SG11202112926YA - Engineering the hinge region to drive antibody dimerization - Google Patents

Engineering the hinge region to drive antibody dimerization

Info

Publication number
SG11202112926YA
SG11202112926YA SG11202112926YA SG11202112926YA SG11202112926YA SG 11202112926Y A SG11202112926Y A SG 11202112926YA SG 11202112926Y A SG11202112926Y A SG 11202112926YA SG 11202112926Y A SG11202112926Y A SG 11202112926YA SG 11202112926Y A SG11202112926Y A SG 11202112926YA
Authority
SG
Singapore
Prior art keywords
engineering
hinge region
antibody dimerization
drive antibody
drive
Prior art date
Application number
SG11202112926YA
Inventor
Fernando Garces
Zhulun Wang
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11202112926YA publication Critical patent/SG11202112926YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
SG11202112926YA 2019-05-30 2020-05-29 Engineering the hinge region to drive antibody dimerization SG11202112926YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962854907P 2019-05-30 2019-05-30
PCT/US2020/035196 WO2020243477A2 (en) 2019-05-30 2020-05-29 Engineering the hinge region to drive antibody dimerization

Publications (1)

Publication Number Publication Date
SG11202112926YA true SG11202112926YA (en) 2021-12-30

Family

ID=72234906

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202112926YA SG11202112926YA (en) 2019-05-30 2020-05-29 Engineering the hinge region to drive antibody dimerization

Country Status (12)

Country Link
US (1) US20220235148A1 (en)
EP (1) EP3976643A2 (en)
JP (1) JP2022534901A (en)
KR (1) KR20220016139A (en)
CN (1) CN114174344A (en)
AU (1) AU2020283890A1 (en)
CA (1) CA3141690A1 (en)
EA (1) EA202193322A1 (en)
MX (1) MX2021014534A (en)
SG (1) SG11202112926YA (en)
TW (1) TW202110877A (en)
WO (1) WO2020243477A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024017371A1 (en) * 2022-07-22 2024-01-25 信达生物制药(苏州)有限公司 Mutant promoting homologous pairing of heavy and light chains of multispecific antibody

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Also Published As

Publication number Publication date
JP2022534901A (en) 2022-08-04
CN114174344A (en) 2022-03-11
KR20220016139A (en) 2022-02-08
AU2020283890A1 (en) 2021-12-16
MX2021014534A (en) 2022-02-11
US20220235148A1 (en) 2022-07-28
WO2020243477A2 (en) 2020-12-03
EA202193322A1 (en) 2022-03-10
WO2020243477A3 (en) 2021-01-07
TW202110877A (en) 2021-03-16
EP3976643A2 (en) 2022-04-06
CA3141690A1 (en) 2020-12-03

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