SU1697830A1 - Composition for preparation of antimicrobial protective bandage - Google Patents

Abstract

This invention relates to medicine, in particular to compositions for the half-scope of antimicrobial protective dressings used in dentistry. The aim of the invention is to increase the antimicrobial activity of the composition. The composition contains the following components: polyvinyl alcohol, starch, glycerin, citric acid, etonite, water, taken in certain quantities. Depending on the amount of glycerin and water used in the composition, protective dressings in the form of films or ointments are obtained. The absorption time and the duration of the antimicrobial action of the composition in the oral cavity is 1-10 days, depending on the ratio of the components used in the composition.

Description

The invention relates to medicine, in particular to compositions for the preparation of antimicrobial protective dressings used in dentistry, in particular to protect the wells after extraction of teeth, elveolitis, treatment of the oral mucosa when infected with various etiologies.

The aim of the invention is to increase the antimicrobial activity of the composition,

The composition for producing an antimicrobial protective dressing contains polyvinyl alcohol (LAN), glycerin, water, starch, citric acid as a crosslinking agent and etheries as an antimicrobial substance in the following ratio, wt.%:

Polyvinyl

alcohol4 - 16

Starch - 16

Glycerin 30 - 60 Lemon

acid 10-15

Зтий1 - 7

Water3-33

Depending on the amount of glycerin and water, when choosing the ratio of components in the base, different variants of antimicrobial protective layers are obtained, which are different in shape and texture, in the form of films and ointments.

The composition for producing an antimicrobial protective dressing is prepared as follows.

for

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00

with about

A weighed amount of starch p glyceae I - It wt.% Suspension is suspended in 5 to 10 ml of water (or glycerol) with vigorous stirring at room temperature. Keeping the mixture in suspension, it is introduced, with stirring, into an appropriate amount of water or glycerin, brought to 80-90 ° C,

With the stirring, a PVA solution is obtained in the resulting solution, obtained by dissolving C-16 wt.% Dry M-brand LAN in water or hypteris, i.e., the amount required according to the recipe,

Under stirring and at a temperature not higher than 0-50CC, the mixture of polymers is introduced dropwise, avoiding foaming, an aqueous solution of ethoni d in an amount of 1-7 May D. The mixture is stirred for 2-15 minutes, then the quantity required according to the recipe is added SUSTAINABLE citric acid solution (s-15 wt.%). Stirring is continued for 15-20 minutes. After that, the resulting composition as an ointment, if glycerin was taken as the main solvent for starch and polyvinyl alcohol, is packaged. If water is used as a solvent, the composition is poured into special forms for forming films

The amount of starch, LAN, glycerin, and water is selected, according to the required temporary regimen of resorption of the polymer base, depending on the desired temporary mode of action of the agon in obtaining protective clothing.

Example 1 In order to obtain a stitch, a weighed amount of starch in the amount of 16 wt.% (16 g) is suspended in 5 ml of water with vigorous stirring at room temperature of 20-22 ° C. While keeping the mixture in suspension state, it is introduced with stirring in 10 ml of water, heated to 80 ° C. With the stirring, an aqueous solution obtained by dissolving C wt% (k g) of dry PVA of mark M in 5 ml of water at room temperature is introduced into the resulting solution. The mixture obtained is added dropwise with stirring and heating to 0 ° C. foaming, aqueous solution of etoni in the amount of 1%, previously dissolved in 3 ml of water. The mixture is stirred for 2 minutes and for

7V 3D / +

which add 30 mt / (30 g) of glycerin, Rateg addition of 15 wt.% citric acid, pdc rRopri-n oh in 5 mp of water, stirring is continued for 1 j min. After this, the received equipment is received in the CSNICI PETRI pair in order to GET -3 mm film, charged film

Q dried poi (0 ° C during the day. The film resorption time and the effect of etoni were 10 su g.

Example /. Ll for obtaining an ointment a quantity of starch in an amount of 16 May, ° {

$ (16 g) is suspended in 5 ml of glycerol with vigorous stirring at room temperature. Maintaining the mixture in suspension, it is injected with stirring in 25 ml

Q of glycerol heated to 90 ° C. B, the resulting solution, with stirring, injected a glycerol solution of polyvinyl alcohol obtained by dissolving k g (A mas) of dry PVA grade M in

5 to 25 ml of glycerol at room temperature. With the stirring and heating to 50 ° C, the resulting mixture is added dropwise 4 not to allow foaming, an aqueous solution of etoni in

0 number of 7 masd, previously dissolved in 3 ml of water, the mixture is stirred for 15 min, during which 15 wt.% (15 g) of dry citric acid is added. Stirring the PRG is held at 50 ° C for 15 minutes, after which the resulting composition is cooled to room temperature and packaged,

The solubility of the ointment in a medium maximally similar in composition to saliva is 10 days. The time regime of etoni is equal to 10 days.

