SG11201810765PA - Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same - Google Patents

Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same

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Publication number
SG11201810765PA
SG11201810765PA SG11201810765PA SG11201810765PA SG11201810765PA SG 11201810765P A SG11201810765P A SG 11201810765PA SG 11201810765P A SG11201810765P A SG 11201810765PA SG 11201810765P A SG11201810765P A SG 11201810765PA SG 11201810765P A SG11201810765P A SG 11201810765PA
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Singapore
Prior art keywords
fatty acid
bhb
california
international
acid esters
Prior art date
Application number
SG11201810765PA
Inventor
Eric Verdin
Scott Ulrich
John Newman
Original Assignee
The J David Gladstone Inst
Univ California
Ithaca College
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Publication date
Application filed by The J David Gladstone Inst, Univ California, Ithaca College filed Critical The J David Gladstone Inst
Publication of SG11201810765PA publication Critical patent/SG11201810765PA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
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    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/003—Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
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Abstract

CBHB Q.41 millimoles 04. C6-BHB 0.21 C8-BHB 0.35 rniiiirnoles C8-BHB 0.18 millimales BHB 025 miltimoles 4- Fasting (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 December 2017 (14.12.2017) WIP0 I PCT 0111111010 0111 inn Holm nacnum (10) International Publication Number WO 2017/213999 Al (51) International Patent Classification: G02F 1/1368 (2006.01) G02F 1/13363 (2006.01) G02B 1/08 (2006.01) G02F 1/1335 (2006.01) G02B 5/30 (2006.01) (21) International Application Number: PCT/US2017/035826 (22) International Filing Date: 02 June 2017 (02.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/346,975 07 June 2016 (07.06.2016) US (71) Applicants: THE J. DAVID GLADSTONE INSTI- TUTES [US/US]; 1650 Owens Street, San Francis- co, California 94158 (US). THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor, Oakland, California 94607 (US). ITHACA COLLEGE [US/US]; 953 Danby Road, Ithaca, New York 14850 (US). (72) Inventors: VERDIN, Eric; 141 Tamalpais Avenue, Mill Valley, California 94941 (US). ULRICH, Scott; 649 Val- ley Rd., Brooktondate, New York 14817 (US). NEWMAN, John; 545 Burnett Ave., Apt 102, San Francisco, California 94131 (US). (74) Agent: RUBIN, Michael B.; Bozicevic, Field & Francis LLP, 201 Redwood Shores Parkway, Suite 200, Redwood City, California 94065 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (54) Title: MEDIUM CHAIN FATTY ACID ESTERS OF BETA-HYDROXYBUTYRATE AND BUTANEDIOL AND COM- POSITIONS AND METHODS FOR USING SAME BHB vs BHB-esters alter injection Figure 6c (57) : Aspects of the present disclosure include fatty acid [3-hydroxyester compounds (e.g., fatty acid esters of (3-hydroxybu- tyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid [3-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described. [Continued on next page] WO 2017/213999 Al MIDEDIMOMOIMIRMEM0011010CMCHIMINHOIS SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
SG11201810765PA 2016-06-07 2017-06-02 Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same SG11201810765PA (en)

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US201662346975P 2016-06-07 2016-06-07
PCT/US2017/035826 WO2017213999A1 (en) 2016-06-07 2017-06-02 Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same

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KR (2) KR102519244B1 (en)
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BR112020001285A2 (en) 2017-07-21 2020-07-28 Buck Institute For Research On Aging beta-hydroxybutyrate and butanediol s-enantiomers and methods for their use
WO2019161047A1 (en) * 2018-02-14 2019-08-22 Bickman Benjamin Oral supplements of fatty acid and amino acid ketone esters to improve metabolic, physical and cognitive health
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BR112021014015A2 (en) * 2019-01-17 2021-09-21 Ioi Oleo Gmbh METHOD FOR THE PRODUCTION OF FATTY ALCOHOL ESTERS OF HYDROXYCARBOXYLIC ACIDS
JP7361124B2 (en) * 2019-01-17 2023-10-13 ケトリピックス セラポーティクス ゲーエムベーハー Method for producing capped 3-hydroxycarboxylic acids and their salts and esters
CN110372502A (en) * 2019-07-25 2019-10-25 润泰化学（泰兴）有限公司 A kind of double esterification synthetic method of 1,3- glycol
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CN116917264A (en) * 2020-07-13 2023-10-20 凯托利皮克斯治疗有限责任公司 Process for preparing hydroxybutyric acid carboxylic ester
CN112341542B (en) * 2021-01-08 2021-05-14 清华大学 3-hydroxybutyrylated modified protein medicine and preparation method and application thereof
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