SG11202000996UA - Antibody-drug conjugate preparation and lyophilization for same - Google Patents
Antibody-drug conjugate preparation and lyophilization for sameInfo
- Publication number
- SG11202000996UA SG11202000996UA SG11202000996UA SG11202000996UA SG11202000996UA SG 11202000996U A SG11202000996U A SG 11202000996UA SG 11202000996U A SG11202000996U A SG 11202000996UA SG 11202000996U A SG11202000996U A SG 11202000996UA SG 11202000996U A SG11202000996U A SG 11202000996UA
- Authority
- SG
- Singapore
- Prior art keywords
- lyophilization
- antibody
- same
- drug conjugate
- conjugate preparation
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title 1
- 229940049595 antibody-drug conjugate Drugs 0.000 title 1
- 238000004108 freeze drying Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017160071 | 2017-08-23 | ||
PCT/JP2018/030882 WO2019039483A1 (en) | 2017-08-23 | 2018-08-22 | Antibody-drug conjugate preparation and lyophilization for same |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000996UA true SG11202000996UA (en) | 2020-03-30 |
Family
ID=65438975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000996UA SG11202000996UA (en) | 2017-08-23 | 2018-08-22 | Antibody-drug conjugate preparation and lyophilization for same |
Country Status (13)
Country | Link |
---|---|
US (1) | US20210128741A1 (en) |
EP (1) | EP3673918A4 (en) |
JP (2) | JP7204651B2 (en) |
KR (1) | KR20200044044A (en) |
CN (1) | CN110944667A (en) |
AU (1) | AU2018320470A1 (en) |
BR (1) | BR112020003474A2 (en) |
CA (1) | CA3073383C (en) |
IL (1) | IL272721A (en) |
MA (1) | MA49987A (en) |
SG (1) | SG11202000996UA (en) |
TW (1) | TW201919710A (en) |
WO (1) | WO2019039483A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102537651B1 (en) * | 2017-01-17 | 2023-05-26 | 다이이찌 산쿄 가부시키가이샤 | Anti-GPR20 Antibodies and Anti-GPR20 Antibody-Drug Conjugates |
EP3923928A4 (en) * | 2019-02-15 | 2022-11-09 | The Regents Of The University Of California | Methods for converting colloidal systems to resuspendable/redispersible powders that preserve the original properties of the colloids |
AU2020225202B2 (en) | 2019-02-18 | 2023-10-26 | Eli Lilly And Company | Therapeutic antibody formulation |
CN113365665A (en) * | 2019-03-26 | 2021-09-07 | 荣昌生物制药(烟台)股份有限公司 | anti-Her 2 antibody drug conjugate pharmaceutical formulations |
CN113939318A (en) * | 2019-05-29 | 2022-01-14 | 第一三共株式会社 | Formulation of antibody-drug conjugates |
WO2021027851A1 (en) * | 2019-08-12 | 2021-02-18 | 凯惠科技发展(上海)有限公司 | Trop2 antibody, preparation method therefor, and conjugate and use thereof |
KR20220157998A (en) * | 2020-03-25 | 2022-11-29 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | Pharmaceutical Compositions Comprising Antibody Drug Conjugates and Uses Thereof |
JP2023523372A (en) * | 2020-05-03 | 2023-06-02 | シャンハイ ミラコーケン インコーポレイティド | Antibody-drug conjugates and preparations thereof |
CN112361726B (en) * | 2020-10-27 | 2022-09-02 | 北京诺康达医药科技股份有限公司 | Freeze-dried preparation water control method and application thereof |
JP2023550533A (en) * | 2020-12-18 | 2023-12-01 | シャンハイ フダン-チャンジャン バイオ-ファーマシューティカル カンパニー リミテッド | Antibody-drug conjugate targeting B7-H3, its production method and use |
WO2023066251A1 (en) * | 2021-10-19 | 2023-04-27 | 同宜医药(苏州)有限公司 | Conjugate drug preparation, preparation method therefor and use thereof |
WO2024041587A1 (en) * | 2022-08-25 | 2024-02-29 | 启德医药科技(苏州)有限公司 | Pharmaceutical composition of antibody drug conjugate |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
ATE255131T1 (en) | 1991-06-14 | 2003-12-15 | Genentech Inc | HUMANIZED HEREGULIN ANTIBODIES |
ATE458007T1 (en) | 1998-04-20 | 2010-03-15 | Glycart Biotechnology Ag | GLYCOSYLATION ENGINEERING OF ANTIBODIES TO IMPROVE ANTIBODIES-DEPENDENT CELL-MEDIATED CYTOTOXICITY |
EP3031917A1 (en) | 1999-04-09 | 2016-06-15 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