Example 3. A portion of starch

d5 in the amount of K) wt.% (10 g) is suspended in 5 ml of water with vigorous stirring at 20-22 C. Then it is also introduced with stirring in 10 ml of water heated to 80 ° C. Dry PVA M in an amount of 10 The masses (10 g) were dissolved in 5 ml of water and injected into the mixture of starch with stirring at room temperature. The mixture was then heated to 0 ° C and 1% of the agoni dissolved in cpc was added dropwise into the mixture. 3 ml of water, with the tolerance of foaming, the CMPCD is stirred for 2 minutes, during which time

0

five

30 m;, g, D glycerol. After that, citric acid in an amount of 15% by weight is dissolved in 5 ml of water and added to the mixture, stirring which is continued at 0 ° C for 15 minutes. The composition is poured into Petri dishes with a layer thickness of 2-3 mm and dried for a day at P ° C.

An example. An ointment is prepared similar to example 1. To do this, a portion of starch is taken in the amount of may,% (Lg) and suspended in 2 ml of glycerin with vigorous stirring. The mixture is then injected with stirring in 25 ml of glycerin heated to 90 ° C. PVA grade M is added to the resulting solution, having previously dissolved 16 g of dry PVA (16 wt.%) In 23 ml of glycerol, after which the mixture is heated to 50 ° C, without stopping stirring. Then,% etoni is added dropwise. dissolved in 3 ml of water and avoiding foaming, the mixture is stirred for 15 minutes, after which citric acid (15 g) dissolved in 5 ml of glycerin is added to it. Stirring is continued at 50 ° C for 15 minutes, after which the mixture is cooled to room temperature and filled. I

The properties of the compositions in the form of films and ointments are presented in the table.

Evaluation of antimicrobial activity (zone of growth inhibition of test culture in mm) was carried out on samples of different compositions using the disc method in 1.5-2% of co-peptone agar. As a test microbe, Staphylococcus aureus is used in an amount of L108 per

0

five

0

Petri dish, Antimicrobial activity is determined by the diameter of the zine inhibition of growth of the test microbe. The discs are made of 0.8-0.9 mm thick films. When testing ointments, discs were prepared from filter paper with a diameter of 0.5– 0.2 cm, on which weighed ointments of 0.29 to 0.30 g per disc were applied. The prepared samples applied to the test culture are incubated at 36.6 - 37.2 ° C for 20 - 2k hours.

The solubility of samples of different composition is determined visually in an environment as close as possible to the composition of saliva.

Thus, the composition used to obtain protective antimicrobial dressings in the form of films or ointments, allows you to adjust the time of resorption and the antimicrobial action of dressings from 1 to 10 days.

Formula

acquisitions

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five

0

A composition for producing an antimicrobial protective dressing comprising polyvinyl alcohol, water, a crosslinking agent, and an antimicrobial substance, in order to increase the antimicrobial activity, the composition additionally contains starch, citric acid as a crosslinking agent, and etonium as an antimicrobial substances in the following ratio, wt.%: Polyvinyl alcohol - 16 Starch - 16

Glycerin 30 - 60

Lemon acid 10 - 15 Etoniy1 - 7

Water 3-33.

(film) 10

ten

thirty

28

15

H (ointment)

sixteen

55

15

2k 21 19 17 13 25

Claims (2)

Claim The composition for producing an antimicrobial protective dressing containing polyvinyl alcohol, water, a crosslinking agent and an antimicrobial substance, characterized in that, in order to increase the antimicrobial activity, the composition additionally contains starch, citric acid as a crosslinking agent and etonium as an antimicrobial substance in the following the ratio of components, md: Polyvinyl alcohol 4-16 Starch 4 -1b Glycerin 30-60 Citric acid 10 -15 Ethony 1 -7 Water 3-33. Example Composition, wt.% Duration of etony, days Dissolution time ’composition, days starch PVA glycerol water limic acid etonium 1 (film) 16 4 thirty 28 fifteen 7 10 . 10 2 (ointment) 16 4 55 3 fifteen 7 10 10 The zone of inhibition of growth of microorganisms, mm day 21 20 18 17 16 15 14 13 12 10 21 19 18 17 16 15 14 13 And 10 3 (film) 10 10 30 28 15 7 5 · 5 2A 21 19 17 13 4 (ointment) h 16 55 3 15 7 25 - - -......