SG11202001783YA - Oligonucleotide compositions and methods thereof - Google Patents
Oligonucleotide compositions and methods thereofInfo
- Publication number
- SG11202001783YA SG11202001783YA SG11202001783YA SG11202001783YA SG11202001783YA SG 11202001783Y A SG11202001783Y A SG 11202001783YA SG 11202001783Y A SG11202001783Y A SG 11202001783YA SG 11202001783Y A SG11202001783Y A SG 11202001783YA SG 11202001783Y A SG11202001783Y A SG 11202001783YA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- oligonucleotide compositions
- oligonucleotide
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762571686P | 2017-10-12 | 2017-10-12 | |
US201862701078P | 2018-07-20 | 2018-07-20 | |
PCT/US2018/055653 WO2019075357A1 (en) | 2017-10-12 | 2018-10-12 | Oligonucleotide compositions and methods thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202001783YA true SG11202001783YA (en) | 2020-03-30 |
Family
ID=66101062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202001783YA SG11202001783YA (en) | 2017-10-12 | 2018-10-12 | Oligonucleotide compositions and methods thereof |
Country Status (5)
Country | Link |
---|---|
US (1) | US11596646B2 (en) |
EP (1) | EP3694530A4 (en) |
JP (1) | JP2020537518A (en) |
SG (1) | SG11202001783YA (en) |
WO (1) | WO2019075357A1 (en) |
Families Citing this family (23)
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US9598458B2 (en) | 2012-07-13 | 2017-03-21 | Wave Life Sciences Japan, Inc. | Asymmetric auxiliary group |
EP4219516A3 (en) | 2012-07-13 | 2024-01-10 | Wave Life Sciences Ltd. | Chiral control |
BR112016016400A2 (en) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | COMPOSITIONS OF CHIRALLY CONTROLLED OLIGONUCLEOTIDES, THEIR USE, THEIR PHARMACEUTICAL COMPOSITION, AND METHODS |
MA43072A (en) | 2015-07-22 | 2018-05-30 | Wave Life Sciences Ltd | COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES |
TW201722439A (en) | 2015-10-09 | 2017-07-01 | 波濤生命科學有限公司 | Oligonucleotide compositions and methods thereof |
CN114685589A (en) | 2016-03-13 | 2022-07-01 | 波涛生命科学有限公司 | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
MA45270A (en) | 2016-05-04 | 2017-11-09 | Wave Life Sciences Ltd | COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES |
EP3463386A4 (en) | 2016-06-03 | 2020-03-04 | Wave Life Sciences Ltd. | Oligonucleotides, compositions and methods thereof |
MA46905A (en) | 2016-11-23 | 2019-10-02 | Wave Life Sciences Ltd | COMPOSITIONS AND SYNTHESIS OF PHOSPHORAMIDITES AND OLIGONUCLEOTIDES |
JP2020522510A (en) | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | Oligonucleotide composition and method of using the same |
CN110997692A (en) | 2017-06-02 | 2020-04-10 | 波涛生命科学有限公司 | Oligonucleotide compositions and methods of use thereof |
JP7402696B2 (en) | 2017-06-21 | 2023-12-21 | ウェイブ ライフ サイエンシズ リミテッド | Compounds, compositions, and methods for synthesis |
AR112779A1 (en) | 2017-08-08 | 2019-12-11 | Wave Life Sciences Ltd | NUCLEOTIDE COMPOSITIONS AND RELATED METHODS |
EP3684755A4 (en) | 2017-09-18 | 2022-03-02 | Wave Life Sciences Ltd. | Technologies for oligonucleotide preparation |
US11596646B2 (en) | 2017-10-12 | 2023-03-07 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
AU2021213822A1 (en) | 2020-01-31 | 2022-09-22 | Avilar Therapeutics, Inc. | ASGPR-binding compounds for the degradation of extracellular proteins |
WO2021174019A1 (en) * | 2020-02-28 | 2021-09-02 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating smn2 |
DE112021002672T5 (en) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EDIT BOTH STRANDS SIMULTANEOUSLY OF A DOUBLE STRANDED NUCLEOTIDE TARGET SEQUENCE |
US20230203484A1 (en) | 2020-05-22 | 2023-06-29 | Wave Life Sciences Ltd. | Double stranded oligonucleotide compositions and methods relating thereto |
WO2023152371A1 (en) | 2022-02-14 | 2023-08-17 | Proqr Therapeutics Ii B.V. | Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia |
WO2024013361A1 (en) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Oligonucleotides for adar-mediated rna editing and use thereof |
WO2024013360A1 (en) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
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EP1520022B1 (en) | 2002-07-10 | 2015-07-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Rna-interference by single-stranded rna molecules |
AU2003261449A1 (en) | 2002-08-07 | 2004-02-25 | Compositions for rna interference and methods of use thereof | |
JP2005089441A (en) | 2003-08-08 | 2005-04-07 | Toudai Tlo Ltd | Manufacturing method of highly stereoregular phosphorus atom-modified nucleotide analogue |
WO2005023828A1 (en) | 2003-09-02 | 2005-03-17 | Takeshi Wada | Process for producing ribonucleotide or ribonucleotide derivative |
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KR20210057223A (en) * | 2009-06-17 | 2021-05-20 | 바이오젠 엠에이 인코포레이티드 | Composition and methods for modulating of smn2 splicing in a subject |
