SG11201909646TA - Trem2 antigen binding proteins and uses thereof - Google Patents

Trem2 antigen binding proteins and uses thereof

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Publication number
SG11201909646TA
SG11201909646TA SG11201909646TA SG11201909646TA SG 11201909646T A SG11201909646T A SG 11201909646TA SG 11201909646T A SG11201909646T A SG 11201909646TA SG 11201909646T A SG11201909646T A SG 11201909646TA
Authority
SG
Singapore
Prior art keywords
california
antigen binding
binding proteins
international
trem2
Prior art date
Application number
Inventor
Ian Foltz
Shilpa Sambashivan
Irwin Chen
Susie Miki Harris
Warshaviak Dora Toledo
Ian Driver
Daniel Lu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11201909646TA publication Critical patent/SG11201909646TA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

3 9„.:-401.73 :'En :P1,4 o 75(.....t.._1 176 (4C5) 1 77 (:1(.1 ., frai.0 HUigG2 i:50 :Rat icKi2b 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIPO I PCT o °nolo mu H loolloiliflo oimIE (10) International Publication Number WO 2018/195506 Al (51) International Patent Classification: A61K 39/00 (2006.01) C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/028691 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/488,691 21 April 2017 (21.04.2017) US 62/530,753 10 July 2017 (10.07.2017) US 62/580,400 01 November 2017 (01.11.2017) US (71) Applicant: AMGEN INC. [US/US]; One Amgen Center, Thousand Oaks, California 91320 (US). (72) Inventors: FOLTZ, Ian; 2018 Knightswood Place, Burn- aby, British Columbia V5A 4B9 (CA). SAMBASHIVAN, Shilpa; 58 Callie Lane, Menlo Park, California 94025 (US). CHEN, Irwin; 1875 Kelton Avenue #202, Los An- geles, California 90025 (US). HARRIS, Susie Miki; 197 Los Vientos Drive, Newbury Park, California 91320 (US). TOLEDO WARSHAVIAK, Dora; 6643 Buttonwood Av- enue, Oak Park, California 91377 (US). DRIVER, Ian; 301 Monterey Boulevard, Apt #4, San Francisco, Califor- nia 94131 (US). LU, Daniel; 5551 Castle Glen Avenue, San Jose, California 95129 (US). (74) Agent: LUO, Chenghua; One Amgen Center, Thousand Oaks, California 91320 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = (54) Title: TREM2 ANTIGEN BINDING PROTEINS AND USES THEREOF Coo.00 rotkin OM) FIG. 1A O 00 O N O (57) : The present invention relates to antigen binding proteins, such as monoclonal antibodies, that specifically bind to and activate human triggering receptor expressed on myeloid cells-2 (TREM2) and pharmaceutical compositions comprising such antigen binding proteins. The agonist antigen binding proteins (e.g. antibodies) of the invention are capable of activating TREM2/DAP12 signaling in myeloid cells in the absence of Fc-mediated cross-linking of the antigen binding proteins. Methods of treating or preventing conditions associated with TREM2 loss of function, such as Alzheimer's disease and multiple sclerosis, using the antigen binding proteins are also described. [Continued on next page] WO 2018/195506 Al MIDEDIM01101 DIDIIMEN11111111111111H1001111111111111101111111111 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))
SG11201909646T 2017-04-21 2018-04-20 Trem2 antigen binding proteins and uses thereof SG11201909646TA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762488691P 2017-04-21 2017-04-21
US201762530753P 2017-07-10 2017-07-10
US201762580400P 2017-11-01 2017-11-01
PCT/US2018/028691 WO2018195506A1 (en) 2017-04-21 2018-04-20 Trem2 antigen binding proteins and uses thereof

Publications (1)

Publication Number Publication Date
SG11201909646TA true SG11201909646TA (en) 2019-11-28

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Family Applications (1)

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SG11201909646T SG11201909646TA (en) 2017-04-21 2018-04-20 Trem2 antigen binding proteins and uses thereof

