SG11202107732XA - Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells - Google Patents
Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cellsInfo
- Publication number
- SG11202107732XA SG11202107732XA SG11202107732XA SG11202107732XA SG11202107732XA SG 11202107732X A SG11202107732X A SG 11202107732XA SG 11202107732X A SG11202107732X A SG 11202107732XA SG 11202107732X A SG11202107732X A SG 11202107732XA SG 11202107732X A SG11202107732X A SG 11202107732XA
- Authority
- SG
- Singapore
- Prior art keywords
- dorsally
- pluripotent stem
- human pluripotent
- oligodendrocyte progenitor
- cells
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962796077P | 2019-01-23 | 2019-01-23 | |
| PCT/US2020/014834 WO2020154533A1 (en) | 2019-01-23 | 2020-01-23 | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202107732XA true SG11202107732XA (en) | 2021-08-30 |
Family
ID=71609769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202107732XA SG11202107732XA (en) | 2019-01-23 | 2020-01-23 | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11603518B2 (en) |
| EP (1) | EP3914264A4 (en) |
| JP (1) | JP7469317B2 (en) |
| KR (1) | KR20210121112A (en) |
| CN (1) | CN113474451A (en) |
| AU (1) | AU2020210757A1 (en) |
| CA (1) | CA3127213A1 (en) |
| SG (1) | SG11202107732XA (en) |
| WO (1) | WO2020154533A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3436567A4 (en) | 2016-03-30 | 2019-10-30 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| CN113474451A (en) | 2019-01-23 | 2021-10-01 | 阿斯特里亚斯生物疗法股份有限公司 | Back-derived oligodendrocyte precursor cells from human pluripotent stem cells |
| WO2022192605A1 (en) * | 2021-03-10 | 2022-09-15 | Lineage Cell Therapeutics, Inc. | Methods of generating oligodendrocyte progenitor cells and use thereof |
| WO2023147512A2 (en) * | 2022-01-28 | 2023-08-03 | Asterias Biotherapeutics, Inc. | Compositions and methods for treating spinal cord injuries |
| WO2023229819A1 (en) * | 2022-05-24 | 2023-11-30 | Bluerock Therapeutics Lp | Methods of making oligodendrocyte progenitor cells |
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| US6361996B1 (en) * | 1997-05-07 | 2002-03-26 | University Of Utah Research Foundation | Neuroepithelial stem cells and glial-restricted intermediate precursors |
| AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| AU2297901A (en) | 1999-10-22 | 2001-04-30 | Washington University | Oligodendrocyte cell cultures and methods for their preparation and use |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| IL151170A0 (en) * | 2000-03-14 | 2003-04-10 | Es Cell Int Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
| AU2003211063A1 (en) | 2002-02-15 | 2003-09-09 | Cornell Research Foundation, Inc. | Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US20050101014A1 (en) | 2002-07-11 | 2005-05-12 | Keirstead Hans S. | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US7390659B2 (en) | 2002-07-16 | 2008-06-24 | The Trustees Of Columbia University In The City Of New York | Methods for inducing differentiation of embryonic stem cells and uses thereof |
| US20050031598A1 (en) | 2002-12-10 | 2005-02-10 | Shulamit Levenberg | Engineering three-dimensional tissue structures using differentiating embryonic stem cells |
| CA2530533C (en) | 2003-06-27 | 2015-02-10 | Ethicon, Incorporated | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
| US7691629B2 (en) | 2004-11-17 | 2010-04-06 | Neuralstem, Inc. | Transplantation of human neural cells for treatment of neurodegenerative conditions |
| US8709797B2 (en) | 2006-06-20 | 2014-04-29 | Cook General Biotechnology Llc | Systems and methods for cryopreservation of cells |
| EP2139497B1 (en) | 2007-04-13 | 2013-11-06 | Stemnion, INC. | Methods for treating nervous system injury and disease |
| EP2028268A1 (en) | 2007-08-20 | 2009-02-25 | Université Libre De Bruxelles | Generation of neuronal cells from pluripotent stem cells |
| KR100941036B1 (en) | 2007-10-05 | 2010-02-05 | 고려대학교 산학협력단 | Three-step Differentiation protocol for generation of spinal cord oligodendrocytes from human embryonic stem cells |
| EP2217252A2 (en) | 2007-10-29 | 2010-08-18 | Hadasit Medical Research Services & Development Limited | Human stem cell-derived neural precursors for treatment of autoimmune diseases of the central nervous system |
| US8227247B2 (en) | 2007-12-20 | 2012-07-24 | Wisconsin Alumni Research Foundation | Method of generating myelinating oligodendrocytes |
| CN105331577A (en) | 2008-01-30 | 2016-02-17 | 阿斯特利亚斯生物治疗股份公司 | Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells |
