ee81. a compound of the formula la and a salt thereof, wherein Ri, the ruler 2 and the rule 3 are hydrogen and wherein a is selected from the group A3. Efl to A3. Ef8 1. a compound of the formula la and a salt thereof, wherein Ri is a fluorenyl group, and a sulphate 3 is a gas and wherein the A group is selected from the group A3. Efl to A3. Ef81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, R2&R3 is a gas and wherein the A is far from the group A3. Efl to A3. Ef81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Egl to A3. Eg81. a compound of the formula la and a salt thereof, wherein R is a methyl group, a sizing rule 2 and a sizing gas, and wherein the A is selected from the group A3. Egl to A3. Eg81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, and a Han 3 hydrogen group and wherein the A group is selected from the group A3. Egl to A3. Eg81. a compound of the formula la and a salt thereof, wherein R1, R2& R3 are hydrogen and wherein a is selected from the group A3. Ehl to A3. Eh81. a compound of the formula la and a salt thereof, wherein Ri is a methyl group, R2 and R3 are hydrogen and wherein A is selected from the group A3 ehl to A3. Eh81. a compound of the formula la and a salt thereof, wherein R1 is ethyl, ... and Han 3 hydrogen, and wherein A is selected from the group A3. Ehl to A3. Eh81. a compound of the formula la and a salt thereof, wherein Ri, ... and R3 are hydrogen and wherein a is selected from the group A3. Eil to A3. Ei81. a compound of the formula la and a salt thereof, wherein Ri is a fluorenyl group, the quaternary 2 and the R 3 are hydrogen and wherein the A is selected from the group A3. Eil to A3. Ei81. 133661. Doc-94· 200917962 Table 422: Table 423: Table 424: Table 425: Table 426: Table 427: Table 428: Table 429: Table 430: Table 431: Table 432: Table 433: Compounds of the formula la and their salts, wherein R Is an ethyl group, R2 and R3 are hydrogen and wherein A is selected from the group A3. Eil to A3. Ei81. a compound of the formula la and a salt thereof, wherein R1, ... and 3 are hydrogen and wherein a is selected from the group A3. Ekl to A3. Ek81. a compound of the formula la and a salt thereof, wherein R1 is a methyl group, and the rule 2 and the rule 3 are hydrogen and wherein the A group is selected from the group A3. Ekl to A3. Ek81. a compound of the formula la and a salt thereof, wherein R1 is an ethyl group, the rule 2 and the rule 3 are hydrogen and wherein the A group is selected from the group A3. Ekl to A3. Ek81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group VIII. 611 to 8 3. 〇181. A compound of the formula la and a salt thereof, wherein R is a methyl group " and a sulphate 3 is hydrogen and wherein the A is selected from the group A3. Ell to A3. El81. A compound of the formula la and a salt thereof wherein Ri is an ethyl group, R2 and R3 are hydrogen and wherein A is selected from the group A3. Ell to A3. El81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Eml to A3. Em8 1. a compound of the formula la and a salt thereof, wherein the methyl group, the rule 2 and the rule 3 are hydrogen and wherein the A group is selected from the group A3. Eml to A3. Em81. a compound of the formula la and a salt thereof, wherein Ri is ethyl, R2 & R3 is hydrogen and wherein A is selected from the group A3. Ernl to A3. Em81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A3. Enl to A3. En81. And a salt thereof, wherein Ri is a fluorenyl group, R2 and r3 are hydrogen and wherein A is selected from the group A3. Enl to A3. En81. 133661. Doc-95- 200917962 Table 434: Compounds of the formula la and salts thereof, wherein R1 is ethyl and R3 is gaseous and wherein A is selected from the group A3. Enl to A3. En81. Table 435: Compounds of the formula la and salts thereof, wherein r1, R2 and R3 are hydrogen and wherein a is selected from the group A3. Eol to A3. Eo81. Table 436: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, r2 and R3 are a gas and wherein the A group is selected from the group A3. Eol to A3. Eo81. Table 437: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A3. Fal to A3. Fa81. Table 438: Compounds of the formula la and salts thereof, wherein R1 is methyl, ft 2 and amp 3 are nitrogen and wherein A is selected from the group A3. Fal to A3. Fa81. Table 439: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2 and R3 are nitrogen and wherein A is selected from the group A3. Fal to A3. Fa81. Table 440: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A3. Fbl to A3. Fb81. Table 44: Compounds of the formula la and salts thereof, wherein R1 is methyl, R2 and r3 are nitrogen and wherein A is selected from the group A3. Fbl to A3. Fb81. Table 442: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2 and r3 are chlorine and wherein A is selected from the group A3. Fbl to A3. Fb81. Table 443: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein A is selected from the group A3. Fcl to A3. Fc81. Table 444: Compounds of the formula la and salts thereof, wherein R1 is a fluorenyl group, R2 and r3 are a gas and wherein A is selected from the group A3. Fcl to A3. Fc81. Table 445: Compounds of the formula la and salts thereof, wherein R1 is ethyl, R2&R3 is a gas and wherein A is selected from the group A3. Fcl to A3. Fc81. 133661. Doc-96- 200917962 Table 446: Compounds of the formula la and salts thereof, wherein Ri, R2 & R3 are hydrogen and wherein a is selected from the group A3. Fdl to A3. Fd81. Table 447: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, a quaternary 2 and a <3 gas and wherein the A is selected from the group A3. Fdl to A3. Fd81. Table 448: Compounds of the formula la and salts thereof, wherein Ri is ethyl, Han 2 and is hydrogen and wherein A is selected from the group A3. Fdl to A3. Fd81. Table 449: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Fel to A3. Fe81. Table 450: Compounds of the formula la and salts thereof, wherein Ri is methyl, and 3 is a gas and wherein A is selected from the group A3. Fel to A3. Fe81. Table 451: Compounds of the formula la and salts thereof, wherein Ri is ethyl, sizing 2 and sizing 3 are hydrogen and wherein A is selected from the group A3. Fel to A3. Fe81. Table 452: Compounds of the formula la and salts thereof, wherein the rule 2 and the rule 3 are hydrogen and wherein the A is selected from the group A3.  Ff 1 to A3.  Ff8 1. Table 453: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, "and a dentate 3 is hydrogen and wherein the A is selected from the group A3. Ffl to A3. Ff81. Table 454: Compounds of the formula la and salts thereof, wherein Ri is ethyl and sulphate is hydrogen and wherein A is selected from the group A3. Ffl to A3. Ff81. Table 455: Compounds of the formula la and salts thereof, wherein Ri, R2 and R3 are hydrogen and wherein A is selected from the group A3. Fgl to A3. Fg81. Table 456: Compounds of the formula la and salts thereof, wherein R is methyl, R2 and R3 are hydrogen and wherein A is selected from the group A3. Fgl to A3. Fg81. Table 457: Compounds of the formula la and salts thereof, wherein Ri is ethyl, R2 and R3 are hydrogen and wherein A is selected from the group A3. Fgl to A3. Fg81. 133661. Doc-97- 200917962 Table 458: Table 459: Table 460: Table 461: Table 462: Table 463: Table 464: Table 465: Table 466: Table 467: Table 468: Table 469: Compounds of the formula la and their salts, wherein Ri , R 2 and R 3 are hydrogen and wherein a is selected from the group A3. Fhl to A3. Fh81. a compound of the formula la and a salt thereof, wherein Ri is a fluorenyl group, and a sulphate 3 system gas and wherein the A group is selected from the group A3. Fhl to A3. Fh81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, and a genus 3 is a gas and wherein the A group is selected from the group A3. Fhl to A3. Fh81. a compound of the formula la and a salt thereof, wherein Ri, ... and 3 are hydrogen and wherein a is selected from the group Α 3. Π1 to Α3. Π81. a compound of the formula la and a salt thereof, wherein Ri is a methyl group, "and a sulphide 3 gas and wherein the A is selected from the group A3. Fi 1 to A3. Π81. a compound of the formula la and a salt thereof, wherein R is an ethyl group, "and a sulphate 3 gas and wherein the A group is selected from the group A3. Fil to A3. Fi81. a compound of the formula la and a salt thereof, wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Fkl to A3. Fk81. a compound of the formula la and a salt thereof, wherein R] is a fluorenyl group, a trans 2 and a trans 3 system gas, and wherein the A group is selected from the group A3. Fkl to A3. Fk81. a compound of the formula la and a salt thereof, wherein is an ethyl group, R2 and R3 are a gas and wherein the A group is selected from the group A3. Fkl to A3. Fk81. a compound of the formula la and a salt thereof, wherein Ri, ... and trans 3 are hydrogen and wherein a is selected from the group A3. Fll to Α3. Π 8 1. a compound of the formula la and a salt thereof, wherein is a fluorenyl group, R2&R3 is a gas and wherein A is selected from the group A3. Fll to A3. Fl81. a compound of the formula la and a salt thereof, wherein Ri is an ethyl group, a ruthenium 2 and a R3 system gas, and wherein the A group is selected from the group A3. Fll to A3. Fl81. 133661. Doc-98- 200917962 Table 470: Compounds of the formula la and salts thereof wherein Ri, R2 and R3 are hydrogen and wherein a is selected from the group A3. Fml to A3. Fm81. Table 471: Compounds of the formula la and salts thereof, wherein Ri is a fluorenyl group, and a Han 3 gas and wherein the A group is selected from the group A3. Fml to A3. Fm81. Table 472: a compound of the formula la and a salt thereof wherein Ri is an ethyl group, and a calilem 3 is a gas and wherein the A group is selected from the group A3. Fml to A3. Fm81. Table 473: Compounds of the formula la and salts thereof, wherein R!, Rule 2 and R3 are hydrogen and wherein a is selected from the group A3. Fnl to A3. Fn81. f Table 474: Compounds of the formula la and salts thereof, wherein Ri is methyl, ft 2 and Han 3 gas and wherein A is selected from the group A3. Fnl to A3. Fn81. Table 475: Compounds of the formula la and salts thereof, wherein Ri is ethyl, "and Han 3 gas and wherein A is selected from the group A3. Fnl to A3. Fn81. Table 476: Compounds of the formula la and salts thereof, wherein R1, R2 and R3 are hydrogen and wherein a is selected from the group A3. F〇l to A3. Fo81. Table 477 . a compound of the formula la and a salt thereof, wherein the Ri is a fluorenyl group, the quaternary 2 and the r3 are hydrogen and wherein the A is selected from the group A3. Fol to A3. F〇81. The compound of formula I or II can be prepared by standard methods of organic chemistry, for example by the methods described below or in the working examples: wherein Si is a ruthenium and X3 is a lone pair of Si compounds according to, for example, a scheme The method illustrated in 1 is activated by activation. It is prepared by reacting (4) biopterin with the 3_aminopyridine compound m (see, for example, Houben_we Juice "Methoden Chemistry] der organ.  Chemie" [Methods 〇f 〇rganic Georg-Thieme-Verlag, Stuttgart, New York Activated α vs. Sputum Derivatives Π 1985, Vol. E5, pp. 941_1〇 45 133661. Doc •99- 200917962 is, for example, a complex, activated brewing, acid needle, 4 nitride, such as chloride, fluoride, bromide, p-nitrophenyl ester, pentafluorophenyl ester 'ice hydroxy amber Amine, hydroxybenzotriazolyl ester. In the scheme, the bases: A R R and R have the above meanings and in particular have the preferred meanings, and X is a suitable leaving group such as _ 素, %, ω phenoxy and the like. < Option 1: A, ΟΙ)

(III)

Wherein X is hydrazine and χ3 is a lone thunder + tube + τ 冤 对 pair of the active compound of formula 1 can also be prepared, for example, according to Scheme 2 by reacting a carbazole carboxylic acid amine quinone bite compound m in the presence of a coupling agent. . In Scheme 2, the radicals, ^ and R3 have the above meanings and in particular have the preferred meanings. Scenario 2 :

Ο R A person OH + Η,

(IV) (Hi) Suitable coupling agents (for example): carbodiimide-based coupling agents, such as N, N,-dicyclohexyl carbyl--- ie X. Sheehan, GP Hess, J Am. Chem. s 〇c. 133661.doc •100- 200917962 1955,77, 1067], N-(3-dimethylaminopropyl)-anthracene-ethylcarbide-imine, - forming a mixed anhydride with carbonate Mixtures, for example 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline [B. Belleau, G. Malek, J. Amer. Chem. Soc. 1968, 90, 1651], 2- Isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline [Y. Kiso, H. Yajima, J. Chem. Soc., Chem. Commun. 1972, 942]; a coupling agent such as (benzotriazol-1-yloxy)tris(dimethylamino)hexafluorophosphate scale [B. Castro, JR Domoy, G. Evin, C. Selve, Tetrahedron Lett. 1975, 14 , 1219], (benzotriazol-1-yl-oxy)tripyrrolidinium hexafluorophosphate scale [j. Coste et al, Tetrahedron Lett. 1990, 31, 205]; - based on strontium salts or with rust N - a coupling agent for an oxide structure, such as ruthenium, osmium, iridium, Ν'-tetradecyl-0-(1H-benzotriazol-1-yl)hexafluorophosphate [R. Knorr, A. Trzeciak, W. Bannwarth, D. Gillessen, Tetrahedron Lett. 1989, 30, 1927], N, N, N', N·-tetramethyl 〇 (-(benzotriazole-1 -based) bismuth tetrafluoroborate, (benzotriazolyloxy) dihexahydropyrene hexafluorohexafluorophosphate [S. Chen, J. xu, Tetrahedn) n Lett. 1992, 33, 647]; Forming a coupling agent for helium, such as bis-(2. oxo-oxazole bite) squamous chlorine [J. Diago-Mesequer, Synthesis 1980, 547] ° where X is 〇, X3 is a lone pair and R1 is not Compound I which is hydrogen can also be prepared by alkylation of indoleamine 1 (wherein R1 is gas and which can be obtained according to Scheme 1 or 2) using a suitable alkylating agent in the presence of a base. 133661.doc -101 - 200917962

Pyrazole carboxylic acid iv and its activated derivative peaks 榀ττ, „ ^ 生物 生物 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 Alternatively, it can be prepared by the methods described in the literature. The compound of formula I wherein X1 is not oxygen can be prepared from compound (iv) by standard methods: wherein X1 is a compound of S can be, for example, according to M. Jesberger The method described in Synthesis 2003, 1929 by using compound 13 with 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiodiphosphane (dithiadiph〇sphetane) The 2,4-disulfide or pentasulfide dish is prepared by reacting. The compound wherein X1 is ΝΙ^ can be, for example, according to v(1)(10), etc., Pharmaceutical Chemistry Journai 2〇〇5, 39(10) ' 533_

The method described in 536 is prepared by reacting Compound 1 & with 2,4-bis(4-decyloxyphenyl)-1,3,2,4-dithiodiphosphane-2,4_ The disulfide reaction is carried out to obtain the corresponding thioguanamine (Compound I, wherein χι is s), which is then reacted with a suitable amine. The compound of formula II wherein X2=SR2a can be used according to v Glushk〇v et al.

The method described in Pharmaceutical Chemistry J〇urnal 2005, 39(10), 533-536 is carried out by reacting a corresponding thioguanamine (Compound I, wherein χι s) with an alkylating agent to cause it to be alkylated. preparation. In a similar manner, X2 is OR2a or NR2bR2ci Compound I. Wherein compound of formula II wherein x2 = s 〇 R2a or s 〇 2R2a 133661.doc • 102· 200917962 can be obtained by oxidizing compound II wherein X2 = SR2a. The compounds of formulas I and 11 wherein X is ruthenium can be prepared by a standard method for preparing pyridinium-oxide by oxidizing a compound in which ruthenium 3 is a lone pair, for example, by c. B〇tteghi et al. Person, Journal 〇f 〇rg following metaiiic

