SG11201810455XA - Methods for making ultrasound contrast agents - Google Patents
Methods for making ultrasound contrast agentsInfo
- Publication number
- SG11201810455XA SG11201810455XA SG11201810455XA SG11201810455XA SG11201810455XA SG 11201810455X A SG11201810455X A SG 11201810455XA SG 11201810455X A SG11201810455X A SG 11201810455XA SG 11201810455X A SG11201810455X A SG 11201810455XA SG 11201810455X A SG11201810455X A SG 11201810455XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- dppc
- road
- pct
- dppe
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002961 echo contrast media Substances 0.000 title abstract 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 abstract 4
- QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003904 phospholipids Chemical class 0.000 abstract 2
- SORGEQQSQGNZFI-UHFFFAOYSA-N [azido(phenoxy)phosphoryl]oxybenzene Chemical compound C=1C=CC=CC=1OP(=O)(N=[N+]=[N-])OC1=CC=CC=C1 SORGEQQSQGNZFI-UHFFFAOYSA-N 0.000 abstract 1
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicinal Preparation (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111 11111 0 11101 010 11111 01 10001101 110111111 100 HO 110 11110 HOED Organization International Bureau (10) International Publication Number (43) International Publication Date .....0 WO 2018/009570 Al 11 January 2018 (11.01.2018) W I PO I PCT (51) International Patent Classification: Charles, Chester [US/US]; 116 Essex Street, Beverly, MA A61K 49/22 (2006.01) 01915 (US). (21) International Application Number: (74) Agent: TREVISAN, Maria, A.; Wolf, Greenfield & Sacks, PCT/US2017/040755 P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 05 July 2017 (05.07.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (30) Priority Data: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 62/359,181 06 July 2016 (06.07.2016) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 15/461,469 16 March 2017 (16.03.2017) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 15/602,580 23 May 2017 (23.05.2017) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicant: LANTHEUS MEDICAL IMAGING, INC. TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [US/US]; 331 Treble Cove Road, North Billerica, MA (84) Designated States (unless otherwise indicated, for every 01862 (US). kind of regional protection available): ARIPO (BW, GH, (72) Inventors; and GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicants: ROBINSON, Simon, P. [GB/US]; 22 Kettell UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, _ Plain Road, Stow, MA 01775 (US). SIEGLER, Robert, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, W. [US/US]; 52 Moore Street, Chelmsford, MA 01824 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = (US). NGUYEN, Nhung, Tuyet [US/US]; 5 Landmark MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Road, Westford, MA 01886 (US). ONTHANK, David, C. TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, = [US/US]; 21 Kirk Farm Road, Groton, MA 01450 (US). KM, ML, MR, NE, SN, TD, TG). — = ANKLEKAR, Tarakeshwar, Vishwanath [US/US]; 109 = Pinehurst Avenue, Billerica, MA 01821 (US). VAN KIRK, = = Title: METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS (54) = = FIG. 2 = = PG PG PG PG PG = +DPPC +DPPC + DPPC + DPPC — = + MPEG5000 + MPEGS000 + MPEG5000 = DPPE DPPE DPPE = + DPPA + CIPPA = +11.1 1.1g Ca+ 2 /g = I im fa- , 601. .. t NM aim` • — 11 /\".4°A art. . . , 4 4 oz__ OC.,, kn . , / OE --, . ' - 48- - I \" i ° ' S .' . \" . . t - 4 ' 9 7 : - - . . . . .-: ' ''.1a'.- 7 -2 __ . . - . - . . \" -.M'•:_*1 --- © CI , t ;. / . ir) ,............ -......::::__p- ..........7 `,....._ ..._.? _.:;:\"; _ _ 0 0 --.... Il N (57) : Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formu- lations. [Continued on next page] WO 2018/009570 Al MIDEDIMOMMIONERIONMENNEHOMMOIS Published: — with international search report (Art. 21(3))
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359181P | 2016-07-06 | 2016-07-06 | |
