SU829101A1

SU829101A1 - Roller for applying paint-and-varnish coatings

Info

Publication number: SU829101A1
Application number: SU792795961A
Authority: SU
Inventors: Петр Трофимович Сягайло; Анатолий Евгеньевич Носарь
Original assignee: Днепропетровский Ордена Трудового Крас-Ного Знамени Медицинский Институт
Priority date: 1979-07-12
Filing date: 1979-07-12
Publication date: 1981-05-15

Description

1one

Изобретение относитс к методам пучени модели заболеваний, в частности .модели острого остеомиелита трубчатык костей, приближа его к клиническим услови м , и может быть использовано дл изучени патогенеза, клиники и лечени острого гематогенного остеомиелита.The invention relates to methods of treating a model of diseases, in particular models of acute osteomyelitis of tubular bones, bringing it closer to clinical conditions, and can be used to study the pathogenesis, clinical picture and treatment of acute hematogenous osteomyelitis.

Известен способ, заключающийс в том, что в перфорированный шилом верхний метафйз бопьшеберцовой кости шприцем ввод т в костномозговой канал суточную культуру белого патогенного стафилококка в смеси с лаполином 10О-25О МП микробных телДЗThe known method consists in introducing into the bone marrow channel a daily culture of white pathogenic staphylococcus in a mixture with lapolin 10 O-25 O MP microbial telesus

Однако, возникающее при этом забопевание не всегда соответствует клинической картине, наблюдаемой у человека, например имеют место сепсис, флегмона м гких тканей, или отсутствие эффекта.However, the arising of this misinterpretation does not always correspond to the clinical picture observed in humans, for example, sepsis, phlegmon of soft tissues, or lack of effect.

Цель изобретени - получение модели острого остеомиелита, приближающейс по клиническому течению морфологическим и рентгенологическнм про влением к острому гематогенному остеомиелиту у человекаThe purpose of the invention is to obtain a model of acute osteomyelitis, approaching the clinical course of morphological and radiological manifestations of acute hematogenous osteomyelitis in humans.

Поставленна цель достигаетс тем, что костномозговой канал дренируют конической трубкой с резьбой (внутренний диаметр трубки 2 мм). Создают патолотическое давление в костномозговом канале 200-400 мм водн. ст. по Вапьдману , которое искусственно поддерживают 15-2О мин, перед тем, как смесь лаполина и. патогенного стафилококка. (ЗОО5ОО микробных тел/мл обеспечивают герметизацию костного канала, накладывают дав щую гипсовую пов зку.The goal is achieved by draining the medullary canal with a conical threaded tube (inner tube diameter 2 mm). Pathogenic pressure is created in the bone marrow canal 200-400 mm aq. Art. according to Wapdman, which is artificially maintained for 15-2 minutes, before the mixture of lapolin and. pathogenic staphylococcus. (ZOO5OO microbial cells / ml provide sealing of the bone canal, impose a pressure plaster cast.

Claims

Example. The dog is a male, weighing 3 kg 20 g, at the age of 3 months give ether-oxygen anesthesia. On the outer surface of the right femur in the middle third, a lumbar skin incision of length cm is made, a tube with a tapered thread is screwed into the femur. When the mandrin is removed from the tube, it releases 1 ml of blood. Using a tee, the tube is connected to the Waldman apparatus, pre-filled with a solution of 0.89% chlorine sodium with the addition of 3 ml of 1 ml of heparin. The level of the water column in the capillary of the apparatus is set at the mark O, and this indicator is on the same plane with the right thigh and the level of the atria. A mixture of pathogenic microbial fSOO microbial cells / ml) with lanolin in a ratio of 3: 1 in a volume of 5 ml at 45 ° C is injected into the bone marrow canal with a tube tucked into the Wapdman’s apparatus and inserted into the syringe . Through Yu min, intraosseous pressure is measured. It is equal to 18O mm Vod. Art. (the measurement is carried out for 10 minutes). Another 2 ml of the mixture was injected into the bone. A tube with a tapered thread, fixed in the bone, O1x; oi in net from the tee, is sealed with a plastic cap. A tight circular belt is applied to the right thigh. From the very first day experimentally the animal becomes restless, the affected limb, which is sharply swollen. By 5-7 days, the state of animal life continues to deteriorate: the dog becomes poor, refuses to eat, and drinks a lot. The affected limb is not supported, the limb is sharply swollen. On day 7, the gypsum is squeezed, the trepan tube is removed. The condition of the experimental animal is improved. There is a fistula at the site of the trepanning orifice. 14 A method for modeling osteomkepit B tubular bones can be applied in research laboratories x. However, it is widely used in research laboratories and the proposed method does not require further work, it is accessible and easy to implement. A method of modeling acute osteomyelitis of the tubular bones in young dogs provides a model of the disease that is 90.4% pathogenetically close to acute human hematogenous osteomyelitis. Claim Formula Osteomyelitis is modeled by introducing a pathogenic staphylococcus culture to an animal in the osteomagical canal, characterized in that, in order to approximate pathologies to the clinical picture in humans, intraosseous pressure is increased to 2OO-400 mm of water after the introduction of the culture of staphylococcus. Art. for 152 O min, then the medullary canal is sealed, and the extremity is superimposed with a Gypsum dressing belt. Sources of information taken into account in the examination 1. Kadakhrov M. A. and others. About obtaining a model of osteomyelitis. Experimental surgeons for anesthesiologists 1966, .№6, p. 32-33 ..