Preparation by the method described in ChemiStry 1989, 3 70, 1 7-3 i In general, the compound of formula 1 or hydrazine can be prepared by the above method. If the individual compounds are not prepared by the above routes, they can be prepared by other compounds or waxes by conventional changes to the synthetic route. By way of example, in some cases, 'some compounds I 哎 and 11 may advantageously be derived from other compounds I or by ester hydrolysis, amide amination, sulphation, cleavage, thinning, emulsification and the like. II to prepare. The reaction mixture can be treated in a conventional manner, for example by mixing with water, separating the phases and, if appropriate, purifying the crude product by chromatography (e.g., on Oxide or Shihua). Some intermediates and final products can be obtained in the form of colorless or light-colored viscous oils. They are freed from volatile components at low pressure and moderate vapority. If the intermediates and final products are obtained in the form of solids, 彳θ & π ^ short oxime, they can be purified by recrystallization or grinding. Since the formula compound has (4) (iv) activity, it can be used to control invertebrate pests. Accordingly, the present invention also provides a method of controlling an invertebrate pest, the method comprising treating a scorpion moth with a pesticidally effective amount of a compound of the formula (1) or (π) as defined above or a salt or cerium-oxide or composition thereof Food supply, its habitat or its breeding grounds, or cultivated plants, planting materials (such as seeds), soils, soils, soils, fields, materials or environments, or To prevent I33661.doc 200917962 from invading or infesting pests, cultivated plants, plant propagation materials (such as seeds), soil, surface or space. Preferably, the method of the invention is used to protect plant propagation material (such as seeds) and plants grown therefrom from invading or infestation by invertebrate pests, and comprises formula (1) as defined above or (I] t) The compound or planting material (e.g., seed) may be treated with the agricultural composition as defined by the compound or its agriculturally acceptable salt or N-oxide or in the context of an insecticidally effective amount; The method of the invention is not limited to the protection of "matrices" (plants, plant propagation materials, soil materials, etc.) which have been treated according to the invention, and thus also for the growth of plants from treated plant propagation material (for example seeds) Sexual effects (eg protection from treated plant propagation material), in which the plant itself is not sunk, and 5, & spinal pests " preferably selected from arthropods and nematodes' It is selected from harmful insects, spiders and nematodes, and even more preferably one is selected from the group consisting of insects, aphids and nematodes. V. b. The U.S. provides for the protection of the invertebrate pests, which contain at least a compound of an effective amount of insecticidal action, or a compound of at least one of the agriculturally available salt silk oxides, and At least one liquid and/or solid inert carrier, and, if desired, at least one surfactant. According to the invention, the composition may comprise a mono-active formula or a compound or a dish or an N-oxide < a right-drying active compound! or a mixture of η or a salt thereof. The present invention may comprise a separate aliquot. Isomers or mixtures of isomers and mixtures of individual tautomers or tautomers. 133661 .doc -104· 200917962 Compounds of formula I or II and insecticidal compositions comprising same thereof control arthropod pests and nematodes An effective agent. Invertebrate worms controlled by a compound of formula I or II include, for example: from Lepidoptera (Lepidoptera, such as small tigers (dgro, yellow tiger) (Jgro, cotton leaf moth) , Lima nocturnal gemwaia/b), apple nest moth co^/wge//a), scorpion worm (Jwiograp/m gamma), pine stalk (5wpa/w5·piWari.ws), fir rough Moth (Cacoecia mwr/nanci) 'Capwa reiicw/ana, winter moth (C/zez·βίοΜα 6rwm<aia), spruce leaf moth {Choristoneura fumiferana), western spruce leaf moth {Choristoneura occidentalis), beauty; ί, state poison worm (Cirphis, apple 蠹(C_y mountain, European pine caterpillar [Dendrolimus pini], melon ff 嗓 {Diaphania nitidalis), 良良米米 [Diatraea, Egyptian vajra 五 (five/like insulana) > South American jade snail snail [Elasmopalpus lignosellus ), Eupoecilia ambiguella 'Evetria bouliana, Feltia subterranea, Galleria mellonella' Graphogitha funebrana, pear "Grapholitha molesta", Heliothis armigera, Heliothis virescens, Heliothis zea, Hellula undalis, Hebrew moth (// 76erm_a c?e/o/i'an_a), American white moth (//_yp/zanir/c! cwnea), apple moth (if_yponc>mewia, 蠹 蠹 133 133661.doc -105- 200917962 {Keiferia lycopersicella) '{Lambdina fiscellaria) 'Beet armyworm exigua), coffee point moth (coffeella), stalking moth ^ {Leucoptera, snail moth {Lithocolletis, Zobeha 6oircma, yellow green scorpion (Loxcmege Siiciica/b), "Lymantria dispar" ' it ^ ^ ^{Lymantria monacha) ' Narrow-winged leaf miner (L_yo«e"iJ! clerkellcT), canopy% QMalacosoma newwr/fl), cabbage moth (Mawairo;, cedar moth psewiioiswgaia ), European corn mold (〇5/W«z_a wwW/flD), winter night moth QPanolis flammea), title [Pectinophora and pie//a), Beans hornworm, 'Phalera bucephala' , Ma Ling integrated 1 weaving (Phthorimaea opercw / eZ / a), orange fine moth cz7re / / a), large cabbage moth, 苜 绿 green night moth (Ρ / αί / ζ less / 7 (9) a, Plutella xylostella {Plutella Xylostella), Soybean larvae (Pseudoplusia, Lobster leaf moth (/?/z_yaciom'a / rwsirawa), Svelbipalpula absoluta, Sitobiga cerealella, S. cerevisiae (Sparganoi) /ib ρί//6η·α«α), Spodoptera frugiperda, Spodo/opiem littoralis, Spodoptera litura (*S/7〇i/〇/>iera / Z'iwrcz), J'haumatopoea pityocampa 'Tortrix viridana', Tyichoplusia «/·) and the cloud {Zeiraphera canadensis) » Aphids (Coleoptera), such as pear long ginkdin (Agrilus -106-133661.doc 200917962 sinuatus), Agriotes lineatus, dark-skinned 0P armor Agriotes obscurus), Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum, Atomaria linearis, Dasong Blastophagus piniperda, Blit'ophaga undata, Bruchus runmanus, Bruchus pisorum, Bruchus lentis, Rhododendron lobes Byetiscus betulae., Cesida nebulosa, Cerotoma trifurcata, Ceuthorrhynchus assimilis, Ceuthorrhynchus napi, Chaetoenema tibialis, Tobacco Needles Conoderus vespertinus, Crioceris asparagi, Diabrotica longicornis, Diabrotica 12-punctata), Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis, Eutinbothrus brasiliensis, Hylobius abietis, Egyptian elephant Yp (Hypera brunneipennis), Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, potato beetle Leptinotarsa decemlineata), Limonius californicus, Lissorhoptrus oryzophilus, Melanotus communis, Meligethes aeneus, and Melodontha 133661.doc •107· 200917962 hippocastani), European tortoise (Melolontha melolontha), Oulema oryzae, Ortiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllantreta chrysocephala, Phyllophaga sp., garden Phyllopertha horticola, Phyllotreta nemorum, Phyllotreta striolata, Popillia japonica, Sitona lineatus, and Sitophilus granaria; Winged insects (Diptera, such as Aedes aegypti, Aedes aegypti), Anastrepha ludens, Anopheles maculipennis, Mediterranean rope (Cerai / 、, sister gold 13⁄4 bezziana) 'Spiral gold rope (C/zrpowya; 7〇wz'm_vora; c), Chrysomya macellaria, Contarinia sorghicolcT, Cordylobia anthropophaga, Culex pipiens Cw/ex Dacwj cwcwrZn7ae, Dacw 〇/eae, Brassica oleracea, yellow-bellied reins (Fa (four) ζ_α cam'cw/arb), bots {Gasterophilusintestinalis, ^^ i^, Glossinamorsitans, Haematobia irritans, Haplodiplosis e-wairh, species radiance | p/aiwro, mosquito cord, Zz'r/omyza saii' Vae), Africa Chrysanthemum (Liriomyza's /o/H), Lepidopteran (Lwcz'"a (10)), Brassica 133661.doc •108- 200917962 (Lucilia cuprina) 'Luciiia sericata', jade neck Musca domestica (Μαγη·ο/α AWrwcior), Musca domestica (Mwca 廄 廄 ( (Mwscka wMw/a), Sheep Swine (Oairw·? ovk), Swedish wheat fly y>" ), beet leaf miner (Pegomya / zwoc awz·), onion fly a/7" "wa", broccoli fly (P/zorha ^ a MZ'cae), wheat fly (p; 2〇rHa coarciak) , cherry fruit fly (sweet 0/如··? ceran'), apple fruit fly (sigh sigh / e mountain pomonella), ^ it (Tabanus bovinus) 'sweep big mosquito (TipuZa oleracea): ^ Huan if\\ Big mosquito [Tipula paludosa") ·, hummer (77〇^«opiera), such as Dichromothrips corbetti, Frankliniella / wsca, FrimWm e//a occWenia/b), Frankliniella tritici, Scirtothrips citrV, rice Suma (Γ/2η>·5 or less zae), palm hummer (77zrz>s pa /m/) and cotton aphid {Thrips tabaci); Hymenoptera (Hymenoptera), such as Athalia rosae, Atta cephalotes, Atta sexdens, and Atta texana ), Hoplocampa minuta, Hoplocampa testudinea, Monomorium pharaonis, Solenopsis geminata, and Solenopsis invicta; Isoparms (Hymenoptera) (Heteroptera)), such as Acrosternum hilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercus cingulatus, 133661.doc -109- 200917962 (Dysdercus intermedius), Eurygaster integriceps, Euschistus impictiventris, Leptoglossus phyllopus, Lygus lineolaris, Lygus pratensis, rice green Wall (Nezara viridula), Pesma quadrata, Solubea insularis and Thyanta perditor; Homoptera (//omopiera), such as red bean ({Acyrthosiphon onobrychis), larch ball (Jc/e/gei laricis), Aphidula nasturtii, Aphis / a6ae, strawberry roots , apple money, cotton money gowypH), gooseberry teeth groww/arz'ae), tea money (/ip/zz··? sc/meWerz·), 缭线菊财(/ίρ/π··?, bone Aphis sambuci, Acyrthosiphon pisum, % gully without web (Aulacorthum · 5〇/α«〇, silver leaf powder chaos (square emb/a, Bemisia tabaci), short Brachycaudus cardui > Lee Macaque 蚜/2e/k/2r less d), Prunus cereus s pem'cae), Pruene koala 蚜, 甘 raw/cae)角钉毛财 (Caphop/zorws /zorm·), cotton winged net bee (Cerosipha gossypii), 萆berry hair f 蚜 (chaetosiphon, life 蘼 蘼 额 额 ( (Cryp/om less r/Ws), Caucasian spheroid (Drey/wha nordmannianae) 'Sycamore vertebrate (Drey/MWa, Ryd Koala round tail ra::/z'c〇/a), Dysaulacorthum psewdosolani, 鳋Pink 蚜 ( Dysaphis 133661.do C -110- 200917962 (10)), Pythium pygma pyW), Empoasca fabae, Hyalopterus pruni, tea vines (i/xperomj/zws lactu-cae), ginseng f Macrosiphum avewae, Macrosz'p/zwm ewp/zorb/ae, Macrohp/^ow rosae, Megahoura Wc/ae, Paloese彩财(Me/awap/n's, 麦麦麦财{Met opol op hi um dirhodum), ^ {Myzodes persicae) 'Myzws c^ca/oWcw', 黑 cherry melanoma (蚜) (10) cerah ), peach aphid (M_yzWly perhC (3e), nuclear xanthoma fronto (from a small heart var/aw), wormwood (iVa>so«ov/a, brown rice bran (w/a_parvaia /wge) , 万 根 6 6 6wriyar? 'Wi5), cane toad (Perh « _e / / a Mcc / mricWa), Python 疣 疣 (P; / 〇r0t / o « do www / z ') , Ping Mufeng (corpse sy/Za Wa//), pear wood milk (corpse π//α pirz·), winter onion tumor 蚜 {Rhopalomyzus ascalonicus), corn tuber 蚜 {Rhopalosiphum maidis, 缢 缢 缢 ( Rhopa丨osiphum /?ac^·), Yu Liyi tube 蚜insertum), pear stone Grass (Sappaphis wa / a), Doberan red round tail wealth Wa / z ·), Mai two and 蚜 (Schizaphis grawkwm), Avocado cotton jacket (Sc / n.zc ^ ewra / (10) wg / wow), Mai Chang Tube (&·/〇&·〇« this), white backed fly {Sogatella / wrcz/era), greenhouse whitefly (JWa/ewoc/w vaporar/orww), orange two (7\? ;c〇/^era awr<a«"i·) and the grape root nodule field [Viteus vitifolii]', white pelicans (Isoptera), such as the European wood white sacrifice (Calotermes flavicollis), European and American termites ( Leucotermes flavipes), yellow-breasted white 133661.doc -111 - 200917962 Ant (Reticulitermes flavipes), Reticuiitermes lucifugus and Termes natalensis; Orthoptera (Orthoptera (Ori/zop(10)α) ), for example, JadeM ί/owai/ca, Oriental Filipino (β/α"α or/ewiaD), Blattella germanica, Forficula auricularia, GryHoiaipa Gryn〇ta!pa), Loewsk wz'grofMWa, double belt Me (Me/a«op/WlS 赤腿蚱蜢(Melanoplus femurrubrum), 墨西蛑蜢 (Melanoplus, Me/a/iop/ws, Melanoplus spretus, m (Nomadacris septemfasciata), American cockroach (Perz>/(d) ek ameWc (four) α), American 蚱amehca« a), Paregrina 蚱蜢 (10)), Stauronotus and greenhouse 蟋螽 (rac / 〇; cz ^ asynamorus); Arachnida (Aflc / moz · heart a) 'eg spider (蜱螨 ycar / wa)) For example, the soft scorpion (drgim·e and e), the hard scorpion (/x〇i/wae), and the scorpion (~rC〇Jp"· and e) 'for example, the American flower 蜱 矽 10 (10) ame ameWc (10) , tropical flower bud (dm6/_yowma vaWegaiwm), Persian concealed (^ is like perWcws), with square head 蜱 (10) (10),), Boophilus decoloratus, micro + burdock iBoophilus micr〇plus, , forest leather 蜱 (Der _s / / varww), long " glazed eyelids (/% / (10) brain, scorpion hard 蜱 (/ ΧΟύ ^ rycz · " (10)), light red hard 蜱 (^^ Heart ^ rubicundus), rabbit office (_〇rnithodorus moubata) 'disability.缉 缉 (Oiohw meg (1)· "/), chicken skin hedgehog (Der-machi to (10) / / i > me), sheep 133661.doc -112- 200917962 pain (Psoroptes ovis) 'tail M monument (Rkipicephalus mountain 'cw/aiws), valgus fan head 蜱ever/), acne worm height ("Sarcopie5·ααά/β/) and 瘿 瘿 ( (5 Hop/zyzWae spp.), such as 瘿 瘿 瘿 (yicw/ Ws ίΆ/π/7ίβ«ΰ?β/ζ·), orange rust (P/z>>//oc;o/?iraia o/e/vora) and citrus buds (five riop/zyes s /ze/i/om·); tree line 瞒科 (Γααο plus w/dae sppj, such as cyclamen snail (corpse / z_yicmemwj pallidus) anti-multiple food woven fabric (Polyphagotarsonemus latus) ·, pseudo-leaf family 7>«Μφα^αίαβ spp.), such as the purple pseudo-leaf (BreWpa/pw p/zoem'cb); the leaf family (7>ira^yc/H'c/(3e 577/?·), such as cinnabar ·Ye worm (reira^yc/zz^ cz'(10)Marz'wws), Shenze's leaf 螨Α: ϊ ζ ζ ν 太平洋 、 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋 太平洋«_yc/2ws ie/arks) and cotton leaf wri/cae), apple full claw 螨 w/w〇, orange full claw 螨 like cz'in') and grass small claw worm ongo / ^ c ^ ws praiewb); Siphonaptera (Siphonatera) 'oriental rat flea e.g. (Xenopsylla cheopsis), the genus Ceratophyllus flea (Ceratophyllus spp).. The composition and the compound of formula I or II can be used to control nematodes, especially plant-parasitic nematodes, such as root knot nematode, Meloidogyne hapla, Meloidogyne incognita, and root-knot nematode (Meloidogyne javanica), and other Meloidogyne species; cyst-forming nematode, Globodera rostochiensis, and other Globodera species; oat cyst nematode (Het) -erodera avenae), soybean cyst nematode 133661.doc •113· 200917962 (Heterodera glycines), beet cyst nematode (Heterodera schachtii), cystosome nematode (Heterodera trifolii), and other cystic nematodes (Heterodera) species; Seed gall nematode, Anguina species; Stem and foliar nematode, Aphelenchoide species; Sting nematode, Belonolaimus longicaudatus And other species of the beetle nematode (Belonolaimus); Pine nematode, Bursaphelenchus xylophilus and other species of Bursaphelenchus; Ring nematode, Criconema species, Criconemella species, Criconemoide species, Central Mesocriconema species; Stem and bulb nematode, Ditylenchus destructor, Ditylenchus dipsaci and other Ditylenchus species; Cone nematodes (Awl nema-tode) , the species of the genus Dolichodorus; Spiral nematode, Heliocotylenchus multicinctus and other species of Helicotyllenchus; Sheath and sheathoid nematode, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; Lance nematode, Hoploaimus species; false rootknot nematode, Nacobbus species; Nematode (Needle nematode), crack Longidorus elongatus and other Longidorus 13366 丨.doc -114- 200917962 species; Pin nematode, Paratylen-chus species; Lesion nematode, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus curvitatus, Pratylenchus goodeyi, and other root rot nematodes (Pratylenchus) species; perforated nematodes ( Burrowing nematode), Radopholus similis and other Radopholus species; Reniform nematode, Rotylenchus robustus and other Rotylenchus species; Scutellonema species; Stubby root nematode, Trichodorus primitivus and other Trichodorus species, Paratrichodorus species; Stunt nematode, Clayton dwarf nematode (Tylenchorhynchus claytoni), indefinite orthodontic Tylenchorhynchus dubius and other species of the genus Tylenchorhynchus; Citrus nematode, Tylenchulus species; Dagger nematode, Taiwanese Xiphinema species; and other plants Parasitic nematode species. In a preferred embodiment of the invention, the compound of formula I or II is used to control insects or spiders, particularly Lepidoptera, Coleoptera, Thysanoptera, and Homoptera and Cocoon. The compounds of the formula I or II according to the invention are especially useful for controlling Thysanoptera and Homoptera insects. The compound of formula I or II or a pesticidal composition comprising the same can be used to protect growing plants and crops by contacting the plant 133661.doc • 115· 200917962/crop with a pesticidally effective amount of a compound of formula I or II. Infested or infested by invertebrate pests (especially insects, worms or spiders). The term "crop" refers to both growing crops and harvested crops. The compounds of formula I or II can be converted into conventional formulations such as solutions, emulsions, suspensions, powders, powders, pastes and granules. The form of application depends on the specific intended purpose; in each case, it should be ensured that the compounds of the invention are capable of being finely and uniformly distributed. Formulations can be prepared in a known manner (for review, see, for example, U.S. Patent No. 3,060,084, European Patent No. EP-A 707 445 (with regard to liquid concentrates), Browning, "Agglomeration", Chemical Engineering, December 1967 4th, 147-48, Perry's Chemical Engineer's Handbook, 4th edition, McGraw-Hill, New York, 1963, pp. 8, 57 and below: WO 91/13546, U.S. Patent No. 4,172,714, U.S. Patent No. 4, 144,050, U.S. Patent No. 3,920,442, U.S. Patent No. 5,180,587, U.S. Patent No. 5,232,701, U.S. Patent No. 5,208,030, U.S. Patent No. 2,095,558, U.S. Patent No. 3,299,566, Klingman, Weed Control as a Science, John Wiley and Sons, New York, 1961, Hance et al., Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989 and Mollet, H., Grubemann, A., Formulation tech-nology, Wiley VCH Verlag GmbH, Weinheim (Germany), 2001 ' 2. DA Knowles, Chemistry and Technology of Agrochemical Formulations, Kluwer 133661.do C -116- 200917962 ,1998 (ISBN 0-7514-0443-

Examples of suitable solvents are water, aromatic solvents (eg SGlvess® products)

Academic Publishers, Dordrecht, 1998 8)), for example by applying an agrochemical and/or carrier, if necessary, an emulsifier, surface >: A D, Shi Kan (eg mineral oil stealing, high)言 / s , m _

Suitable emulsifiers are nonionic and anionic emulsifiers (e.g., polyoxyethylene fatty alcohol ethers, alkyl sulfonates, and aryl sulfonates). Examples of dispersing agents are lignin-sulfite waste liquors and methylcellulose. Suitable surfactants used are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, dibutylnaphthalenesulfonic acid, alkylarylsulfonate, alkylsulfate, alkylsulfonate, fatty alcohol sulfate , alkali metal, alkaline earth metal and ammonium salt of fatty acid and sulfated fatty alcohol glycol ether; and condensate of sulfonated naphthalene and naphthalene derivatives with awakening, condensate of naphthalene or naphthalenesulfonic acid with phenol and furfural, poly Oxyethylene octyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl phenol polyglycol ether, tributyl phenyl polyglycol ether, tristearyl benzene Polyglycol ether, alkyl aryl polyether alcohol, alcohol and fatty alcohol / ethylene oxide condensate, ethoxylated castor oil, polyoxyethylene alkyl ether; ethoxylated polyoxypropylene 133661. Doc -117- 200917962 :,, lauryl alcohol polyglycol ether acetal, sorbitol ester, bismuth sulfite waste liquid and methyl cellulose. , in the preparation of a solution, emulsion, ointment or oil dispersion which can be directly sprinkled, has a medium to high boiling mineral oil fraction, such as kerosene or diesel, ',, 'from and plant 〆 or animal oil' fat Smoke, ring smoke and aromatic hydrocarbons, such as female mouth - toluene, paraffin, tetrahydronaphthalene, alkylated naphthalene or its derivatives, methanol, ethanol, propylene _ % butyl, hexanol, cyclohexanone, isophor Ketones, highly polar solvents, such as _H column such as monomethyl hard, N-methylpyrrolidone or water. Antifreezes such as glycerin, 7^-ethyl alcohol, propylene glycol, and bactericides may also be added to the formulation. Suitable antifoaming agents are, for example, antifoaming agents based on strontium or magnesium stearate. Suitable preservatives are, for example, dichlorophenol. Seed treatment for 6 weeks may additionally comprise binders and (as needed) colorants Adhesive may be added to improve the adhesion of the active material to the seed after treatment. Suitable binder is block copolymer EO/PO surfactant, and also polyethylene glycol, polyb-baked "Bilobutanone, Polypropylene roasting acid, polymethyl acrylate vinegar, polybutene , polystyrene, polyvinylamine, vinyl amide, polyethyleneimine (LUpas〇i®, P〇lymin8), polyether, polyamine phthalate, polyethylene acetate, methyl cellulose ( Tylose) and copolymers derived from such polymers. Colorants may also be included in the formulation, as appropriate. Suitable colorants or dyes for seed treatment formulations are Rhodamin B, CI Pigment Red. 112, CI·solvent red hydrazine, pigment blue 15:4, pigment blue 15:3, pigment blue 133661.doc -118- 200917962 Pigment blue 1 5, 1, pigment blue 8 〇, pigment yellow 1, pigment yellow 1 3, Pigment red 112, pigment red 48:2, pigment red 48:1, pigment red 57:1, pigment red pigment dial 43, pigment orange 34, pigment dial 5, pigment green 3 6, pigment green 7, pigment white 6, pigment Brown 25, alkaline violet 10, basic violet 49, acid red 5 1, acid red 52, acid red 14, acid blue 9, acid yellow 23, alkaline red 1 碱性, alkaline red 1 〇 8. Gelling agent An example is Satiegel (g). A powder (ie, a material for spreading and a spreadable product) can be prepared by mixing or simultaneously grinding the active material with a solid carrier. Particles are prepared by binding the active compound to a solid carrier, such as coated particles, impregnated particles, and homogeneous particles. Examples of solid carriers are mineral soils (eg, silicone, silicate, talc, kaolin, American activated clay (attaclay), limestone, lime, chalk, red basalt, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials), fertilizer (such as ammonium sulfate, Lin Acidic, ammonium sulphate, urea) and plant-derived products (such as cereal meal, bark meal, wood flour and nutshell meal), cellulose powder and other solid carriers. In general, the formulation comprises from 0.01% to 95% by weight, preferably from 00% to 90% by weight, of the active compound. In this case, the purity of the active compound is between 90% and 100% by weight, and the car is preferably between 95% and 1% by weight (according to NMR spectrum). For seed treatment purposes, each formulation may be diluted 2 to 1 fold so that the weight ratio of active compound in the ready-to-use formulation is between qqi _ 6 g wt% 133661.doc -119- 200917962, preferably between 0 · 1 - 40 0% by weight. The formula 1 or the hydrazine compound can be used as it is by spraying, spraying, spreading, spreading or perfusion in the form of its formulation or the form prepared therefrom, for example, a solution, a powder, a suspension or a dispersion which can be directly sprayed. , emulsion 1 dispersion, paste, spreadable product, spreading material, or granular form. The use form is entirely dependent on the intended purpose; it is intended to ensure, in each case, that the active compound of the invention achieves the finest possible distribution. The aqueous use form can be prepared by adding water from an emulsion concentrate, a paste or a wettable powder (a sprayable powder, an oil dispersion). For the preparation of emulsions, guest or oil dispersions, the materials which are untreated or dissolved in oil or solvent can be homogenized in water by means of wetting agents, adhesives, dispersants or emulsification. Narrowly, it is also possible to prepare concentrates consisting of active substances, wetting agents, adhesives, dispersing agents and, if appropriate, solvents or oils, and such concentrates are suitable for dilution with water. The concentration of the active compound in the ready-to-use formulations can vary over a relatively wide range. Usually, the concentration of the active compound is 〇.__1 (%), and the preferred active compound can also be successfully used in the ultra low amount method (ulv), and can be applied: a formulation containing more than 95% by weight of the active compound, or It is even possible to apply an active compound which does not contain an additive. The following are examples of formulations: The product of the L blade application diluted with water. These products can be applied to the seed in diluted or undiluted form for seed treatment purposes. A) Water-soluble concentrate (SL, LS) 1 part by weight of the active compound is dissolved in 9 parts by weight of water or water-soluble 133661.doc -120-200917962w. As an alternative, a wetting agent or other adjuvant may be added. The active compound is dissolved after dilution with water' to thereby obtain a formulation containing 丨〇% (w/w) of the active compound. B) Dispersible Concentrate (DC) 20 parts by weight of the active compound are dissolved in 7 parts by weight of cyclohexanone, and 10 parts by weight of a dispersing agent (e.g., polyethylene D to singeone) is added. The dispersion was diluted with water to obtain a formulation containing 20% (w/w) of the active compound. c) emulsifiable concentrate (EC) 15 parts by weight of the active compound dissolved in 7 parts by weight of xylene under the addition of calcium dodecylbenzenesulfonate and ethoxylated castor oil (each added 5 parts by weight) in. Dilute with water to obtain an emulsion, thereby obtaining a formulation containing 15% (w/active compound. D) emulsion (EW, EO, ES)

25 parts by weight of the active compound was dissolved in 35 parts by weight of dimethyl sulfonate, and calcium dodecylbenzenesulfonate and ethoxylated cannabis oil (5 parts by weight each) were added. This mixture is introduced into (10) parts by weight of water by means of an emulsifier (e.g., Ultraturrax) to form a homogeneous emulsion. It is diluted with water to give an emulsion, whereby a formulation containing 25 ° / 〇 (w / w) of the active compound is obtained. E) Suspension (SC, 〇D, FS) In the shaker 1 ball mill, 20 parts by weight of live dan / eight cylinders \ jade & add to ιυ垔..., wetting agent and 70 weight The mixture is pulverized in water or an organic solvent to obtain a stable suspension of the fine active compound liquid compound, whereby a formulation containing 2:::::133661.doc 121 200917962 is obtained. F) water-dispersible granules and water-soluble granules (WG, SG) finely grind 50 parts by weight of the active compound with the addition of 50 parts by weight of a dispersing agent and a wetting agent, and by means of technical equipment (for example, an extruder, The spray tower, fluidized bed) is made into water-dispersible or water-soluble particles. Dilution with water gives a stable dispersion or solution of the active compound, whereby it is obtained to contain 5 Å. (w/w) a formulation of the active compound.