| US15/461,469 US9789210B1 (en) | 2016-07-06 | 2017-03-16 | Methods for making ultrasound contrast agents |
| US15/602,580 US9913919B2 (en) | 2016-07-06 | 2017-05-23 | Methods for making ultrasound contrast agents |
| PCT/US2017/040755 WO2018009570A1 (en) | 2016-07-06 | 2017-07-05 | Methods for making ultrasound contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810455XA true SG11201810455XA (en) | 2018-12-28 |
Family
ID=60022856
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201913353YA SG10201913353YA (en) | 2016-07-06 | 2017-07-05 | Methods for making ultrasound contrast agents |
| SG11201810455XA SG11201810455XA (en) | 2016-07-06 | 2017-07-05 | Methods for making ultrasound contrast agents |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201913353YA SG10201913353YA (en) | 2016-07-06 | 2017-07-05 | Methods for making ultrasound contrast agents |
Country Status (14)
| Country | Link |
|---|---|
| US (12) | US9789210B1 (en) |
| EP (1) | EP3458110A4 (en) |
| JP (2) | JP7316793B2 (en) |
| KR (1) | KR102500959B1 (en) |
| CN (2) | CN109562194A (en) |
| AU (1) | AU2017291815A1 (en) |
| BR (1) | BR112018074469A2 (en) |
| CA (1) | CA3025580A1 (en) |
| EA (1) | EA201892568A1 (en) |
| IL (2) | IL297660A (en) |
| MX (2) | MX2018015930A (en) |
| SG (2) | SG10201913353YA (en) |
| TW (1) | TW201815424A (en) |
| WO (1) | WO2018009570A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102618877B1 (en) | 2014-12-31 | 2023-12-28 | 랜티우스 메디컬 이메징, 인크. | Lipid-encapsulated gas microsphere compositions and related methods |
| EP3452108A4 (en) | 2016-05-04 | 2019-12-25 | Lantheus Medical Imaging, Inc. | Methods and devices for preparation of ultrasound contrast agents |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
| US10508503B2 (en) * | 2016-09-23 | 2019-12-17 | Baker Hughes, A Ge Company, Llc | Cutting elements, earth-boring tools including the cutting elements, and methods of forming the earth-boring tools |
| CN108020602B (en) * | 2016-11-02 | 2021-01-29 | 广东嘉博制药有限公司 | Method for simultaneously and quantitatively measuring phospholipid and fatty glyceride in pharmaceutical preparation |
| CN114615957A (en) | 2019-01-04 | 2022-06-10 | 加州理工学院 | Method for removing eye lens by using cavitation micro bubble |
| US11717570B2 (en) | 2019-05-15 | 2023-08-08 | Bracco Suisse Sa | Gas-filled microvesicles |
| US20200360289A1 (en) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
| CN112618734A (en) * | 2020-12-24 | 2021-04-09 | 南京恒远科技开发有限公司 | Liposome microbubble preparation for injection and preparation process thereof |
| NL2027237B1 (en) * | 2020-12-27 | 2022-07-21 | Solstice Pharmaceuticals B V | Process for controlled manufacturing of mono-disperse microbubbles |
| JP2024501982A (en) * | 2020-12-27 | 2024-01-17 | ソルスティス ファーマシューティカルズ ビー．ブイ． | Cartridge for mixing phospholipid compositions intended for internal use |
Family Cites Families (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3873564A (en) | 1971-03-03 | 1975-03-25 | Synvar Ass | 2-Imidazolinyl-3-oxide-1-oxypropionic acid |
| CH588887A5 (en) | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
| CH621479A5 (en) | 1977-08-05 | 1981-02-13 | Battelle Memorial Institute | |
| CH624011A5 (en) | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| US4276885A (en) | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| EP0052575B1 (en) | 1980-11-17 | 1986-01-08 | Schering Aktiengesellschaft | Composition generating microbubbles |
| DE3141641A1 (en) | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION |
| US4718433A (en) | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
| SE463651B (en) | 1983-12-21 | 1991-01-07 | Nycomed As | DIAGNOSTIC AND CONTRACTOR |
| JPH0753661B2 (en) | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | Pro-liposome composition and method of making an aqueous dispersion of liposomes |
| EP0231091B1 (en) | 1986-01-24 | 1993-03-31 | Children's Hospital Medical Center | Stable emulsions of highly fluorinated organic compound |
