SG11202108459QA - Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment - Google Patents

Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment

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Publication number
SG11202108459QA
SG11202108459QA SG11202108459QA SG11202108459QA SG11202108459QA SG 11202108459Q A SG11202108459Q A SG 11202108459QA SG 11202108459Q A SG11202108459Q A SG 11202108459QA SG 11202108459Q A SG11202108459Q A SG 11202108459QA SG 11202108459Q A SG11202108459Q A SG 11202108459QA
Authority
SG
Singapore
Prior art keywords
tumor
immune cells
immunostimulatory bacteria
resident immune
bacteria engineered
Prior art date
Application number
SG11202108459QA
Inventor
Christopher Thanos
Laura Glickman
Justin Skoble
Alexandre Iannello
Haixing Kehoe
Original Assignee
Actym Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actym Therapeutics Inc filed Critical Actym Therapeutics Inc
Publication of SG11202108459QA publication Critical patent/SG11202108459QA/en

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • C12N2310/50—Physical structure
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SG11202108459QA 2019-02-27 2020-02-27 Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment SG11202108459QA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962811521P 2019-02-27 2019-02-27
US201962828990P 2019-04-03 2019-04-03
US201962934478P 2019-11-12 2019-11-12
US202062962140P 2020-01-16 2020-01-16
PCT/US2020/020240 WO2020176809A1 (en) 2019-02-27 2020-02-27 Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment

Publications (1)

Publication Number Publication Date
SG11202108459QA true SG11202108459QA (en) 2021-09-29

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SG11202108459QA SG11202108459QA (en) 2019-02-27 2020-02-27 Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment

Country Status (12)

Country Link
US (1) US20220135980A1 (en)
EP (1) EP3931210A1 (en)
JP (1) JP2022524951A (en)
KR (1) KR20220004959A (en)
CN (1) CN113748124A (en)
AU (1) AU2020229875A1 (en)
BR (1) BR112021016728A2 (en)
CA (2) CA3176660A1 (en)
IL (1) IL285608A (en)
MX (1) MX2021010273A (en)
SG (1) SG11202108459QA (en)
WO (1) WO2020176809A1 (en)

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BR112021000315A2 (en) * 2018-07-11 2021-08-03 Actym Therapeutics, Inc. Genetically modified immunostimulant bacterial strains and their uses
EP4196139A2 (en) 2020-08-12 2023-06-21 Actym Therapeutics, Inc. Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms
CN112444629B (en) * 2020-12-09 2023-09-29 青岛科技大学 Exosome detection method based on hairpin nucleic acid molecule signal amplification circuit and application
CN112852698B (en) * 2021-01-30 2022-11-29 军事科学院军事医学研究院军事兽医研究所 Construction method and application of Brucella A19 strain asd gene deletion strain
AU2022246895A1 (en) * 2021-03-31 2023-10-19 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
CN113249382B (en) * 2021-04-12 2023-05-12 右江民族医学院 SiRNA for down regulating TRIM56 gene expression and application thereof
CN113549621B (en) * 2021-07-14 2022-07-19 山西大学 Minimal promoter for enhancing activity and expression of foreign protein in bacteria
WO2023064755A2 (en) * 2021-10-11 2023-04-20 University Of Florida Research Foundation, Incorporated A novel poultry salmonella vaccine and diagnostic methodology to control foodborne salmonellosis
WO2023086796A2 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment
CN115356320B (en) * 2022-10-20 2023-01-17 上海诚益生物科技有限公司 In-vitro RIG-I activation detection method based on homogeneous phase time-resolved fluorescence technology
WO2024107827A1 (en) * 2022-11-16 2024-05-23 The Broad Institute, Inc. Therapeutic exploitation of sting channel activity

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