G) Water-dispersible powder and water-soluble powder (WP, SP, SS, WS) 75 parts by weight of the active compound were ground in a rotor-precipitator mill by adding 25 parts by weight of a dispersant, a wetting agent and silicone. A stable dispersion or solution of the active compound is obtained by diluting with water, whereby a formulation containing an active compound of 75 ° (w/w) is obtained. H) gel formulation (GF) in agitating ball mill, adding 1 part by weight of dispersant, 1 part by weight of agglomerating agent (5) wet agent and 70 parts by weight of water or organic solvent, 2 parts by weight The number of active compounds is comminuted to obtain a fine suspension of the active compound. Dilution with water gives a stable suspension of the active compound, whereby a formulation containing 20% (w/w) of active compound is obtained. 2. For the application of leaf application without dilution. For seed treatment, the products may be applied to the seed in a diluted or undiluted form. U-sprayable powder (DP, DS) 5 parts by weight of activated human extracts, ground, and thoroughly mixed with 95 parts by weight of refined mulch. Thus, 133661, doc-122·200917962 J) granules (GR, FG, GG, MG) of the active compound having a W (Ww) activity are obtained, and 0.5 parts by weight of the active compound are finely ground and 95 parts by weight The carrier 1J was mixed 'by this to obtain a formulation containing 0.5% (w/w) of the active compound. Current methods are extrusion, spray drying or fluidized beds. This results in particles that are used in blade applications without dilution. K) ULV solution (UL) 10 parts by weight of the active compound are dissolved in 9 parts by weight of an organic solvent such as xylene. This gives a product containing 1% (w/w) of active compound which can be used for blade application without dilution. Compounds of formula II or II are also suitable for the treatment of plant propagation material (eg seeds). Conventional seed treatment formulations include, for example, flowable concentrate FS, solution LS, dry treatment powder DS, water dispersible slurry treatment powder ws, water soluble powder ss and emulsion ES&EC and gel formulation GF . The formulations can be applied to the seed in diluted or undiluted form. Seeds can be applied prior to sowing, either directly to the seed or after pre-emergence of the seed. In a preferred embodiment, the FS formulation is used for seed treatment. Usually FS formulations can contain from 1 to 800 g/1 active ingredient! Up to 2〇〇g/i surfactant, 〇 to 200 g/Ι antifreeze, 〇 to 4〇〇g/丨 binder, 〇 to 2〇〇g/i pigment and up to 1 liter of solvent (water is preferred) . Other preferred fs formulations of the compound of formula I or 11 for seed treatment comprise from 0.5 to 80% by weight of active ingredient, 〇.〇5_5 wt% wetting agent, 〇5_15 wt% dispersant, 0.1-5 wt% thickening Agent '5_20 wt% antifreeze' 〇"_2 wt% defoamer, 1-20 wt% pigment and / or dye, 〇 _ 15 wt% adhesive / binder, 133661.doc -123 - 200917962 0-75 wt % filler/vehicle, and ow].% preservative. If appropriate, various types of oils, wetting agents, adjuvants, herbicides, fungicides, other insecticides or bactericides (tank mix) may be added to the active ingredient just prior to use. These agents are usually mixed with the reagent of the present invention in a weight ratio of 1:1 Torr to 1 Torr. Compounds of formula I or II may be effective by contact (via soil, glass, walls, mosquito nets, carpets, part A or animal parts) and ingestion (feeding or plant parts). When the cockroach is used against ants, termites, wasps, flies, mosquitoes, cockroaches, cockroaches, the compound of formula I or II is preferably used in the form of a stimulating composition. The mutin can be a liquid, solid or semi-solid preparation (e.g., a gel). Solid baits can be formed into different shapes and forms suitable for a variety of applications, such as granules, blocks, rods, trays. Liquid lures can be charged into various devices to ensure proper application 'e.g., open containers, spray devices, droplet sources, or evaporation sources. Condensation can be based on aqueous or oily matrices and can be formulated according to the specific needs of the viscosity, thirst retention or aging characteristics. 〆 Combination shots (4) (4) Fully attractive (4) Inducing insects such as code ants, ants, page bees, flies, mosquitoes, cockroaches, or Fischers. The stimulant or sexual pheromone can be used to manipulate the non-exclusive genus @ έ ", 5 thorns, selected from, for example, animal and/or vegetable proteins (meat, oil y, insect parts, egg yolk) ), animal and / or plant derived fats and oils or early sugar, oligosaccharides or organic polysaccharides, female, 1 π dextrose, glucose 1 powder =:::, lactose, fructose, pectin or even molasses or honey. Secondary, crop, plant, animal, insect fresh or rotted parts or: 2 13366] .doc •124· 200917962 Can also be used as a food stimulant. Sex hormones are known to have greater insect specificity. Specific pheromones are described in the literature and are known to those skilled in the art. - milk bath gel (for example, the formulation of the compound of formula I or II in the form of WW, 丨厂/«7 -beixiang or pump spray is very suitable for non-professional users to control such as fly, cockroach, cockroach , pests such as mosquitoes or cockroaches. Milk > gluten formula is preferably composed of the following substances: active compound; solvent, sensible, such as lower alcohol (eg sterol, ethanol, propanol, butanol), _ class (such as C-, mercaptoethyl network), paraffin hydrocarbons (such as ^ oil) with a boiling point between about 50 and 250 t, dimethyl decylamine, N-methyl pyrrolidine _, - Tian Jian π a T-based sulfoxide, an aromatic hydrocarbon (such as toluene, xylene), water; and an adjuvant, such as an emulsifier (such as sorbitol monooleate, having 3-7 moles 7 ^ 轧An oil-based ethoxylate, an ethoxylated fatty alcohol; an aromatic oil (such as an essential oil), an ester of a medium-carbon fatty acid and a lower alcohol, an aromatic carbonyl compound σ σ, (if appropriate) a stabilizer (eg sodium benzoate), amphoteric surfactant, 4 low oxime epoxide, triethyl orthoformate and, if necessary, propellant ( For example, C-burn, J hospital, nitrogen, compressed air, dimethyl mystery, carbon dioxide, nitrous oxide or ρ of these gases.) Also because of the use of propellant, oily spray formulation and U (four) forest 〇 1 or The compounds and their respective compositions can also be used in mosquito coils and smoked musk, fumigation, evaporation boards or long-acting evaporators, H f ... Μ T for insect-resistant main paper, insect-resistant main mat or other evaporators without heating In the system. "Formula 1 or 11 compounds and their respective compositions to control transmission by insects 133661.doc •125- 200917962 Sexually transmitted diseases (eg malaria, dengue and yellow fever, lymphatic filariasis, and leish The method of leishmaniasis also includes the treatment of sheds and house surfaces, air spraying and dipping curtains, tents, clothing, mosquito nets, tsetse traps or the like. Applied to fabrics, fabrics, knitwear, non- The insecticidal composition of the fabric, mesh material or foil and tarpaulin preferably comprises a mixture comprising an insecticide, (as needed) a protective agent and at least one binder. For example, a suitable protective agent N, N-Diethyl-m-toluidine (DEET), N,N-diethylphenylacetamide (DEpA), ^-cyclohexyl _ carbonyl)-2-methylhexahydropyridine , (2-hydroxydecylcyclohexyl)acetic acid lactone, 2-ethyl-1,3-hexanediol, indole oxime, decyl neodecylamine (MNDA), not used for insect control Pyrethroids (eg, {(+/_)_3_allyl-2-methyl-4-oxocyclopenta-2-(+)-alkenyl-(+)-trans-chrysanthemate (sbiothrin)) from plant extracts or the same protective agents as plant extracts (such as lemon olein, eugenol, ( + ) _Eucamal 〇 1 (1), (a) small table _ Eucamalol), or derived from Crude plant extracts of the following plants: Eucalyptus maculata, vitex r〇tundif〇lia, Cymb〇P〇gan martinii, Lemongrass (Cymb〇p〇gan) Cit considers S) (lemon grass), lemongrass (Cym〇p〇gan 丽 steal 3) (ciu〇nella). For example, 'suitable binders are selected from the group consisting of polymers and copolymers of the following materials: vinyl esters of aliphatic acids (such as vinyl acetate and vinyl versatate), acrylates of alcohols and methyl groups. Acrylates (e.g., butyl acrylate, 2-ethylhexyl acrylate, and decyl acrylate), mono- and diethylene-based unsaturated hydrocarbons (e.g., styrene), and aliphatic diolefins (e.g., butadiene). 133661.doc • 126 - 200917962 Curtain / s: / shell is usually carried out by soaking the textile material in an emulsion or dispersion of the formula j and π active compound or spraying it onto the fabric. In principle, the methods which can be used to treat seeds are all suitable seed treatment techniques known in the art, and in particular, techniques for seeding, such as seed coating (e.g., seed pelleting), powder dressing, and seed swelling (e.g., seed soaking). In this context, "seed treatment" refers to all methods of making seeds and formula or π compounds in contact with each other 'and' seed dressings are directed to the seed treatment method of the formula (10) compound, ie, the production of the inclusion compound compound Seeds. In principle, the seed can be treated at any time after seed harvesting until seeding. Seeds can be treated using, for example, a "sowbox" method prior to planting the seed or during planting the seed. However, it is also possible to carry out the treatment in the form of seed dressing for several weeks or several months (e.g., up to 12 months) before planting the seed' where no significant decrease in potency is observed. Untreated seeds can be conveniently treated. The term "unseeded seeds" as used herein, is meant to include seeds that are harvested from seed to seed at any stage during the germination and growth of the plant for the purpose of plant germination. In particular, certain procedures are followed in the treatment, A suitable device, such as a mixing device for mixing solid or solid/liquid complexes, is mixed with the desired untreated or pre-water diluted seed treatment formulation until the composition is Hooked on the seed. If appropriate, the drying step is carried out afterwards. The compounds of the formula I or II or their enantiomers or veterinary acceptable salts are also especially suitable for combating parasites in and on animals. 133661.doc • 127- 200917962 Accordingly, another object of the present invention is to provide a novel method of controlling parasites in and on animals. Another object of the present invention is to provide a safer insecticide for animals. An animal insecticide that can be used at a lower T dose than the current insecticide. Another object of the present invention is to provide an animal that can provide long-lasting control of parasites. The invention also relates to a composition comprising a parasiticidally effective amount of a compound or an enantiomer or a veterinarily acceptable salt thereof and an acceptable carrier for use in an animal The body surface is resistant to parasites. The invention also provides a method for treating, controlling, preventing and protecting an animal against parasitic axis infestation and sensation, comprising administering to the animal an oral, topical or parenteral administration or application of a parasiticidally effective amount. Formula I or a guanidine compound or an enantiomer or veterinary acceptable salt thereof or a composition comprising the same. The invention also provides for the preparation, treatment, control, prevention or protection of an animal against parasites or A method of infecting a composition comprising a parasiticidally effective amount of a compound of the formula or an enantiomer or a veterinary acceptable salt thereof or a composition comprising the same. The activity does not indicate that it has the adaptability of endoparasites and ectoparasites in the body and on the surface of the body, such as the need for adaptation (at the time of oral administration), low dose of non-emetic, metabolic compatibility with animals, low toxicity, Operational safety. Incidentally, it has been found that the compounds are suitable for combating endoparasites and ectoparasites in and on animals. Formula I or hydrazine compounds or their enantiomers or veterinary The accepted salt and the compositions comprising the same are preferably used for controlling and preventing infestation to animals: Sense 133661.doc -128- 200917962 Dyeing, including warm-blooded animals (including humans) and fish. For example, it is suitable for control And prevention of infestation and infection of the following animals: mammals such as cattle, latitude sheep, pigs, road riders, deer, horses, piglets, poultry, rabbits, goats, dogs and cats, buffalo, donkeys, flat-horned deer and reindeer; And fur animals such as hair, ', milk and bottle, birds, such as hens, cranes, turkeys and ducks; and ', :, such as freshwater fish and saltwater fish, such as squid, fish and oysters The compound of formula I or II, or an enantiomer or veterinary acceptable salt thereof, and compositions comprising the same are preferably used to control and prevent infestation and infection to livestock, such as dogs or cats. Infestations in warm-blooded animals and fish include (but are not limited to) cockroaches, cockroaches, cockroaches, larvae, larvae, biting worms, fly-like worms, flies, larvae, cockroaches, cockroaches, cockroaches And 蚤. The compound of formula I or II, or an enantiomer or veterinary acceptable salt thereof, and compositions comprising the same are suitable for systemic and/or non-systemic control of ectoparasites and/or endoparasites. It is effective against all or some stages of development. The compounds of formula I or II are especially useful against ectoparasites. The compounds of formula I or II are especially useful for combating the following and various parasites (Siphonaptera), such as Cten〇cephalides felis, Ctenocephalides canis, Xenopsylla cheopis, puiex irritans, Tunga penetrans, and Nosopsynus fasciatus, Blattaria-Blattodea, such as Germany Small cockroach, Asian cockroach (Blattella asahinae), American cockroach (Peripianeta 133661.doc -129· 200917962 americana), Japanese giant cockroach (Periplaneta japonica), brown cockroach (Periplaneta brunnea), black-breasted cockroach (peripianeta fuligginosa) , Periplaneta australasiae, and Blatta orientalis, fly 'Diptera (Diptera)' such as Aedes aegypti, Aedes albopictus, Aedes aegypti, Mexican orange fly , Anopheles sinensis, Anopheles crucians, Anopheles albimanus, Anopheles gambiae, Anophe Eles freeborni), Anopheles leucosphyrus, Anopheles mini-mus, Anopheles quadrimaculatus, Calliphora vicina, cockroach fly, spiral gold fly, meat Chrysops discalis, Chrysops silacea, Chrysops atlanticus, Cochliomyia hominivorax, Tumor flies, Culicoides furens Culex pipiens pallens, Culex nigripalpus, Culex quinquefasciatus, Culex tarsalis, Culiseta inornata, Culiseta melanura, human Dermatobia hominis, yellow-bellied scorpion fly, squid, tsetse fly, Glossina palpalis, Glossina fuscipes, Glossina tachinoides, harassment horn, saddle瘿瘿 mosquitoes, Hippelates spp·, mosquito flies, Lep-toconops torrens, sheep green fly, pheasant fly, silky green fly, jade neck rope, Mandonia Spp.) House rope, carrion can, sheep nose, silver foot white 133661.doc -130- 200917962 (Phlebotomus ar-gentipes), Colombian scale mosquito (psor〇ph〇ra columbiae), color-changing mosquito (Psorophora discolor), plum Prosimulium mixtum, Sar-cophaga haemorrhoidalis, Sarcophaga sp., Simulium vittatum, Stomoxys calcitrans, Burdock, North American blackbird (Tabanus) Atratus), Tabanus lineola, and Tabanus similis, Phthiraptera, such as pediculus humanus capitis, Pediculus humanus corporis, and yin Pthirus pubis), Haematopinus eurysternus, Haematopinus suis, Linognathus vituli, Bovicola bovis, Menopon gallinae, Menacanthus Stramineus) ' and Solenopotes capillatus, monument and parasitic worm (Parasitiformes): 蜱 (Ixodida), such as the shoulder torsion (lx〇de s scapularis), Ixodes holocyclus, Ixodes pacificus, JH Rhiphicephalus sanguineus, Dermacentor andersoni, Dermacentor variabilis, American bud, Ambryomma maculatum, Ornithodorus hermsi, Ornithodoros turicata, and parasitic worm (Mesostigmata), such as the tropical locust (Orni) -thonyssus bacoti) and chicken skin snail, Actinedida (Prostigmata) and powder worm 133661.doc -131 - 200917962 (Acaridida) (Astigmata) such as 螨Genus (Acarapis spp.), Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergates spp., Demodex Spp.), Trombula spp., Listrophorus spp., Acarus spp. 'Tyrophagus spp., Caloglyphus spp. , low dynasty (Hyp〇dectes spp.) Pterolichus spp_, Psoroptes spp., Chorioptes spp., 〇t〇dectes spp., Sarcoptes spp., ear Notoedres spp., Knemidocoptes spp., cytodites spp., and Laminosioptes spp., bedbug (Heteropterida): temperate zone Bedbug (Cimex lectularius), tropical bug (Cimex hemipterus), Reduvius senilis, Triatoma spp., Triatoma spp., Panstrongylus ssp_ and round A (Arilus, . critatus), Anoplurida ' For example, Haematopinus spp., Linognathus spp., pediculus spp., Phtirus spp. Solenopotes spp., Mallophagida (Amblycerina and Ischnocerina), such as Trimenopon spp., Menopon spp., Trinoton spp. , Bovicola spp., Werneckiella spp, Lepikentron spp, 133661.doc -132- 200917962 genus (Trichodectes spp.) and genus Felicola spp., Roundworms Nematoda: Wipeworms And Trichinosis (Trichosyringida), such as Trichinellidae (Trichinella spp.), Trichuridae (Trichuris spp.), Capillaria spp., Rhabditida, such as Rhabditis spp., Strongyloides spp., Helicephalobus spp., A. elegans (Strongylida), for example, Strongylus spp., Ancylostoma spp., Necator americanus, Bunosto-mum spp. (Hookworm), Trichostrongylus spp., Haemonchus contortus, Ostertagia spp., Cooperia spp., Nematodirus spp. ), net tail line Dictyocaulus spp., Cyathostoma spp., Oesophagostomum spp., Stephanurus dentatus, OUulanus spp., Chastera Chabertia spp.), Syngamus trachea, Uncinaria spp., Globocephalus spp., Necator spp., Metastrongylus spp. , Muellerius capillaris, Protostrongylus spp., A. elegans (Angiostrongylus 133661.doc -133 - 200917962 SPP·), Parelaphostrongylus spp., Omega Aleurostrongylus abstrusus and Dioctophyma renale » Intestinal roundworms (Ascaridida), such as Ascaris lumbricoides, Ascaris suum, chicken worms Ascaridia galli), Parascaris equorum, Enterobius vermicularis (Threadworm), Toxoplasma gondii (Tox Ocara canis), Toxascaris leonine, ''Skrjabinema spp.'), and Oxyuris equi, Camallanida, such as Dracunculiasis (Dracunculus medinensis) (guinea worm), Spirurida, such as Thelazia spp., Wuchereria spp., Brugia spp., Onchocerca Spp·), 9Dirofilari spp.), Dipetalonema spp., Setaria .·: ' spp., Elaeophora spp., Lushi tail Helicobacter species (Spirocerca lupi) and Hab-ronema spp. » Thorny headed worms (Acanthocephala) such as Acanthocephalus SPP·, pig giant Machae an thorhynchus hirudinaceus, and 〇ncic〇ia spp., Planarians (Plathelminthes): Flukes (Fagidae) Trematoda)), for example, flukes 133661.doc -134 - 200917962 (Faciola spp.), Fascioloides magna, Paragonimus spp., Dicrocoelium spp., Fasciolopsis buski , Clonorchis sinensis, Schistosoma spp., Trichobilharzia spp., Alaria alata, Paragonimus spp .), and Nanocyetes spp., Cercomeromorpha, especially Cestoda (Tapeworms), such as Diphyllobothrium spp. ), Tenia spp., Echinococcus spp., Dipylidium caninum, Multiceps spp., Hymenolepis spp. Mesocestoides spp., Vampirolepis spp., Moniezia spp., Anoplocephala spp., Sirometra spp ·), Anopi〇cephala spp., And the genus Hymenolepis spp., the compound of formula I or II and compositions comprising the same are particularly useful for controlling pests of the order Diptera, Acarina and Sphaerocephala. Furthermore, the compounds of formula I or II and compositions comprising the same are particularly useful for combating mosquitoes. Another preferred embodiment of the invention is a compound of formula 1 or II and compositions comprising the same for use in combating flies. In addition, the compounds of formula I or II and compositions comprising the same are particularly useful for combating eggs 133661.doc • 135. 200917962. Another preferred embodiment of the invention is a compound of formula I or π and a composition comprising the same for use in combating mites. The compound of formula I or II and the group comprising the same, and the sigma is also particularly useful for combating endogenous insects (microbes, echinoderms and planarians). Administration can be implemented in a prophylactic and therapeutic manner. Administration of the active compound is carried out in an oral, topical/transdermal or parenteral manner, either directly or in a suitable formulation.