Country Status (20)

Country Link
US (2) US11186636B2 (en)
EP (1) EP3612218A4 (en)
JP (2) JP7252134B2 (en)
KR (1) KR20200018778A (en)
CN (1) CN110709100A (en)
AU (2) AU2018254600B2 (en)
BR (1) BR112019021991A2 (en)
CA (1) CA3060409A1 (en)
CL (1) CL2019003000A1 (en)
CO (1) CO2019012998A2 (en)
CR (2) CR20210171A (en)
JO (1) JOP20190248A1 (en)
MA (1) MA52273A (en)
MX (1) MX2019012364A (en)
PE (1) PE20200485A1 (en)
PH (1) PH12019502356A1 (en)
SG (1) SG11201909646TA (en)
TW (1) TWI812619B (en)
UY (1) UY37698A (en)
WO (1) WO2018195506A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL279606B (en) 2014-08-08 2022-08-01 Alector Llc Anti-trem2 antibodies and methods of use thereof
JOP20190248A1 (en) 2017-04-21 2019-10-20 Amgen Inc Trem2 antigen binding proteins and uses thereof
WO2019028292A1 (en) 2017-08-03 2019-02-07 Alector Llc Anti-trem2 antibodies and methods of use thereof
UY38407A (en) 2018-10-15 2020-05-29 Novartis Ag TREM2 STABILIZING ANTIBODIES
CN113302206A (en) 2018-11-26 2021-08-24 戴纳立制药公司 Methods of treating lipid metabolism disorders
WO2020121195A1 (en) * 2018-12-10 2020-06-18 Mor Research Applications Trem2 antibodies and uses thereof
US20220133808A1 (en) * 2019-02-01 2022-05-05 Avrobio, Inc. Compositions and methods for treating neurocognitive disorders
SG11202108734VA (en) 2019-02-20 2021-09-29 Denali Therapeutics Inc Anti-trem2 antibodies and methods of use thereof
WO2020194317A1 (en) 2019-03-28 2020-10-01 Yeda Research And Development Co. Ltd. Method of treating lipid-related disorders
JP2022543114A (en) * 2019-08-02 2022-10-07 シーティーティーキュー－アケソ（シャンハイ） バイオメド テク カンパニー リミテッド Anti-PD-1 Antibodies and Medical Uses Thereof
TW202128771A (en) * 2020-01-13 2021-08-01 美商戴納立製藥公司 Anti-trem2 antibodies and methods of use thereof
IL294655A (en) 2020-01-13 2022-09-01 Denali Therapeutics Inc Anti-trem2 antibodies and methods of use thereof
EP4110814A1 (en) 2020-02-24 2023-01-04 Alector LLC Methods of use of anti-trem2 antibodies
JP2023520516A (en) 2020-04-03 2023-05-17 アレクトル エルエルシー Method of using anti-TREM2 antibody
KR20230130630A (en) * 2020-12-04 2023-09-12 비질 뉴로사이언스 인코포레이티드 Treatment of diseases associated with ATP-binding cassette transporter 1 dysfunction using TREM2 agonists
WO2023047100A1 (en) * 2021-09-21 2023-03-30 Quell Therapeutics Ltd Anti-trem2 chimeric antigen receptor
WO2023092146A1 (en) * 2021-11-22 2023-05-25 Vigil Neuroscience, Inc. Anti-trem2 antibody and uses thereof
TW202340235A (en) 2021-12-17 2023-10-16 美商戴納立製藥公司 Polypeptide engineering, libraries, and engineered cd98 heavy chain and transferrin receptor binding polypeptides
WO2023164516A1 (en) 2022-02-23 2023-08-31 Alector Llc Methods of use of anti-trem2 antibodies
WO2023192288A1 (en) 2022-03-28 2023-10-05 Denali Therapeutics Inc. Monovalent anti-trem2 binding molecules and methods of use thereof
WO2023192282A1 (en) 2022-03-28 2023-10-05 Denali Therapeutics Inc. Methods for treating brain glucose hypometabolism
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
WO2024052343A1 (en) 2022-09-06 2024-03-14 Institut National de la Santé et de la Recherche Médicale Trem-2 agonists for the treatment of marfan syndrome
CN117964768A (en) * 2024-04-02 2024-05-03 上海宏成药业有限公司 Anti-TREM 2 antibodies and uses thereof

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878687B1 (en) 1997-03-07 2005-04-12 Human Genome Sciences, Inc. Protein HMAAD57
CA2284131A1 (en) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 human secreted proteins
CA2331386A1 (en) 1998-06-26 2000-01-06 Incyte Pharmaceuticals, Inc. Human signal peptide-containing proteins
AUPQ873300A0 (en) 2000-07-12 2000-08-03 Medvet Science Pty. Ltd. A binding motif of a receptor (2)
MXPA02010011A (en) 2000-04-11 2003-04-25 Genentech Inc Multivalent antibodies and uses therefor.
