SG11201907095UA - DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS - Google Patents
DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTSInfo
- Publication number
- SG11201907095UA SG11201907095UA SG11201907095UA SG11201907095UA SG11201907095UA SG 11201907095U A SG11201907095U A SG 11201907095UA SG 11201907095U A SG11201907095U A SG 11201907095UA SG 11201907095U A SG11201907095U A SG 11201907095UA SG 11201907095U A SG11201907095U A SG 11201907095UA
- Authority
- SG
- Singapore
- Prior art keywords
- imidazo
- heterocycloalkyl
- pyrimidin
- cycloalkyl
- pyridine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017900290A AU2017900290A0 (en) | 2017-02-01 | Pyrimidin-2-amine derivatives as therapeutic compounds | |
| PCT/AU2018/000011 WO2018141002A2 (en) | 2017-02-01 | 2018-02-01 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201907095UA true SG11201907095UA (en) | 2019-08-27 |
Family
ID=63039275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201907095UA SG11201907095UA (en) | 2017-02-01 | 2018-02-01 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11111245B2 (en) |
| EP (1) | EP3577116A4 (en) |
| JP (1) | JP7113528B2 (en) |
| CN (1) | CN110418789B (en) |
| AU (1) | AU2018214431B2 (en) |
| CA (1) | CA3051604A1 (en) |
| SG (1) | SG11201907095UA (en) |
| WO (1) | WO2018141002A2 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200143376A (en) | 2018-03-13 | 2020-12-23 | 샤이어 휴먼 지네틱 테라피즈 인크. | Substituted imidazopyridines and uses thereof as plasma kallikrein inhibitors |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| CN111362852B (en) * | 2018-12-25 | 2023-06-16 | 浙江瑞博制药有限公司 | Preparation method of medicine intermediate 1-tert-butoxycarbonyl-3-azetidinone |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| US11472791B2 (en) | 2019-03-05 | 2022-10-18 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| WO2021003517A1 (en) * | 2019-07-10 | 2021-01-14 | Aucentra Therapeutics Pty Ltd | Derivatives of 4-(imidazo[l,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin- 2-amine as therapeutic agents |
| AR119765A1 (en) | 2019-08-14 | 2022-01-12 | Incyte Corp | IMIDAZOLIL PYRIMIDINILAMINE COMPOUNDS AS CDK2 INHIBITORS |
| EP4031245A1 (en) | 2019-09-18 | 2022-07-27 | Takeda Pharmaceutical Company Limited | Heteroaryl plasma kallikrein inhibitors |
| JP2022548696A (en) | 2019-09-18 | 2022-11-21 | 武田薬品工業株式会社 | Plasma kallikrein inhibitors and uses thereof |
| WO2021072232A1 (en) | 2019-10-11 | 2021-04-15 | Incyte Corporation | Bicyclic amines as cdk2 inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE69720965T2 (en) | 1996-02-13 | 2004-02-05 | Astrazeneca Ab | CHINAZOLE DERIVATIVES AND THEIR USE AS VEGF INHIBITORS |
| WO1997032856A1 (en) | 1996-03-05 | 1997-09-12 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| TR200500745T2 (en) | 1999-02-10 | 2005-05-23 | Astrazeneca Ab | Quinazoline derivatives as inhibitors of vascular development. |
| KR20030013433A (en) | 2000-05-31 | 2003-02-14 | 아스트라제네카 아베 | Indole derivatives with vascular damaging activity |
| UA73993C2 (en) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Quinazoline derivatives for the treatment of tumours and a pharmaceutical composition |
| CA2411160A1 (en) | 2000-07-07 | 2002-01-17 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
| JP2004504391A (en) | 2000-07-07 | 2004-02-12 | アンギオジェン・ファーマシューティカルズ・リミテッド | Corkinol derivatives as angiogenesis inhibitors |
| PL366827A1 (en) | 2001-06-21 | 2005-02-07 | Smithkline Beecham Corporation | Imidazo[1,2-a]pyridine derivatives for the prophylaxis and treatment of herpes viral infections |
| US7196095B2 (en) * | 2001-06-25 | 2007-03-27 | Merck & Co., Inc. | (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds |
| WO2003031446A1 (en) * | 2001-10-05 | 2003-04-17 | Smithkline Beecham Corporation | Imidazo-pyridine derivatives for use in the treatment of herpes viral infection |
| UA80296C2 (en) * | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
| WO2006038001A1 (en) * | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Aminopyrimidine derivatives as jnk inhibitors |
| US7855205B2 (en) * | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| CN101437602B (en) * | 2004-10-29 | 2011-04-06 | 特瑞克股份有限公司 | Ion balance monitor |
| US8124764B2 (en) | 2008-07-14 | 2012-02-28 | Gilead Sciences, Inc. | Fused heterocyclyc inhibitor compounds |
| TW201022262A (en) | 2008-10-29 | 2010-06-16 | Astrazeneca Ab | Novel compounds 515 |
| CN102325771B (en) * | 2009-02-24 | 2014-10-29 | 霍夫曼-拉罗奇有限公司 | Imidazo [1, 2 -a] pyridines as jnk modulators |
| JP2013527214A (en) * | 2010-06-04 | 2013-06-27 | エフ．ホフマン−ラ ロシュ アーゲー | JNK inhibitor |
| WO2012066065A1 (en) * | 2010-11-17 | 2012-05-24 | Novartis Ag | Phenyl-heteroaryl amine compounds and their uses |
| PL3126352T3 (en) * | 2014-04-04 | 2019-04-30 | Syros Pharmaceuticals Inc | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| JP6842458B2 (en) | 2015-08-04 | 2021-03-17 | オーセントラ セラピュティクス ピーティーワイ エルティーディーＡｕｃｅｎｔｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｐｔｙ Ｌｔｄ | N- (pyridin-2-yl) -4- (thiazole-5-yl) pyrimidine-2-amine derivative as a therapeutic compound |
-
2018
- 2018-02-01 CA CA3051604A patent/CA3051604A1/en active Pending
- 2018-02-01 US US16/482,867 patent/US11111245B2/en active Active
- 2018-02-01 EP EP18748523.0A patent/EP3577116A4/en active Pending
- 2018-02-01 SG SG11201907095UA patent/SG11201907095UA/en unknown
- 2018-02-01 AU AU2018214431A patent/AU2018214431B2/en active Active
- 2018-02-01 JP JP2019541271A patent/JP7113528B2/en active Active
- 2018-02-01 CN CN201880015860.9A patent/CN110418789B/en active Active
- 2018-02-01 WO PCT/AU2018/000011 patent/WO2018141002A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018141002A3 (en) | 2018-11-22 |
| US11111245B2 (en) | 2021-09-07 |
| US20200231586A1 (en) | 2020-07-23 |
| EP3577116A4 (en) | 2020-12-02 |
| JP2020505419A (en) | 2020-02-20 |
| CN110418789B (en) | 2022-03-25 |
| JP7113528B2 (en) | 2022-08-05 |
| EP3577116A2 (en) | 2019-12-11 |
| CA3051604A1 (en) | 2018-08-09 |
| WO2018141002A2 (en) | 2018-08-09 |
| AU2018214431B2 (en) | 2021-07-29 |
| AU2018214431A1 (en) | 2019-08-29 |
| CN110418789A (en) | 2019-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201907095UA (en) | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS | |
| PH12015502780B1 (en) | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | |
| MX2016015762A (en) | Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain. | |
| SG10201810660QA (en) | Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain | |
| ZA201701214B (en) | Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication | |
| PT3500571T (en) | Imidazo[1,2-a]pyridin compounds, compositions comprising them, methods for treating diseases using them, and methods for preparing them | |
| FI3697784T5 (en) | Imidazo[4,5-b]pyridine compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders | |
| ZA202003514B (en) | Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines | |
| IL275293B2 (en) | Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines | |
| IL272988A (en) | Imidazo[1,5-a]pyrazine derivatives as pi3kdelta inhibitors | |
| PH12017500342A1 (en) | 7 - (morpholinyl) -2- (n-piperazinyl) methyl thieno [2,3-c] pyridine derivatives as anticancer drugs | |
| PT3277687T (en) | 7-(morpholin-4-yl)pyrazole[1,5-a]pyrimidine derivatives which are useful for the treatment of immune or inflammatory diseases or cancer | |
| EP3727379A4 (en) | Salts of pyrazolo[1,5-a]pyridine derivative and use thereof |