For oral administration of warm-blooded animals, the compounds of formula I or II can be formulated into animal feed, animal feed premix, animal feed tumbling, pellets, solutions, ointments, suspensions. , veterinary use of drugs, gel, (four) Bu Da pills and capsules. Alternatively, the compound of formula I or π can be administered in the form of drinking water | animal. For oral administration of 'selected dosage forms, animals should be given 0.01 mg/kg to (10) called (10) animal weight/day of the formula or „compound, preferably from 05 mg/kg to 100 mg/kg animal body weight/day. The compound can be administered to the animal parenterally (for example by intratumor, intramuscular, intravenous or subcutaneous injection). The formula compound can be dispersed or dissolved in a physiologically acceptable carrier. For subcutaneous injection. Or 'the compound can be formulated as an implant for subcutaneous administration. In addition, the compound can be administered to the animal transdermally. For parenteral administration, the selected dosage form should be administered to the animal. A compound of formula 1 or II is provided in a concentration of 0.01 to 1 in cent. of the animal. The compound of formula I or II can also be applied topically to the animal in the form of a powder, a powder, a circle of love, a charm, Spraying agent, shampoo, spot application 133661 .doc -136· 200917962 and note S-wedding, and ointment or oil-in-water or water-in-oil emulsion. For topical application, infusions and sprays usually contain 0.5 ppm. Up to 5 〇〇〇ppm and preferably i ppm to 3 000 ppm In addition, formula compounds can be formulated into ear tags for animals (especially tetrapods such as cattle and sheep). Suitable formulations are: solutions, such as oral solutions, orally administered concentrates after dilution, for application to the skin or body cavity. Solution, formulation, gel; emulsion or suspension for oral or transdermal administration; semi-solid preparation; preparation of active compound by ointment-based or oil-in-water or water-in-oil emulsion base; solid Formulations, for example, powders, premixes or concentrates, granules, tablets, lozenges, boluses, capsules; aerosols and inhalants, and shaped articles containing active compounds. Suitable compositions for injection by active ingredients Prepare in a suitable solvent and add other ingredients such as acids, bases, buffer salts, preservatives, and solubilizers as needed. Sterile filtration and filling of the solution. Suitable solvents are physiologically tolerant solvents, such as Water, alkanols such as ethanol, butanol, stupid methanol, glycerol, propylene glycol, polyethylene glycol, hydrazine-methylpyrrolidone, 2-pyrrolidone, and mixtures thereof. The active compound may be dissolved in a physiologically tolerable vegetable oil or synthetic oil suitable for injection, as appropriate. Suitable and bulking agents are those which promote dissolution or prevent precipitation of the active compound in the main solvent. Vinyl pyrrolidone, "vinyl alcohol, polyoxyethylated castor oil, and polyoxyethylated sorbitan ester. 133661.doc -137- 200917962 Suitable preservatives are benzyl alcohol _ ιΤ τ and 虱Fermentation, parabens, and the butanol.: The solution is directly administered. After pre-dilution to the concentration used, oral administration, % of the solution, oral solution and concentrate are according to the current technology and the needle solution as above The method is prepared to make the sterilization process unnecessary. The solution used on the skin is sprayed, coated, rubbed, sprinkled or sprayed onto the skin. The solution for application to the skin is prepared according to the current techniques and as described above for the injection solution. The disinfection process is not required. Other suitable solvents are polypropylene glycol, phenylethyl alcohol, phenoxyethanol, esters (for example, acetic acid s or butyl acetate, benzoic acid f-based s), _ (for example, stretching / mono-alcohol alkyl ether) 'eg dipropylene glycol monomethyl ether), ketones (eg acetone, methyl ethyl ketone), aromatic hydrocarbons, vegetable oils and synthetic oils, dimethylformamide, dimethyletheneamine, ethylene glycol monoethyl _ 、, 嗣 嗣 glycerol (solkeul), propylene carbonate, and mixtures thereof. \ During the preparation period, it is better to add _ ^ suitable to increase (four) series: inorganic thickeners such as bentonite, colloidal tannic acid, aluminum monostearate; organic two additives, such as cellulose derivatives, polyvinyl alcohols and Its copolymer, acrylic acid and methyl acetoacetate are intended. The gel is applied to or applied to the skin or into the body cavity. The gel is prepared by treating a solution prepared as described in the case of an injection solution with a sufficient amount of a thickening agent to produce a clear material having an ointment-like consistency. The thickener used is the thickener given above. The formulation is poured or sprayed onto a defined area of the skin, activity 133661.doc -138- 200917962 The compound penetrates into the skin and acts in a systemic manner. The formulations are prepared by dissolving, suspending or emulsifying the active compound in a suitable skin compatible solvent or solvent mixture. If appropriate, other adjuvants such as coloring agents, biological inhalation enhancers, antioxidants, light stabilizers, and adhesives may be added. Suitable solvents are water, alkanol, diol, polyethylene glycol, polypropylene glycol, glycerin, aromatic alcohols (such as stupid methanol, phenylethanol, phenoxyethanol), esters (such as ethyl acetate, butyl acetate) , benzyl benzoate), ethers (such as alkylene glycol alkyl ethers, such as dipropylene glycol monomethyl ether, diethylene glycol monobutyl ether), ketones (such as acetone, methyl ethyl ketone) ), cyclic carbonates (eg, propylene carbonate, ethylene carbonate), aromatic and/or aliphatic hydrocarbons, vegetable oils or synthetic oils, DMF, dimethyl decylamine, n-alkyl pyrrolidone (eg Methyl sputum _, positive base ketone or n-octyl carbaryl ketone), N-decyl pyrrolidone, 2 pyrrolidone, 2,2 dimethyl _4 _ oxygen - methylene Base-1,3-dioxolane and glycerol formal. Suitable colorants are all materials used in animals and can be used as feedstocks. Suitable absorption systems are, for example, DMS(R), expansion oils (eg, isopropyl sulfonium myristate), propylene glycol phthalate, oxime Oil and its copolymer with polyether, fatty acid esters, triglycerides, fatty alcohols. Suitable antioxidants are sulfite or metabisulfite (9) potassium citrate), ascorbic acid, butyric acid toluene, butyl group-based bacteria:: raw; Suitable light stabilizers are, for example, n〇vantis〇Hcacid. 133661.doc -139- 200917962 Suitable adhesives are, for example, fiber sulphuric acid vinegar, natural polymers (such as barium sulphate, temple powder derivatives, polyacrylic acid salts), gelatin. The f solution can be administered by mouth or percutaneous injection. The emulsion is either a water-in-oil or an oil-in-water type. It is prepared by dissolving the active compound in a hydrophobic or hydrophilic phase, and in a suitable emulsifier and oxime, and other adjuvants (eg, coloring agents, absorption enhancing substances, preservatives, The aid of the color-enhancing substance does not 盥1 his viscosity...the solvent of the other phase is homogenized together. Suitable hydrophobic phase (oil) system: 'Liquid Dendrobium, Shishi Oxygen Oil, natural vegetable oil (such as sesame oil, almond oil, sesame oil), synthetic glycerol _ (such as caprylic acid / citric acid diglycerin brewing and chain length. 8 - 12 plant fatty acids or other specially selected natural fatty acid glycerol trisole mixtures, may also contain a mixture of saturated or unsaturated fatty acid glycerol esters, c8_Ci. fatty acid monoglycerides and diglycerols, fatty acids (eg stearic acid ethyl hexahydrate, di-n-butyric acid adipic acid vinegar, hexyl hexanoate, dipropylene glycol phthalate), medium chain length branched fatty acids and chain length saturated fatty alcohol esters, meat Isoprozil mesylate paste: isopropyl vinegar, chain length Cu-C〗 8 octanoic acid / phthalic acid ester of saturated fatty alcohol, isopropyl stearate, oleic acid ester, oleic acid oleate, Ethyl oleate, ethyl lactate, waxy fatty acid esters (eg synthetic duck tail fat), dibutyl citrate, diisopropyl adipate, ester mixtures associated with the latter, fatty alcohols (eg Isotridecyl alcohol, 2-octyldodecanol, cetyl Lipidyl alcohol, oleyl alcohol), and fatty acids (such as oleic acid) and mixtures thereof. Suitable hydrophilic phase: water, alcohol (such as propylene glycol, glycerin, sorbitol) and 133661.doc -140- 200917962 mixture thereof. Dosage system: non-ionic surfactants, such as polyethoxylated castor oil, polyethoxylated mountain aldol monooleic acid _, sorbitol monostearic acid s, monostearic acid glycerol s 曰 polyoxyethylene Alkyl stearate, alkylphenol polyglycol ether; amphoteric surfactant, such as N-moons earth basin, month & base-p-iminodipropionate disodium or lecithin; anionic surface activity柯麻丨/£Ϊ .. million! For example, sodium lauryl sulfate, fatty alcohol ether sulfate, / / vJ^70 soil 3k glycol ether orthophosphate monoethanolamine salt; cationic active surfactant For example, gasified cetyltrimethylammonium. Other H« adjuvants: substances that enhance viscosity and stabilize emulsions, such as fluorenyl cellulose, sulfhydryl cellulose and other cellulose and starch derivatives Since the purpose, alginate, gelatin, gum arabic, poly-baked mouth is more than 7 Also a copolymer of metocol, methyl vinyl ether and maleic anhydride, polyethylene=alcohol, wax, colloidal acid or a mixture of the substances mentioned. Widely. The liquid can be administered orally or locally. And the following is a method in which the compound is suspended in a suspending agent, and if appropriate, an auxiliary j is added, such as a wetting agent, a coloring agent, a bioabsorption promoter, a preservative, an antioxidant, and a stabilizer. The liquid suspension is a mixture of all homogeneous solvents and solvents. Suitable moisturizers (dispersants) are the emulsifiers given above. Other adjuvants which may be mentioned are those given above.丨 can be administered orally or locally 'transdermally. It differs from the above suspensions and emulsions only in that it has a higher viscosity. For the production of solid preparations, the active compound and suitable excipients are considered 133661.doc - 141 - 200917962 The right and appropriate adjuvants are added to the mouth and made into the desired form. Use the == agent for all physiologically acceptable solid inert substances. The more (Example 2, "Several substances and organic matter. Inorganic systems (for example) gasification sodium, 2 ° calcium carbonate citrate), bicarbonate, alumina, titanium oxide 'tannic acid, sticky:: Shen Dian or colloid II Oxygen-cut, or acid-filled. Organic systems (for example) private, vitamins, grain and feed (eg milk powder, animal meal, coarse grain and crumbs, starch.) Adjuvants are mentioned above Preservatives, antioxidants, and/or colorants. Hydrogen and adjuvants (such as magnesium stearate, stearic acid, talc, bentonite), disintegration (such as temples) Powder or cross-linked polyene ratio '(4), adhesive (such as temple powder, gelatin or linear polyacetate than hexanone), and dry binder (such as microcrystalline cellulose), " An effective amount of parasiticidal means the amount of active ingredient required to achieve an observable effect on growth, including effects on necrosis, death, stagnation, and removal, destruction or reduction. For the various compounds/compositions used in the present invention, the parasitic touch is effective. The parasiticidally effective amount of the composition may also vary depending on the primary conditions (e.g., desired parasiticidal effect and duration, target species, mode of administration, and the like). The compositions used in the present invention may generally comprise from about 0.001 to about 95. Compound of formula 1 or π of °/〇. In general, the compound of formula I or II is advantageously applied in a total amount of from 0.5 mg/kg to 100 mg/kg/day, preferably i mg/kg S50 mg/kg/day. 133661.doc -142- 200917962 The song p is compounded with ly resistant parasites, preferably ectoparasites, with a degree of 10 rush (7) to a weight % 'better 〇 weight %, more preferably 1 _ 5 〇 weight 〇 /° 'Optimum 5-40% by weight. The concentration of the compound resistant to ectoparasites contained in the diluted preparation before use is 〇_5'% by weight, preferably 1-50% by weight. Further resistance contained in the preparation The concentration of the endoparasite! or the hydrazine compound is 1 〇PPm 2 罝%, preferably 0.05-0.9% by weight, excellent 〇·〇05_〇·25% by weight. In the preferred embodiment of the invention, the inclusion formula The composition of the compound is administered transdermally/topically. In another preferred embodiment, the topical application is in the form of a package. The form of the shaped article containing the compound is applied to, for example, a collar, a round ornament, an ear tag, a band attached to the body part, and an adhesive tape and a foil. In general, it is advantageous to apply solids within a three-week course of treatment. Formulation, which is released at a total weight of 10 mg/kg to 300 mg/kg, preferably 2 mg/kg D〇〇mg/kg, and optimally 25 mg/kg to 160 mg/kg of treated animal body weight Or II compound. For the preparation of shaped articles, thermoplastics and flexible plastics, as well as elastomers and thermoplastics (tetra), suitable for plastics and elastomers, and polyethylene resins and polyamines, which are fully compatible with the formula. Acid ester, polyacrylic acid brewing, epoxy resin, cellulose, cellulose derivative 4, poly-bristamine and poly-brew. A detailed list of plastics and elastomers for forming articles and preparation procedures are set forth, for example, in WO 03/086075. Compositions intended for use in accordance with the present invention may also contain other active ingredients, for example, 133661.doc • 143·200917962 U worms, insecticides, herbicides, fungicides, or bactericidal fertilizers (eg, nitrates, Exhibitors 'unloading, and over-filling salts), phytochemicals and plant growth regulators, safeners and nematicides. These additional wounds may be used sequentially or in combination with the above compositions, and may be added just prior to use (tank mixing) if appropriate. For example, the plants can be sprayed with the compositions of the invention after or after treatment with other active ingredients. The tanning agent can be mixed with the reagent used in the present invention in a weight ratio of 1:10 to 1 :1. Mixing Compound I or hydrazine or a composition comprising the same with other insecticides in the form of insecticide use generally achieves a broader range of insecticidal action. The following list Μ shows insecticides that can be used with the compounds 丨 or η of the present invention and which can be used to produce potential synergistic effects. The list is intended to illustrate possible combinations 'without any restrictions: Μ.Ι.Organic (thio) Phosphate: acephate, azamethiphos, azinph〇s_ethyl, azinphos-methyl, chlorethoxyfos, chlorfenvinphos, gas Chymium (Chl〇rmephos), chlorpyrifos, chlorpyrifos-methyl, coumaphos, cyanophos, demeton-S-methyl ), diazinon, dichlorvos / DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton EPN, ethyl sulphur (ethion), exthoprophos, famphur, fenamiphos, fenitrothion, fenthion, fluorosis 133661.doc -144- 200917962 (flupythiaophos), sigh ° sitting scales (fosthiazate) Heptenophos, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, Monocrotophos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, rice Phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos-methyl ), profenofos, propetamphos, prothiofos, pyrracofos, pyridaphenthion, quinalphos, zhiqilin Sulfotep), butyl 0^ bite (tebupirimfos), temephos, terbufos, tetrachlorvinphos, thiometon, three. Sitting on triazophos, trichlorfon, vamidothion; Μ.2. urethane: aldicarb, alanycarb, ° (bendiocarb), benfuracarb, butocarboxim, butadiene, butoxycarboxim, carbaryl, carbofuran, carbosulfan ), ethiofencarb, fenobucarb, formetanate, furathiocarb, isoprocarb 133661.doc -145 - 200917962 (isoprocarb), chlorpyrifos ( Methiocarb), methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb ( Thiodicarb), thiofanox, trimethacarb, XMC, xylylcarb. Take triazamate; 1^.3. Pyrethrins: flumethrin (&^11&1;]11411), pyrethroid (allethrin), dextro-cis-trans propylene Cordyceps, dextro-pyridyl pyrethrum, bifenthrin, bioallethrin, S-cyclopentyl anti-propylene pyrethrum, pyrethrin (bioresmethrin), Cycloprothrin, cyfluthrin, cold cyfluthrin, cyhalothrin, lambda-cyfluthrin, 7-cyfluthrin, cypermethrin, alpha-gas Cypermethrin, cypermethrin, Θ-cypermethrin, ζ-cypermethrin, cyphenothrin, deltamethrin, empenthrin, killing Aju Esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, τ-fluoroamine Tau-fluvalinate, halfenprox, imiprothrin, permethrin, phenoxyline (p Henothrin), prallethrin, resmethrin, RU 1 5525, silafluofen, tefluthrin, tetramethrin, tetra Tralomethrin, transfluthrin, ZXI 8901; 133661.doc -146- 200917962 M.4. Probiotic hormones: hydroprene, kinoprene Methoprene, fenoxycarb, mosquito rope &| (pyriproxyfen); Μ. 5. Smoking receptor agonist/antibodal compound: acetamiprid, insecticidal Bensultap, cartap hydrochloride, clothianidin, dinotefuran, 11 imidacloprid, thiamethoxam, nitenpy blue (nitenpyram) , nicotine, spinosad (allosteric agonist), thiacloprid, thiocyclam, thiosultap-sodium, and AKD 1022. M.6. GABA-gated chloride channel antagonist compounds: chlordane, endosulfan, 7-HCH (lindane); acetoprole, ethiprole , fipronil (fipronil), than pyraproll (pyrafluprole), pyriprole, vaniliprole (vaniliprole), formula Μ 1-6 phenyl. Sitting compound

Ο S

Μ.7. Air ion channel activator: abamectin, emamectin benzoate, milbemectin, lepimectin; 133661.doc -147- 200917962 Μ· 8. ΜΕΤΙ I compound: fenazaquin.芬pyroximate 11 pyrimidifen, pyridaben, D than tebufenpyrad, tolfenpyrad, fiufenerim, rotenone (r〇 Ten〇ne); M.9. METI II and III compounds: aceqUjn〇Cyi, fluacyprim, hydrarnethylnon; Μ·1 0. Oxidation and acidification solution Coupling agent: chi〇rfenapyr, DNOC; Μ. 11 · Inhibitor of oxidative sulphation: three. Sitting on tin (az〇CyCi〇tin), cyhexatin, diafenthiuron, fenbutatin oxide, pr〇pargjte, tetradifon M.12. Quercemic interfering agent. Cyr〇mazine, chromafenozide, _ 芬 〇 oz oz ' ' methoxy methoxy methoxy methoxy methoxy methoxy methoxy methoxy methoxy methoxy methoxy methoxy methoxy methoxy te te te te te te te te te te M.13. Synergistic agent. Piper〇nyi butoxide 'tribufos'; M.I4·sodium channel blocker compound: Indoxacarb, US fluoride Metaflumizone; M.15. fumigant: mercapto bromide, chl〇r〇picrin sulfuryl fluoride; Μ·16. selective feeding blocker: cryolite (cryi〇tie ), pymetrozine, fl〇nicamid; Μ·1 7. Insulin growth inhibitor: ci〇fentezine, β serotonin 133661.doc -148· 200917962 (hexythiazox), Ito. Etoxazole; Μ·1 8. Chitin synthesis inhibitors: probuprofen (buprofezin), bistrifluron, chlorfluazuron, diflubenzuron, Flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, polyfluoro 1 urea (11〇¥1!'111]11111· .]!), flubenzuron (teflubenzuron), triflumuron; Μ.19. Lipid biosynthesis inhibitors: spirodiclofen, spiromesifen, snail vinegar (spirotetramat); Μ.20. Octapaminergic agonist: amitraz ί Μ 21. Ryanodine receptor modulator: flubendiamide; M.22. A variety of: filled aluminum, amidoflumet, benclothiaz, benzoximate, bifenazate, borax, bromopropylate, Emulsion, cyenopyrafen, cyflumetofen, chinomethionate, Difolf, fluoroacetate, phosphine, pyridalyl, pyrifluquinazon, sulfur, organic sulfur compounds, tartar emetic, bismuth imine compounds Μ22· 1, 133661.doc -149- 200917962

N-CN cr n (M22.1) M22.2, cr

O N-CN (M22·2)

Or M22.3, pyrimidinyl alkynyl ether compound M22.4 or thiadiazolyl alkynyl ether compound M22.5,

M22·5 wherein RM-22 is methyl or ethyl and Het* is 3,3-dimercaptopyrrolidin-1-yl, 3-methylhexahydropyridin-1-yl, 3,5-dimethyl Hexahydropyridin-1-yl, 3-trifluorodecylhexahydropyridin-1-yl, hexahydroazin-1-yl, 2,6-dimercaptohexahydroazin-1-yl or 2,6 - 曱 吗 吗 -4 -4 - 4 - base; M, 23. NR; -2,2-dihalo-1-R" cyclopropane oxime 2_(2,6-dichloro-α,α, Α-trifluoro-p-tolyl) oxime or NR,-2,2-di(R'M)propanamide-2-(2,6-di-gas-α,α,α-trifluoro-p-nonylbenzene Base)-腙, wherein R is methyl or ethyl, halogen is chlorine or bromine, R'' is hydrogen or methyl and R" is methyl or ethyl; M.24. Aminophenylamine · Chloranthraniliprole, formula M24.1 compound 133661.doc -150- 200917962