JP2004522742A (en) 2000-12-08 2004-07-29 ベイラー　カレッジ　オブ　メディシン TREM-1 splice variants for use in modifying an immune response
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
US8231878B2 (en) 2001-03-20 2012-07-31 Cosmo Research & Development S.P.A. Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
CA2342376C (en) 2001-03-20 2013-11-12 Marco Colonna A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
EP1439857B1 (en) 2001-10-12 2009-02-25 Schering Corporation USE OF BISPECIFIC ANTIBODIES BINDING TO THE ACTIVATING RECEPTOR FcEpsilonRI AND TO THE INHIBITING RECEPTOR OX2Ra (CD200Ra) TO REGULATE IMMUNE RESPONSES
WO2003080667A2 (en) 2002-03-22 2003-10-02 Bioxell S.P.A. A novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
WO2003099331A1 (en) 2002-05-24 2003-12-04 Takeda Pharmaceutical Company Limited Insulin resistance improving agents
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
GB0401730D0 (en) 2004-01-27 2004-03-03 Bioxell Spa Diagnosis method
PL2314620T3 (en) 2004-05-27 2013-11-29 Crucell Holland Bv Method of identifying binding molecules capable of neutralizing rabies virus
US7700099B2 (en) 2005-02-14 2010-04-20 Merck & Co., Inc. Non-immunostimulatory antibody and compositions containing the same
US8101345B1 (en) 2005-03-25 2012-01-24 Isis Pharmaceuticals, Inc. Proinflammatory nucleic acids
KR20060135280A (en) 2005-06-24 2006-12-29 전남대학교산학협력단 A cloning of trem-2 involving innate immunity
EP1959969A2 (en) 2005-07-01 2008-08-27 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
US20070041905A1 (en) 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
DE202006007499U1 (en) 2006-05-11 2007-01-11 Osaka University Using composition that inhibits interaction between plexin-A1 and DAP-12 for treatment and prevention of inflammatory, autoimmune or bone resorption diseases
CA2654317A1 (en) 2006-06-12 2007-12-21 Trubion Pharmaceuticals, Inc. Single-chain multivalent binding proteins with effector function
CA2551163A1 (en) 2006-07-17 2008-01-17 Boehringer Ingelheim International Gmbh Methods for treating inflammatory, autoimmune or bone resorption diseases
US7553936B2 (en) 2006-12-04 2009-06-30 The United States of America as represented by Secretary Department of Health and Human Services Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions
BRPI0806680A2 (en) 2007-01-16 2015-06-16 Wyeth Corp Treatment, detection and monitoring of train-1 inflammation
GR1007327B (en) 2007-08-08 2011-06-27 Ευαγγελος Γιαμαρελλος-Μπουρμπουλης Soluble triggering receptor s-trem-1 used for activating the myeloid cells and controlling the efficiency of the peptic ulcer treatment
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
KR100960684B1 (en) 2008-02-22 2010-05-31 전남대학교산학협력단 TREM-2 gene as an inhibitor of expression of GA733-2, and transgenic animals comprising the same and uses thereof
WO2010045479A1 (en) 2008-10-15 2010-04-22 The Board Of Trustees Of The University Of Illinois Phospholipid micellar and liposomal compositions and uses thereof
CA2759978C (en) 2009-04-28 2020-06-02 Life & Brain Gmbh Method for obtaining human microglial precursor cells from pluripotent stem cells
WO2010132370A2 (en) 2009-05-11 2010-11-18 Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Soluble tlt-1 for the treatment and diagnosis of sepsis
CN102802661B (en) 2009-06-22 2016-01-13 米迪缪尼有限公司 For the engineered Fc district of site-specific conjugation
US8513185B2 (en) 2009-10-13 2013-08-20 Alexander B. Sigalov Inhibition of TREM receptor signaling with peptide variants
CN102038698A (en) 2009-10-14 2011-05-04 山东绿叶天然药物研究开发有限公司 New application of morroniside
JO3244B1 (en) * 2009-10-26 2018-03-08 Amgen Inc Human il-23 antigen binding proteins
CN102127168A (en) 2010-01-19 2011-07-20 中国人民解放军第二军医大学 Recombinant fusion protein of triggering receptor-1 expressed on myeloid cells (TREM-1) and application thereof
KR20110086460A (en) 2010-01-22 2011-07-28 한국교원대학교산학협력단 Soluble receptor library and method for screening cytokine expression-regulating gene using the same
WO2011124685A1 (en) 2010-04-08 2011-10-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof
WO2011137362A1 (en) 2010-04-30 2011-11-03 Rother Russell P Antibodies having reduced immunogenicity in a human
WO2012016333A1 (en) 2010-08-06 2012-02-09 University Health Network Biomarkers for malaria
US20130130354A1 (en) 2010-09-28 2013-05-23 CTI Salud S.A. Novel genes and uses thereof, expression profile of colon, gastric and pancreatic cancer
WO2012088302A2 (en) 2010-12-22 2012-06-28 Abbott Laboratories Half immunoglobulin binding proteins and uses thereof
US20120195900A1 (en) 2010-12-22 2012-08-02 Abbott Laboratories Tri-variable domain binding proteins and uses thereof
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
MX2013010172A (en) * 2011-03-11 2013-10-25 Amgen Inc Method of correlated mutational analysis to improve therapeutic antibodies.