| CA2723382A1 (en) | 2008-05-08 | 2009-11-12 | University Of Rochester | Treating myelin diseases with optimized cell preparations |
| EP2283115A1 (en) | 2008-05-09 | 2011-02-16 | The University Court Of The University Of Glasgow | Materials and methods relating to cell based therapies |
| US20100158878A1 (en) | 2008-12-23 | 2010-06-24 | Alexandra Capela | Target populations of oligodendrocyte precursor cells and methods of making and using same |
| WO2010151782A1 (en) | 2009-06-25 | 2010-12-29 | Geron Corporation | Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes |
| WO2011059920A2 (en) | 2009-11-10 | 2011-05-19 | The J. David Gladstone Institutes | Methods of generating neural stem cells |
| CN102160546B (en) | 2010-02-24 | 2016-01-20 | 库克通用生物科技有限责任公司 | The system and method for Cell Cryopreservation |
| EP2603221A4 (en) | 2010-08-13 | 2014-02-26 | Univ Georgetown | Ggf2 and methods of use |
| WO2012096705A1 (en) | 2010-10-26 | 2012-07-19 | Case Western Reserve University | Differentiation methods for production of glial cell populations |
| EP2651973B1 (en) * | 2010-12-17 | 2016-08-31 | Biolamina AB | Recombinant laminin-521 |
| CN109749996A (en) | 2011-01-12 | 2019-05-14 | 城户常雄 | Obtain and maintain the mammalian neural stem cells group of purifying or enrichment and/or the cultural method of neural progenitor cell group |
| JP6204976B2 (en) | 2012-05-16 | 2017-09-27 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | Cell surface properties for isolation of neurons from pluripotent stem cell-derived cell cultures |
| EP3766962A1 (en) | 2013-02-06 | 2021-01-20 | University of Rochester | Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders |
| US10160950B2 (en) * | 2013-03-01 | 2018-12-25 | Wisconsin Alumni Research Foundation | Methods of maintaining, expanding and differentiating neuronal subtype specific progenitors |
| PT2970903T (en) | 2013-03-15 | 2024-02-26 | Astellas Inst For Regenerative Medicine | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| WO2015088625A2 (en) | 2013-09-25 | 2015-06-18 | Case Western Reserve University | Compounds and methods of promoting myelination |
| US9694036B2 (en) | 2014-03-21 | 2017-07-04 | Cellular Dynamics International, Inc. | Production of midbrain dopaminergic neurons and methods for the use thereof |
| KR102585909B1 (en) | 2014-05-22 | 2023-10-05 | 뉴욕 스템 셀 파운데이션, 인코포레이티드 | Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same |
| WO2016103269A1 (en) | 2014-12-23 | 2016-06-30 | Ramot At Tel-Aviv University Ltd. | Populations of neural progenitor cells and methods of producing and using same |
| US10286009B2 (en) | 2015-05-16 | 2019-05-14 | Asterias Biotherapeutics, Inc. | Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury |
| EP3448985A4 (en) * | 2016-01-27 | 2019-08-21 | Memorial Sloan-Kettering Cancer Center | Differentiation of cortical neurons from human pluripotent stem cells |
| EP3436567A4 (en) | 2016-03-30 | 2019-10-30 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| KR20210068050A (en) | 2018-09-19 | 2021-06-08 | 리니지 셀 테라퓨틱스, 인크. | Methods for Differentiating Pluripotent Stem Cells in Dynamic Suspension Culture |
| CN113474451A (en) | 2019-01-23 | 2021-10-01 | 阿斯特里亚斯生物疗法股份有限公司 | Back-derived oligodendrocyte precursor cells from human pluripotent stem cells |
-
2020
- 2020-01-23 CN CN202080016840.0A patent/CN113474451A/en active Pending
- 2020-01-23 WO PCT/US2020/014834 patent/WO2020154533A1/en unknown
- 2020-01-23 CA CA3127213A patent/CA3127213A1/en active Pending
- 2020-01-23 SG SG11202107732XA patent/SG11202107732XA/en unknown
- 2020-01-23 US US16/750,975 patent/US11603518B2/en active Active
- 2020-01-23 AU AU2020210757A patent/AU2020210757A1/en active Pending
- 2020-01-23 EP EP20745781.3A patent/EP3914264A4/en active Pending
- 2020-01-23 KR KR1020217026687A patent/KR20210121112A/en unknown
- 2020-01-23 JP JP2021543274A patent/JP7469317B2/en active Active
-
2022
- 2022-12-02 US US18/074,272 patent/US20230139899A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US11603518B2 (en) | 2023-03-14 |
| WO2020154533A1 (en) | 2020-07-30 |
| CA3127213A1 (en) | 2020-07-30 |
| US20200231932A1 (en) | 2020-07-23 |
| CN113474451A (en) | 2021-10-01 |
| US20230139899A1 (en) | 2023-05-04 |
| JP7469317B2 (en) | 2024-04-16 |
| KR20210121112A (en) | 2021-10-07 |
| EP3914264A4 (en) | 2022-11-23 |
| JP2022520722A (en) | 2022-04-01 |
| EP3914264A1 (en) | 2021-12-01 |
| AU2020210757A1 (en) | 2021-08-05 |
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