SG11202003700TA - Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv) - Google Patents
Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv)Info
- Publication number
- SG11202003700TA SG11202003700TA SG11202003700TA SG11202003700TA SG11202003700TA SG 11202003700T A SG11202003700T A SG 11202003700TA SG 11202003700T A SG11202003700T A SG 11202003700TA SG 11202003700T A SG11202003700T A SG 11202003700TA SG 11202003700T A SG11202003700T A SG 11202003700TA
- Authority
- SG
- Singapore
- Prior art keywords
- hbv
- hepatitis
- virus
- novel
- carboxamides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17199687 | 2017-11-02 | ||
| PCT/EP2018/000502 WO2019086141A1 (en) | 2017-11-02 | 2018-11-02 | Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003700TA true SG11202003700TA (en) | 2020-05-28 |
Family
ID=60201941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003700TA SG11202003700TA (en) | 2017-11-02 | 2018-11-02 | Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv) |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US11267825B2 (en) |
| EP (1) | EP3704127A1 (en) |
| JP (1) | JP2021501764A (en) |
| KR (1) | KR20200083551A (en) |
| CN (1) | CN111448199A (en) |
| AR (1) | AR113826A1 (en) |
| AU (1) | AU2018361364B2 (en) |
| BR (1) | BR112020008762A2 (en) |
| CA (1) | CA3081386A1 (en) |
| CL (1) | CL2020001145A1 (en) |
| CU (1) | CU20200037A7 (en) |
| EA (1) | EA202091113A1 (en) |
| EC (1) | ECSP20029558A (en) |
| GE (1) | GEP20227373B (en) |
| IL (1) | IL274298A (en) |
| MA (1) | MA50524A (en) |
| MX (1) | MX2020004839A (en) |
| PH (1) | PH12020550525A1 (en) |
| SG (1) | SG11202003700TA (en) |
| TW (1) | TW201930315A (en) |
| UY (1) | UY37962A (en) |
| WO (1) | WO2019086141A1 (en) |
| ZA (1) | ZA202002249B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY38434A (en) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | NEW 6,7-DIHYDRO-4H-PYRAZOLE [1,5-A] PIRAZIN INDOL-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) |
| UY38436A (en) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | NEW 6,7-DIHYDRO-4H-PYRAZOLE [1,5-A] PYRAZININDOL-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) |
| SG11202111236UA (en) * | 2019-04-30 | 2021-11-29 | Aicuris Gmbh & Co Kg | Novel indole-2-carboxamides active against the hepatitis b virus (hbv) |
| KR20230124583A (en) | 2020-11-23 | 2023-08-25 | 이난타 파마슈티칼스, 인코포레이티드 | Novel spiropyrrolidine-derived antiviral agent |
| WO2022235605A1 (en) | 2021-05-04 | 2022-11-10 | Enanta Pharmaceuticals, Inc. | Novel macrocyclic antiviral agents |
| US11919910B2 (en) | 2021-11-12 | 2024-03-05 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| WO2023086350A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| WO2023107419A1 (en) | 2021-12-08 | 2023-06-15 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
| WO2023137007A1 (en) * | 2022-01-11 | 2023-07-20 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 4,6,7-trifluoro-1h-indole-2-carboxylic acid |
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| WO1998040385A1 (en) | 1997-03-07 | 1998-09-17 | Novo Nordisk A/S | 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE |
| DE19817264A1 (en) | 1998-04-18 | 1999-10-21 | Bayer Ag | New dihydropyrimidine derivatives and their corresponding mesomers useful as antiviral agents |
| AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
| AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
| DE10012823A1 (en) | 2000-03-16 | 2001-09-20 | Bayer Ag | New alkyl-6-aminoalkyl-dihydropyrimidine-5-carboxylate derivatives, useful for the treatment of viral, especially hepatitis B, infections |
| ES2679744T3 (en) | 2003-11-12 | 2018-08-30 | Daiichi Sankyo Company, Limited | Procedure to produce thiazole derivatives |
| WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
| AU2007225273A1 (en) | 2006-03-10 | 2007-09-20 | Neurogen Corporation | Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues |
| UY30867A1 (en) | 2007-01-12 | 2008-09-02 | Astrazeneca Ab | NEW ANALOGS OF PIRIDINA VII 543 |
| WO2009147188A1 (en) | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
| US8024013B2 (en) | 2008-07-09 | 2011-09-20 | Sony Ericsson Mobile Communications Ab | Regulating power duty cycle of an RF transmitter/receiver responsive to distance moved |