| JPS6360943A (en) | 1986-09-01 | 1988-03-17 | Green Cross Corp:The | Contrasting agent for ultrasonic diagnosis |
| FR2608942B1 (en) | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOCAPSULES |
| FR2634375B3 (en) | 1988-06-30 | 1991-07-05 | Centre Nat Rech Scient | PROCESS FOR THE PREPARATION OF DISPERSIBLE COLLOIDAL LIPID AMPHIPHILIC SYSTEMS IN THE FORM OF SUBMICRON LIPOSOMES |
| US5219538A (en) | 1987-03-13 | 1993-06-15 | Micro-Pak, Inc. | Gas and oxygen carrying lipid vesicles |
| JPS63277618A (en) | 1987-03-31 | 1988-11-15 | Noebia:Kk | Production of liposome |
| CH672733A5 (en) | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa | |
| IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| DE3803972A1 (en) | 1988-02-05 | 1989-08-10 | Schering Ag | Ultrasound contrast media |
| DE3812816A1 (en) | 1988-04-16 | 1989-11-02 | Lawaczeck Ruediger Dipl Phys P | METHOD FOR SOLUBILIZING LIPOSOMES AND / OR BIOLOGICAL MEMBRANES AND THE USE THEREOF |
| US5171755A (en) | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
| US5045304A (en) | 1988-08-31 | 1991-09-03 | Wayne State University | Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same |
| GB8824593D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
| US5114703A (en) | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
| FR2649335B1 (en) | 1989-07-05 | 1991-09-20 | Texinfine Sa | METHOD AND DEVICE FOR THE DIRECT PRODUCTION OF LIPOSOMES |
| US5843473A (en) | 1989-10-20 | 1998-12-01 | Sequus Pharmaceuticals, Inc. | Method of treatment of infected tissues |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US5088499A (en) | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5705187A (en) | 1989-12-22 | 1998-01-06 | Imarx Pharmaceutical Corp. | Compositions of lipids and stabilizing materials |
| US5656211A (en) | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
| US5352435A (en) | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
| US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US5305757A (en) | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
| US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US5209720A (en) | 1989-12-22 | 1993-05-11 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US5123414A (en) | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5334381A (en) | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5773024A (en) | 1989-12-22 | 1998-06-30 | Imarx Pharmaceutical Corp. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US5149319A (en) | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
| US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
| US5230882A (en) | 1989-12-22 | 1993-07-27 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5228446A (en) | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| IN172208B (en) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US5358702A (en) | 1990-04-10 | 1994-10-25 | Unger Evan C | Methoxylated gel particle contrast media for improved diagnostic imaging |
| US5368840A (en) | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
| ATE185489T1 (en) | 1990-04-10 | 1999-10-15 | Imarx Pharmaceutical Corp | POLYMERS AS CONTRAST AGENTS IN MAGNETIC RESONANCE |
| AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| IS1685B (en) | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Method of making liposomes that are endowed with enhanced ability to absorb and contain foreign matter |
| GB9106673D0 (en) | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
| US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| JP3299745B2 (en) | 1991-06-18 | 2002-07-08 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | New liposome drug delivery system |
| US5409688A (en) | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| MX9205298A (en) | 1991-09-17 | 1993-05-01 | Steven Carl Quay | GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA |
