SG11202112429PA - Dosage of an antibody-drug conjugate - Google Patents
Dosage of an antibody-drug conjugateInfo
- Publication number
- SG11202112429PA SG11202112429PA SG11202112429PA SG11202112429PA SG11202112429PA SG 11202112429P A SG11202112429P A SG 11202112429PA SG 11202112429P A SG11202112429P A SG 11202112429PA SG 11202112429P A SG11202112429P A SG 11202112429PA SG 11202112429P A SG11202112429P A SG 11202112429PA
- Authority
- SG
- Singapore
- Prior art keywords
- antibody
- dosage
- drug conjugate
- conjugate
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962853970P | 2019-05-29 | 2019-05-29 | |
| US201962896478P | 2019-09-05 | 2019-09-05 | |
| PCT/IB2020/055078 WO2020240467A1 (en) | 2019-05-29 | 2020-05-28 | Dosage of an antibody-drug conjugate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202112429PA true SG11202112429PA (en) | 2021-12-30 |
Family
ID=71083673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202112429PA SG11202112429PA (en) | 2019-05-29 | 2020-05-28 | Dosage of an antibody-drug conjugate |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230270870A1 (en) |
| EP (1) | EP3976113A1 (en) |
| JP (1) | JP2022534725A (en) |
| KR (1) | KR20220015445A (en) |
| CN (1) | CN113939318A (en) |
| AU (1) | AU2020285681A1 (en) |
| BR (1) | BR112021023901A2 (en) |
| CA (1) | CA3142119A1 (en) |
| IL (1) | IL288485A (en) |
| SG (1) | SG11202112429PA (en) |
| TW (1) | TW202108180A (en) |
| WO (1) | WO2020240467A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3202303A1 (en) * | 2020-12-18 | 2022-06-23 | Qingsong GUO | Trop2 targeting antibody-drug conjugate, and preparation method and use therefor |
| TW202245844A (en) * | 2021-01-13 | 2022-12-01 | 紀念斯隆凱特琳癌症中心 | Anti-dll3 antibody-drug conjugate |
| CA3222269A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-cancer agents |
| CA3222752A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| TW202330504A (en) | 2021-10-28 | 2023-08-01 | 美商基利科學股份有限公司 | Pyridizin-3(2h)-one derivatives |
| WO2023077030A1 (en) | 2021-10-29 | 2023-05-04 | Gilead Sciences, Inc. | Cd73 compounds |
| TW202329936A (en) | 2021-11-18 | 2023-08-01 | 英商阿斯特捷利康英國股份有限公司 | Combination of antibody-drug conjugate and parp1 selective inhibitor |
| US20230242508A1 (en) | 2021-12-22 | 2023-08-03 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| WO2023122581A2 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| TW202339805A (en) | 2021-12-28 | 2023-10-16 | 英商阿斯特捷利康英國股份有限公司 | Combination of antibody-drug conjugate and atr inhibitor |
| WO2023138635A1 (en) * | 2022-01-18 | 2023-07-27 | 甘李药业股份有限公司 | Exatecan derivative-antibody conjugate and medical use thereof |
| WO2023143387A1 (en) * | 2022-01-26 | 2023-08-03 | Beigene , Ltd. | ANTI-DXd ANTIBODIES AND METHODS OF USE |
| TW202340168A (en) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Parp7 inhibitors |
| US20230373950A1 (en) | 2022-03-17 | 2023-11-23 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| WO2023201268A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating tumor antigen expressing cancers |
| WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| TW202400138A (en) | 2022-04-21 | 2024-01-01 | 美商基利科學股份有限公司 | Kras g12d modulating compounds |
| TW202400140A (en) | 2022-04-27 | 2024-01-01 | 日商第一三共股份有限公司 | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
| WO2024006929A1 (en) | 2022-07-01 | 2024-01-04 | Gilead Sciences, Inc. | Cd73 compounds |
| WO2024023750A1 (en) | 2022-07-28 | 2024-02-01 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and bispecific checkpoint inhibitor |
| WO2024051762A1 (en) * | 2022-09-07 | 2024-03-14 | Xadcera Biopharmaceutical (Suzhou) Co., Ltd. | Anti-trop2/egfr antibodies and uses thereof |
| WO2024097812A1 (en) | 2022-11-04 | 2024-05-10 | Gilead Sciences, Inc. | Therapy for treating bladder cancer |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| WO1993006213A1 (en) | 1991-09-23 | 1993-04-01 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| PT1024191E (en) | 1991-12-02 | 2008-12-22 | Medical Res Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
| EP0656941B1 (en) | 1992-03-24 | 2005-06-01 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| JP3359955B2 (en) | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | Antitumor agent |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| AU690171B2 (en) | 1993-12-03 | 1998-04-23 | Medical Research Council | Recombinant binding proteins and peptides |