KR20120112973A (en) 2011-04-04 2012-10-12 전남대학교산학협력단 A composition for preventing or treating obesity or type 2 diabetes
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
EP3418306B1 (en) 2011-10-11 2023-12-06 F. Hoffmann-La Roche AG Improved assembly of bispecific antibodies
SG11201401658SA (en) 2011-10-21 2014-07-30 Stemgenics Inc Functionalized nanoparticles for intracellular delivery of biologically active molecules
PT2773671T (en) 2011-11-04 2021-12-14 Zymeworks Inc Stable heterodimeric antibody design with mutations in the fc domain
CA2854806A1 (en) 2011-11-07 2013-05-16 Medimmune, Llc Multispecific and multivalent binding proteins and uses thereof
EP3539982A3 (en) 2011-12-23 2020-01-15 Pfizer Inc Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
CN102517287B (en) 2012-01-10 2013-09-11 广西大学 Short hairpin ribonucleic acid (shRNA) for inhibiting expression of buffalo triggering receptor expressed on myeloid cells 1 (TREM1) gene, lentiviral expression vector of shRNA and construction method and application of lentiviral expression vector
KR20130114951A (en) 2012-04-10 2013-10-21 한양대학교 산학협력단 Composition for preventing or treating th17-mediated diseases comprising poly-gamma-glutamic acid
DK2892920T3 (en) 2012-09-07 2020-06-08 Inst Nat Sante Rech Med Inhibitory Peptides Derived from Trigger Receptor Expressed on Myeloid Cells-1 (TREM-1) TRIM-LIKE TRANSCRIPT 1 (TLT-1) AND APPLICATIONS THEREOF
CA3139031A1 (en) 2012-10-04 2014-04-10 Dana-Farber Cancer Institute, Inc. Human monoclonal anti-pd-l1 antibodies and methods of use
US9890216B2 (en) 2012-10-23 2018-02-13 Board Of Regents, The University Of Texas System Antibodies with engineered IgG Fc domains
WO2014074942A1 (en) 2012-11-08 2014-05-15 Illumina, Inc. Risk variants of alzheimer's disease
US9066928B1 (en) * 2012-12-04 2015-06-30 University Of Kentucky Research Foundation Method, composition, and kit useful for treatment of alzheimer's disease
US9580486B2 (en) 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
KR20150010326A (en) 2013-07-19 2015-01-28 전남대학교산학협력단 The biarylamide product derived compounds for preventing or treating obesity or type 2 diabetes or liver steatosis
CA2825821A1 (en) 2013-08-28 2015-02-28 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of alzheimer's disease and multiple sclerosis
KR101402921B1 (en) 2013-08-28 2014-06-02 전남대학교산학협력단 Use of resveratol derivatives for treating obesity or type 2 diabetes
WO2015037000A1 (en) 2013-09-11 2015-03-19 Compugen Ltd Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
CN103555829B (en) 2013-10-12 2015-10-21 厦门人瑞生物医药科技有限公司 A kind of probe, test kit and method detecting TREM2 gene R47H and suddenly change
EP3092494A4 (en) 2014-01-06 2017-10-18 Children's Medical Center Corporation Biomarkers for dementia and dementia related neurological disorders
JOP20200096A1 (en) 2014-01-31 2017-06-16 Children’S Medical Center Corp Antibody molecules to tim-3 and uses thereof
CN103866041A (en) 2014-04-04 2014-06-18 厦门大学 Mutation detection kit for Parkinson disease and leukoaraiosis and detection method thereof
PT3129406T (en) 2014-04-11 2019-04-24 Medimmune Llc Conjugated compounds comprising cysteine-engineered antibodies
CN105218669A (en) 2014-06-10 2016-01-06 河北翰林生物科技有限公司 Prepare the method for the human monoclonal antibodies of anti-human R47H-TREM2 mutant
US20170218091A1 (en) 2014-07-03 2017-08-03 Abbvie Inc. Monovalent binding proteins