| KR100191303B1 (en) | 1991-09-17 | 1999-06-15 | 씨. 큐웨이 스티븐 | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media |
| WO1993006869A1 (en) | 1991-10-04 | 1993-04-15 | Mallinckrodt Medical, Inc. | Gaseous ultrasound contrast agents |
| GB9200387D0 (en) | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5558855A (en) | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| EP0680341B1 (en) | 1993-01-25 | 2001-05-09 | Sonus Pharmaceuticals, Inc. | Phase shift colloids as ultrasound contrast agents |
| GB9305349D0 (en) | 1993-03-16 | 1993-05-05 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| GB9305351D0 (en) | 1993-03-16 | 1993-05-05 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| DE4313402A1 (en) | 1993-04-23 | 1994-10-27 | Hexal Pharma Gmbh | Transdermal preparation of active compound |
| US5853755A (en) | 1993-07-28 | 1998-12-29 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
| DE69434119T3 (en) | 1993-07-30 | 2011-05-05 | Imcor Pharmaceutical Co., San Diego | STABILIZED MICROGAS BLOWER COMPOSITIONS FOR ECHOGRAPHY |
| GB9318288D0 (en) | 1993-09-03 | 1993-10-20 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| HUT74509A (en) | 1993-09-09 | 1997-01-28 | Schering Ag | Active principles and gas containing microparticles, their use for realising active principles in ultrasonically controlled manner, and process for preparing them |
| JPH08505882A (en) | 1993-11-05 | 1996-06-25 | アムジエン・インコーポレーテツド | Method for preparing liposome and method for encapsulating substance |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| HU225495B1 (en) | 1993-12-15 | 2007-01-29 | Bracco Research Sa | Gas mixtures useful as ultrasound contrast media |
| NO940711D0 (en) | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrast agents for diagnostic imaging |
| US5776488A (en) | 1994-03-11 | 1998-07-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Liposome preparation |
| DE69527194T2 (en) | 1994-03-28 | 2003-02-06 | Nycomed Imaging As | LIPOSOME CONTAINING AN X-RAY OR ULTRASONIC CONTRAST |
| US5736121A (en) | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
| US6066331A (en) | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
| US5562893A (en) | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
| JPH08151335A (en) | 1994-09-27 | 1996-06-11 | Otsuka Pharmaceut Co Ltd | Ultrasonic contrast medium and production thereof |
| US5540909A (en) | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| US5830430A (en) | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
| US5558092A (en) | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
| US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
| US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US5897851A (en) | 1995-06-07 | 1999-04-27 | Sonus Pharmaceuticals, Inc. | Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging |
| DE69632401T2 (en) | 1995-06-07 | 2005-05-19 | Imarx Pharmaceutical Corp., Tucson | NEW TARGETED MEANS FOR DIAGNOSTIC AND THERAPEUTIC USE |
| US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
| US6120794A (en) | 1995-09-26 | 2000-09-19 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
| DE69736981D1 (en) | 1996-05-01 | 2007-01-04 | Imarx Pharmaceutical Corp | IN VITRO PROCESS FOR INTRODUCING NUCLEIC ACIDS INTO A CELL |
| US6214375B1 (en) | 1996-07-16 | 2001-04-10 | Generex Pharmaceuticals, Inc. | Phospholipid formulations |
| US5837221A (en) | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
| US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
| US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| DE69718519T2 (en) | 1996-09-11 | 2003-11-06 | Imarx Pharmaceutical Corp | IMPROVED METHODS FOR DIAGNOSTIC IMAGE GENERATION USING A CONTRAST AND VASODILATOR |
| JP2001502349A (en) | 1996-10-21 | 2001-02-20 | ニユコメド・イメージング・アクシエセルカペト | Improvements in or related to contrast agents |
| EP0991427A2 (en) | 1996-10-28 | 2000-04-12 | Marsden, John Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| EP0973552B1 (en) | 1996-10-28 | 2006-03-01 | Amersham Health AS | Improvements in or relating to diagnostic/therapeutic agents |