Μ.25. Malononitrile compound: CF2HCF2CF2CF2CH2C(CN)2 CH2CH2CF3, (2-(2,2,3,3,4,4,5,5-octafluoropentyl)-2-(3,3,3 -Trifluoro-propyl)malononitrile), 〇?3((:1^2)2(:(€]^)2(:112(〇卩2)50?2^1,(2-(2 , 2,3,3,4,4,5,5,6,6,7,7 -12-glyptyl)-2-(3,3,3-tris-propyl)-malononitrile , CF3(CH2)2C(CN)2(CH2)2C(CF3)2F (2-(3,4,4,4-tetrafluoro-3-trifluoromethyl-butyl)-2-(3,3 , 3-trifluoro-propyl)-malonitrile, CF3(CH2)2C(CN)2(CH2)2(CF2)3CF3 (2-(3,3,4,4,5,5,6, 6,6_ nonafluorohexyl)-2-(3,3,3-trifluoroi-propyl)-malononitrile), cf2H (CF2)3CH2C(CN)2CH2(CF2)3CF2H (2,2-bis- (2,2,3,3,4,4,5,5-octafluoropentyl)-malononitrile), CF3(CH2)2C(CN)2CH2(CF2)3CF3 (2_ (2,2,3, 3,4,4,5,5,5-nonafluoropentyl)-2-(3,3,3-trifluoro-propyl)-malononitrile, CF3(CF2)2CH2C(CN)2CH2(CF2 ) 3CF2H (2-(2,2,3,3,4,4,4-heptafluoro-butyl)-2-(2,2,3,3,4,4,5,5-octafluoropentyl) )-Malonitrile (CF2CF2CH2C) ,3,3-pentafluoro-propyl)-malononitrile), CF2HCF2CF2CF2CH2C(CN)2CH2CH2CF2CF3(2-(2,2,3,3,4,4,5,5 - octafluoropentyl)-2-(3,3,4,4,4-pentafluorobutyl)-malononitrile), CF3(CH2)2C(CN)2CH2(CF2)3CF2H (2-(2, 2,3,3,4,4,5,5-octafluoropentyl)-2-(3,3,3-trifluoro-butyl)-propanoid); M.26. Microbial Interfering Agent: Su Yunjin Bacillus Israel subspecies 133661.doc -151 - 200917962 (Israelensi), Baciiius sphaericus, Bacillus thuringiensis subspecies (Aizawai), Bacillus thuringiensis, Kurstaki, I. Breeding subspecies (Tenebri〇nis); among other publications, 'commercial compounds of the group can be found in pesticide

Manual ’ Brother 13 Edition ' British Crop Protection Council (2003) ° Formula M6.1 thioguanamine and its formulations are described in w〇 98/28279. Leptocin is disclosed in Agro pr0ject, pjB Publications Ltd., in mid-November. Phenyl cruzed and its formulations are described in European Patent No. EP-A1 45462 1. The smear and parax x 〇 and its formulations are described in Farm Chemicals Handbook, Vol. 88, Meister Publishing, ' Acetyl nitrile and its formulations are described in WO 98/28277. Methotrexate and its formulations are described in European Patent No. EP-A1 462 456. The specific gas ratio (Flupyrazofos) is described in Pesticide Science 54, 1988, pages 237-243 and U.S. Patent No. 4,822,779. Tefrop and its preparations are described in Japanese Patent No. 2002193709 and WO 01/00614. Bipro and its formulations are described in WO 98/45274 and U.S. Patent No. 63,357,357. The guanamine fibrate and its preparation are described in U.S. Patent No. 6,221,890 and Japanese Patent No. 21010907. Fluorophenol and its formulations are described in WO 03/007717 and WO 03/007718. AKD 1022 and its formulations are described in U.S. Patent No. 6,300,348. Chloranthraniliprole is described in WO 01/70671, WO 03/0155 19 and WO 05/11 δ552. The amine benzophenone derivatives of the formula M24.1 are described in WO 01/70671, WO 04/067528 and WO 05/1 18552. Butylfluorocarbon 133661.doc -152- 200917962 Esters and their formulations are described in WO 04/080180. Aminoquinazolinone compounds are described in European Patent No. A 109 7932. The M22 l, M22.2 or M22.3 quinone imine derivatives or analogues thereof and processes for their preparation are described in WO 2006/060029. The alkynyl ether compounds M22.4 and M22.5 are described, for example, in Japanese Patent No. 2006131529. Organic sulfur compounds are described in WO 2007060839. The malononitrile compound is described in 02/089579, WO 02/090320, WO 02/090321, 04/006677, WO 05/068423, WO 05/068432 and W〇05/063694 t °. The fungicidal mixed complex is selected from the following The group consisting of: acid alanines such as benalaXyi, metalaxyi, ofurace, oxadixyl; amine derivatives such as adimorpholine (aldimorph), dodine, dodemorph, fenpr〇pim〇rph, fenpropidin, guazatine, pefulang ( Iminoctadine), spir〇xamin, tridemorph, this % spray, such as pyrimethanil, mepanipyrim or eyr〇dinyi; antibiotics, for example Cycloheximide, griseofulvin, kasugamyCin, natamycin, polyoxin or streptomycin; azoles, For example, biphenyl triazole alcohol (bitertan〇i), bromoconazole, cyclopropanol (Cypr〇c〇na) Z〇ie), difenoconazole, dinic 〇na z〇le, oxiconazole 133661.doc -153- 200917962 (epoxiconazole), fenbuc〇nazole , fluquiconazole, flusilaz〇le, hexaconazole, imazalil, metconazole, myclobutanil, and sulphate. Sitting (penconazole), a ring. Place (propiconazole), propionate * (prochloraz), thiophene. Sit (pr〇thioconazole), pent. Tebuconazole, triadimefon, triadimenol, triflumizol, triticonazole, fluramide (flutriaf〇i); dicarboxymethylimine, for example Isoridine, myclozolin, procymidon, vinci〇z〇iin; dithiocarbamic acid S, such as ferbate, ferbate Nabam, maneb, mancozeb, metam, metiram, propineb, polycarbamate, Thiram, ziram, zineb 'heterocyclic compounds' such as aniiazine, benomyl, boscelid, multi-bacteria Carbendazim, carboxin, oxidized rust, Cyazofamid, dazomet, dithianon, famoxadon, fenamid 〇n), fenarimol, fuberidazole, flutlanil, furametpyr, rice dish (Isoprothiolane), destroy mines amine (mepronil), Ming-fluorophenyl 0 given alcohol (nuarimol), dilute propylbenzene ° plugs. Probenazole, pr〇qUinazid, plaque two 133661.doc -154- 200917962 (pyrifenox), pyroquinone (pyroquilon), quinoxyfen (quinoxyfen), 矽托凡 (silthiofam ), thiabendazole, thifluzamid, thioph an at e-methyl, tiadinil, tricyclic. Tricyclazole, triforine; copper fungicides, such as Bordeaux mixture, copper acetate, copper oxide, basic copper sulfate; ruthenyl phenyl derivatives, such as binapacryl , Dinocap, dinobuton, nitro-isopropyl isopropyl; phenyl 0 than the mouth 'for example, fenpiclonil or fludioxonil; sulfur; other kill Fungicides, such as S-methyl acibenzolar-S_methyl, benthiavalicarb, carpropamid, chl〇rothalonil, siaphine nano (cyflufenamid), cymoxanil, diclomezin, diclocymet, diethofencarb, edifen-phos, ethaboxam, Fenhexamid, fentin-acetate, fenoxanil, ferimzone, fluazinam, fosetyl, forsythia Aluminium, iprovalicarb, six gas stupid, mechafen〇n, bink (pencycuron), pr〇parnocarb, phthalide, 〇基特科拉夫斯(t〇i〇ci〇f〇s_methyl), pentachlorozene (quintozene), β sit Zoxamid; strobilurin, such as azulosis, azxyxytubin, dimoxystrobin, flu〇xastr〇bin, phenoxy Ester 133661.doc -155- 200917962 (kresoxim-methyl), phenoxystrobin (me_torninostrobin), ossastrobin (orsastrobin), picoxistin (pic〇xystr〇bin) or trifloxystrobin (trifloxystrobin); Acid derivatives such as captafol, captan, dichlofluanid, folpet, t〇lylfluanid; cinnamylamine and analogues' For example, dimethomorph, flumetover or flumorph. The invertebrate pests (i.e., arthropods and nematodes), the plants, the soil in which the plants are grown, or the water can be contacted with the compound of the present invention I or II or a composition containing the same by any application method known in the art. Thus, "contact" includes direct contact (application of the compound/composition directly to an invertebrate pest or plant _ usually applied to the leaves, stems or roots of the plant) and indirect contact (application of the compound/composition to the invertebrate) The location of the pest or plant). In addition, vertebral pests can be controlled by contacting an insecticidally effective amount of a compound or compound with a pest free, food supply, habitat, breeding ground or locus thereof. Thus, administration can be carried out before or after infection of the locus, the growing crop or the harvested crop by the pest. "Location' means a habitat or habitat for growing or growing pests or parasites, cultivated plants, plant propagation material (e.g., seeds), soil, area, material, or environment. In general, an effective amount of insecticide means to achieve an observable effect on growth (including necrosis, death, lag, prevention, and the effect of removing, destroying or reducing the incidence and activity of the target organism). The amount of active ingredient required. For the various compounds/compositions used in the present invention, the insecticidal effective daniel 133661.doc • 156·200917962 is changed. The insecticidally effective amount of the composition also varies depending on the insecticidal effect and duration, weather and the like. According to the main conditions (such as desired, target species, location, application model tree): and its composition can be used to protect wood materials (for example: can also be used to protect building materials, furniture, leather, fiber products B), Wires and electricity are protected from ants and/or termites. = Sacrifice and white sacrifice so that they do not cause damage to crops or humans (When the insects enter the house and public facilities). The workmanship or bismuth compound can be applied not only to the surrounding soil surface or under the floor soil to protect the wood material, but also to block objects (such as underfloor concrete, closet columns, beams, plywood, furniture, etc.) , wooden items (for example: flower board half board, etc.) and B-made products (such as enameled wire, Ethylene board, barrier material (such as benzene and ethylene), etc.). The ant control agent of the present invention can be applied to the crop or to the surrounding soil or directly to the ant nest or the like under the application of the anti-purple ant to the crop or human. It is also possible to prevent the compound of the formula w π from being applied to the place where the intended pest will occur. The compound or compound II can also be used to protect a growing plant from pest infestation or infestation by contacting the plant with a pesticidally effective amount of a compound of formula wn. Thus, "contact" includes direct contact (application of the compound/composition directly to the pest and/or plant - typically to the leaves, stems or roots of the plant) and indirect contact (8) of the composition/composition of the application of i pests and / Or ^ Location of the object. 133661.doc -157- 200917962 In the case of soil treatment or application to pest colonies or nests, the amount of active ingredient is between 0._!· g/1G() m2 (better in please Within the range of i2() g/i〇〇m2). The ratio of material protection to normal application is, for example, between 〇〇1 to 1〇〇〇g of active compound / πΛ of treated material, preferably between 〇ι § to 5〇§/ A. The insecticidal composition for impregnated materials usually contains 〇〇〇ι_95 weight

%, preferably (M-45% by weight, and more preferably ^% by weight of at least one type of protective agent and/or insecticide. For the use of the bait composition, the active ingredient is usually present in an amount of 0.' weight of the active compound. % to 15% by weight, preferably 〇〇〇1% by weight to 5% by weight 〇/〇. For the application of the spray composition, the content of the ramie is between 0 〇〇i _% by weight, preferably between 〇·〇1, between % by weight, and optimally between 〇· 01 -15% by weight. For the treatment of crop plants, the application rate of the active ingredient of the present invention may be between (Μ 4 g/ha) Preferably, it is between 25 and 5 hectares, more preferably between 50 g and 500 g/ha. When the seed is treated, the application rate of the active ingredient is generally 系 心 〇 kg/1 〇〇 kg of seed, preferably lgLkg / 1 〇〇 kg seeds, particularly preferably 200 g / 100 kg seeds. The invention will now be further illustrated in detail by the following examples: 1. Preparation Examples The procedures described in the following synthesis examples were used by appropriate starting materials Repair 133661.doc •158- 200917962 to prepare other compounds of formula i. The data are listed in Tables I and II below. The product was characterized by HPLC (High Performance Liquid Chromatography Mass Spectrometry) using an analytical RP-18 column operating at 4 ° C (Chromolith from Merck KgaA, Gemany) Speed ROD) was carried out to carry out HPLC using acetonitrile having (Μ volume % trifluoroacetic acid / water mixture and 〇 丨 volume % trifluoroacetic acid as mobile phase; flow rate: 1.8 mL / min and injection volume: 2 μ1. Example 1 3 1 -Methyl-3 -dimurium _ 1 Η- ° than 嗤-4-carboxylic acid. 2 _5 g (12.9 mmol) in 25 mL 环境 at ambient temperature. 1-mercapto-3-3-trifluoromethyl]indole-pyrazole_4_decanoic acid and 2·1 g (12·9 mmol) in Ν-dimercaptocaramine (DMF) Ν,Ν'- The carbonyl diimidazole (CDI) was stirred for 1 hour, after which 1.2 g (12.9 mmol) of 3-aminopyridine was added. After three days of mixing, the solvent was evaporated. The residue was dissolved in di-methane, and saturated solution of NaHC03 and water was used. Wash twice. Evaporate the combined organic phases and purify the crude product by flash column chromatography (e.g., EtOAc, m. Compound. Example 29: 1-A 3-trifluoromethyl-1H-pyrazole-4-carboxylic acid methyl-pyridine-3-yl-bristamine was stirred at ambient temperature 1.0 g (3.7 mmol) from Example 13 and stored in 1 mL of tetrahydrogen. 1 - mercapto-3-trifluoromethyl 丨 H-吼ϋ sitting _4_pyridylpyridin-3-yl-decylamine and 3.7 g (11·! mm〇1) cesium carbonate And 79 〇 mg (5 '55 mmol) mothane was added to the mixture. After stirring for two days, the suspension was filtered. 'The solvent was evaporated and purified by flash column chromatography (c.c., using I33661.doc - 159 - 200917962 hexane/ethyl acetate) to obtain 327 mg (31%). The crude product is guanidinated with guanamine. Table I: Compounds of formula I

A

(I) Example A R1 R2 R3 Physico-chemical data rt [mini 1 卜 methyl-1H-« ratio " sit-3-yl Η Η nd nd 2 1-GU--gas phenoxy A certain 1H_pyridinium 3.·············· Η Η Η Η 1.543 5 5-Ga-1-methyl-1 Η·pyrazol-3-ylindole Η Η 1.499 6 1-Methyl-5-trifluoromethyl ΐΗ-indoleazole-3-yl hydrazine Η Η 1.779 7 4-气-ί·曱基-1Η·pyrazole-3-ylindole Η 353 1.353 8 1-methylphenyl-1H-pyrazole-3-ylindole Η Η 2.124 9 2-methyl -5-phenyl-2H-t--3-ylindole Η Η 2.193 10 1,5-dimethyl-1 oxapyrazole-3- Η Η Η 1.311 11 2-methyltrifluoromethyl-2H -pyrazol-3-ylindole Η 954 1.954 12 2-mercapto-2H-pyrazole-3-ylindole Η 1.125 13 1-mercapto-3·trifluoromethyl-1H.比 嗤 Η Η 548 548 1.548 14 3-Difluorodecyl-1-indolyl-1H-pyrazole-4-ylindole Η 295 1.295 15 1-(6-Chloro ratio bite-2·base)_5_ Tri-gas sulfhydryl-iH-t sits -4 Η Η Η 273 2.273 16 1-member base-5-three 1 曱 base-old-. 〇 -4- -4- Η Η Η Η 2.290 17 1-ethyl-3-trifluoromethyl-11^-〇 ratio. -4--4-基Η Η Η 1.771 1-ethyl-5-trifluoromethyl-1Η-η ratio 吐-4-基Η Η 704 1.704 19 1-Lactyl-3-trisyl fluorenyl-111- 〇 11 11 -4- Η Η Η 187 2.187 20 5-Difluoromethyl-1-methyl-1 Η-pyrazole-4-yl' Η Η Η 1.588 21 5-cyano-1 - (2,4 -Dichlorophenyl)-1 Η-° 比啥·4-基Η Η Η 2.475 22 5-Trifluoromethyl-1-(4-phenylphenyl)-1Η-pyrazole-4-ylindole Η Η 2.517 23 5-Trifluoromethyl-1-phenyl-1Η-.比 -4- -4- 基 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 185 · Deficient phenyl)-5-methyl·1Η-° ratio. Sodium-4-yl Η Η Η 1.834 26 1-(2,2,2-trifluoroethyl)-5-dioxmethyl ratio. _ 4-基Η Η Η 1.980 27 5-Chloro-1-methyl-3-trifluoromethyl-1 Η-oxazol-4-yl-' Η Η Η 1.651 28 1-methyl-3-trifluoro Mercapto-m-'bazol-4-ylbenzyl hydrazine 457 2.457 133661.doc -160· 200917962 Example A R1 R2 R3 Physical-chemical data rt [min] 29 1-mercapto-3-trifluoromethyl- 1 Η-pyrazol-4-yl ch3 Η Η 1.504 30 1 -T-butyl-5-trifluoromethyl-1Η-pyrazole-4-ylindole Η 197 2.197 31 1-(4-nitrophenyl )-5-trifluoromethyl-1Η-"Bizozol-4-ylindole Η 269 2.269 32 1-(5-apyridin-2-yl)-5-trifluorodecyl-1H-pyrazole-4 - Η Η Η 339 2.339 33 1-mercapto-3-trifluoromethyl-1H-pyrazole-4-ylindole Η ch3 1.793 34 1-mercapto-3-trifluoromethyl-1H-pyrazole-4 -based ΗCl 2.444 35 5-difluorodecyl-1-indenyl-1H-pyrazol-4-yl c2h5 Η Η 1.645 36 5-difluoromethyl-1-methyl-1H-pyrazole-4 -based ch3 Η Η 1.487 37 1-mercapto-3-trifluoromethyl-1H-pyrazole-4-ylindole cf cf3 2.844 38 1-mercapto-3-trifluoromethyl-1H-pyrazole-4 -based Η F 2.194 39 isopropyl-3-trifluoromethyl-1H-indazole-4-ylindole Η Η 2.041 40 1-isobutyl-3-trifluoromethyl-1H-pyrazole- 4-基Η Η Η 2.271 41 1-methyl-3-trifluoromethyl-1H-pyrazole-4-ylindole ch3 Η 1.597 42 5-Gas-1,3-dimethyl-1H-pyrazole-4-ylindole Η Η 1.385 43 1-propyl-3-trifluoromethyl-1H-pyrazole-4-ylindole Η Η 2.040 44 1-methyl-3-ethoxy-1H-pyrazole-4-ylindole Η Η 1.550 45 1 -propyl-5-trifluoromethyl-1H-pyrazole-4-ylindole Η Η 2.101 46 5-trifluoromethyl-1H-pyrazole-4-ylindole Η Η 1.410 47 3-cyclopropyl- 1-mercapto-1H-pyrazole-4-ylindole Η 491 1.491 48 1 -(2,2,2-trifluoroethyl)-5-trifluorodecyl-1 H-pyrazole-4-yl ch3 Η Η 2.032 49 1-(2,2,2-Trifluoroethyl)-5-trifluoromethyl-1H-. Bisazo-4-yl C2H5 Η Η 2.281 50 1-(2,2,2-trifluoroethyl)-5-trifluoromethyl-1H-. Biazol-4-ylisobutylphosphonium 767 2.767 51 1 -mercapto-3-trifluoromethyl-1 H-°boxazol-4-ylindole C1 Η 1.868 52 1 -methyl-3-trifluoromethyl -1H-carbazole-4-ylindole OCH 3 Η 1.652 53 3-methoxy-1-methyl-1H-pyrazole-4-ylindole Η 333 1.333 54 5-bromo-2-(3- gas Pyridin-2-yl)-2H-pyrazol-3-ylindole Η 1,92 55 2-(3-Apyridin-2-yl)-5-trifluoromethyl-2Η-»Bizozol-3-yl 283 Η Η 2.283 56 3-Trifluorodecyl-1-(4-phenylphenyl)-1Η-«bizozol-4-ylindole Η 548 2.548 57 H4-decyloxyphenyl)-5-fluorenyl- 1Η-»Bizozol-4-ylindole Η Η 2.005 58 5-phenyl-1H-pyrazole-4-ylindole Η 504 1.504 59 1-ethyl-5-mercapto-1H-pyrazol-4-yl 426 Η Η 1.426 60 1-Methyl-5-phenyl-1H-pyrazole-4-ylindole Η 751 1.751 61 1,3-Dimethyl-11^-pyrazole-4-ylindole Η Η 1.219 62 2-mercapto-5-t-butyl-2H-pyrazole-3-ylindole Η 78 1.78 63 2-mercapto-4-pyrene-2H-pyrazole-3-ylindole Η Η 1.49 64 2-( 3-oxi.pyridin-3-yl)-5-trifluoromethyl-2H-pyrazole-3-ylindole Η 2.28 65 4-isopropyl-1-methyl-1H-pyrazole-3-基Η Η Η 1.81 66 5-isopropyl-2-mercapto-2H-pyrazole-3-ylindole Η Η 1.56 • 16]- 133661.do c 200917962 Example A R1 R2 R3 Physical-chemical data rt [min] 67 5-ethyl-2-mercapto-2H-pyrazole-3-ylindole Η Η 1.53 68 4,5-dimercapto-2-yl -2-2H-pyrazol-3-ylindole Η Η 1.42 69 2-methyl-5-n-propyl-2H-pyrazole-3-ylindole Η 76 1.76 rt retention time nd not determined Table II: Formula I. A1 compound

Ex. R41 R51 R61 R1 R2 R3 rt [min] ΐ mp [°C] 70 H ch3 ch3 Η Η Η 1.27 nd 71 phenyl Η ch3 Η Η Η 1.80 nd 72 ch3 Η c2h5 Η Η Η 1.47 nd 73 H cf3 4 -chlorophenyl hydrazine Η 59 2.59 nd 74 phenyl hydrazine Η Η Η Η 1.50 nd 75 ch3 Η 4-曱 oxy-phenyl Η Η Η 2.01 nd 76 4-fluoro-phenyl Η Η Η Η Η 1.57 nd 77 2-11 塞 Η Η 47 47 F Η 47 1.47 nd 78 F cf3 ch3 Η Η Η 1.63 nd 79 n-propyl fluorene 4-phenylphenyl hydrazine Η Η 2.53 nd 80 chf2 Η 1-meryl-1,3,4 -三嗓-2-基Η Η Η nd· 130 81 Η Η 4-gasbenzyl Η Η nd nd 218 82 Η 苄 benzyl Η Η nd nd 165 83 Cl Η ch3 Η Η nd nd 186 84 Η ch3 phenyl Η Η Η 2.08 nd 85 chf2 Η 4-(Trifluoromethyl)phenyl Η Η Η 2.75 nd 86 chf2 Η 4-chlorophenyl Η Η Η 2.55 nd 87 Η Η Η Η Η Η 0.54 nd 88 chf2 Η 4- (曱-sulfonyl)-phenylhydrazine Η Η 1.89 nd 89 cyclopropyl hydrazine ch3 Η Η Η 1.41 nd 90 isopropyl hydrazine ch3 Η Η Η 1.65 nd 133661.doc -162- 200917962