SG11201700250WA (en) 2014-07-17 2017-02-27 Novo Nordisk As Site directed mutagenesis of trem-1 antibodies for decreasing viscosity
IL279606B (en) * 2014-08-08 2022-08-01 Alector Llc Anti-trem2 antibodies and methods of use thereof
KR101756417B1 (en) 2014-08-21 2017-07-10 한국유나이티드제약 주식회사 Pharmaceutical compositions comprising gold compound for preventing or treating fibrosis or cirrhosis of the liver
IL283834B (en) 2014-09-28 2022-07-01 Univ California Modulation of stimulatory and non-stimulatory myeloid cells
WO2016064895A1 (en) 2014-10-20 2016-04-28 The Brigham And Women's Hospital, Inc. Targeting apolipoprotein e (apoe) in neurologic disease
US10081792B2 (en) 2014-12-31 2018-09-25 Wisconsin Alumni Research Foundation Derivation of human microglia from pluripotent stem cells
CA2982246A1 (en) 2015-04-17 2016-10-20 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
JP2018516901A (en) 2015-05-18 2018-06-28 シナプテック・ディヴェロップメント・エルエルシーＳｙｎａｐｔｅｃ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｌｃ Galantamine clearance of amyloid β
JP2018518491A (en) 2015-06-12 2018-07-12 アレクトル エルエルシー Anti-CD33 antibody and method of use thereof
CA2988982A1 (en) 2015-06-12 2016-12-15 Alector Llc Anti-cd33 antibodies and methods of use thereof
CA2991209C (en) 2015-07-04 2023-02-07 Emory University Use of trem-1 inhibitors for treatment, elimination and eradication of hiv-1 infection
WO2017011342A1 (en) 2015-07-10 2017-01-19 Abbvie Inc. Igm-or-ige-modified binding proteins and uses thereof
PE20231958A1 (en) 2015-07-30 2023-12-06 Macrogenics Inc BINDING MOLECULES TO PD-1 AND METHODS OF USE THEREOF
EP3341411A1 (en) 2015-08-28 2018-07-04 Alector LLC Anti-siglec-7 antibodies and methods of use thereof
WO2017058866A1 (en) 2015-09-28 2017-04-06 Precision Immune, Inc. Anti-trem2 antibodies and uses thereof
CA2997960A1 (en) * 2015-10-06 2017-04-13 Alector Llc Anti-trem2 antibodies and methods of use thereof
AU2016343987B2 (en) 2015-10-29 2023-11-23 Alector Llc Anti-Siglec-9 antibodies and methods of use thereof
US20170218058A1 (en) 2016-01-28 2017-08-03 Alector, LLC Anti-apoe4 antigen-binding proteins and methods of use thereof
EP3442543A4 (en) 2016-02-11 2020-01-22 The Johns Hopkins University Compositions and methods for neuralgenesis
WO2017147509A1 (en) 2016-02-25 2017-08-31 Marco Colonna Compositions comprising trem2 and methods of use thereof
JP7023853B2 (en) 2016-03-04 2022-02-22 アレクトル エルエルシー Anti-TREM1 antibody and its usage
US10875919B2 (en) 2016-04-26 2020-12-29 Alector Llc Chimeric receptors and methods of use thereof
WO2017191274A2 (en) 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein
WO2017210343A1 (en) 2016-06-01 2017-12-07 The University Of Virginia Patent Foundation Methods and compositions for modulating lymphatic vessels in the central nervous system
JP2019531332A (en) 2016-07-22 2019-10-31 ドイチェス ツェントルム フュール ノイロデゲネラティフェ アークランクンゲン エー．ファウ．（デーツェットエンエー） TREM2 cleavage modulator and use thereof
CN106244682B (en) 2016-07-29 2019-11-26 中山大学 TREM-2 gene is identifying pig to the application in blue ear virus susceptibility
CN106636330B (en) 2016-09-21 2017-12-15 郁金泰 The diagnosis of Alzheimer disease and medicine
CA3040687A1 (en) 2016-10-14 2018-04-19 Childrens' Medical Center Corporation Compositions and methods for treating diseases and disorders of the central nervous system
CA3044684A1 (en) 2016-12-09 2018-06-14 Alector Llc Anti-sirp-alpha antibodies and methods of use thereof