| EP1007101B1 (en) | 1996-10-28 | 2006-05-17 | GE Healthcare AS | Improvements in or relating to diagnostic/therapeutic agents |
| WO1998018498A2 (en) | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| GB9717588D0 (en) | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| GB9717542D0 (en) | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Process |
| US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
| US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| ES2244169T3 (en) | 1998-02-09 | 2005-12-01 | Bracco International B.V. | ADDRESSED SUPPLY OF BIOLOGICALLY ACTIVE MEDIA. |
| US6572840B1 (en) | 1999-07-28 | 2003-06-03 | Bristol-Myers Squibb Pharma Company | Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent |
| EP1371041A4 (en) | 2001-02-02 | 2006-04-19 | Bristol Myers Squibb Pharma Co | Apparatus and methods for on-line monitoring of fluorinated material in headspace of vial |
| US20030044354A1 (en) | 2001-08-16 | 2003-03-06 | Carpenter Alan P. | Gas microsphere liposome composites for ultrasound imaging and ultrasound stimulated drug release |
| US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| EP1701745B1 (en) | 2003-12-22 | 2014-12-10 | Bracco Suisse S.A. | Gas-filled microvesicle assembly for contrast imaging |
| CN102600485B (en) * | 2004-06-04 | 2014-10-22 | 阿库斯菲尔公司 | Ultrasonic contrast medium dosage formula |
| WO2006028959A2 (en) | 2004-09-03 | 2006-03-16 | Imarx Therapeutics, Inc. | Apparatus and method to prepare a microsphere-forming composition |
| CN101229382A (en) | 2008-02-04 | 2008-07-30 | 许川山 | Novel type radiographic contrast suitable for multi-imaging pattern |
| US8459462B2 (en) | 2008-10-10 | 2013-06-11 | Quest Diagnostics Investments Incorporated | System and method for sorting specimen |
| JP2012213475A (en) | 2011-03-31 | 2012-11-08 | Panasonic Corp | Ultrasonic contrast medium infusion set |
| US9101895B2 (en) | 2011-04-15 | 2015-08-11 | General Electric Company | System for mixing and dispersing microbubble pharmaceuticals |
| US10279053B2 (en) | 2011-07-19 | 2019-05-07 | Nuvox Pharma Llc | Microbubble compositions, method of making same, and method using same |
| KR102076069B1 (en) | 2011-08-24 | 2020-02-11 | 캘리포니아 인스티튜트 오브 테크놀로지 | Targeting microbubble |
| JP2015002752A (en) | 2011-12-09 | 2015-01-08 | パナソニック株式会社 | Drug container |
| CN110237878B (en) | 2012-07-18 | 2022-11-15 | 莱伯曼兹有限公司 | Automated solution dispenser |
| WO2014124440A2 (en) | 2013-02-11 | 2014-08-14 | Bloch Andrew E | Apparatus and method for providing asymmetric oscillations |
| EP2968825A4 (en) | 2013-03-15 | 2016-09-07 | Childrens Medical Center | Gas-filled stabilized particles and methods of use |
| EP3570040B1 (en) | 2013-04-05 | 2024-02-14 | F. Hoffmann-La Roche AG | Analysis method for a biological sample |
| TWI552761B (en) | 2013-05-03 | 2016-10-11 | 博信生物科技股份有限公司 | An lipid-based micro/nano-bubble, and an optimized preparing method and equipment thereof |
| TWI504413B (en) | 2013-07-24 | 2015-10-21 | Univ Nat Chiao Tung | Composite polymer contrast agent and drug carrier in nano-scale |
| GB201405735D0 (en) | 2014-03-31 | 2014-05-14 | Ge Healthcare As | Ultrasound precursor preparation method |
| US9801959B2 (en) | 2014-06-12 | 2017-10-31 | Microvascuar Therapeutics Llc | Phospholipid composition and microbubbles and emulsions formed using same |
| CA2965851C (en) | 2014-10-30 | 2022-04-05 | Lantheus Medical Imaging, Inc. | Lipid encapsulated gas microsphere compositions and related methods |
| KR102618877B1 (en) | 2014-12-31 | 2023-12-28 | 랜티우스 메디컬 이메징, 인크. | Lipid-encapsulated gas microsphere compositions and related methods |
| EP3452108A4 (en) | 2016-05-04 | 2019-12-25 | Lantheus Medical Imaging, Inc. | Methods and devices for preparation of ultrasound contrast agents |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
-
2017
