SG11201907278VA - Anti-tigit antibodies - Google Patents
Anti-tigit antibodiesInfo
- Publication number
- SG11201907278VA SG11201907278VA SG11201907278VA SG11201907278VA SG11201907278VA SG 11201907278V A SG11201907278V A SG 11201907278VA SG 11201907278V A SG11201907278V A SG 11201907278VA SG 11201907278V A SG11201907278V A SG 11201907278VA SG 11201907278V A SG11201907278V A SG 11201907278VA
- Authority
- SG
- Singapore
- Prior art keywords
- tigit
- international
- suite
- seattle
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
Abstract
human TIGIT cell line 8 .;.- V ,7 5'.# - .74. 5 “ijL, 5 293-cyno TIGIT cell line 293-mouse TIGIT cell line (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT 0111111010 0111 °nolo omioonmonmwo oimIE (10) International Publication Number WO 2018/160704 Al (51) International Patent Classification: A61K 39/00 (2006.01) A61P 35/00 (2006.01) A61K 39/395 (2006.01) CO7K 14/47 (2006.01) (21) International Application Number: PCT/US2018/020239 (22) International Filing Date: 28 February 2018 (28.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/464,529 28 February 2017 (28.02.2017) US 62/616,779 12 January 2018 (12.01.2018) US (71) Applicant: ADIMAB LLC [US/US]; 7 Lucent Drive, Lebanon, New Hampshire 03766 (US). (72) Inventors: PIASECKI, Julia C.; 2601 Fourth Avenue, Suite 500, Seattle, Washington 98121 (US). BEERS, Courtney; 2601 Fourth Avenue, Suite 500, Seattle, Wash- ington 98121 (US). PETERSON, Scott; 2601 Fourth Av- enue, Suite 500, Seattle, Washington 98121 (US). PRINZ, Bianka; c/o Adimab LLC, 7 Lucent Drive, Lebanon, New Hampshire 03766 (US). (74) Agent: FLANAGAN, Lisa Dornbach et al.; Kilpatrick Townsend & Stockton LLP, Mailstop: IP Docketing - 22, 1100 Peachtree Street, Suite 2800, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (54) Title: ANTI-TIGIT ANTIBODIES FIG. 1-1 71' N 1-1 (57) : Isolated antibodies or antigen-binding portions that bind to human TIGIT (T- cell immunoreceptor with Ig and ITIM domains) are provided. In some embodiments, the antibody or antigen-binding portion thereof has a binding affinity (KD) for human TIGIT of less than 5 nM. In some embodiments, the anti-TIGIT antibody blocks binding of CD 155 and/or CD112 to TIGIT. O [Continued on next page] WO 2018/160704 Al MIDEDIMOMOIDEIREEMOMOHINIMIIMEMOVH TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762464529P | 2017-02-28 | 2017-02-28 | |
US201862616779P | 2018-01-12 | 2018-01-12 | |
PCT/US2018/020239 WO2018160704A1 (en) | 2017-02-28 | 2018-02-28 | Anti-tigit antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201907278VA true SG11201907278VA (en) | 2019-09-27 |
Family
ID=63370305
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202103227YA SG10202103227YA (en) | 2017-02-28 | 2018-02-28 | Anti-tigit antibodies |
SG11201907278VA SG11201907278VA (en) | 2017-02-28 | 2018-02-28 | Anti-tigit antibodies |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202103227YA SG10202103227YA (en) | 2017-02-28 | 2018-02-28 | Anti-tigit antibodies |
Country Status (13)
Country | Link |
---|---|
US (3) | US20200040082A1 (en) |
EP (1) | EP3589313A4 (en) |
JP (3) | JP2020510422A (en) |
KR (1) | KR20190123749A (en) |
CN (1) | CN111050788A (en) |
AU (2) | AU2018227489B2 (en) |
BR (1) | BR112019017550A2 (en) |
CA (1) | CA3053486A1 (en) |
IL (1) | IL268517A (en) |
MA (1) | MA47694A (en) |
MX (2) | MX2019010206A (en) |
SG (2) | SG10202103227YA (en) |
WO (1) | WO2018160704A1 (en) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101855381B1 (en) | 2008-04-09 | 2018-05-09 | 제넨테크, 인크. | Novel compositions and methods for the treatment of immune related diseases |
MA40835A (en) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | ANTI-GPIIB / IIIA ANTIBODIES AND THEIR USES |
MA40861A (en) * | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | ANTI-GLYCOPROTEIN IIB / IIIA ANTIBODIES |
EP3548071A4 (en) | 2016-11-30 | 2020-07-15 | OncoMed Pharmaceuticals, Inc. | Methods for treatment of cancer comprising tigit-binding agents |
MA50957A (en) | 2017-05-01 | 2020-10-14 | Agenus Inc | ANTI-TIGIT ANTIBODIES AND THEIR METHODS OF USE |