EP3558340A4 (en) 2016-12-23 2020-07-22 Genervon Biopharmaceuticals LLC Methods of using gm6 in diagnosing and treating alzheimer's disease
CN110573167A (en) 2017-01-12 2019-12-13 杜克大学 Compositions and methods for treating demyelinating diseases
WO2018134815A2 (en) 2017-01-17 2018-07-26 Yeda Research And Development Co. Ltd. Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells
US20190365830A1 (en) 2017-01-18 2019-12-05 Evelo Biosciences, Inc. Methods of treating cancer
US20190336615A1 (en) 2017-01-27 2019-11-07 Silverback Therapeutics, Inc. Tumor targeting conjugates and methods of use thereof
US10143187B2 (en) 2017-02-17 2018-12-04 Denali Therapeutics Inc. Transferrin receptor transgenic models
US20210293794A1 (en) 2017-02-24 2021-09-23 University Of Hawii Cancer Center Metabolic biomarkers for the identification and characterization of alzheimers disease
WO2018160496A1 (en) 2017-02-28 2018-09-07 The Regents Of The University Of California Differentiation and use of human microglia-like cells from pluripotent stem cells and hematopoietic progenitors
CA3057289A1 (en) 2017-03-21 2018-09-27 The Jackson Laboratory A genetically modified mouse expressing human apoe4 and mouse trem2 p.r47h and methods of use thereof
KR101936249B1 (en) 2017-04-04 2019-01-08 경희대학교 산학협력단 Composition for preventing, improving or treating cancer comprising kumatakenin
JOP20190248A1 (en) 2017-04-21 2019-10-20 Amgen Inc Trem2 antigen binding proteins and uses thereof
US20180318379A1 (en) 2017-05-01 2018-11-08 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of triggering receptor expressed on myeloid cells 1 (trem1) to treat central nervous system disorders
WO2018213316A1 (en) 2017-05-16 2018-11-22 Alector Llc Anti-siglec-5 antibodies and methods of use thereof
WO2018218090A1 (en) 2017-05-24 2018-11-29 Nanosomix, Inc. Detection of biomarkers on vesicles for the diagnosis and prognosis of diseases and disorders
JP2020522266A (en) 2017-06-05 2020-07-30 ヤンセン バイオテツク，インコーポレーテツド Engineered multispecific antibodies and other multimeric proteins with asymmetric mutations in the CH2-CH3 region
JP7356970B2 (en) 2017-06-25 2023-10-05 システィミューン， インク． Multispecific antibodies and their production and use methods
CN109206503A (en) 2017-07-07 2019-01-15 厦门大学 A kind of albumen is used to prepare the purposes of prevention and treatment Alzheimer disease drugs
US20190008812A1 (en) 2017-07-07 2019-01-10 Washington University Methods for treating microglial dysfunction
WO2019016784A1 (en) 2017-07-21 2019-01-24 Universidade De Coimbra Anti-nucleolin antibody
AU2018307877A1 (en) 2017-07-27 2020-01-02 Novartis Ag Sheddase resistant TREM2 variants
WO2019028292A1 (en) 2017-08-03 2019-02-07 Alector Llc Anti-trem2 antibodies and methods of use thereof
CN110662765B (en) 2017-08-03 2023-09-29 艾利妥 anti-CD 33 antibodies and methods of use thereof
WO2019032624A1 (en) 2017-08-08 2019-02-14 Pionyr Immunotherapeutics, Inc. Compositions and methods for disabling meyloid cells expressing trem1
JP7403441B2 (en) 2017-09-14 2023-12-22 デナリ セラピューティクス インコーポレイテッド Anti-TREM2 antibody and method of use thereof
US20200309788A1 (en) 2017-09-29 2020-10-01 The General Hospital Corporation Methods for identifying and treating adrenomyeloneuropathy (amn)
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
EP3692158A4 (en) 2017-10-03 2021-08-04 Prevail Therapeutics, Inc. Gene therapies for lysosomal disorders
