TN2010000320A1 - AZABICYCLIC CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF - Google Patents

AZABICYCLIC CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF

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Publication number
TN2010000320A1
TN2010000320A1 TNP2010000320A TN2010000320A TN2010000320A1 TN 2010000320 A1 TN2010000320 A1 TN 2010000320A1 TN P2010000320 A TNP2010000320 A TN P2010000320A TN 2010000320 A TN2010000320 A TN 2010000320A TN 2010000320 A1 TN2010000320 A1 TN 2010000320A1
Authority
TN
Tunisia
Prior art keywords
nitrogen atom
preparation
ring
therapeutic use
carboxamide derivatives
Prior art date
Application number
TNP2010000320A
Other languages
French (fr)
Inventor
Laurent Dubois
Yannick Evanno
David Machnik
Andre Malanda
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/FR2009/000052 external-priority patent/WO2009112678A2/en
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of TN2010000320A1 publication Critical patent/TN2010000320A1/en

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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne les composés de formule générale (I)dans laquelle X1, X2, X3, et X4 représentent, indépendamment l'un de l'autre, un atome d'azote ou un groupe C-R1; Z1, Z2, Z3 et Z4 représentent, indépendamment l'un de l'autre, un atome d'azote, ou un groupe C-R2; Ra et Rb forment ensemble avec les atomes de carbone qui les portent un cycle à cinq chaînons, ce cycle comportant un atome d'azote et des atomes de carbone, ce cycle étant partiellement saturé ou insaturé et étant éventuellement substitué par un ou plusieurs substituants R3 ; W représente un atome d'oxygène ou de soufre; n est égal à 0, 1, 2 ou 3; y représente un aryle ou un hétéroaryle éventuellement substitué; à l'état de base ou de sel d'addition à un acide, ainsi qu'à l'état d'hydrate ou de solvate. Procédé de préparation et application en thérapeutique.The invention relates to compounds of general formula (I) wherein X1, X2, X3, and X4 independently of one another represent a nitrogen atom or a group C-R1; Z1, Z2, Z3 and Z4 represent, independently of one another, a nitrogen atom, or a C-R2 group; Ra and Rb form together with the carbon atoms which carry them a five-membered ring, this ring comprising a nitrogen atom and carbon atoms, this ring being partially saturated or unsaturated and being optionally substituted with one or more substituents R3 ; W represents an oxygen or sulfur atom; n is 0, 1, 2 or 3; y is optionally substituted aryl or heteroaryl; in the form of a base or an addition salt with an acid, as well as with the hydrate or solvate state. Preparation process and therapeutic application

TNP2010000320A 2009-01-20 2010-07-08 AZABICYCLIC CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF TN2010000320A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/FR2009/000052 WO2009112678A2 (en) 2008-01-22 2009-01-20 Azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof

Publications (1)

Publication Number Publication Date
TN2010000320A1 true TN2010000320A1 (en) 2011-12-29

Family

ID=55024447

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2010000320A TN2010000320A1 (en) 2009-01-20 2010-07-08 AZABICYCLIC CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF

Country Status (1)

Country Link
TN (1) TN2010000320A1 (en)

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