TH112298B - New Pyridinone and Pyridavinone - Google Patents
New Pyridinone and PyridavinoneInfo
- Publication number
- TH112298B TH112298B TH901000463A TH0901000463A TH112298B TH 112298 B TH112298 B TH 112298B TH 901000463 A TH901000463 A TH 901000463A TH 0901000463 A TH0901000463 A TH 0901000463A TH 112298 B TH112298 B TH 112298B
- Authority
- TH
- Thailand
- Prior art keywords
- phenyl
- btk
- pyridin
- transfer
- iii
- Prior art date
Links
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- IJUIPRDMWWBTTQ-UHFFFAOYSA-N 3-phenyl-1H-pyridazin-6-one Chemical compound N1C(=O)C=CC(C=2C=CC=CC=2)=N1 IJUIPRDMWWBTTQ-UHFFFAOYSA-N 0.000 abstract 1
- 210000003719 B-Lymphocytes Anatomy 0.000 abstract 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 200000000018 inflammatory disease Diseases 0.000 abstract 1
- 239000000546 pharmaceutic aid Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Abstract
เอกสารคำขอสิทธิบัตรนี้ได้เปิดเผยถึงอนุพันธ์ของ 5-ฟีนิล-1H-ไพริดิน-2-โอน (5- phcnyl-1H-pyridin-2-one) และ 6-ฟีนิล-2H-ไพริดาซิน-3-โอน (6-phenyl-2H-pyridazin-3-one) ตามสูตร ทั่วไป I-III; (สูตรเคมี) โดยที่, ตัวแปร R, X, Y2, Y2, Y3, Y4, n และ m ถูกนิยามไว้ดังที่อธิบายไว้ในที่นี้, ซึ่งยับยั้ง Btk สารประกอบที่ถูกเปิดเผยไว้ในที่นี้จะมีประโยชน์ที่จะควบคุมฤทธิ์ของ Btk และบำบัดโรคเกี่ยวข้องกับ ฤทธิ์ที่มากเกินของ Btk สารประกอบจะมีประโยชน์ต่อไปที่จะบำบัดโรคเกี่ยวกับการอักเสบและ ภูมิต้านตนเอง ที่เกี่ยวข้องกับการเพิ่มจำนวนที่ผิดปกติของ B-เซลล์ เช่น โรคข้ออักเสบรูมาตอยด์ อีกทั้งได้เปิดเผยถึงองค์ประกอบทีมีสารประกอบตามสูตร I-III และอย่างน้อยหนึ่งอย่างของพาหะ, ตัวเจือจาง หรือส่วนเติมเนื้อยา This patent application discloses the derivatives of 5- phenyl-1H-pyridin-2-transfer (5- phcnyl-1H-pyridin-2-one) and 6-phenyl-2H-pyridacin-3-transfer. (6-phenyl-2H-pyridazin-3-one) according to the general formula I-III; (Chemical formula) where, the variables R, X, Y2, Y2, Y3, Y4, n and m are defined as described here, which inhibits Btk. The compound revealed here is useful to control. The effects of Btk and disease therapy are related to The excessive activity of Btk compounds is further useful in the treatment of inflammatory diseases and Autoimmune Associated with abnormal proliferation of B-cells such as rheumatoid arthritis It also discloses the constituents with the I-III compound and at least one carrier, diluent or drug additive.
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH112298B true TH112298B (en) | 2012-02-20 |
| TH112298A TH112298A (en) | 2012-02-20 |
Family
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
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