Ex. R41 R51 R61 R1 R2 R3 rt [min]; mp [°C] 91 2-methyl-propyl H ch3 Η Η Η 2.71 ; nd 92 chf2 H 4-(seven-isopropyl)-phenyl Η ch Η 3.12 ; nd 93 chf2 H 4-(trifluoro-methylthio)-phenylhydrazine Η Η 2.94 ; nd 94 chf2 H 4-fluorophenyl Η Η Η 2.39 ; nd 95 chf2 H 4-(trifluoro -methoxy)-phenylindole Η 73 2.73 ; nd 96 c(=o)nh2 H ch3 Η Η Η nd ; 230 97 HH isopropyl hydrazide Η nd ; 174 98 HH 2-mercaptopropyl hydrazine 143 nd ; 143 99 HH 2,2-difluoro-ethyl Η Η nd nd ; 152 100 H cf3 ch3 Η Η Η 1.69 ; nd (as N-oxide) 101 chf2 H 2,6-diox-4- (trifluoro-indenyl)phenylindole Η Η 2.91 nd 102 HH ethyl Η Η nd nd 126 103 HH 2,2,2-trifluoroethyl Η Η nd 191 104 H cf3 4-(trifluoro-A ))-thiazolin-2-ylindole Η Η nd 194 105 HH 0 ratio °-2-ylindene Η nd nd 244 106 HH phenyl Η Η nd nd 241 107 HH ch3 Η Η Η nd 180 108 HH positive Η Η nd nd 119 109 cf3 H ch3 Η Η Η 1.51 nd 110 H ochf2 ch3 Η Η Η 1.43 nd 111 H cf3 benzyl 34 Η Η 2.34 nd 112 H cf2ci ch3 Η Η Η 1.69 nd 113 HH 4-fluorophenyl Η Η nd nd 235 114 HH (4-nitro-° ratio. sit-1 -yl)-fluorenyl Η Η nd 227 115 ch3 H 1-mercapto-1,3,4-tri. Qin-2-ylindole Η 206 nd; 206 116 ch3 H thiazol-2-ylindole Η Η nd ; 205 117 chf2 H 4-(trifluoro-indenyl)thiazol-2-ylindole Η Η nd ; 171 118 ch3 H 4-(Trifluoromethyl)thiazol-2-ylindole Η nd· ; 240 119 HH cyclopropyl Η Η nd nd ; 145 120 isopropyl H phenyl Η Η Η 2.32 i nd 133661.doc -163 - 200917962

Ex. R41 r51 R61 R1 R2 R3 r,t. [min]; mp [°C] 121 ch3 H 4,5-dimethyl-thiazol-2-ylindole Η Η nd ; 235 122 chf2 H 4,5- Didecyl-thiazol-2-ylindole Η nd ; 182 123 Cl H phenyl hydrazine Η nd ; 171 124 IH 4-fluorophenyl Η Η Η nd ; 188 125 H 2 · fluoro-ethyl ch3 Η Η Η 1.22 ; nd 126 H cf3 ch3 cyclopropyl-fluorenyl hydrazine 2.13 ; nd 127 H cf3 ch3 ethyl hydrazine Η 1.73 ; nd 128 chf2 H 3-methyl-3H-1,3,4-triazine-2 - Η Η Η 1.18 ; nd 129 H cf3 ch3 n-propyl hydrazine Η 2.06 ; nd 130 H cf3 ch3 isopropyl hydrazine Η 2.00 ; nd 131 H cf3 ch3 (1-mercapto-3-(trifluoro-fluorenyl) )-°bizozol-4-yl)carbonyl Η 186 186 ; nd 132 H cf3 ch3 third butoxy-carbonyl Η nd ndnd 133 H cf3 ch3 third butyl-carbonyl Η Η 2.83 nd 134 H cf3 ch3 醯基Η nd 143 135 chf2 H 2,4-DifluorophenylΗ Η Η 2.38 nd 136 H cf3 ch3 Benzene sulfonyl hydrazine Η 2.98 nd 137 chf2 H 3,5-diphenylphenyl Η Η 77 2.77 nd 138 chf2 H 4-曱phenylΗ Η Η 2.43 nd 139 H cf3 ch3 ch2-cn Η Η 1.88 Nd 140 HH n-heptyl Η Η Η 2.63 nd 141 H cf3 ch3 2-propynyl Η Η 1.89 nd 142 ch3 H 4-Phenylphenyl Η Η Η 2.26 nd 143 Ethyl H 4-chlorophenyl Η Η Η 2.42 Nd· 144 ethyl H 4-nitrophenyl hydrazine Η 2.26 nd 145 ethyl H 4-(trifluoro-methyl)phenyl hydrazine Η 2.69 nd 146 ethyl H 4-fluorophenyl Η Η Η 2.26 Nd 147 chf2 H 3-(trifluoro-methyl)phenyl Η Η Η 2.61 nd 148 chf2 H 2-phenylphenyl Η Η 24 2.24 nd 149 chf2 H 2-(trifluoro-indenyl)phenyl Η Η Η 2.38 nd 150 chf2 H 2-decyloxy-phenylindole Η Η 2.12 nd 151 chf2 H 3-vapor-4-fluorophenyl Η Η Η 2.54 nd 152 chf2 H 4-tert-butylphenyl Η Η Η 2.95 Nd 133661.doc -164- 200917962

Ex. R41 R51 R61 R1 R2 R3 r,t. [min]; mp [°C] 153 chf2 H 3-nitrophenylhydrazine HH 2.25 nd 154 chf2 H 3,4-digas-phenylhydrazine HH 2.75 nd 155 chf2 H 2,4-diqi-phenylhydrazine HH 2.62 nd 156 chf2 H 2-indole hydrazine HH 2.34 nd 157 chf2 H 3-phenylphenyl hydrazine HH 2.46 nd 158 chf2 H 3-hydrazino hydrazine HH 2.42 nd 159 chf2 H 4-chloro-2-fluorophenyl hydrazine HH 2.57 nd 160 chf2 H 2,4,6-trichloro-phenylhydrazine HH 2.79 nd 161 chf2 H 2,3,4-trichloro-stupyl Η HH 2.85 nd 162 chf2 H 2,6-difluoro-phenylhydrazine HH 2.29 nd 163 H cf3 ch3 ethoxy-carbonyl HH nd· ; 104 164 H cf3 ch3 ethoxy-fluorenyl HH 2.19 ; nd 165 ch3 H 4-fluorophenylhydrazine HH 2.17 ; nd; (as N-oxide) 166 ch3 H 4-(trifluoro-methyl) stupyl hydrazine HH 2.50 ; nd 167 chf2 H ch3 Η HH nd ; 172 ; Hydrochloride) 168 cf3 H 2,2,2·trifluoro-ethylethylhydrazine HH 2.52 ; nd 169 cf3 H 2,2,2-trifluoro-ethyl ch3 HH nd ; 131 ; (as N-oxidation 170 H chf2 ch3 Η HH 1.67 ; nd; (as N-oxide) 171 H chf2 4-nitrobenzene Η HH 2.46 nd 172 ch3 H 2,2,2-digas-ethyl hydrazine HH 1.65 nd 173 ch3 H 2,2,2-trifluoro-ethylch3 HH 1.79 nd 174 cf3 H ch3 ch3 HH 1.44 nd 175 chf2 H 2,2,2-trifluoro-ethylhydrazine HH 2.07 nd 176 chf2 H 2,2,2-trifluoro-ethylch3 HH 1.82 nd 177 HH ch3 ch3 HH 0.85 nd 178 ch3 H ch3 ch3 HH 0.99 nd 179 Ch3 H ch3 Η HH 1.32 nd 180 ch3 H ethyl ch3 HH 1.22 nd 181 H chf2 ethyl hydrazine HH 2.00 nd 182 H chf2 ethyl ch3 HH 1.39 nd 183 H cf3 ethyl ch3 HH 1.77 nd 184 ethyl H ethyl HHH 1.59 nd 185 Ethyl H Ethyl ch3 HH 1.49 nd 186 cf3 H Ethyl ch3 HH 1.89 nd 187 HH Ethyl ch3 HH 1.11 nd 133661.doc -165 - 200917962

Ex. R41 R51 R61 Ri R2 R3 rt [min]; mp [°C] 188 chf2 H chf2 HHH 1.73 ; nd 189 chf2 H chf2 ch3 HH 1.66 ; nd 190 cf3 H chf2 HHH 2.00 ; nd 191 cf3 H chf2 ch3 HH 2.05 ; nd 192 H cf3 chf2 HHH 1.90 ; nd 193 H cf3 chf2 ch2-cn HH 2.43 ; nd 194 H chf2 chf2 HHH 1.82 ; nd 195 H cf3 chf2 ch3 HH 1.77 ; nd 196 H cf3 ch3 HHH 1.49 ; nd; Acid salt) 197 chf2 H ch3 HHH 1.46 ; nd; (as hydrochloride) 198 cf3 H 2,2,2-trifluoro-ethyl HHH 1.93 ; nd; (as hydrochloride) 199 cf3 H 4 nitro Phenyl HHH 2.23; nd; (as hydrochloride) 200 HH isopropyl HHH 1.36; nd; (as hydrochloride) 201 chf2 H 3-methyl-3 Η-HHH 1.11 ; nd; 1,3,4 -triazin-2-yl (as hydrochloride) 202 H cf3 ch3 n-propyl HH 1.98; nd; (as hydrochloride) 203 ch3 H 2,2,2-trifluoro-ethyl ch3 HH 1.43 ; (as hydrochloride) 204 HH 2,2-difluoro-ethyl ch3 HH 1.10 ; nd 205 HH cf3 HHH nd ; 208 206 H chf2 ethyl ch2-cn HH 1.75 ; nd 207 cf3 H chf2 ch2-cn HH 2.47 ; nd 208 ch3 H chf2 HHH 1.50 ; nd 209 H ch3 chf2 HHH 1.54 ; nd 210 chf2 H chf2 CN HH 2.10 ; nd 211 cf3 H ch3 ch2-cn HH 2.02 ; 212 ch3 H ch3 ch2-cn HH 1.47 ; nd 213 HH chf2 HHH nd ; 174 214 chf2 H cf3 ch2-cn HH 2.21 ; nd 215 ch3 H 2,2,2-trifluoro-ethylch2-cn HH 1.76 ; nd 216 chf2 H ch3 ch2-cn HH 2.29 ; nd 217 cf3 H ethyl ch2-cn HH 2.04 ; nd 218 ethyl H ethyl ch2-cn HH 1.70 ; nd 219 HH 2,2,2-trifluoro-ethyl ch3 HH nd ; 90 220 ch3 H chf2 ch3 HH 1.35 ; nd 221 ch3 H chf2 ch2-cn HH 1.72 ; n*d. 133661.doc -166- 200917962

Ex, R41 R51 R61 ri R2 R3 rt [min]; mp [°C] 222 HH chf2 ch3 HH 1.11 ; nd 223 HH ch3 ch2-cn HH 1.53 ; nd 224 HH ethyl ch2-cn HH 1.34 ; nd 225 cf3 H 4-(Trifluoro-methyl)phenyl HHH 2.68 ; n,d· 226 cf3 H 4-decyloxy-phenyl HHH 2.25 ; nd 227 cf3 H 4-(methyl-sulfonyl)-phenyl HHH 1.85 ; nd 228 cf3 H 4-fluorophenyl HHH 2.26 ; nd 229 H ch3 chf2 ch3 HH 1.40 ; nd 230 H ch3 chf2 ch2-cn HH 1.76 ; nd 231 ch3 H 4-Shischyl phenyl HHH 2.04 ; nd 232 H cf3 2,2-diqiethylHHH 1.81; nd 233 HH cf3 ch3 HH 1.49 ; nd 234 H cf3 2,2_difluoroethyl ch3 HH 1.76 ; nd 235 HH 2,2-disorder-ethyl ch2-cn OH 236 HH 2.40 ; ; nd 239 cf3 H 3,5-diqi-phenyl HHH 2.87 ; nd 240 H chf2 ch3 ch2-cn HH 1.57 ; nd 241 H chf2 ch3 ch3 HH 1.29 ; ndrt retention time mp hyun nd untested Other compounds 242 and 243 may be prepared according to the method described above.

(243): rt = 2.24 min h3c 2. Evaluation of insecticidal activity: 133661.doc -167- 200917962 II.1 cotton aphid (aphisgossypii, mixed life) at 50:50 (vol: volume) acetone : Water and sputum 1111 ^ 1 ^ 丨 Ding " surfactant in the preparation of active compounds. Cotton plants (one plant/pot) in the cotyledonary stage are disturbed by placing the heavily infested main community leaves on top of each cotyledon. The overnight stay was carried out to transfer the aphids to the host plants and the leaves for transfer of the aphids were removed. The cotyledons are soaked in the test solution and allowed to dry. After 5 days, mortality counts were performed. In this test, compound \ 5, 6, 10, 11, 13, 14, 15 22 ' 23, 24, 25, 26, 28, 37, 38, 39, 40, 41 compared to the untreated control , 43, 50, 51, 62 ' 65, 66, 67, 80, 82, 83, 85, 86, 87, 95 ' 96. 97 , 98 , 99 ' 1〇〇, 108, 109, 110, 115, 1 16, 123, 124, 125, 126, 127, 133, 134, 135, 136, 137, 144, 145, 147, 148, 149 157, 158, 161, 163, 164 170, 172, 173, 174, 175 181 , 182 , 183 , 184 , 185 191 , 192 , 193 , 194 , 195 202 , 203 , 204 , 205 , 206 212 , 213 , 214 , 215 , 216 16 , 17 , 18 , 19 , 20 , 21 , 29 , 30 , 31, 32, 35, 36, 44, 45, 46, 47, 48, 49, 69, 70, 71, 72, 73, 75, 88, 89, 91, 92, 93, 94, 102, 1〇3 , 104, 1〇5, 1〇7, 118, 119, 120, ! 21, 122, 128, 129, 130, 131, 132, 138, 139, 141, 142, 143, 150, 151, 154, 155, 156, 165 ' 166, 167, 168, 169, 176, 177, 178, 179 , 18 〇 , 186 ' 187 , 188 , 189 , 190 , 196 , 197 , 199 , 200 , 201 , 207 , 208 , 209 , 210 , 21 1 , 217 , 218 , 219 , 220 , 221 , 133661.doc • 168- 200917962 222, 223, 224, 225, 226, 227, 228, 229, 230, 233, 242 and 243 exhibit at least 75% mortality at 300 ppm, respectively. II.2 Myzus persica (Myzuspersicae, mixed life) The active compound is formulated in 50:50 (vol:vol) acetone:water and 1 〇〇ppm KineticaTM surfactant. By placing the infested leaf portion on top of the test plant, infesting 2 pairs of leaf stage pepper plants with about 4 实 laboratory-grown insects (variety)

Wonder’). After 24 hours, the blade portion was removed. The leaves of the whole plant are soaked in the gradient solution of the test compound and allowed to dry. The test plants were kept under fluorescent light (24 hours light, 』) under the hunger and 2〇_4〇% relative humidity. The mortality rate of the treated plants was determined for the mortality of the plants. . In this test, 'Compound 丨, 3 6 1〇, 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 22 , 23 , 24 , 25 , 26 compared to the untreated control , 27 37, 39, 40, 41, 43, 45 65, 66, 67, 69, 70, 71 83, 85, 86, 87, 88, 89 97, 98, 99, 1 〇〇, 1 〇 2, 1 〇9, 110, 115, 116, 118 124, 125, 126, 127, 128 134, 135, 136, 137, 138 144, 145, 147, 148, 149 157, 158, 161, ι63, 164, 29, 30 , 31, 32, 35, 36, 46 '47, 48, 49, 50, 62, 73, 75, 79, 80, 81, 82, 91, 92, 93, 94 '95, 96, 103, 1〇4,1〇5,1〇7,108, 119'120 > 121 '122 '123 > 129, 130, 131, 132, 133, 139, 140, 141, 142, 143, 150, 151, 154, 155, 156, 165, 166, 167, 168, 169, 133661.doc • 169- 200917962 170, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181 ' 182, 183, 184 , 185, 186, 187 , 188 , 189 , 190 , 192 , 193 , 194 , 195 , 196 , 197 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 '215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 233, 242 and 243 exhibited at least 50% mortality at 300 ppm, respectively. II.3 Sr Beans (aphis craccivora) The active compound is formulated in 50:50 (vol:vol) acetone:water. The test solution was prepared on the day of use. After recording the pest population, the potted red bean plants that had migrated to different stages of the mites were sprayed. Population reduction was assessed after 24, 72, and 120 hours. In this test, Compounds 1, 3, 5, 6, 7, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 were compared to untreated controls. , 23, 24, 25, 26, 28, 29, 30, 31, 33, 35, 36, 38, 39 '40, 43, 44, 45, 46, 47, 62, 65, 66, 67, 69, 70 , 72, 73, 75, 79, 80, 81, 82, 83, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 97, 98, 99, 100, 1〇2 , 1〇3,1〇4,1〇6,107,108,1〇9, 110, 113, 114, 115' 116, 117, 118, 119, 120, 121, 122, 123, 124, 132, 133 , 134, 135, 136, 138, 139, 141, 142, 143, 144, 145, 147, 148, 149, 156, 157, 158, 161, 163, 164, 165, 166, 167, 168, 169, 17 133, 133661.doc -170· 200917962 172 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194, 195, 196, 197, 198, 199, 20 0, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 242 and 243 exhibited at least 75% mortality at 300 ppm, respectively. II.4 Soybean meal (Broadbean meal) The active compound is formulated in 50:50 (vol:vol) acetone:water and 1 〇〇 ppni KineticaTM surfactant. A pair of leaf stage nasturtium plants (variety 'Mixed Jewel,') grown in the Metro mix was infested with the infested plants at the top of the test plants with about 2_3 〇 of the laboratory-cultured worms. The cut plants were removed after 24 hours. Each plant was immersed in the test solution to completely cover the leaves, stems, protruding seed surface and surrounding cube surface and allowed to dry in a fume hood. The treated plants were stored under approximately 25 t and continuous fluorescent lamps. Determination of aphid mortality after 3 days 〇 In this test 'Compounds 13, 14, 18, 20, 29, 75, 80, 94, 116, 122, 123, 126, 127, 129 compared to untreated controls 135, 142, 143, 166, and 168 exhibited at least 90% mortality at 1 〇 ppm, respectively. II·5 Silver leaf powder (bemisiaargentif〇iii, adult) The active compound is formulated in 5:50 (vol:vol) acetone:water and 10〇ppm KineticaTM surfactant. 133661.doc -171 - 200917962 Growth of selected cotton plants to cotyledon stage plants/pots). The cotyledons are soaked into the test solution to immerse the leaves, and the kings cover the leaves and place them in a well ventilated area. Each potted seedling was placed in a plastic cup and introduced into two private larvae (about 3 to 5 days old p using an aspirator and a 0.6 cm non-toxic Tyg〇n8 tube connected to the tip of the barrier pipette (r_36〇3) Collecting insects.,:: Gently insert the tip of the δ collected insect into the soil containing the treated plant, so that the insect climbs out of the tip to reach the feeding leaf. Use a reusable net cover (15〇 Micro-mesh polyester screen PeCap (from Tetko) covers the cup. The test (4) is kept in the storage room for about 3 days at a relative humidity of about 25tA2〇4 (), avoiding direct exposure to the worklight (24). J, special light cycle) to prevent heat accumulation in the cup. The mortality was evaluated after treating the plants for 3 days. In this test, compounds 16, 18, 21, 26, 29, 35 were compared with the untreated control. , 46, 48, 49, 5〇, 62, 73, 75, 8〇, 82, 83, 84, 89, 1〇〇, 102, 1〇9, 133, 134, 163, 173 18〇, 212, 21 5 and 229 show at least 50% mortality at 300 ppm respectively. ΙΙ·6 brown air (niiaparvata iugens) will be active Formulated to 5 〇: 5 〇 (vol: volume) propylene _: aqueous solution. Add surfactant (Aikamuis) in a ratio of 0.1 / 〇 (vol / vol.) Wash and wash the rice seedlings for 24 h before spraying. Use 5 ^ The test solution was sprayed with potted rice seedlings, air-dried, placed in a cage and transferred to 10 adults. The treated rice plants were maintained at 28-29. (: and 50-60% relative humidity. Percent mortality was recorded after 72 hours. 133661.doc -172- 200917962 In this test, compounds 36, 65, 176, and 195 exhibited at least 50% mortality at 3 〇〇 ppm, respectively, compared to untreated controls. Mycosis (Spoodoptera eridania, 2nd instar larvae) Formulated with active compound in 50:50 (vol:vol) acetone:water and 1 〇〇ppni KineticaTM surfactant. The first true leaf of Sieva lima bean was immersed in the test solution, and allowed to dry in the liquid. The leaves were then placed in a plastic porous zipper package and ten second instar larvae were added. On day 4, mortality and food intake were observed. In this test, compared to untreated controls Compounds 48, %, 77, 78, 79, 92, 98, 118, 155, 157, 158, 170, 173, 174, 175, 179, 189, 191, 196, 199, 201, 209, 213, 215, 218 219 '220, 221, 223, 224, 228, and 233 exhibited at least 5% mortality at 300 ppm, respectively. Π.8巢菜修尾财(Weigh the active compound in 1:3 (volume: volume) DMS0: water with different compound concentration S. Place the denier disc with 0 8% far fat and 2 5 〇pusTM2 In a microtiter plate, spray the leaf disc with 2.5 μΐ test solution and place (8) adult adult insects in a microtiter plate, then close the microtiter plate and incubate at 23 ± rC and 50% relative humidity Keep under the lamp for 6 days. Based on survival and complexity

