SG11201909882SA - Targeted neoepitope vectors and methods therefor - Google Patents

Targeted neoepitope vectors and methods therefor

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Publication number
SG11201909882SA
SG11201909882SA SG11201909882SA SG11201909882SA SG 11201909882S A SG11201909882S A SG 11201909882SA SG 11201909882S A SG11201909882S A SG 11201909882SA SG 11201909882S A SG11201909882S A SG 11201909882SA
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Singapore
Prior art keywords
international
california
pct
methods
vectors
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Kayvan Niazi
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Nantcell Inc
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Application filed by Nantcell Inc filed Critical Nantcell Inc
Publication of SG11201909882SA publication Critical patent/SG11201909882SA/en

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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2710/10011—Adenoviridae
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

00 2 10 14 QMAIMV ••• Figure 11A (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT ill 1111u°11111DIVIIl ono o oil Eno iflo oimIE (10) International Publication Number WO 2018/200389 Al (51) International Patent Classification: C12N 15/70 (2006.01) A61K 39/00 (2006.01) C12N 15/81 (2006.01) A61K 39/12 (2006.01) C07K 14/47 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/028889 (22) International Filing Date: 23 April 2018 (23.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/489,102 24 April 2017 (24.04.2017) US (71) Applicant: NANTCELL, INC. [US/US]; 9920 Jefferson Boulevard, Culver City, California 90232 (US). (72) Inventor: NIAZI, Kayvan; 9920 Jefferson Boulevard, Culver City, California 90232 (US). (74) Agent: FESSENMAIER, Martin; 1920 Main Street, Suite 750, Irvine, California 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with amended claims (Art. 19(1)) with sequence listing part of description (Rule 5.2(a)) (54) Title: TARGETED NEOEPITOPE VECTORS AND METHODS THEREFOR SubQ Delivery of Claw 11-target Polytope-expressing MV (57) : Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate recom- • bmant nucleic acids that encode one or more polytopes that are optimized for proper trafficking and processing. In preferred methods, 0 the polytopes are encoded in a plasmid and/or a viral expression system for use as a therapeutic agent.
SG11201909882S 2017-04-24 2018-04-23 Targeted neoepitope vectors and methods therefor SG11201909882SA (en)

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US201762489102P 2017-04-24 2017-04-24
PCT/US2018/028889 WO2018200389A1 (en) 2017-04-24 2018-04-23 Targeted neoepitope vectors and methods therefor

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CN (2) CN110662841B (en)
AU (1) AU2018258119B2 (en)
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