TR201900264T4 - İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar. - Google Patents

İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar. Download PDF

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TR201900264T4
TR201900264T4 TR2019/00264T TR201900264T TR201900264T4 TR 201900264 T4 TR201900264 T4 TR 201900264T4 TR 2019/00264 T TR2019/00264 T TR 2019/00264T TR 201900264 T TR201900264 T TR 201900264T TR 201900264 T4 TR201900264 T4 TR 201900264T4
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rna
polyethylene glycol
liposome
immunogen
delivery
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TR2019/00264T
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Geall Andrew
Verma Ayush
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Glaxosmithkline Biologicals Sa
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Abstract

Nükleik asit immünizasyonuna, bir PEGile edilmiş lipozom içerisine kapsüle edilmiş RNA vermek suretiyle ulaşılır. RNA, ilgili bir immünojeni şifreler. PEG'nin ortalama moleküler kütlesi, 3kDa'nın üzerinde ancak 11kDa'nın altındadır. Böylece buluş, bir sulu göbeği kapsüle eden bir lipit ikili katmanına sahip bir lipozom sağlar; burada: (i) lipit ikili katmanı, bir polietilen glikol yarımını kapsayan en az bir lipit içerir; böylelikle lipozomun dışında polietilen glikol mevcut olur, burada polietilen glikolün ortalama moleküler kütlesi, 3kDa'nın üzerinde ancak 11kDa'nın altındadır; ve (ii) sulu göbek, bir immünojeni şifreleyen bir RNA içerir. Bu lipozomlar, RNA'nın bir omurgalı hücresine in vivo verilmesi için uygundur ve bu yüzden bunlar, süjeleri çeşitli hastalıklara karşı immünize etmeye yönelik farmasötik kompozisyonlar içerisinde bileşenler olarak faydalıdır.
TR2019/00264T 2011-08-31 2012-08-31 İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar. TR201900264T4 (tr)

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US201161529878P 2011-08-31 2011-08-31

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TR201900264T4 true TR201900264T4 (tr) 2019-02-21

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TR2019/00264T TR201900264T4 (tr) 2011-08-31 2012-08-31 İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar.

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US (3) US20140255472A1 (tr)
EP (2) EP3508220A1 (tr)
JP (1) JP2014525461A (tr)
CN (1) CN103974719A (tr)
AU (1) AU2012301715B2 (tr)
BR (1) BR112014004607A2 (tr)
CA (1) CA2846043A1 (tr)
CY (1) CY1121122T1 (tr)
DK (1) DK2750707T3 (tr)
ES (1) ES2705498T3 (tr)
HR (1) HRP20190032T1 (tr)
HU (1) HUE041800T2 (tr)
LT (1) LT2750707T (tr)
MX (1) MX366055B (tr)
PL (1) PL2750707T3 (tr)
PT (1) PT2750707T (tr)
RU (1) RU2628705C2 (tr)
SG (2) SG11201400250UA (tr)
SI (1) SI2750707T1 (tr)
TR (1) TR201900264T4 (tr)
WO (1) WO2013033563A1 (tr)

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