NZ531426A (en) | 1999-06-25 | 2005-10-28 | Genentech Inc | Method of treating cancer wherein the cancer expresses epidermal growth factor receptor comprising administration of humanized anti-ErbB2 antibodies |
WO2002031140A1 (en) | 2000-10-06 | 2002-04-18 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions |
WO2003038043A2 (en) | 2001-11-01 | 2003-05-08 | Uab Research Foundation | Combinations of dr5 antibody and other therapeutic agents |
US20060246060A1 (en) | 2002-07-02 | 2006-11-02 | Nesta Douglas P | Novel stable formulation |
MX369959B (en) * | 2003-05-14 | 2019-11-27 | Immunogen Inc | Drug conjugate composition. |
NZ599176A (en) | 2005-08-03 | 2014-04-30 | Immunogen Inc | Immunoconjugate formulations |
AR056857A1 (en) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | DIRECTED ANTIBODIES TO HER-3 (RECEIVER OF THE HUMAN EPIDERMAL GROWTH FACTOR-3) AND ITS USES |
SI2129396T1 (en) | 2007-02-16 | 2013-12-31 | Merrimack Pharmaceuticals, Inc. | Antibodies against erbb3 and uses thereof |
CA3150199A1 (en) | 2009-01-09 | 2010-07-15 | Seagen Inc. | Weekly dosing regimens for anti-cd30 vc-pab-mmae antibody drug-conjugates |
TW201247222A (en) * | 2011-04-21 | 2012-12-01 | Daiichi Sankyo Co Ltd | Antibody liquid formulation |
LT2907824T (en) * | 2012-10-11 | 2018-06-11 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
ES2782248T3 (en) | 2012-10-19 | 2020-09-11 | Daiichi Sankyo Co Ltd | Antibody-drug conjugate produced by binding through a linker having a hydrophilic structure |
JP6366111B2 (en) | 2012-12-13 | 2018-08-01 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | Administration of immunoconjugate consisting of antibody and SN-38 for improved efficacy and reduced toxicity |
SG10201707633VA (en) * | 2013-03-15 | 2017-11-29 | Abbvie Deutschland | Anti-egfr antibody drug conjugate formulations |
EP3060256B1 (en) | 2013-10-25 | 2019-05-08 | Bayer Pharma Aktiengesellschaft | A novel stable formulation |
HUE042512T2 (en) | 2013-12-25 | 2019-07-29 | Daiichi Sankyo Co Ltd | Anti-trop2 antibody-drug conjugate |
HRP20211848T1 (en) | 2014-01-31 | 2022-03-04 | Daiichi Sankyo Company, Limited | Anti-her2 antibody-drug conjugate |
JP2017114763A (en) | 2014-03-26 | 2017-06-29 | 第一三共株式会社 | Anti-CD98 antibody-drug conjugate |
SG11201607306PA (en) | 2014-04-07 | 2016-09-29 | Seattle Genetics Inc | Stable formulations for anti-cd19 antibodies and antibody-drug conjugates |
EP3130608B1 (en) | 2014-04-10 | 2019-09-04 | Daiichi Sankyo Co., Ltd. | (anti-her2 antibody)-drug conjugate |
KR102239413B1 (en) * | 2014-04-10 | 2021-04-12 | 다이이찌 산쿄 가부시키가이샤 | Anti-her3 antibody-drug conjugate |
CN116059395A (en) * | 2015-06-29 | 2023-05-05 | 第一三共株式会社 | Method for selectively producing antibody-drug conjugates |
JP6522806B2 (en) * | 2015-07-10 | 2019-05-29 | シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. | Composition comprising antibody duocarmycin drug conjugates |
WO2018066626A1 (en) * | 2016-10-07 | 2018-04-12 | 第一三共株式会社 | Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate |
TW201828993A (en) * | 2016-12-12 | 2018-08-16 | 日商第一三共股份有限公司 | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
KR102537651B1 (en) | 2017-01-17 | 2023-05-26 | 다이이찌 산쿄 가부시키가이샤 | Anti-GPR20 Antibodies and Anti-GPR20 Antibody-Drug Conjugates |
AU2018327171B2 (en) * | 2017-08-31 | 2023-03-09 | Daiichi Sankyo Company, Limited | Improved method for producing antibody-drug conjugate |
JP7248578B2 (en) * | 2017-08-31 | 2023-03-29 | 第一三共株式会社 | Novel methods for producing antibody-drug conjugates |
CA3101906A1 (en) * | 2018-05-28 | 2019-12-05 | Daiichi Sankyo Company, Limited | Treatment of her2-mutated cancer by administering anti-her2 antibody-drug conjugate |
KR20210038904A (en) * | 2018-07-25 | 2021-04-08 | 다이이찌 산쿄 가부시키가이샤 | Effective method for preparing antibody-drug conjugates |