- 2017-03-16 US US15/461,469 patent/US9789210B1/en active Active
- 2017-05-23 US US15/602,580 patent/US9913919B2/en active Active
- 2017-07-05 CA CA3025580A patent/CA3025580A1/en active Pending
- 2017-07-05 KR KR1020187038022A patent/KR102500959B1/en active IP Right Grant
- 2017-07-05 SG SG10201913353YA patent/SG10201913353YA/en unknown
- 2017-07-05 EP EP17824829.0A patent/EP3458110A4/en active Pending
- 2017-07-05 EA EA201892568A patent/EA201892568A1/en unknown
- 2017-07-05 SG SG11201810455XA patent/SG11201810455XA/en unknown
- 2017-07-05 IL IL297660A patent/IL297660A/en unknown
- 2017-07-05 MX MX2018015930A patent/MX2018015930A/en unknown
- 2017-07-05 CN CN201780040503.3A patent/CN109562194A/en active Pending
- 2017-07-05 AU AU2017291815A patent/AU2017291815A1/en active Pending
- 2017-07-05 CN CN202310597151.9A patent/CN116370659A/en active Pending
- 2017-07-05 JP JP2018568907A patent/JP7316793B2/en active Active
- 2017-07-05 US US16/315,643 patent/US11266749B2/en active Active
- 2017-07-05 BR BR112018074469-7A patent/BR112018074469A2/en unknown
- 2017-07-05 IL IL263205A patent/IL263205B2/en unknown
- 2017-07-05 WO PCT/US2017/040755 patent/WO2018009570A1/en unknown
- 2017-07-06 TW TW106122700A patent/TW201815424A/en unknown
-
2018
- 2018-02-06 US US15/889,429 patent/US11344636B2/en active Active
- 2018-03-29 US US15/940,932 patent/US10220104B2/en active Active
- 2018-12-17 MX MX2022011694A patent/MX2022011694A/en unknown
-
2019
- 2019-01-31 US US16/264,176 patent/US10583208B2/en active Active
-
2021
- 2021-05-19 US US17/325,176 patent/US11266750B2/en active Active
- 2021-05-19 US US17/325,173 patent/US11857646B2/en active Active
-
2022
- 2022-03-07 US US17/688,532 patent/US11529431B2/en active Active
- 2022-03-07 US US17/688,601 patent/US20220184237A1/en active Pending
-
2023
- 2023-04-12 JP JP2023064866A patent/JP2023100646A/en active Pending
- 2023-05-19 US US18/320,890 patent/US20230330274A1/en active Pending
- 2023-05-22 US US18/321,714 patent/US11925695B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201810455XA (en) | Methods for making ultrasound contrast agents | |
| SG11201808135SA (en) | Delivery system for prosthetic heart valve | |
| SG11201810034XA (en) | ANTI-cMet ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE | |
| SG11201908740VA (en) | Sustained release delivery systems comprising traceless linkers | |
| SG11201804814YA (en) | Materials and methods for delivering nucleic acids to cochlear and vestibular cells | |
| SG11201808231VA (en) | Delivery system | |
| SG11201803906PA (en) | Control of cellular redox levels | |
| SG11201807784SA (en) | 3-desoxy derivative and pharmaceutical compositions thereof | |
| SG11201909303TA (en) | Point of delivery cold slurry generation | |
| SG11201900975XA (en) | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same | |
| SG11201811442UA (en) | Formulation of a peptide vaccine | |
| SG11201900238UA (en) | Compounds and methods for modulation of smn2 | |
| SG11201909155VA (en) | Ask1 inhibitor compounds and uses thereof | |
| SG11201809908TA (en) | Stabilized glycopeptide antibiotic formulations | |
| SG11201901995TA (en) | Crystalline and salt forms of ppar agonist compounds | |
| SG11201900546UA (en) | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof | |
| SG11201901986SA (en) | Process for the manufacture of a solid pharmaceutical adminstration form | |
| SG11201901925RA (en) | Methods of treating acute kidney injury | |
| SG11201809788VA (en) | Nanoliposomal irinotecan for use in treating small cell lung cancer | |
| SG11201804587QA (en) | Isoindole compounds | |
| SG11201810793XA (en) | Pharmaceutical combinations | |
| SG11201903198TA (en) | An inserter for an intrauterine system | |
| SG11201811311VA (en) | Compounds for imaging tau protein aggregates | |
| SG11201807478QA (en) | Methods and compositions for increased double stranded rna production | |
| SG11201808777UA (en) | Improvements in cancer treatment |