| EP2327704A4 (en) | 2008-08-29 | 2012-05-09 | Shionogi & Co | Ring-fused azole derivative having pi3k-inhibiting activity |
| WO2010114971A1 (en) | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| US9090632B2 (en) | 2010-08-31 | 2015-07-28 | Vanderbilt University | Bicyclic oxazole and thiazole compounds and their use as allosteric modulators of mGluR5 receptors |
| MX354852B (en) | 2010-09-02 | 2018-03-22 | Suven Life Sciences Ltd Star | Heterocyclyl compounds as histamine h3 receptor ligands. |
| EP2720695A4 (en) | 2011-06-15 | 2014-11-12 | Nono Inc | Agents and methods for treating ischemic and other diseases |
| WO2013006394A1 (en) | 2011-07-01 | 2013-01-10 | Institute For Hepatitis And Virus Research | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
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| ES2610758T3 (en) | 2012-08-28 | 2017-05-03 | Janssen Sciences Ireland Uc | Condensed bicyclic sulfamoyl derivatives and their use as medicines in the treatment of hepatitis B |
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| WO2014184365A1 (en) | 2013-05-17 | 2014-11-20 | Janssen R&D Ireland | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
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| CN109415368B (en) | 2016-07-14 | 2021-04-30 | 豪夫迈·罗氏有限公司 | Carboxy 6, 7-dihydro-4H-pyrazolo [1,5-a ] pyrazine compounds for the treatment of infectious diseases |
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| CA3081399A1 (en) * | 2017-11-02 | 2019-05-09 | Aicuris Gmbh & Co. Kg | Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv) |
-
2018
- 2018-11-02 AR ARP180103202A patent/AR113826A1/en unknown
- 2018-11-02 KR KR1020207015662A patent/KR20200083551A/en not_active Application Discontinuation
- 2018-11-02 JP JP2020524457A patent/JP2021501764A/en active Pending
- 2018-11-02 MA MA050524A patent/MA50524A/en unknown
- 2018-11-02 BR BR112020008762-9A patent/BR112020008762A2/en not_active IP Right Cessation
- 2018-11-02 EP EP18811439.1A patent/EP3704127A1/en not_active Withdrawn
- 2018-11-02 AU AU2018361364A patent/AU2018361364B2/en not_active Ceased
- 2018-11-02 CA CA3081386A patent/CA3081386A1/en not_active Abandoned
- 2018-11-02 WO PCT/EP2018/000502 patent/WO2019086141A1/en unknown
- 2018-11-02 CN CN201880079554.1A patent/CN111448199A/en active Pending
- 2018-11-02 SG SG11202003700TA patent/SG11202003700TA/en unknown
- 2018-11-02 GE GEAP201815351A patent/GEP20227373B/en unknown
- 2018-11-02 MX MX2020004839A patent/MX2020004839A/en unknown
- 2018-11-02 TW TW107139067A patent/TW201930315A/en unknown
- 2018-11-02 EA EA202091113A patent/EA202091113A1/en unknown
- 2018-11-02 CU CU2020000037A patent/CU20200037A7/en unknown
- 2018-11-02 US US16/761,189 patent/US11267825B2/en active Active
- 2018-11-05 UY UY0001037962A patent/UY37962A/en not_active Application Discontinuation
-
2020
- 2020-04-27 IL IL274298A patent/IL274298A/en unknown
- 2020-04-30 PH PH12020550525A patent/PH12020550525A1/en unknown
- 2020-04-30 CL CL2020001145A patent/CL2020001145A1/en unknown
- 2020-05-04 ZA ZA2020/02249A patent/ZA202002249B/en unknown
- 2020-06-01 EC ECSENADI202029558A patent/ECSP20029558A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN111448199A (en) | 2020-07-24 |
| ECSP20029558A (en) | 2020-07-31 |
| AR113826A1 (en) | 2020-06-17 |
| CU20200037A7 (en) | 2021-03-11 |
| GEP20227373B (en) | 2022-04-25 |
| US11267825B2 (en) | 2022-03-08 |
| WO2019086141A1 (en) | 2019-05-09 |
| IL274298A (en) | 2020-06-30 |
| BR112020008762A2 (en) | 2020-10-20 |
| MA50524A (en) | 2020-09-09 |
| AU2018361364B2 (en) | 2020-11-26 |
| JP2021501764A (en) | 2021-01-21 |
| PH12020550525A1 (en) | 2021-04-26 |
| MX2020004839A (en) | 2020-10-16 |
| US20200354379A1 (en) | 2020-11-12 |
| EP3704127A1 (en) | 2020-09-09 |
| WO2019086141A8 (en) | 2019-08-29 |
| AU2018361364A1 (en) | 2020-05-21 |
| CL2020001145A1 (en) | 2020-10-09 |
| EA202091113A1 (en) | 2020-08-28 |
| KR20200083551A (en) | 2020-07-08 |
| UY37962A (en) | 2019-05-31 |
| ZA202002249B (en) | 2022-01-26 |
| TW201930315A (en) | 2019-08-01 |
| CA3081386A1 (en) | 2019-05-09 |
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