SG11202104030TA - Pretreatment of blood for classifying blood cells using microchannel - Google Patents

Pretreatment of blood for classifying blood cells using microchannel

Info

Publication number
SG11202104030TA
SG11202104030TA SG11202104030TA SG11202104030TA SG11202104030TA SG 11202104030T A SG11202104030T A SG 11202104030TA SG 11202104030T A SG11202104030T A SG 11202104030TA SG 11202104030T A SG11202104030T A SG 11202104030TA SG 11202104030T A SG11202104030T A SG 11202104030TA
Authority
SG
Singapore
Prior art keywords
blood
microchannel
pretreatment
classifying
blood cells
Prior art date
Application number
SG11202104030TA
Inventor
Tomohiro Kubo
Tomoyuki KANEIWA
Hiroaki Yamanaka
Ryohei Seki
Original Assignee
Tl Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tl Genomics Inc filed Critical Tl Genomics Inc
Publication of SG11202104030TA publication Critical patent/SG11202104030TA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0255—Investigating particle size or size distribution with mechanical, e.g. inertial, classification, and investigation of sorted collections
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4915—Blood using flow cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • G01N15/01—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
SG11202104030TA 2018-10-25 2019-09-26 Pretreatment of blood for classifying blood cells using microchannel SG11202104030TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018200712 2018-10-25
PCT/JP2019/038044 WO2020085000A1 (en) 2018-10-25 2019-09-26 Blood pretreatment for microfluidic blood cell sorting

Publications (1)

Publication Number Publication Date
SG11202104030TA true SG11202104030TA (en) 2021-05-28

Family

ID=70330681

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202104030TA SG11202104030TA (en) 2018-10-25 2019-09-26 Pretreatment of blood for classifying blood cells using microchannel

Country Status (8)

Country Link
US (1) US20210382035A1 (en)
EP (1) EP3872488A4 (en)
JP (1) JP7316674B2 (en)
KR (1) KR102526641B1 (en)
CN (1) CN112912725A (en)
CA (1) CA3115966C (en)
SG (1) SG11202104030TA (en)
WO (1) WO2020085000A1 (en)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1041424A (en) * 1974-05-09 1978-10-31 Lars-Olov Andersson Isolation of coagulation factors from biological material
CN1055880A (en) * 1991-06-07 1991-11-06 北京市海淀四达技术开发中心 Processs for comprehensive recvery of blood
JPH105329A (en) * 1996-06-21 1998-01-13 Kanegafuchi Chem Ind Co Ltd Carrier for adsorbent used for direct blood perfusion and its grain size reduction method
EP1204859B1 (en) * 1999-07-16 2006-11-22 The Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
GB2355717A (en) * 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
CN1220531C (en) * 2001-01-30 2005-09-28 钟渊化学工业株式会社 Body fluid processor enabling direct hemoperfusion
WO2004046716A1 (en) * 2002-11-19 2004-06-03 Sekisui Chemical Co., Ltd. Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane
JP2004294388A (en) * 2003-03-10 2004-10-21 Arkray Inc Component-analyzing apparatus
JP2008511340A (en) * 2004-04-30 2008-04-17 バイオフェレシス テクノロジーズ， インコーポレイテッド Method and system for removing soluble TNFR1, soluble TNFR2, and soluble IL2 in a patient
KR101290558B1 (en) * 2004-07-30 2013-07-31 퓨리셀렉트 게엠베하 Device and method for isolating cells, bioparticles and/or molecules from liquids for use with animals, in biotechnology, (including biotechnological research) and medical diagnostics
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
JP2007071711A (en) * 2005-09-07 2007-03-22 Fujifilm Corp Analytic chip
JP2007175684A (en) 2005-12-26 2007-07-12 Minoru Seki Flow passage structure and method for concentration and classification of fine particle
WO2012142180A1 (en) * 2011-04-12 2012-10-18 Tianxin Wang Methods to detect and treat diseases
JP5834559B2 (en) * 2011-07-12 2015-12-24 コニカミノルタ株式会社 Target cell inspection method
WO2014061631A1 (en) * 2012-10-15 2014-04-24 国立大学法人名古屋大学 Microchannel chip for microparticle separation, microparticle separation method and system for microparticle separation using chip
EP3633349B1 (en) * 2012-10-24 2023-09-06 The Regents of the University of California System for deforming and analyzing particles
JP2016527494A (en) * 2013-07-05 2016-09-08 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション Methods, compositions and systems for microfluidic assays
WO2015054697A1 (en) 2013-10-11 2015-04-16 Visa International Service Association Network token system
JP6234542B1 (en) 2016-12-27 2017-11-22 株式会社 ＴＬ Ｇｅｎｏｍｉｃｓ Method for obtaining chromosomal DNA derived from fetal cells
CN107262171A (en) * 2017-07-12 2017-10-20 华讯方舟科技有限公司 A kind of blood separation and culture chip and blood separating mechanism
CN107702973A (en) * 2017-09-08 2018-02-16 深圳市太赫兹科技创新研究院有限公司 A kind of whole blood blood plasma piece-rate system and method

Also Published As

Publication number Publication date
CA3115966A1 (en) 2020-04-30
EP3872488A1 (en) 2021-09-01
CN112912725A (en) 2021-06-04
CA3115966C (en) 2023-03-14
KR20210073564A (en) 2021-06-18
WO2020085000A1 (en) 2020-04-30
TW202032122A (en) 2020-09-01
US20210382035A1 (en) 2021-12-09
JPWO2020085000A1 (en) 2021-09-09
JP7316674B2 (en) 2023-07-28
KR102526641B1 (en) 2023-04-26
EP3872488A4 (en) 2022-11-09

Similar Documents

Publication Publication Date Title
HK1245350A1 (en) Compositions and methods for screening t cells with antigens for specific populations
EP3433277A4 (en) Novel anti-pd-l1 antibodies
AU2016243120B2 (en) Genetically modified NK-92 cells and monoclonal antibodies for the treatment of cancer
EP3332006A4 (en) Novel anti-pd-l1 antibodies
EP3307777A4 (en) Novel anti-pd-l1 antibodies
EP3824080A4 (en) Methods of analyzing cells
IL268617A (en) Modified nk-92 hank003 cells for the clinic
EP3318876A4 (en) Biological sample reaction box
ZA201705120B (en) Cell penetrating antibodies
LT3619319T (en) Single cell analysis
EP3820612A4 (en) Microfluidic methods for the preparation of cells
GB2562858B (en) Method for the cytometric analysis of cell samples
GB201813449D0 (en) Skin cell analysis
IL278022A (en) Microfluidic method for single cell analysis
IL269559A (en) Stable multispecific antibodies
SG11202011268VA (en) Monospecific and multispecific anti-tmeff2 antibodies and there uses
GB201900893D0 (en) Cell contamination assay
GB201806504D0 (en) Sample holder
IL268330A (en) Methods for determining interaction between biological cells
EP3669163A4 (en) Devices and methods for separating circulating tumor cells from biological samples
SG11202104030TA (en) Pretreatment of blood for classifying blood cells using microchannel
EP3821035A4 (en) Methods for analyzing cells
SG11202008063YA (en) Improvements to processes for immobilising biological entities
EP3480598A4 (en) Method for screening antibody using patient-derived cells
EP3386549A4 (en) Cell penetrating cyanine-coupled antibodies