WO2020027100A1 (en) * | 2018-07-31 | 2020-02-06 | 第一三共株式会社 | Treatment of metastatic brain tumor by administration of antibody-drug conjugate |
AU2019320336A1 (en) * | 2018-08-06 | 2021-03-04 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and tubulin inhibitor |
-
2018
- 2018-08-22 TW TW107129228A patent/TW201919710A/en unknown
- 2018-08-22 BR BR112020003474-6A patent/BR112020003474A2/en unknown
- 2018-08-22 SG SG11202000996UA patent/SG11202000996UA/en unknown
- 2018-08-22 CA CA3073383A patent/CA3073383C/en active Active
- 2018-08-22 KR KR1020207007993A patent/KR20200044044A/en not_active Application Discontinuation
- 2018-08-22 MA MA049987A patent/MA49987A/en unknown
- 2018-08-22 EP EP18849166.6A patent/EP3673918A4/en active Pending
- 2018-08-22 CN CN201880054464.7A patent/CN110944667A/en active Pending
- 2018-08-22 WO PCT/JP2018/030882 patent/WO2019039483A1/en unknown
- 2018-08-22 AU AU2018320470A patent/AU2018320470A1/en active Pending
- 2018-08-22 JP JP2019537642A patent/JP7204651B2/en active Active
- 2018-08-22 US US16/640,914 patent/US20210128741A1/en active Pending
-
2020
- 2020-02-17 IL IL272721A patent/IL272721A/en unknown
-
2022
- 2022-12-28 JP JP2022211501A patent/JP2023036900A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2018320470A1 (en) | 2020-02-13 |
CA3073383A1 (en) | 2019-02-28 |
JPWO2019039483A1 (en) | 2020-10-01 |
KR20200044044A (en) | 2020-04-28 |
CA3073383C (en) | 2023-10-31 |
IL272721A (en) | 2020-04-30 |
WO2019039483A1 (en) | 2019-02-28 |
JP2023036900A (en) | 2023-03-14 |
RU2020111448A3 (en) | 2021-11-29 |
BR112020003474A2 (en) | 2020-10-20 |
EP3673918A4 (en) | 2021-05-19 |
US20210128741A1 (en) | 2021-05-06 |
CN110944667A (en) | 2020-03-31 |
TW201919710A (en) | 2019-06-01 |
MA49987A (en) | 2020-07-01 |
JP7204651B2 (en) | 2023-01-16 |
RU2020111448A (en) | 2021-09-24 |
EP3673918A1 (en) | 2020-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL272721A (en) | Antibody-drug conjugate preparation and lyophilization for same | |
IL268102A (en) | Anti-gpr20 antibody and anti-gpr20 antibody-drug conjugate | |
ZA202003833B (en) | Conjugates and preparation and use thereof | |
EP3626825A4 (en) | Anti-cdh6 antibody and anti-cdh6 antibody-drug conjugate | |
IL290959A (en) | Antibody-drug conjugate compisitions and methods for producing same | |
IL291337A (en) | Camptothecin derivative and conjugate thereof | |
ZA202001219B (en) | Bcma monoclonal antibody-drug conjugate | |
EP3473270A4 (en) | Antibody-drug conjugate | |
HK1231367A1 (en) | Antibody-drug conjugates, their preparation and their therapeutic use | |
SG11202101719PA (en) | Antibody-drug conjugate and application thereof | |
IL253712B (en) | Hemiasterlin derivatives for conjugation and therapy | |
EP3380126A4 (en) | Antibody-drug conjugates comprising branched linkers and methods related thereto | |
HK1243957B (en) | Anti-erbb2 antibody-drug conjugate and composition thereof, preparation method therefor, and application thereof | |
EP3501548A4 (en) | Tissue factor-targeted antibody-drug conjugate | |
EP3412315A4 (en) | Anti-her2 antibody-drug conjugate and application thereof | |
EP3617218A4 (en) | Dihydroartemisinin-steroid conjugate and preparation method and use thereof | |
IL275208A (en) | Hsp90-targeting conjugates and formulations thereof | |
EP3599249A4 (en) | Anti-5t4 antibody-drug conjugate and use thereof | |
IL265838A (en) | Cysteine modified antibody-drug conjugate and preparation method thereof | |
IL277791A (en) | Hsp90-targeting conjugates and formulations thereof | |
IL269321A (en) | Drug-polymer conjugate | |
IL266112A (en) | Anti-edb antibodies and antibody-drug conjugates | |
FI3666787T3 (en) | Antibody-drug conjugates including hemiasterlin derivative | |
EP3441088A4 (en) | Antibody-drug conjugate comprising modified antibody | |
EP3666788A4 (en) | Hemiasterlin derivatives and antibody-drug conjugates including same |