Colony of the worms § parity death 裘. Lack of your raI sheep... and visually evaluate the mortality and fertility of locusts. In this test, 'Compound 3'9, ", 13, 14, 16, 17, 18, 133661.doc -173- 200917962 19, 20, 21, 22, 23, 24, 25, 26, 28, 29, 62, 65, 66, 67 '69, 71, 72, 73, 75, 85 '87, 89, 91 '93, 94, 95, 96, 97, 98 '99, 100 ' 102, 103, 104, 107, 108, 109, 110, 112, 116, 117, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 138, 140, 141, 142, 143, 144, 145, 147, 148, 149 > 150, 152, 153, 154, 155, 156, 157, 158, 159, 161, 162, 163, 164, 165, 166, 167 , 181 , 182 , 183 , 184 , 185 , 186 , 189 , 190 , 191 , 193 , 194 , 195 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 210 , 218 , 220 , 221 , 225 , 226 227, 228, 230, 231, 232, 234, 242, and 243 exhibited at least 80% mortality at a test solution concentration of 2500 mg/L, respectively. II.9 Cotton larvae (Anth〇n〇mus grandis) Compounds are formulated in 75:25 (vol:vol) water:dms. Regarding the evaluation of the control of the cotton weevil (cotton bell), the test unit consisted of a 24-well microtiter plate containing 'insect bait and 20-30 boll-like eggs. Different concentrations of the formulated compound were sprayed onto the insect part 1 at 2 〇 μ1 using a custom micro sprayer and repeated twice. After application, the microtiter plates were incubated for $day at 23 ± 1 °C and 50 ± 5% relative humidity. The mortality of eggs and larvae was then visually evaluated. In this test 'compounds 19, 33, 62, 65, 66, 69, μ, 85, 86, 87, 88, 92, 93, 94, 95, 99 ' ι〇ι, 104, 1〇5, 1 〇6, 1〇7, 1〇8, 1〇9, 11〇, 116, 138, (4), 133661.doc -174- 200917962 145, 147, 148, 149, 150, 151, 153, 154, 155, 156 , 157 , 159 , 160 , 161 , 162 , 166 , 167 , 171 , 185 , 186 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 206 , 207 , 220 , 221 , 234 and 243 respectively at 2500 mg /L test solution concentration shows 100% mortality. In this test, the compound! ! , 13, 14, 16, 20, 22, and 30 exhibited at least 50% mortality at a test solution concentration of 2500 mg/L, respectively. II.10 Activity against Mediterranean fruit fly (Ceratitis capitata) The active compound was formulated in 1:3 (vol: volume) DMSO: water. For the evaluation of the control of the fruit fly, the test unit consists of a microtiter plate containing insect bait and 50 to 80 cone-shaped stalks. Different concentrations of the formulated compound or mixture were sprayed onto the insect bait in an amount of 5 μl using an armored microinjection spray and repeated twice. After application, at 28 ± 1 C and 80 ± 5 ° /. The microtiter plates were incubated for 5 days at relative humidity. The eggs and larvae were then visually observed for mortality. In this test 'via 2,500 ppm of compounds 7, 21, 62, 63, 77, 79, 84, 92, 100, 1, 1, 1, 128, 147, 166 ' 181, 183, 184, 23 1, 232 and 234 treated eggs showed 5% mortality, 〇-175- 133661.doc

Claims (1)