EP3719040A1 (en) * | 2017-07-27 | 2020-10-07 | iTeos Therapeutics SA | Anti-tigit antibodies |
MA53434A (en) * | 2018-08-23 | 2021-12-01 | Seagen Inc | ANTI-TIGIT ANTIBODIES |
EP3849558B1 (en) | 2018-09-11 | 2024-06-05 | iTeos Belgium SA | Thiocarbamate derivatives as a2a inhibitors, pharmaceutical composition thereof and combinations with anticancer agents |
US11376255B2 (en) | 2018-09-11 | 2022-07-05 | iTeos Belgium SA | Thiocarbamate derivatives as A2A inhibitors, pharmaceutical composition thereof and combinations with anticancer agents |
JP2022514702A (en) | 2018-12-21 | 2022-02-14 | オーエスイー・イミュノセラピューティクス | Bifunctional anti-PD-1 / IL-7 molecule |
WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
EP3985025A4 (en) * | 2019-06-13 | 2023-09-13 | Green Cross Corporation | Antibody to tigit and use thereof |
WO2020257760A1 (en) * | 2019-06-21 | 2020-12-24 | Single Cell Technology, Inc. | Anti-tigit antibodies |
IL292757A (en) * | 2019-11-05 | 2022-07-01 | Merck Patent Gmbh | Anti-tigit antibodies and uses thereof |
TW202136287A (en) | 2019-12-17 | 2021-10-01 | 法商Ose免疫治療公司 | Bifunctional molecules comprising an il-7 variant |
CN112409450B (en) * | 2020-03-29 | 2023-01-24 | 郑州大学 | Affinity agent of TIGIT-IgV and application thereof |
CN113563470B (en) * | 2020-04-29 | 2023-02-10 | 广州昂科免疫生物技术有限公司 | Antibody combined with TIGIT antigen and preparation method and application thereof |
CA3176497A1 (en) | 2020-05-07 | 2021-11-11 | Fatima MECHTA-GRIGORIOU | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
US11820824B2 (en) | 2020-06-02 | 2023-11-21 | Arcus Biosciences, Inc. | Antibodies to TIGIT |
AU2021293507A1 (en) | 2020-06-18 | 2023-02-02 | F. Hoffmann-La Roche Ag | Treatment with anti-TIGIT antibodies and PD-1 axis binding antagonists |
WO2021258337A1 (en) * | 2020-06-24 | 2021-12-30 | Huahui Health Ltd. | Human monoclonal antibodies against tigit for immune related diseases |
CN111718415B (en) * | 2020-07-03 | 2021-02-23 | 上海洛启生物医药技术有限公司 | anti-TIGIT nano antibody and application thereof |
TW202216778A (en) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Tigit and cd112r blockade |
EP4192883A1 (en) * | 2020-08-05 | 2023-06-14 | Crystal Bioscience Inc. | Anti-tigit antibody and methods of use thereof |
US20230365709A1 (en) | 2020-10-08 | 2023-11-16 | Affimed Gmbh | Trispecific binders |
WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
WO2022148781A1 (en) | 2021-01-05 | 2022-07-14 | Institut Curie | Combination of mcoln activators and immune checkpoint inhibitors |
US20240141436A1 (en) | 2021-02-17 | 2024-05-02 | iTeos Belgium SA | Compounds, Compositions and Methods of Treatment Thereof |
EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
AU2022253351A1 (en) | 2021-04-09 | 2023-10-12 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
TW202304965A (en) | 2021-05-04 | 2023-02-01 | 美商艾吉納斯公司 | Anti-tigit antibodies, anti-cd96 antibodies, and methods of use thereof |
WO2023010094A2 (en) | 2021-07-28 | 2023-02-02 | Genentech, Inc. | Methods and compositions for treating cancer |
AU2022320948A1 (en) | 2021-07-30 | 2024-01-18 | Affimed Gmbh | Duplexbodies |
WO2023056403A1 (en) | 2021-09-30 | 2023-04-06 | Genentech, Inc. | Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists |
WO2023215719A1 (en) | 2022-05-02 | 2023-11-09 | Arcus Biosciences, Inc. | Anti-tigit antibodies and uses of the same |
WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220042248A (en) * | 2013-07-16 | 2022-04-04 | 제넨테크, 인크. | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
WO2015073682A1 (en) * | 2013-11-13 | 2015-05-21 | Oregon Health And Science University | Methods of detecting cells latently infected with hiv |
CN110256558B (en) * | 2014-12-23 | 2023-07-04 | 百时美施贵宝公司 | Antibodies to TIGIT |
TWI715587B (en) * | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit-binding agents and uses thereof |
CA2994555A1 (en) * | 2015-08-14 | 2017-02-23 | Merck Sharp & Dohme Corp. | Anti-tigit antibodies |
KR102279524B1 (en) * | 2015-09-25 | 2021-07-20 | 제넨테크, 인크. | Anti-TIGIT antibodies and methods of use thereof |
-
2018
