SI1926749T1 - Cepitev prekurzorjev insulinov z varianto tripsina - Google Patents

Cepitev prekurzorjev insulinov z varianto tripsina

Info

Publication number
SI1926749T1
SI1926749T1 SI200631146T SI200631146T SI1926749T1 SI 1926749 T1 SI1926749 T1 SI 1926749T1 SI 200631146 T SI200631146 T SI 200631146T SI 200631146 T SI200631146 T SI 200631146T SI 1926749 T1 SI1926749 T1 SI 1926749T1
Authority
SI
Slovenia
Prior art keywords
insulins
trypsin
precursors
cleavage
variant
Prior art date
Application number
SI200631146T
Other languages
English (en)
Inventor
Frank Geipel
Stephan Glaser
Christoph Hoh
Erhard Kopetzki
Rainer Mueller
Frank Zocher
Original Assignee
Sanofi Aventis Deutschland
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland, Hoffmann La Roche filed Critical Sanofi Aventis Deutschland
Publication of SI1926749T1 publication Critical patent/SI1926749T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
SI200631146T 2005-09-14 2006-08-26 Cepitev prekurzorjev insulinov z varianto tripsina SI1926749T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05077086 2005-09-14
EP06791678A EP1926749B1 (en) 2005-09-14 2006-08-26 Cleavage of precursors of insulins by a variant of trypsin
PCT/EP2006/008380 WO2007031187A1 (en) 2005-09-14 2006-08-26 Cleavage of precursors of insulins by a variant of trypsin

Publications (1)

Publication Number Publication Date
SI1926749T1 true SI1926749T1 (sl) 2011-11-30

Family

ID=36190640

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631146T SI1926749T1 (sl) 2005-09-14 2006-08-26 Cepitev prekurzorjev insulinov z varianto tripsina

Country Status (20)

Country Link
US (1) US7981635B2 (sl)
EP (1) EP1926749B1 (sl)
JP (1) JP5027812B2 (sl)
KR (1) KR101304958B1 (sl)
CN (1) CN101253196B (sl)
AR (1) AR055428A1 (sl)
AT (1) ATE517919T1 (sl)
AU (1) AU2006291780B2 (sl)
BR (1) BRPI0616054B8 (sl)
CA (1) CA2621344C (sl)
CY (1) CY1112667T1 (sl)
ES (1) ES2370657T3 (sl)
HK (1) HK1124341A1 (sl)
IL (1) IL189887A (sl)
MX (1) MX2008003362A (sl)
MY (1) MY146082A (sl)
PL (1) PL1926749T3 (sl)
PT (1) PT1926749E (sl)
SI (1) SI1926749T1 (sl)
WO (1) WO2007031187A1 (sl)

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DE102008025007A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
JP5695909B2 (ja) 2008-01-09 2015-04-08 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体
DE102008025008A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003566A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
MY161892A (en) * 2008-02-19 2017-05-15 Biocon Ltd A method of obtaining a purified, biologically active heterologous protein
RS56632B1 (sr) 2008-10-17 2018-03-30 Sanofi Aventis Deutschland Kombinacija insulina i glp-1-agonista
WO2011030347A1 (en) * 2009-09-10 2011-03-17 Biocon Limited Novel prolipase-bovine trypsinogen fusion proteins
PT3345593T (pt) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
ES2855146T3 (es) 2009-11-13 2021-09-23 Sanofi Aventis Deutschland Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
HUE031181T2 (en) 2010-08-30 2017-06-28 Sanofi Aventis Deutschland Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2013015697A1 (en) * 2011-07-28 2013-01-31 Mabion S.A. A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
CN103917241A (zh) 2011-08-29 2014-07-09 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
ES2665853T3 (es) * 2012-03-29 2018-04-27 Biocon Limited Secreción de insulina glargina funcional directamente en el medio de cultivo mediante la sobreexpresión intracelularmente de Kex2p
CN102816785B (zh) * 2012-05-24 2016-03-09 上海仁会生物制药股份有限公司 一种甘精胰岛素及其类似物的制备方法
CN102994600A (zh) * 2012-12-11 2013-03-27 鲁南新时代生物技术有限公司 甘精胰岛素前体的酶切转化方法
JP6970615B2 (ja) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン／リキシセナチド固定比処方
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN108018277A (zh) * 2016-11-04 2018-05-11 江苏万邦生化医药股份有限公司 重组牛胰蛋白酶突变体及其制备方法
KR20190036956A (ko) 2017-09-28 2019-04-05 한미약품 주식회사 지속형 단쇄 인슐린 아날로그 및 이의 결합체
KR20200124255A (ko) 2018-02-22 2020-11-02 사노피-아벤티스 도이칠란트 게엠베하 돼지 트립신의 변이체
EP3650541A1 (en) * 2018-11-08 2020-05-13 BioPharma Translationsinstitut Dessau Forschungs GmbH Trypsin mutant for c- and n-terminal modification of polypeptides
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
KR20220112817A (ko) 2019-12-10 2022-08-11 사노피 설폰아미드 및 폴리펩티드의 콘주게이트를 형성하는 방법
CN113773391B (zh) * 2020-06-09 2023-10-20 宁波鲲鹏生物科技有限公司 一种门冬胰岛素的制备方法

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Also Published As

Publication number Publication date
US20100196953A1 (en) 2010-08-05
ATE517919T1 (de) 2011-08-15
PL1926749T3 (pl) 2011-12-30
MX2008003362A (es) 2008-03-25
EP1926749A1 (en) 2008-06-04
JP2009507500A (ja) 2009-02-26
CN101253196A (zh) 2008-08-27
CY1112667T1 (el) 2016-02-10
CA2621344A1 (en) 2007-03-22
IL189887A0 (en) 2008-11-03
AU2006291780A1 (en) 2007-03-22
US7981635B2 (en) 2011-07-19
KR101304958B1 (ko) 2013-09-17
WO2007031187A1 (en) 2007-03-22
CA2621344C (en) 2014-12-16
BRPI0616054B1 (pt) 2019-08-06
AR055428A1 (es) 2007-08-22
HK1124341A1 (en) 2009-07-10
IL189887A (en) 2012-02-29
BRPI0616054B8 (pt) 2021-05-25
PT1926749E (pt) 2011-09-29
EP1926749B1 (en) 2011-07-27
CN101253196B (zh) 2012-09-05
WO2007031187A8 (en) 2007-08-16
BRPI0616054A2 (pt) 2011-06-07
AU2006291780B2 (en) 2011-12-08
KR20080055843A (ko) 2008-06-19
MY146082A (en) 2012-06-29
ES2370657T3 (es) 2011-12-21
JP5027812B2 (ja) 2012-09-19

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