SG179311A1 - Methods and apparatus relating to integrated nir fluorescence and reflectance imaging and spectroscopy with polarization for improving tissue diagnosis and characterization - Google Patents
Methods and apparatus relating to integrated nir fluorescence and reflectance imaging and spectroscopy with polarization for improving tissue diagnosis and characterization Download PDFInfo
- Publication number
- SG179311A1 SG179311A1 SG2010069227A SG2010069227A SG179311A1 SG 179311 A1 SG179311 A1 SG 179311A1 SG 2010069227 A SG2010069227 A SG 2010069227A SG 2010069227 A SG2010069227 A SG 2010069227A SG 179311 A1 SG179311 A1 SG 179311A1
- Authority
- SG
- Singapore
- Prior art keywords
- nir
- imaging
- spectroscopy
- polarization
- colon
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/31—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes, colonoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
- A61B1/00167—Details of optical fibre bundles, e.g. shape or fibre distribution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
Abstract
Methods and apparatus relating to integrated NIR fluorescence and reflectanceimaging and spectroscopy with polarization for improving tissue diagnosis andcharacterizationAbstractWe report on the development of the near-infrared (NIR) autofluorescence (AF)spectroscopy technique for in vivo identification of neoplastic polyps in the colon atcolonoscopy. In vivo NIR AF spectra from colonic tissue can be acquired within 1 secondusing the 785 nm laser excitation power of 1.0 W/cm2. Significant differences in in vivoNIR AF spectra are observed among normal (n=116), hyperplastic polyp (n=48) andadenomatous polyp (n=34) colonic tissue from 96 patients. The multivariate analysis [i.e.,principal components analysis (PCA) and linear discriminate analysis (LDA)], togetherwith the leave-one tissue site-out, cross validation on in vivo NIR AF spectra yields apredictive accuracies of 90%, 82.6% and 90.2%, respectively, for differentiation amongnormal, hyperplastic and adenomatous polyps in the colon. This work demonstrates for thefirst time that NIR AF spectroscopy associated with PCA-LDA diagnostic algorithms haspotential for the noninvasive, in vivo diagnosis of neoplastic polyps in the colon duringclinical colonoscopy screening. In the mean time, we have further evaluated the diagnosticfeasibility of the integrated near-infrared (NIR) autofluorescence (AF) and NIR diffusereflectance (DR) imaging technique developed for colonic cancer detection. A total of 48paired colonic tissue specimens (normal vs. cancer) were measured using the integratedNIR DR (850-1100 nm) and NIR AF imaging at the 785 nm laser excitation. The resultsshowed that NIR AF intensities of cancer tissues are significantly lower than those ofnormal tissues (p<0.001, paired 2-sided Student's t-test, n=48). NIR AF imaging underpolarization conditions gives a higher diagnostic accuracy (of -92-94%) compared to non-polarized NIR AF imaging or NIR DR imaging. Further, the ratio imaging of NIR DR toNIR AF with polarization provides the best diagnostic accuracy (of -96%) among the NIRAF and NIR DR imaging techniques. This work suggests that the integrated NIR AFspectroscopy and NIR AF/DR imaging under polarization condition has the potential togreatly improve the early diagnosis and detection of malignant lesions in the colon.Figure 1.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG2010069227A SG179311A1 (en) | 2010-09-22 | 2010-09-22 | Methods and apparatus relating to integrated nir fluorescence and reflectance imaging and spectroscopy with polarization for improving tissue diagnosis and characterization |
| PCT/SG2011/000322 WO2012039679A2 (en) | 2010-09-22 | 2011-09-20 | System for near-infrared autofluorescence measurement of a subject, and method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG2010069227A SG179311A1 (en) | 2010-09-22 | 2010-09-22 | Methods and apparatus relating to integrated nir fluorescence and reflectance imaging and spectroscopy with polarization for improving tissue diagnosis and characterization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG179311A1 true SG179311A1 (en) | 2012-04-27 |
Family
ID=45874264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2010069227A SG179311A1 (en) | 2010-09-22 | 2010-09-22 | Methods and apparatus relating to integrated nir fluorescence and reflectance imaging and spectroscopy with polarization for improving tissue diagnosis and characterization |
Country Status (2)
| Country | Link |
|---|---|
| SG (1) | SG179311A1 (en) |
| WO (1) | WO2012039679A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017212307A1 (en) | 2016-06-06 | 2017-12-14 | Hajdu Imre | Diagnostic medical device |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271714A (en) * | 2013-05-27 | 2013-09-04 | 上海大学 | Microcosmic fiber optic endoscope |
| CN103263244A (en) * | 2013-05-27 | 2013-08-28 | 上海大学 | Endoscope device using single optical fiber to achieving imaging |
| EP3004870B1 (en) | 2013-05-28 | 2019-01-02 | Todos Medical Ltd. | Differential diagnosis of benign tumors |
| CN103705201B (en) * | 2014-01-16 | 2015-11-04 | 福建师范大学 | A kind of multimode spectroscopic analysis system being applicable to Alimentary tract disease and detecting |
| GB201415439D0 (en) * | 2014-09-01 | 2014-10-15 | Univ Singapore | A pressure-sensitive fiber optic probe for real-time in vivo tissue optical spectroscopy,a system incorporating the same and a method for using the same |
| WO2016189701A1 (en) * | 2015-05-27 | 2016-12-01 | 一郎 宮井 | Brain activity feedback system |
| US11579088B2 (en) | 2016-03-14 | 2023-02-14 | Massachusetts Institute Of Technology | Device and method for imaging shortwave infrared fluorescence |
| US11147453B2 (en) | 2017-10-03 | 2021-10-19 | Canon U.S.A., Inc. | Calibration for OCT-NIRAF multimodality probe |
| WO2024073557A1 (en) * | 2022-10-01 | 2024-04-04 | Photothermal Spectroscopy Corp. | Autofluorescence enhanced photothermal infrared spectroscopy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004031746A1 (en) * | 2002-10-02 | 2004-04-15 | Lumen Health Innovations, Inc. | Apparatus and methods relating to high speed spectroscopy and excitation-emission matrices |
| EP4235157A3 (en) * | 2008-07-30 | 2023-11-22 | Vanderbilt University | Process and system for intra-operative use of fluorescence and applications of same |
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2010
- 2010-09-22 SG SG2010069227A patent/SG179311A1/en unknown
-
2011
- 2011-09-20 WO PCT/SG2011/000322 patent/WO2012039679A2/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017212307A1 (en) | 2016-06-06 | 2017-12-14 | Hajdu Imre | Diagnostic medical device |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012039679A3 (en) | 2012-07-26 |
| WO2012039679A2 (en) | 2012-03-29 |
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