- 2018-02-28 CN CN201880027323.6A patent/CN111050788A/en active Pending
- 2018-02-28 SG SG10202103227YA patent/SG10202103227YA/en unknown
- 2018-02-28 KR KR1020197027438A patent/KR20190123749A/en not_active Application Discontinuation
- 2018-02-28 MX MX2019010206A patent/MX2019010206A/en unknown
- 2018-02-28 WO PCT/US2018/020239 patent/WO2018160704A1/en active Search and Examination
- 2018-02-28 MA MA047694A patent/MA47694A/en unknown
- 2018-02-28 BR BR112019017550A patent/BR112019017550A2/en unknown
- 2018-02-28 AU AU2018227489A patent/AU2018227489B2/en active Active
- 2018-02-28 JP JP2019546327A patent/JP2020510422A/en not_active Withdrawn
- 2018-02-28 SG SG11201907278VA patent/SG11201907278VA/en unknown
- 2018-02-28 EP EP18760515.9A patent/EP3589313A4/en active Pending
- 2018-02-28 CA CA3053486A patent/CA3053486A1/en active Pending
-
2019
- 2019-08-05 IL IL268517A patent/IL268517A/en unknown
- 2019-08-15 US US16/541,575 patent/US20200040082A1/en not_active Abandoned
- 2019-08-27 MX MX2023006212A patent/MX2023006212A/en unknown
-
2020
- 2020-10-28 US US17/082,586 patent/US20210269527A1/en not_active Abandoned
-
2022
- 2022-06-29 US US17/853,134 patent/US20230134375A1/en not_active Abandoned
- 2022-07-26 JP JP2022118823A patent/JP2022141910A/en active Pending
-
2024
- 2024-01-10 AU AU2024200157A patent/AU2024200157A1/en active Pending
- 2024-02-26 JP JP2024026609A patent/JP2024057038A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2018160704A9 (en) | 2019-10-17 |
BR112019017550A2 (en) | 2020-04-14 |
AU2024200157A1 (en) | 2024-01-25 |
JP2024057038A (en) | 2024-04-23 |
KR20190123749A (en) | 2019-11-01 |
CA3053486A1 (en) | 2018-09-07 |
US20200040082A1 (en) | 2020-02-06 |
AU2018227489A1 (en) | 2019-08-22 |
US20210269527A1 (en) | 2021-09-02 |
WO2018160704A1 (en) | 2018-09-07 |
MA47694A (en) | 2021-05-19 |
MX2019010206A (en) | 2019-12-11 |
MX2023006212A (en) | 2023-06-09 |
IL268517A (en) | 2019-09-26 |
JP2020510422A (en) | 2020-04-09 |
SG10202103227YA (en) | 2021-04-29 |
US20230134375A1 (en) | 2023-05-04 |
AU2018227489B2 (en) | 2023-10-19 |
JP2022141910A (en) | 2022-09-29 |
CN111050788A (en) | 2020-04-21 |
EP3589313A4 (en) | 2021-05-19 |
EP3589313A1 (en) | 2020-01-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201907278VA (en) | Anti-tigit antibodies | |
SG11201901126UA (en) | Combination therapy for cancer | |
SG11201810933QA (en) | Anti-c5 antibodies and uses thereof | |
SG11201907299XA (en) | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer | |
SG11202000073XA (en) | Anti-cd8 antibodies and uses thereof | |
SG11201907753TA (en) | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof | |
SG11201807279QA (en) | Binding proteins and methods of use thereof | |
SG11201908238SA (en) | Anti-c5 antibodies and uses thereof | |
SG11201905699XA (en) | Anti-icos agonist antibodies and uses thereof | |
SG11201907855QA (en) | Multispecific binding proteins targeting caix, ano1, mesothelin,trop2, cea, or claudin-18.2 | |
SG11201900815UA (en) | Expression of pten-long with ocolytic viruses | |
SG11201805709RA (en) | Anti-pro/latent myostatin antibodies and methods of use thereof | |
SG11201808979UA (en) | Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof | |
SG11201908056QA (en) | Anti-par2 antibodies and uses thereof | |
SG11201806496SA (en) | Antigen binding proteins that bind pd-l1 | |
SG11201900201YA (en) | Methods for quantitating individual antibodies from a mixture | |
SG11201805420SA (en) | Antibodies and conjugates thereof | |
SG11201903771XA (en) | Binding molecules specific for asct2 and uses thereof | |
SG11201810927QA (en) | Pd-l1-specific antibodies and methods of using the same | |
SG11201803703UA (en) | Anti-complement factor c1q fab fragments and uses thereof | |
SG11201805828YA (en) | Method of treating c3 glomerulopathy | |
SG11201908678XA (en) | Methods and compositions for reduction of immunogenicity | |
SG11201804673WA (en) | Novel anti-claudin antibodies and methods of use | |
SG11201907646YA (en) | Proteins binding her2, nkg2d and cd16 | |
SG11201809620UA (en) | The contorsbody - a single chain target binder |