WO2019079529A1 (en) 2017-10-17 2019-04-25 The Translational Genomics Research Institute Trem2 agonists for the stimulation of microglia and methods of identification
US10597462B1 (en) 2017-11-08 2020-03-24 University Of Puerto Rico Anti-TLT-1 antibody and uses thereof
JP2021502977A (en) 2017-11-15 2021-02-04 ユニバルシテ ラバル Use of SRSF3 agonists for the treatment and / or prevention of neurological conditions, cancer, bacterial or viral infections
CN109837330A (en) 2017-11-28 2019-06-04 上海中优精准医疗科技股份有限公司 A kind of probe and method detecting TREM2 gene pleiomorphism
BR112020011833A2 (en) 2017-12-12 2020-11-24 Pionyr Immunotherapeutics, Inc. anti-trem2 antibodies and related methods
US11470827B2 (en) 2017-12-12 2022-10-18 Alector Llc Transgenic mice expressing human TREM proteins and methods of use thereof
US11472874B2 (en) 2018-01-31 2022-10-18 Alector Llc Anti-MS4A4A antibodies and methods of use thereof
CN111971397A (en) 2018-02-14 2020-11-20 耶鲁大学 Compositions for modulating TREM or TREML proteins and methods of use thereof
NL2020520B1 (en) 2018-03-02 2019-09-12 Labo Bio Medical Invest B V Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
US20210000807A1 (en) 2018-03-22 2021-01-07 Nsc Therapeutics Gmbh Compounds and methods for use in the treatment of microglia-mediated disorders
KR20200139219A (en) 2018-04-02 2020-12-11 브리스톨-마이어스 스큅 컴퍼니 Anti-TREM-1 antibodies and uses thereof
US20210059977A1 (en) 2018-04-09 2021-03-04 The General Hospital Corporation Combination therapies for the treatment of amyotrophic lateral sclerosis and related disorders
CN112218893A (en) 2018-05-25 2021-01-12 艾利妥 anti-SIRPA antibodies and methods of use thereof
WO2019236965A1 (en) 2018-06-08 2019-12-12 Alector Llc Anti-siglec-7 antibodies and methods of use thereof
CN108752482B (en) 2018-06-12 2019-04-30 南京卡提医学科技有限公司 Carry the Chimeric antigen receptor and its application of truncation or not truncated myeloid cell triggering property receptor signal structure
WO2019246483A1 (en) 2018-06-21 2019-12-26 The Jackson Laboratory Genetically modified mouse models of alzheimer's disease
AU2019293589A1 (en) 2018-06-29 2021-01-21 Alector Llc Anti-SIRP-beta1 antibodies and methods of use thereof
EP3820520A4 (en) 2018-07-12 2022-05-11 Corvus Pharmaceuticals, Inc. Methods for detecting and treating cancers having adenosine pathway activation
US11278575B2 (en) 2018-07-12 2022-03-22 Duke University Compositions and methods for the treatment of demyelinating conditions
US20210311076A1 (en) 2018-07-16 2021-10-07 University Of Virginia Patent Foundation Compositions and methods of diagnosis and treatment for neurological diseases
CN109112214A (en) 2018-07-27 2019-01-01 复旦大学附属中山医院 Application of the pattern recognition receptors TREM2 in prognosis in hcc and treatment
EA202190183A1 (en) 2018-07-27 2021-05-18 Алектор Ллс ANTIBODIES TO SIGLEC-5 AND METHODS OF THEIR APPLICATION
EA202190235A1 (en) 2018-08-31 2021-07-02 Алектор Ллс ANTIBODIES TO CD33 AND METHODS OF THEIR APPLICATION
WO2020051322A1 (en) 2018-09-05 2020-03-12 The General Hospital Corporation Methods of treating cytokine release syndrome
JP2022500081A (en) 2018-09-11 2022-01-04 ワシントン・ユニバーシティWashington University Anti-TREM-2 agonist antibody
WO2020056114A1 (en) 2018-09-12 2020-03-19 Board Of Regents Of The University Of Nebraska Antimicrobial compositions and methods
JP2022513324A (en) 2018-09-28 2022-02-07 イノトレム Use of soluble TREM-1 levels to identify subjects who are more responsive to anti-inflammatory therapy