| DK2180007T4 (en) | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosylation technique for antibodies to enhance antibody-dependent cell cytotoxicity |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| JP2002060351A (en) | 2000-03-22 | 2002-02-26 | Dai Ichi Seiyaku Co Ltd | Dds compound comprising drug having hydroxy group |
| MXPA03002974A (en) | 2000-10-06 | 2004-05-05 | Kyowa Hakko Kogyo Kk | Cells producing antibody compositions. |
| AU2002360307B2 (en) | 2001-11-01 | 2008-01-17 | The Uab Research Foundation | Combinations of DR5 antibody and other therapeutic agents |
| EP1483295B1 (en) | 2002-03-01 | 2008-12-10 | Immunomedics, Inc. | Rs7 antibodies |
| US20080131428A1 (en) | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| HUE062339T2 (en) | 2009-02-13 | 2023-10-28 | Immunomedics Inc | Immunoconjugates with an intracellularly-cleavable linkage |
| WO2011068845A1 (en) | 2009-12-02 | 2011-06-09 | Immunomedics, Inc. | Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy |
| JP5859434B2 (en) | 2010-05-17 | 2016-02-10 | 株式会社カイオム・バイオサイエンス | Anti-human TROP-2 antibody having antitumor activity in vivo |
| JPWO2011155579A1 (en) | 2010-06-10 | 2013-08-15 | 北海道公立大学法人 札幌医科大学 | Anti-Trop-2 antibody |
| MX2014005728A (en) | 2011-11-11 | 2014-05-30 | Rinat Neuroscience Corp | Antibodies specific for trop-2 and their uses. |
| US9427464B2 (en) | 2011-11-22 | 2016-08-30 | Chiome Bioscience Inc. | Anti-human TROP-2 antibody having an antitumor activity in vivo |
| RU2705367C2 (en) * | 2013-12-25 | 2019-11-07 | Дайити Санкио Компани, Лимитед | Anti-trop2 antibody-drug conjugate |
| KR20180021723A (en) * | 2015-06-29 | 2018-03-05 | 다이이찌 산쿄 가부시키가이샤 | Method for selectively manufacturing antibody-drug conjugate |
| CA3046293A1 (en) * | 2016-12-12 | 2018-06-21 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
| KR20200044044A (en) * | 2017-08-23 | 2020-04-28 | 다이이찌 산쿄 가부시키가이샤 | Antibody-drug conjugate preparation and freeze-drying method thereof |
| CN117838881A (en) * | 2017-08-31 | 2024-04-09 | 第一三共株式会社 | New method for preparing antibody-drug conjugate |
| JP7366745B2 (en) * | 2017-08-31 | 2023-10-23 | 第一三共株式会社 | Improved manufacturing method for antibody-drug conjugates |
| TW202016148A (en) * | 2018-07-09 | 2020-05-01 | 大陸商艾比瑪特生物醫藥（上海）有限公司 | Antibodies specific to trophoblast antigen 2 (trop2) |
| EP3831853A4 (en) * | 2018-07-27 | 2022-06-01 | Daiichi Sankyo Company, Limited | Protein recognizing drug moiety of antibody-drug conjugate |
| SG11202100947SA (en) * | 2018-07-31 | 2021-03-30 | Daiichi Sankyo Co Ltd | Treatment of metastatic brain tumor by administration of antibody-drug conjugate |
| JP7458981B2 (en) * | 2018-08-06 | 2024-04-01 | 第一三共株式会社 | Combination of antibody-drug conjugate and tubulin inhibitor |
| AU2019396895A1 (en) * | 2018-12-11 | 2021-07-08 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with PARP inhibitor |
-
2020
- 2020-05-28 CA CA3142119A patent/CA3142119A1/en active Pending
- 2020-05-28 BR BR112021023901A patent/BR112021023901A2/en unknown
- 2020-05-28 TW TW109117829A patent/TW202108180A/en unknown
- 2020-05-28 JP JP2021570332A patent/JP2022534725A/en active Pending
- 2020-05-28 US US17/612,765 patent/US20230270870A1/en active Pending
- 2020-05-28 CN CN202080039800.8A patent/CN113939318A/en active Pending
- 2020-05-28 SG SG11202112429PA patent/SG11202112429PA/en unknown
- 2020-05-28 WO PCT/IB2020/055078 patent/WO2020240467A1/en unknown
- 2020-05-28 KR KR1020217042735A patent/KR20220015445A/en unknown
- 2020-05-28 AU AU2020285681A patent/AU2020285681A1/en active Pending
- 2020-05-28 EP EP20732322.1A patent/EP3976113A1/en active Pending
-
2021
- 2021-11-28 IL IL288485A patent/IL288485A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022534725A (en) | 2022-08-03 |
| EP3976113A1 (en) | 2022-04-06 |
| WO2020240467A1 (en) | 2020-12-03 |
| US20230270870A1 (en) | 2023-08-31 |
| BR112021023901A2 (en) | 2022-01-18 |
| CA3142119A1 (en) | 2020-12-03 |
| TW202108180A (en) | 2021-03-01 |
| CN113939318A (en) | 2022-01-14 |
| AU2020285681A1 (en) | 2022-01-27 |
| KR20220015445A (en) | 2022-02-08 |
| IL288485A (en) | 2022-01-01 |
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