SG11201809626PA - Modulation of lipid metabolism for protein production - Google Patents
Modulation of lipid metabolism for protein productionInfo
- Publication number
- SG11201809626PA SG11201809626PA SG11201809626PA SG11201809626PA SG11201809626PA SG 11201809626P A SG11201809626P A SG 11201809626PA SG 11201809626P A SG11201809626P A SG 11201809626PA SG 11201809626P A SG11201809626P A SG 11201809626PA SG 11201809626P A SG11201809626P A SG 11201809626PA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- kent
- lipid metabolism
- modulation
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0097—Oxidoreductases (1.) acting on reduced flavodoxin as donor (1.19)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
25 T u 0.20 U o. 0.15 5 U -0 0.10 2 0. U 1. 5 0.05 U Control SCD1 SREBF1 Cell Pool SREB410 0.00 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 November 2017 (09.11.2017) WIP0 I PCT omit Ill Hot 0 mu OH °minima oimIE (10) International Publication Number WO 2017/191165 Al 01 N O C (51) International Patent Classification: C12P 21/00 (2006.01) CO7K 14/47 (2006.01) C12N 9/02 (2006.01) (21) International Application Number: PCT/EP2017/060484 (22) International Filing Date: 03 May 2017 (03.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/330,973 03 May 2016 (03.05.2016) US (71) Applicant: LONZA LTD [CH/CH]; Lonzastrasse, 3930 Visp (CH). (72) Inventors: BUDGE, James; The University of Kent, The Registry, Canterbury Kent CT2 7NZ (GB). SMALES, Christopher Mark; 37 Ethelbert Rd, Canterbury Kent CT1 3NF (GB). KNIGHT, Tanya; 32 Kings Road, Herne Bay, Kent Kent CT6 5DA (GB). YOUNG, Robert; Research & Technology, Lonza Biologics Plc, 228 Bath Road, Slough Berkshire SL1 (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) — (54) Title: MODULATION OF LIPID METABOLISM FOR PROTEIN PRODUCTION FIG. 16B (57) : The present disclosure features methods and compositions for modulating lipid metabolism to achieve improved pro- duction and quality of recombinant products, such as next generation biologics. Modulation of lipid metabolism as described herein includes, for example, introducing a lipid metabolism modulator described herein to a cell or a cell-free system. Also encompassed by the present disclosure are engineered cells with improved production capacity and improved product quality, methods for engineering such cells, and preparations and mixtures comprising the products from such cells.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330973P | 2016-05-03 | 2016-05-03 | |
| PCT/EP2017/060484 WO2017191165A1 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201809626PA true SG11201809626PA (en) | 2018-11-29 |
Family
ID=58745198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201809626PA SG11201809626PA (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10655111B2 (en) |
| EP (1) | EP3452608B1 (en) |
| JP (1) | JP6959942B2 (en) |
| KR (1) | KR102536221B1 (en) |
| CN (1) | CN109415748A (en) |
| AU (1) | AU2017259010B2 (en) |
| BR (1) | BR112018072434A2 (en) |
| CA (1) | CA3023038C (en) |
| EA (1) | EA201892503A1 (en) |
| ES (1) | ES2938626T3 (en) |
| IL (2) | IL294241B2 (en) |
| MX (1) | MX2018013499A (en) |
| SG (1) | SG11201809626PA (en) |
| WO (1) | WO2017191165A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102536221B1 (en) | 2016-05-03 | 2023-05-23 | 론자 리미티드 | Modulation of lipid metabolism for protein production |
| US20210324366A1 (en) * | 2018-07-11 | 2021-10-21 | Cornell University | Supported plant plasma membrane lipid bilayer on-a-chip |
| WO2020084528A1 (en) * | 2018-10-24 | 2020-04-30 | Selexis Sa | Expression systems, recombinant cells and uses thereof |
| US11504390B2 (en) | 2019-03-20 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors |
| CN110317799A (en) * | 2019-07-18 | 2019-10-11 | 江南大学 | A kind of prokaryotic expression method and products thereof of source of people fucosyl transferase 8 |
| EP4058583A1 (en) | 2019-11-14 | 2022-09-21 | Lonza Ltd. | Methods of cell selection |
| CN115029307A (en) * | 2022-07-28 | 2022-09-09 | 吉林大学 | Method for delaying aging of MSCs |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| ES2301198T3 (en) | 1997-06-12 | 2008-06-16 | Novartis International Pharmaceutical Ltd. | ARTIFICIAL POLYPEPTIDES OF ANTIBODIES. |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| AU2002321989A1 (en) | 2001-02-02 | 2002-12-03 | Bayer Corporation | Methods of modulating surfactant phospholipid production |
| AU2004248165A1 (en) | 2003-06-11 | 2004-12-23 | Biogen Idec Ma Inc. | Method to increase protein production in culture |
| WO2005100573A2 (en) | 2004-04-16 | 2005-10-27 | Dsm Ip Assets B.V. | Fungal promoters for expressing a gene in a fungal cell |
| US20080182249A1 (en) * | 2006-09-01 | 2008-07-31 | Fox Brian G | Expression systems for mammalian and mycobacterial desaturases |
| WO2009062789A1 (en) | 2007-11-13 | 2009-05-22 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Improving the secretory capacity in host cells |
| CN114045301A (en) * | 2008-11-18 | 2022-02-15 | 联邦科学技术研究组织 | Enzymes and methods for producing omega-3 fatty acids |
| SG10201803758XA (en) * | 2013-02-01 | 2018-06-28 | Selexis Sa | Enhanced Transgene Expression and Processing |
| KR102536221B1 (en) * | 2016-05-03 | 2023-05-23 | 론자 리미티드 | Modulation of lipid metabolism for protein production |
-
2017
- 2017-05-03 KR KR1020187034453A patent/KR102536221B1/en active IP Right Grant
- 2017-05-03 MX MX2018013499A patent/MX2018013499A/en unknown
- 2017-05-03 EP EP17724770.7A patent/EP3452608B1/en active Active
- 2017-05-03 CA CA3023038A patent/CA3023038C/en active Active
- 2017-05-03 US US15/585,570 patent/US10655111B2/en active Active
- 2017-05-03 JP JP2018557851A patent/JP6959942B2/en active Active
- 2017-05-03 SG SG11201809626PA patent/SG11201809626PA/en unknown
- 2017-05-03 IL IL294241A patent/IL294241B2/en unknown
- 2017-05-03 IL IL262646A patent/IL262646B/en unknown
- 2017-05-03 CN CN201780039286.6A patent/CN109415748A/en active Pending
- 2017-05-03 ES ES17724770T patent/ES2938626T3/en active Active
- 2017-05-03 EA EA201892503A patent/EA201892503A1/en unknown
- 2017-05-03 WO PCT/EP2017/060484 patent/WO2017191165A1/en active Application Filing
- 2017-05-03 BR BR112018072434-3A patent/BR112018072434A2/en unknown
- 2017-05-03 AU AU2017259010A patent/AU2017259010B2/en active Active
-
2020
- 2020-03-13 US US16/818,162 patent/US11434474B2/en active Active
-
2022
- 2022-07-27 US US17/815,465 patent/US20230047838A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10655111B2 (en) | 2020-05-19 |
| US20230047838A1 (en) | 2023-02-16 |
| US20200231944A1 (en) | 2020-07-23 |
| KR102536221B1 (en) | 2023-05-23 |
| CA3023038A1 (en) | 2017-11-09 |
| MX2018013499A (en) | 2019-09-11 |
| EA201892503A1 (en) | 2019-09-30 |
| EP3452608A1 (en) | 2019-03-13 |
| US11434474B2 (en) | 2022-09-06 |
| JP2019514399A (en) | 2019-06-06 |
| AU2017259010B2 (en) | 2021-04-22 |
| BR112018072434A2 (en) | 2019-02-19 |
| EP3452608B1 (en) | 2022-11-30 |
| ES2938626T3 (en) | 2023-04-13 |
| IL262646A (en) | 2018-12-31 |
| AU2017259010A1 (en) | 2018-11-22 |
| CA3023038C (en) | 2023-03-14 |
| IL294241B2 (en) | 2023-10-01 |
| KR20190003651A (en) | 2019-01-09 |
| IL262646B (en) | 2022-08-01 |
| JP6959942B2 (en) | 2021-11-05 |
| US20170321194A1 (en) | 2017-11-09 |
| WO2017191165A1 (en) | 2017-11-09 |
| CN109415748A (en) | 2019-03-01 |
| IL294241B1 (en) | 2023-06-01 |
| IL294241A (en) | 2022-08-01 |
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