UY38407A (en) 2018-10-15 2020-05-29 Novartis Ag TREM2 STABILIZING ANTIBODIES
KR102096282B1 (en) 2018-10-15 2020-04-02 재단법인대구경북과학기술원 Method for effective purification of human TREM2 proteins using recombinant baculovirus
KR102156165B1 (en) 2018-10-29 2020-09-15 재단법인대구경북과학기술원 Monoclonal antibody with specificity for human TREM2 protein, hybridoma cell line producing the same and use thereof
CN111135185A (en) 2018-11-02 2020-05-12 杭州星鳌生物科技有限公司 Natural immune activation through regulating medullary cell triggering receptor TREM2 to inhibit chronic inflammation of cerebral nerve
US20220127373A1 (en) 2018-11-08 2022-04-28 The Regents Of The University Of California Systems and methods for targeting cancer cells
CN113302206A (en) 2018-11-26 2021-08-24 戴纳立制药公司 Methods of treating lipid metabolism disorders
WO2020121195A1 (en) 2018-12-10 2020-06-18 Mor Research Applications Trem2 antibodies and uses thereof
AR117453A1 (en) 2018-12-20 2021-08-04 Genentech Inc CF OF MODIFIED ANTIBODIES AND METHODS TO USE THEM
WO2020142659A2 (en) 2019-01-04 2020-07-09 Trio Pharmaceuticals, Inc. Multi-specific protein molecules and uses thereof
CN109646668B (en) 2019-01-04 2019-10-18 厦门大学 A kind of polypeptide is used to prepare the purposes of prevention and treatment Alzheimer disease drugs
US20220119532A1 (en) 2019-01-14 2022-04-21 University Of Virginia Patent Foundation Use of integrin inhibitors for treatment or prevention of a neurological immunity disorder and/or nervous system injury
US20220104468A1 (en) 2019-01-22 2022-04-07 St. Jude Children's Research Hospital Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration
US20220099659A1 (en) 2019-01-23 2022-03-31 The Regents Of The University Of California Human Genomic Construct Reporter Cells and Mouse Models to Screen Therapeutics against Microglia-expressed Disease Associated Genes
US20220133808A1 (en) 2019-02-01 2022-05-05 Avrobio, Inc. Compositions and methods for treating neurocognitive disorders
EP3917623A4 (en) 2019-02-01 2022-10-19 Avrobio, Inc. Compositions and methods for treating neurocognitive disorders
AU2020214807A1 (en) 2019-02-01 2021-08-05 Seattle Children's Hospital (dba Seattle Children's Research Institute) Microenvironment sensors to regulate engineered gene expression
SG11202108734VA (en) 2019-02-20 2021-09-29 Denali Therapeutics Inc Anti-trem2 antibodies and methods of use thereof
WO2020194317A1 (en) 2019-03-28 2020-10-01 Yeda Research And Development Co. Ltd. Method of treating lipid-related disorders
CN110320368A (en) 2019-05-30 2019-10-11 广州医科大学附属第一医院（广州呼吸中心） Diagnostic kit based on TREM2 and its application on diagnosis of Parkinson disease product
CN110241208A (en) 2019-08-02 2019-09-17 辽宁中医药大学 Application of the TREM2 as the molecular marker of early diagnosis coronary heart disease
CN110511240B (en) 2019-08-27 2022-03-08 南京医科大学 Endogenous ligand of myeloid cell trigger receptor 2 and application thereof
CN110882262A (en) 2019-11-06 2020-03-17 南京医科大学 Medicine for activating marrow cell trigger receptor 2 and application thereof
BR112022007944A2 (en) 2019-11-22 2022-07-12 Lilly Co Eli TREM2 ANTIBODIES AND USES THEREOF
KR20220110537A (en) 2019-12-05 2022-08-08 알렉터 엘엘씨 How to Use Anti-TREM2 Antibodies
CN111184742B (en) 2020-02-13 2022-06-24 中山大学附属第五医院 Application of TREM-2+ T cells in preparation of drugs for treating tuberculosis

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