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TW201722439A (en) | 2015-10-09 | 2017-07-01 | 波濤生命科學有限公司 | Oligonucleotide compositions and methods thereof |
CN114685589A (en) | 2016-03-13 | 2022-07-01 | 波涛生命科学有限公司 | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
MA45270A (en) | 2016-05-04 | 2017-11-09 | Wave Life Sciences Ltd | COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES |
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MA46905A (en) | 2016-11-23 | 2019-10-02 | Wave Life Sciences Ltd | COMPOSITIONS AND SYNTHESIS OF PHOSPHORAMIDITES AND OLIGONUCLEOTIDES |
CN110997692A (en) | 2017-06-02 | 2020-04-10 | 波涛生命科学有限公司 | Oligonucleotide compositions and methods of use thereof |
JP2020522510A (en) | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | Oligonucleotide composition and method of using the same |
TW201908483A (en) | 2017-06-02 | 2019-03-01 | 新加坡商波濤生命科學有限公司 | Oligonucleotide composition and method of use thereof |
JP7402696B2 (en) | 2017-06-21 | 2023-12-21 | ウェイブ ライフ サイエンシズ リミテッド | Compounds, compositions, and methods for synthesis |
WO2019002237A1 (en) | 2017-06-28 | 2019-01-03 | Roche Innovation Center Copenhagen A/S | Multiple coupling & oxidation method |
AR112779A1 (en) | 2017-08-08 | 2019-12-11 | Wave Life Sciences Ltd | NUCLEOTIDE COMPOSITIONS AND RELATED METHODS |
EP3684755A4 (en) | 2017-09-18 | 2022-03-02 | Wave Life Sciences Ltd. | Technologies for oligonucleotide preparation |
US11596646B2 (en) | 2017-10-12 | 2023-03-07 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
AU2019252680A1 (en) | 2018-04-12 | 2020-10-22 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
CA3098624A1 (en) | 2018-05-11 | 2019-11-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
EP3891284A4 (en) | 2018-12-06 | 2023-04-12 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
WO2020160336A1 (en) | 2019-02-01 | 2020-08-06 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
AU2020241559A1 (en) | 2019-03-20 | 2021-11-11 | Wave Life Sciences Ltd. | Technologies useful for oligonucleotide preparation |
WO2020196662A1 (en) | 2019-03-25 | 2020-10-01 | 国立大学法人東京医科歯科大学 | Double-stranded nucleic acid complex and use thereof |
BR112021021203A2 (en) | 2019-04-25 | 2022-01-04 | Wave Life Sciences Ltd | oligonucleotide; chirally controlled oligonucleotide composition; pharmaceutical composition; method for preventing, treating or ameliorating an ush2a-related condition, disorder or disease and/or preventing, delaying the onset, development and/or progress of, and/or treating an ush2a-related condition, disorder or disease in a susceptible individual or who suffers from it; method for increasing the skip level of a deleterious exon in an ush2a gene transcript or its gene product in a cell; method for preventing, delaying the onset or progression of, treating or ameliorating an ush2a-related condition, disorder or disease in an individual susceptible to or suffering from the same; method for skipping a harmful exon 13 on an ush2a allele in an individual; method for producing or increasing the level of a skip 13 ush2a protein exon in a system; and compound, oligonucleotide, composition or method |
AU2020262485A1 (en) | 2019-04-25 | 2021-11-11 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
JP2022532169A (en) | 2019-05-09 | 2022-07-13 | ウェイブ ライフ サイエンシズ リミテッド | Oligonucleotide composition and its usage |
BR112022006205A2 (en) | 2019-10-06 | 2022-07-19 | Wave Life Sciences Ltd | OLIGONUCLEOTIDE; PHARMACEUTICAL COMPOSITION; OLIGONUCLEOTIDE COMPOSITION; PHOSPHORAMIDITE; METHOD OF PREPARING AN OLIGONUCLEOTIDE OR COMPOSITION; METHOD FOR CHARACTERIZING AN OLIGONUCLEOTIDE OR A COMPOSITION; METHOD FOR MODIFYING A TARGET ADENOSINE INTO A TARGET NUCLEIC ACID; METHOD TO DEAMINATE A TARGET ADENOSINE INTO A TARGET NUCLEIC ACID; METHOD FOR PREVENTING OR TREATMENT OF A DISEASE, DISORDER OR DISEASE POSSIBLY TO A MUTATION FROM G TO A; AND COMPOUND, OLIGONUCLEOTIDE, COMPOSITION OR METHOD |
IL291974A (en) | 2019-10-06 | 2022-06-01 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods of use thereof |
TW202146650A (en) | 2020-03-01 | 2021-12-16 | 新加坡商波濤生命科學有限公司 | Oligonucleotide compositions and methods thereof |
EP4153604A1 (en) | 2020-05-22 | 2023-03-29 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
-
2018
- 2018-10-12 US US16/755,544 patent/US11596646B2/en active Active
- 2018-10-12 SG SG11202001783YA patent/SG11202001783YA/en unknown
- 2018-10-12 WO PCT/US2018/055653 patent/WO2019075357A1/en unknown
- 2018-10-12 EP EP18865960.1A patent/EP3694530A4/en not_active Withdrawn
- 2018-10-12 JP JP2020519679A patent/JP2020537518A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3694530A4 (en) | 2021-06-30 |
EP3694530A1 (en) | 2020-08-19 |
WO2019075357A1 (en) | 2019-04-18 |
US20210228615A1 (en) | 2021-07-29 |
US11596646B2 (en) | 2023-03-07 |
JP2020537518A (en) | 2020-12-24 |
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