200917962 X. Patent application scope · 1. A method for controlling invertebrate pests, which comprises treating the pests with an insecticidally effective amount of a pyrazole compound of the formula I or II or a salt thereof or a muoxide thereof, and the food supply thereof , their habitat or their breeding grounds, or plants, seeds, soils, areas that are grown or can grow such pests, materials or environments, or materials, plants, seeds, soils that are intended to be protected from pest infestation or infestation, Surface or space: A system of Al, A2 or A3 is more than σ R41 A2 A3 represents a binding site to the rest of formula I or 11; X1 is s, 0 or NRla; X2 is 〇R2a, NR2bR2c, s(〇)mR2d; X3 is a lone pair or oxygen; R is hydrogen, CN , CVCw alkyl, Ci_Cl () _ alkyl, c3_Ci 〇 % alkyl, C3-C10-halocycloalkyl,. {(1)cycloalkylmethyl I3366l.doc 200917962 c3-c10-ii cycloalkylmethyl, c2_Cl0-alkenyl, c2_Cl0_haloalkenyl, C2-C10-alkynyl, c3-C10-haloalkynyl, CVC4-alkylene-CN, 〇Ra, Cl_c4-alkyl-ORa, C(Y)Rb, CVC4-alkylene-C(Y)Rb, C(Y)ORc, C--C4-desane -C(Y)ORc, S(〇)2Rd, NReRf, q-CV alkylene-NReRf, C(Y)NRgRh, Ci-C4-alkylene-C(Y)NRgRh, S(0)mNReRf , C(Y)NRiNReRf, phenyl, heteroaryl, phenyl-c--C4-alkyl and heteroaryl_Ci_c4-alkyl, wherein the aromatic ring of the last four groups described above may be unsubstituted or May have 1, 2, 3, 4 or 5 identical or different substituents Rx; R2 is hydrogen, halogen, CVCV alkyl, CVC4-haloalkyl, (VCV alkoxy, CVCU-haloalkoxy, CVC4-alkyl sulfide , CVC 4-haloalkylthio, Cf-Cr alkylsulfinyl, Cl_C4_haloalkylsulfinylene, Ci-C4-alkylsulfonyl, Cl_c4_haloalkylsulfonyl, C3-C6-ring Homo-based, c3-C6-ii-substituted cycloalkyl, c2-C4-alkenyl, C2-C4-haloalkenyl, C2-C4-alkynyl or alkoxy-CVC4-alkyl; R3 hydrogen, Halogen, CrCV alkyl, CVCV haloalkyl CVC4-alkoxy, C--C4-haloalkoxy, Ci-C4-alkylthio, CVC4-halosulfonyl, G-C4-alkyl sulfite, Cj-Cf halosulfinyl Sulfhydryl, Ci-C: 4-alkylsulfonyl, CrCr haloalkylsulfonyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, c2-C4-alkenyl, C2-C4 -haloalkenyl, C2-C4-alkynyl or Ci_c4_alkoxy_CVC4-alkyl; 133661.doc 200917962 m is 0, 1 or 2; R41, R42, R43 are selected from the group consisting of hydrogen , halogen, CN, N〇2, Ci-C10-alkyl, c3-C10-cycloalkyl, C5-C10_ ring, C3-C10-cycloalkyl, c2-C10-alkenyl, c2- C10-block group, wherein the aliphatic or cyclic moiety of the last six groups described above may be unsubstituted, may be partially or completely converted or may have 1, 2 or 3 identical or different substituents Ry, 〇Ra , SRa, C(Y)Rb, C(Y)ORe, S(0)2Rd, NReRf, C(Y)NRgRh, phenyl, phenyl-CVC4-alkyl, phenoxy s_Cl_c4_alkyl, 5-member An aryl group and a heterocyclic-CrC4-alkyl group, wherein the heterocyclic group and the aromatic ring of the last five groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substitutions. Rx;, halogen, CN, N02, C, -c5-c1G-cycloalkenyl, C3_Ci()_R51 are selected from the group consisting of hydrogen, C10-alkyl, C3-C1Q-cycloalkyl, c-ring Alkylmethyl, C2_c10-alkenyl, C2_Ci〇-alkynyl, wherein the aliphatic or cyclic moiety of the last six of the above groups may be unsubstituted, partially or fully halogenated or may have! , , 2 or 3 identical or different substitutions 4 or 5 identical or different substituents rx; No2, CVC]. -alkyl, C3-C10-cycloalkyl, C5-C1G-cyclopropene 133661.doc 200917962, C3-CIG-cyclodextyl f, C2-C1()-saturated, c2-c10-blockyl' Wherein the aliphatic or cyclic moiety of the last one of the above groups may be unsubstituted, partially or fully halogenated or may have 2 or 3 identical or different substituents Ry, ORa, SRa, c(Y)Rl), C(Y)ORc, S(0)2Rd, NReRf, C(Y)NRgRh, heterocyclic group, phenyl group, phenyl-C, -C4_alkyl group, phenoxy-Ci_C4_alkyl group and heterocyclic ring_ GC: 4-alkyl, wherein the heterocyclic group and the aromatic ring of the last five groups described above may be unsubstituted or may have 2, 3, 4 or 5 identical or different substituents Rx; R61, R63 The following components are selected: hydrogen, N〇2, Ci_Ci❶-hospital, c3-c1g-cycloalkyl, C5_Cig_cycloalkenyl, c3_Cig_cycloalkylmethyl, C2-Cl0_thinyl, c2_Ci〇_ Fast group, the last six of which are the above, the aliphatic or cyclic moiety of the group may be unsubstituted, partially or fully commercialized or may have J, 2 or 3 identical or different substituents NReRf〇Ra, SRa , c(Y)Rb, C(7)(4), s(0)2Rd, =, c〇〇NRgRh, s(())mNReRf, c(7) </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> <RTIgt; 2, 5 J and different substituents Rx; R6' is selected from the group consisting of: anthracenyl, C5 C:, N〇2, Cl_^, C χ 5 10 % alkenyl, C3-C丨ο- a cycloalkyl group of a cycloalkyl group: a C, C1 °  alkynyl group wherein the last 6 months of the above-mentioned or acyclic moiety may be unsubstituted, may be partially or 133661.doc 200917962 fully halogenated or Having 1, 2 or 3 identical or different substituents Ry, ORa, SRa, C(Y)Rb, C(Y)ORc, S(0)2Rd, NReRf, C(Y)NRgRh, s(0)mNReRf, C(Y)NRiNReRf, phenyl, phenyl-Ci-CV alkyl, phenoxy-c]-c4-alkyl, 5-membered heteroaryl and heterocyclic-CrC4-alkyl, wherein the last five groups described above The heterocyclic group and the aromatic ring may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents rx; Y system or S; Rla is selected from hydrogen, q-Cw alkyl, CVCVii alkyl, c3-C1()-cycloalkyl, C3_C10-cycloalkylmethyl, C3_C10-halocycloalkyl, c2-c10-ene , c2_Cl〇_haloalkenyl, c2_Cl〇-alkynyl, c10-alkoxy-CrCV alkyl, 〇Ra, phenyl, heteroaryl, phenyl-Ci-C: 4-alkyl and heteroaryl _Cl_C4_alkyl, wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2, j, 4 or 5 substituents independently of each other selected from the group consisting of halogen, cyanide a base, a nitro group, a Cl-C4-alkyl group, a Cl_c4_haloalkyl group, a C1-C4-alkoxy group, and a Cl_c4_haloalkoxy group; the R2a group is selected from the group consisting of cvcv alkyl group, Cl_c4_haloalkyl group, c3_C6_cycloalkyl group, C3-C6-# cycloalkyl, alkenyl, C2_C4_self-alkenyl' c2-c4-alkynyl, Cl-C4_alkoxy_Ci_c4_alkyl, phenyl, heteroaryl, phenyl- Cl-C4-alkyl and heteroarylalkyl wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2 '3, 4 or 5 independently of each other selected from the group consisting of Substituents: i, cyano, nitro, Cl_c4_alkyl, Ci_c^ 133661.doc 200917962 thiol Cl-C4_ methoxy and Cl_C4-self alkoxy; R2, R, independently of each other From hydrogen, Ci 々 alkyl, c 々 々 alkyl, c3-c6- ring c3_C6 choline cycloalkyl, c2 heart-bake base, c2-c4- abused base, c2_C4_ block, Ci_C4_homoyloxy; CVCV alkyl, Cl_C4_croplex (tetra), Ci_CH alkyl group, CyC4·alkylsulfonyl, Ci_C4__alkylsulfonyl, phenyl 'benyl carbon, phenyl fluorenyl, heteroaryl, heteroaryl, heteroaryl, phenyl And a heteroaryl 々C4 alkyl group, wherein the aromatic ring in the last 8 groups may be unsubstituted or may have 1 '2, 3, 4 or 5 independently of each other selected from the group consisting of Substituents of the group: a pixel, a cyano group, a nitro 'c丨_c4-alkyl group, a Cl_C4 alkyl group, a Ci_C4_ alkoxy group, and a dentate alkoxy group; Mie and its bonded nitrogen atom form a 5 or 6 membered saturated or unsaturated heterocyclic ring 'which may have another hetero atom selected from fluorene as a ring member atom and wherein the heterocyclic ring may be unsubstituted or Having i, 2, 3, 4 or 5 substituents independently of one another selected from the group consisting of: a phytol, a cyano group, a nitro group, a Cl_C4 {yl group, an alkyl group, a CVCV alkoxy group, and a CVC^haloalkane氧基; R is selected from (VC4-alkyl, q-cv-alkyl, c3_C6_cycloalkyl, C3-C6-halocyclo, c2_c4_dilute, C2_C4_ _, dilute, C2- C4-alkynyl, CVC4-alkoxy-Ci_c4-alkyl, phenyl, heteroaryl, phenyl-CrC4-alkyl and heteroaryl·Ci_c4_alkyl, wherein the last four groups are aromatic The ring may be unsubstituted or may have 133661.doc 200917962 R8 R (Re 1, 2, 3, 4 or 5 are independently selected from each other consisting of: a base: a cyclin, a cyano group, a thiol group, a Ci oxime a group, a c-alkyl group, a Cl_C4_ alkoxy group, and a Ci_C4-sodium alkoxy group; the ～ groups are independently selected from the group consisting of hydrogen, Ci oxime, Ci_c^, alkyl, C3_C6_cycloalkyl, c3-c6 ·Circular base methyl, C"C6 self-generation ring burning Base, q-CV fluorenyl group, C2_C4•equivalent alkenyl group, c2_c: group, Cl-C4-alkoxy group _Cl oxime group, phenyl group, heteroaryl group: the group -C丨-(V alkyl group and a heteroaryl group, wherein the aromatic ring of the above four groups may be unsubstituted or may have i, 2, 3, 4 or 5 substituents independently of each other selected from the group consisting of dentate, cyanide a nitro group, a cyanoalkyl group, a Ci(R) group, a CVC4. alkoxy group, and a Ci_C4_haloalkoxy group; selected from the group consisting of CVC4-alkyl, C1 々 々 alkyl, C3_C6_cycloalkyl' C3-c6-cycloalkylmethyl, C3_C6 definite cycloalkyl, dilute, c2_c4_Southern alkenyl, C2_C4_alkynyl, Ci_c4_homolyl_ycv alkyl, stupyl, heteroaryl, benzene Based on ''alkyl and heteroaryl-Cl-C4_alkyl, wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 independently selected from each other Substituents of the group consisting of: γ, aryl, nitro, cvk, Ci_C4_haloalkyl, sulfoxy and Ci-C4-haloalkoxy; independently selected from each other Hydrogen, Ci_C4_alkyl, Ci_c4^, f, C3-C6-ring, C3_C6•cycloalkane Sulfhydryl, C3_C6_functional cycloalkyl, C2-(V alkenyl, C2_C4_ by alkenyl, c2 core-block 133661.doc 200917962, kcv morphoxy_Cl_C4), Ci_c4_alkyl , Cl-CV dentate alkylcarbonyl, c^c4-alkylsulfonyl, Ci_C4-dentate, aryl, phenyl, phenyl, phenylphenyl, heteroaromatic heteroaryl Carbonyl, heteroarylsulfonyl, phenyl_C|_C4_alkyl, heterocyclyl-CrCV alkyl group. The aromatic ring in the last 8 base circles described above may be unsubstituted or may have J, 2 , 3, 4 or 5 substituents independently of one another selected from the group consisting of dentate, cyano, nitro, CVCV alkyl, Cl_c4_descriptive, Ci_c4 methoxy and Ci-Cr haloalkoxy Or R and R and the nitrogen atom to which they are bonded form a 5- or 6-membered saturated or unsaturated t-heterocyclic ring which may have another hetero atom selected from the group consisting of fluorene, s &amp; N as a ring member atom and wherein the The ring may be unsubstituted or may have i, 2, 3, 4 or 5 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, Cl_c4_alkyl, Ci_c alkyl, CrC4 ·Alkoxy and (^-(:4-haloalkane) Rg, Rh are independently selected from hydrogen, Cl_c4_alkyl, Ci_c4__alkyl, c3-c6-cycloalkyl, C3-C6-i cycloalkyl, c2_c44, C2-C4- Halogenated, C2-C4-blockyl, Cl_c4•院oxy_Cl-C4-alkyl, phenyl, heteroaryl, phenyl-(:1&lt;4-alkyl and heteroaryl-C^ -C4.alkyl, wherein the aromatic % of the last four groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 substituents independently of one another selected from the group consisting of: a cyano group, a nitro group, a CVC4-Huan group, (VC4-haloalkyl group, Cl-c4-alkoxy group, and C1-C4-halodecyloxy group; 133661.doc 200917962 R, selected from the group consisting of: A , Cl-c4-alkyl, Cl-C4 dentate alkyl, c3-c6-ring; 13⁄4, c3_c6 cycloalkyl, C3_C6_white, alkyl, C2-C4-, c2_c4_ _ a C2_C4_alkynyl group, a C1-C4_alkoxy-C丨-cv alkyl group, a phenyl group and a phenyl-Cl_4 alkyl group, wherein the benzene ring in the last two groups may be unsubstituted or may have 1, 2 '3, 4 or 5 substituents independently of each other selected from the group consisting of: halogen, cyano, nitro, Ci_c4_alkane a group, c^-c: 4-haloalkyl, Cl_C4_alkoxy and Ci_C4_haloalkane; Rx is selected from the group consisting of halogen, cyano, nitro, Cl_C4-alkyl, VC4-haloalkyl, CVC4-alkoxy, CVC4-haloalkoxy, (VC4-alkylthio, CVC4-haloalkylthio, C,-C4-alkyl sulphate, Ci-C4_halogenation) a genus, a C 1 -c4-alkylsulfonyl group, a Ci-Cr haloalkylsulfonyl group, a c,-c4-alkylcarbonyl group, a CVC 4-haloalkylcarbonyl group, a c3-c6-cycloalkyl group, C3-c6-halocycloalkyl, c2-c4-alkenyl, c2-c4-haloalkenyl, c2-c4-alkynyl and CVC4-alkoxy-CrCU-alkyl; Ry is independently selected from each other From C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-halooxy, C1-C4-sulfuryl, C1-C4-halogenated Sulfur-based, ci-c4-alkyl sulphate, Ci_C4_haloalkyl sulfhydryl, C1-C4_alkyl sulfhydryl, Cl_C4_haloalkylsulfonyl, C3-C6- Cycloalkyl, CVCe-halocycloalkyl, C2·C4-alkenyl, C2-C4-haloalkenyl, C2-C4-alkynyl, G-C4-alkoxy-CVC4-alkyl, and CVCn- Alkylcarbonyl. 133661.doc -9- 200917962 2. The method of claim 1, wherein the pyrazole compound is a compound of formula j. 3. The method of claim 1, wherein the pyrazole compound is a compound wherein X1 in formula I is oxygen. 4. The method of claim 1, wherein the pyrazole compound is a hydrazine compound, wherein R1 is hydrogen, CN, Cl-Cl0-alkyl, Cl-Cl〇-haloalkyl, c2·Cio-alkenyl, C2-C10-haloalkenyl, C2-C10-alkynyl, C^-CV alkoxy-Cl~cio-alkyl, CVC4-alkylene-CN, 〇Ra, C(Y)Rb, c( Y) 〇 Re or s(o) 2Rd. 5. The method of claim 4, wherein R is hydrogen, CrCV alkyl or Cl_c4_extension-CKf. 6. For example, π! A method wherein R2 is hydrogen, decyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy. 7: The method of claim, wherein r3 is hydrogen, methyl, difluoromethyl, tri-gas: methoxy, difluoromethoxy or trifluoromethoxy = &gt; The method of 6 or 7, wherein the groups are hydrogen. 4 夕1固 9 · The claim 8 $ t &amp; method, wherein the groups R2 and R3 are both hydrogen. 1〇_If the request item is 7 to η. If the request item ίο is the party* Γ is the group A1. , CN, 法, 中R4丨 and R51 are independently selected from hydrogen, tooth ', , Cl-C1G-mercapto, C, Γ « 广C2-C丨0-alkyne, 甘屮1〇-echane The aliphatic, 1 part of the last 4 groups of the above-mentioned C2-C-decenyl group and N8 may be unsuppressed by π Α Τ夂钿 禊 or % η ° 邛 or completely halogenated or may have} Biting two identical or different substituents Ry. A 2 phases 12 · as claimed in 丨 ', where R41 and R51 are independently selected from each other 133661.doc -10- 200917962 wind, CN, halogen, C丨-c4-alkyl, C丨-c4- _ generation Alkyl, c3_c decyl and C3_C6· _cycloalkyl. 13. The method of claim 12, wherein R41 and R51 are independently selected from the group consisting of hydrogen, CN, halogen, CH3, CH2f, CHf2, and cf3. 14. The method of claim 13, wherein R41 or R51 is hydrogen or both R41 and R51 are 15. The method of claim 10, wherein R61 is selected from the group consisting of: Cl ClG_alkyl, Dai Hyun , C3-C1G-cycloalkyl, c3_c10_halogenated alkyl, C3_C10-cycloalkylmethyl, C3-C10-halocycloalkylmethyl, c2-c10-alkenyl, c2-C10-dentate Alkenyl, CrCr alkoxy_Ci_c1〇-alkyl, phenyl, benzyl, phenoxy-fluorenyl, 5- or 6-membered heteroaryl, 5- or 6-membered heteroarylmethyl, wherein The (hetero)aromatic ring in the last 5 groups may be unsubstituted or may have an anthracene, 2, 3, 4 or 5 identical or different substituents RX selected from halogen, Ci_C4_alkyl, alkane a method of claim 15, wherein the method is the method of claim 15, wherein the method comprises the method of claim 15, wherein the method is the method of claim 15, wherein the method is the method of claim 15, wherein the method of claim 15 R6, is a method of any one of the preceding claims, wherein A is a group A2. 18. The method of claim 17, wherein the R42 is Selected from hydrogen, halogen, c4-hospital, Cl-c4 deuterated, C3_C]G_cycloalkyl, 匕_^__ a cycloalkyl group and a phenyl group which may be unsubstituted or may have an anthracene, 2, 3, 4 or 5 identical or different substituents V selected from the group consisting of halogen, Ci_C4 alkyl, CVCV haloalkyl, CVCV alkoxylate And //halohaloalkoxy. 133661.doc -11 - 200917962 19. The method of claim jg彳s 4 &amp; 8, wherein R42 is selected from the group consisting of hydrogen, halogen, CN 匕 4 · hospital base, Γ , 匕1-i-C4-haloalkyl, C3-C6-cycloalkyl and cc cycloalkyl. &quot;·sighing halogen 20·as requested jg〗 7 + + hydrogen, from ♦, R52 is selected from The following groups: ", CN, c] - cI0 - pit base, Cl_Cl " generation cc ^ C3_Cl 〇 - halocycloalkyl, c3-c10-cycloalkylmethyl, 3 cycloalkyl fluorenyl, C2 -CI()-alkenyl, ^yl-c]-c丨0-alkyl, phenyl, benzyl, phenoxy A_ T -3⁄4 ' AL· λ*- ** sulphate, 5- or 6-membered heteroarylmethyl, wherein the (hetero)aromatic ring in the upper, ten, and 2 groups may be unsubstituted or may have 1 appearance group 4 or: one: the same ^ C1-C4-resolution Alkyl, Ci_c4_alkoxy, h-c4-halo 1 c4-alkylindenyl, and Ci_ 21.沉基%醯基. Nitrogen, 1Γ' wherein R52 is selected from the group consisting of: leucovorin, TM, Cl_Cl. -alkyl, CH dentate, Cio-cycloalkyl, c Γ 占 k ((3- CC ^ halocycloalkyl, 4-(^- ring-based methyl, 3 10 ·'----- Methyl, c2-cI0-alkenyl, cc and Ci-C4-; Jt oxygen A p ^ 2-C1 (r卣 alkenyl hydrazide-Ci_C丨0-alkyl. 22. The method wherein r62 is selected from the group consisting of hydrogen, kc10, and CVC, and CVC is a group consisting of C3-C 1 Cl0-haloalkyl, C3-Cl0-cycloalkyl, c"i〇·self-generation ring, c"Ci0•环院基甲 alkylmethyl, C, C, method 1 c3-c丨0-_-cyclic group-CVC ^ Cl^ 归 、, Cl-C4_ oxynitride 1丨c丨〇- Alkyl, phenyl, oxime, benzyl, phenoxy and phenoxy fluorene can be unsubstituted or can be 133661.doc -12- 200917962 has 1 , 2, 3, 4 or 5 identical or different substituents RX selected from halogen, CVCV alkyl, (Vc4-haloalkyl, cvcv alkoxy, C1-C4-halogenated emulsifier, G-C4 - A sulphate base, and a Q-C4-halogenated p-based base. 23. The method of claim 22 wherein R62 is hydrogen, c丨-C4-alkyl or halodecyl. The method of any one of claims 1 to 7, wherein a is a group A3. 25. The method of claim 24, wherein R43 is selected from the group consisting of hydrogen, halogen, CN, r c4_alkyl, C丨-C4-haloalkyl, c3_Cl〇-cycloalkyl, c3_Ci〇_Southern cycloalkyl and phenyl which may be unsubstituted or may have 1 '2, 3, 4 or 5 identical or different substituents Rx, It is selected from the group consisting of halogen, Ci_C4_alkyl, CVC4-haloalkyl, CVC4-alkoxy, Cl_C4_haloalkoxy, C1-C4.alkylsulfonyl, and Ci-C*-haloalkylsulfonyl. 26. The method of claim 2, wherein r43 is selected from the group consisting of hydrogen, halogen, CN, c4-alkyl, CVC4-haloalkyl, c3_c6-cycloalkyl, and c3_c6•halocycloalkyl. The method wherein R53 is selected from the group consisting of hydrogen, halogen, CN, (:, -(:)-alkyl, (:,-(:]-haloalkyl' c3_ Ci〇-cycloalkyl 'C3-C10-halocycloalkyl, c3_C10-cycloalkylindenyl, c3-c丨0-halocycloalkylindenyl, C2_Ci〇•alkenyl, C2_Ci〇_ _alkenyl, Ci-cv Alkoxy _Cl-Cl (r alkyl, strepyl, benzyl, phenoxy fluorenyl, 5- or 6 a heteroaryl, 5- or 6-membered heteroarylmethyl group, wherein the (hetero)aromatic ring in the last five of the above groups may be unsubstituted or may have i, 2, 3, 4 or 5 identical or different Substituent RX, which is selected from the group consisting of halogen, 133661.doc -13· 200917962 c4-alkyl, CVC4-halogenyl, Cl_C4_alkoxy'c〗_c4-haloalkoxy, CVC4-alkylsulfonyl And the Cl_C4_ letter generation base. 28. The method of claim 27, wherein r53 is selected from the group consisting of hydrogen, halogen, CN, Ci-Cio-alkyl, Ci-C10_haloalkyl, 匸3_ Ci〇-ring, C3_Ci〇-halogenated cycloalkyl, C3_Ci〇-i alkyl, C3-C10-halocycloalkyl, C2-C10-dilute, C2-C10-halogenated or C 1 - C 4 -theoremium_C 1 -C 1 0 -alkyl. 29. The method of claim 24, wherein R63 is selected from the group consisting of: murine, Ci-Ci〇-alkyl, Ci-Ci〇-halogen, C3-C10-cycloalkyl, C3-C10 -halocycloalkyl, C3-C10-cycloalkylmethyl, C3-C10-halocycloalkyl, C2-Ci〇-dilute, C2-C10-halogenated, Ci-C4- ^oxy-CrC^o-alkyl, phenyl, benzyl, phenoxy-fluorenyl, 5- or 6-membered heteroaryl, 5- or 6-membered heteroarylmethyl, of which the last five The (hetero)aromatic ring in the group may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents Rx ' selected from halogen, Cl_C4_alkyl, Ci_C4-acid Base, CVC 4-homoyloxy, Ci-C4-halo-oxyl, decyl-acid group, and Ci-C4-haloalkylsulfonyl. 30. The method of claim 29, wherein r53 or R63 is hydrogen, Ci_C4_alkyl or GC: 4-haloalkyl, and the other group of R53, R63 is selected from the group consisting of: - alkyl, Ci-Ci. - haloalkyl, C3-C丨. -cycloalkyl, c3-c: 10-s-cycloalkyl, c3_Ci〇-cycloalkylindenyl, halo=alkylmethyl, c2-Ci〇-alkenyl, C2-C10-haloalkenyl , Ci_d alkane-based, CrCw, base, stupid, stupidoxy-methyl, berylungyl, 5-^6昼, pen, and Tiangan++丄6, 6-membered hetero-based fluorenyl, Wherein the (hetero)aromatic ring in the last five groups 133661.doc 200917962 may be unsubstituted or may have the same or different substituent RX, which is selected from the group consisting of #素, Cl-. C4-alkyl\Ci_C4-haloalkyl, C|_c4-alkoxy, c,-c4-autoalkoxy, C|- cv alkylsulfonyl, and Ci_C4_haloalkylsulfonyl. The method of any one of claims 1 to 7, wherein the invertebrate pests are arthropod pests and/or nematodes. 32. The method of claim 31, wherein the invertebrate pest is an insect. The method of claim 32, wherein the invertebrate pest is a H. moptera insect. The method of any one of items 1 to 7 wherein the invertebrate pests are worms. 35. A method of protecting a plant propagation material and/or a plant grown therefrom, the method comprising using a pesticidally effective amount of a compound of formula I or II as defined in any one of claims 3 to 3 or agricultural The seed is treated with an acceptable salt or N-oxide. (36) A plant propagation material comprising at least one compound of the formula as defined in the claims to claim 3 and/or an agriculturally acceptable salt or N-oxide thereof. The use of any of the claims β30, or a pharmaceutically acceptable salt or N-oxide thereof, for the manufacture of a medicament for the treatment or protection of an animal from parasite infestation or infection 38. —Formula I or π.Biazole compound 133661.doc •15- 200917962 R1 R&quot; (0 where A, X1, X2, R R and R3 are as defined in the claims, and the salts and N-oxides do not include the formula: - A has the formula A2, X1 is hydrazine, and Ri, R2, R3, r42 and r62 are each hydrogen. And R53 is 2-hydroxyphenyl, 2-hydroxymethylphenyl, oxime hydroxy-5-ethylphenyl, 2-hydroxy-5-phenylphenyl, 2-hydroxy- 4,5-dimethyl basic , 2-3⁄4 base-3,4-mercaptophenyl or 2-butyryl-3,5-diindenylphenyl, -A has the formula A3 'X is Ο 'R1, R2, R3, R4 3 and R6 3 is each hydrogen ' and R53 is phenyl, 4-fluorophenyl, 4-methoxyphenyl, 4-anthracenephenyl, 4-chlorophenyl, 4-methylphenyl, 4-ethoxyl Phenyl, 2,4-dimethylphenyl, 2-hydroxyphenyl, 2-hydroxymethylphenyl, benzyl-5-ethylphenyl, 2-yl-5-chlorophenyl, 2- -4,5-dimethylphenyl, 2-hydroxy-3,4-dimethylphenyl or 2-hydroxy-3,5-dimethylphenyl, -X1 is 0, R1, R2 and R3 Each is hydrogen and A is 1-(phenylindenyl)-3-nitropyrazol-5-yl, 1-methylpyrazol-5-yl, 1-methyl-4-chloropyrazole-5- The base, 1-ethyl-4-indol is higher than the -3-yl, 1-ethyl-3-methyl 0 ratio. -4-yl, 1-mercapto-3-trifluoromethylpyrazol-4-yl, 1-phenyl-5phenylnonylaminocarbazole-4-yl, 1-(4-phenylphenyl --3-phenylaminocarbonyl-5-methylpyrazol-4-yl, 1-phenyl-5-[(4-methylphenyl)carbonyl]aminocarbazole-4-yl, 4- Iopyrazole-3-yl, 1-methylpyrazol-3-yl, 5-gas-1-133661.doc •16- 200917962 decylpyrazol-3-yl, 5-nitrocarbazole-3- Base, ι_(4_gasphenyl)_5-di-Imethyl 0 is more than sp-4-yl, 1-phenyl-3-porphin-2-yl. Sodium 4-yl, 1-phenyl-3,5-dimethylpyrazol-4-yl, 4-bromo-5-zinopyrazol-3-yl, 5-%propyl_1_(1, 1-Dioxotetrahydro 11-cepan-3-yl)-11^-0-pyrazol-3-yl; and does not include the following compounds: &quot;1_(4·气笨基)-5-Trifluoromethane Base-1Η-.嗤_4-carboxylic acid "» than bit-3-yl decylamine, - fluorenyl-phenyl-3-thiophen-2-yl-1 Η-pyrazole-4-carboxylic acid pyridine · 3 - decylamine, -3, 5_Dimercapto-1-phenyl-1 oxime-oxazole-4-carboxylic acid guanidinium _3_ decylamine. 39. A compound of claim 38 which has the formula I. 40. A compound of formula I according to claim 38, wherein X1 is oxygen. 41. The compound of formula j of claim 38, wherein Ri is hydrogen, Ci_Ci〇-alkyl, CN li_C10-halothylenyl, c; 2-Ci〇-dilute, c:2_c10_haloalkenyl, C2 -C1G-alkynyl, CVC4-alkoxy-CVCw alkyl, C丨-C4-alkylene-CN, 〇Ra, C(Y)Rb, C(Y)〇Rc^s(〇)2Rd. 42. The compound of claim 41, wherein R1 is argon, Ci_C3_alkyl or fluorene-alkyl-CN. 43. The compound of claim 38, wherein R2 is hydrogen, methyl, difluorodecyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy. 44. The compound of claim 38, wherein R3 is hydrogen, decyl, difluorodecyl, di-methylmethyl, methoxy, difluoromethoxy or trifluoromethoxy. 45. The compound of claim 43 or 44, wherein at least one of the groups 2 or r3 is hydrogen. 133661.doc 17- 200917962 46. The compound of claim 45 wherein both the groups R2 and R3 are nitrogen. 47. The compound of claim 38 to 44, wherein A is a group A1. 48. The compound of claim 47, wherein R41 and R51 are independently selected from the group consisting of oxygen, i, cn, Ci-Ci. - an alkyl group, a c3-c1Q-ring group, a c2_Ci()_returned and a C2_C10-fast group, wherein the aliphatic or cyclic moiety of the last four groups described above may be unsubstituted, partially or completely Or it may have 1 or 2 identical or different substituents Ry. 49. The compound of claim 48, wherein the oxime and the ruthenium 5 are independently selected from the group consisting of hydrogen, halogen, CN, C-C4-alkyl, CVC4-haloalkyl, C3_C6_cycloalkyl, and C3-C6- Halogenated cycloalkyl. 50. The compound of claim 49, wherein R41 and R" are independently of each other selected from the group consisting of hydrogen, halogen, CN, CH3, CH2F, CHF2 & CF3. 51. The compound of claim 50, wherein r414R5i is hydrogen or R4i and rS1 is both ammonia. 52. The compound of claim 47, wherein R6! is selected from the group consisting of: ci-c10-alkyl, c, -c10-functional alkyl, c3-c10-cycloalkane Base, C3_Ci.-dentate cycloalkyl, (VC10-cycloalkylmethyl, C3_Ci〇_halocycloalkyl) C2-C10-alkenyl, C2-Ci〇-halogenated, c^- Cf oxyalkyl, phenyl, benzyl, phenoxy-methyl, 5- or 6-membered heteroaryl, 5- or 6-membered heteroaryl fluorenyl' among the last five of the above ( The heteroaromatic ring may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents Rx selected from halogen, Ci_C4_alkyl, haloalkyl, C^CV alkoxy, CVC4·haloalkoxy, Cl_c4_alkyl sulphate and Ci-C4-haloalkylsulfonyl. 133661.doc •18· 200917962 53. The compound of claim 52, wherein R0 is a Ci_C4_alkyl or c __c4__ Alkenyl. 5 4 'If the item is 3 8 A compound of 44, wherein the A group A2. % is a compound of claim 54, wherein r42 is selected from the group consisting of hydrogen, nitrite, cn, Ci-c4, cyclyl, Cl_c4_ _, and C3_C]G ^10- Cycloalkyl and phenyl, which may be unsubstituted or may have hydrazine, 2, 3, 4 or 5 identical or different substituents RX' which is selected from the group consisting of dentate, c]-c4-alkyl, H-cv halo-based, c] anthracene oxy, Ci dentate alkoxy-Ci-Cc alkylsulfonyl, and Ci_C4_haloalkylsulfonyl. 56. The compound of claim 55, Wherein r42 is selected from the group consisting of hydrogen, (4), (3), CVCV alkyl, Cl_c4-halo oxime, Γ 甘 甘 环 。 。 。 代 。 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代 代R52 is selected from the group consisting of: =, 素, CN, Cl-ClQ-alkyl, C--C1 (r _ alkyl, c _ V alkyl, C3_c "cycloalkyl, oxime." Cycloalkylmethyl: group c = cycloalkylalkyl, c2-ClQ-alkenyl, c2_Ci. decene 1 4 alkyl lactyl, stupid, benzyl, phenoxy: yl, 5· Or 6-membered heteroaryl, 5 or 6-membered heteroarylmethyl: the last 5 groups of r--, middle and upper fans The (hetero) aromatic ring may be unsubstituted or may have U, , or: or 5 identical or different substituents RX, which are selected from the group consisting of C4-yard, CVC 4 alkyl, Ci_C4_morphyloxy , "Alkoxy, Ci 々 alkyl sulfonyl =1 4-Self 58. The compound of claim 54, wherein two or two. Widely burned base continued to brew. Hydrogen, C丨-Cl_俨, „ Free group of the following: ° 70 &quot; '广^0· _ alkyl, C3-C丨〇-cycloalkyl, 133661.doc -19· 200917962 c3-c10 -halocycloalkyl, c3-C10-cycloalkylmethyl, c3-c10-halocycloalkylmethyl, C2-C10-alkenyl, C2-C10-haloalkenyl, Ci-Cr alkoxy Alkyl, phenyl, 5-membered heteroaryl, benzyl and phenoxymethyl' wherein the aromatic ring of the last four groups described above may be unsubstituted or may have 1, 2, 3, 4 or 5 The same or different substituent Rx, which is selected from the group consisting of a phytosin, a cvcv alkyl group, a (VCV haloalkyl group, a cvcv alkoxy group, a Ci-C4_haloalkoxy group, a q-C4-alkylsulfonyl group, and a CVC4-halogen 59. A compound according to claim 58 wherein r62 is hydrogen, Ci_c alkyl, 11 _C4 _ alkyl, c3-C6-cycloalkyl or C3-C6-s. 60. The compound of claim 44, wherein a is a group A3. 61. The compound of claim 6 wherein r43 is selected from the group consisting of hydrogen, halogen, CN, Ci-C4-alkyl, crC4-haloalkyl, C3-C10-cycloalkyl, c3-c dentate cycloalkyl and phenyl' which may be unsubstituted or may have 1, 2 , 3, 4 or 5 identical or different substituents Rx selected from halogen, C]-C4, alkyl C1-C4-haloalkyl, (3^-C4-methoxy), C1-C4-halogen A gas-fired C1 C4-alkyl sulphate base and a halogenated sinter base. 62. The compound of claim 61, wherein R43 is selected from the group consisting of hydrogen, halogen, CN, Cl_C4-alkyl, C丨_c4 a halogenated alkyl group, a C3-C6-cycloalkyl group, and a c3_c teraalkylene group. 63. The compound of claim 60, wherein the R53 is selected from the group consisting of: wind, south, CN, CVC, Alkyl, (: 丨-(: 10-haloalkyl, ^ 3 - 1 fluorene-cycloalkyl, c3-c10-decylcycloalkyl, c3-c10-cycloalkylindolyl, C3_CW _cycloalkane Base group, C2_Cl0_alkenyl, C2_Ci〇__代代133661.doc •20- 200917962 methyl" heteroaryl group, 5 or 6 membered heteroarylmethyl group, of which 5 groups are taken from the above The (hetero)aromatic ring may be unsubstituted or may have 1, 2, 3, 4 or 5 identical or different substituents rx selected from the group consisting of dentate, _c4-alkyl, c丨-C4- Halogenated 桉^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ . The compounds' wherein R63 selected from the group consisting of the group consisting of:!: Alkyl,.夂"Alkenyl, Μι.·cycloalkyl, ^7] 〇-_ ring ring base, _ ^ ^ ^ ^ alkyl group, eve M ~ Cl ° · tooth ring A c 2 10, soil, C2_Cl〇-haloalkenyl, C丨-C4_alkoxy-C丨-Ct alkyl, phenyl, benzyl, arylaryl, 5- or 6-membered heteroaryl r-methyl, 5- or 6-membered Miscellaneous (#)^ # ^ ' soil, wherein the (hetero) aromatic ring in the last five groups above may be unsubstituted or different substituents have the same alkyl, c, -c4 - alkoxy, 1 4'* w )-cv haloalkoxy, CrCV, # A 醯 醯, and c, -c4m 醯 醯 4. 4 pit base A as claimed in the compound, its towel r53 or Burning base or ... substitute base, while R53, R63] CN, C&lt; group consisting of: C|_c group is selected from C, -cycloalkyl, c3C "..., Cl-Cl ° 'South Alkenyl, C3-hc丨0-dentate cycloalkyl, C3_c C3-C "cycloalkylmethyl h-m-methyl, 12-base, ρ ρ-group, kcv-oxo-Ci_Ci-ruthenium, benzene Base, knot = 晞 = base, 5- or 6-membered heteroaryl, 5_" heteroaryl aryl base - the soil of the last 5 groups, wherein the above (hetero)-fragrance ring Unsubstituted or may have 133661.doc -21 . 200917962 2, 3, 4 or 5 interphase + τ J or different substituent Rx selected from halogen, C, - c4-alkyl, cvc4-haloalkyl , Ci_C4_alkoxy, Ci_C4_haloxanoxy, Ci-C4_alkyl, and Ci_C4_haloalkyl, wherein R53 may also be halogen. 66. An agricultural composition comprising at least one of Formula I or a hydrazine compound as defined in any one of claims 38 to 65 and/or an agriculturally acceptable salt or N-oxide thereof and at least one liquid Or a solid carrier. 133661.doc 22- 200917962 VII. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbol of the symbol of the representative figure is simple: 8. If there is a chemical formula in this case, please reveal the best display invention. Characteristic chemical formula: 133661.doc -6 ·