SG11201808909WA - Ex vivo bite-activated t cells - Google Patents
Ex vivo bite-activated t cellsInfo
- Publication number
- SG11201808909WA SG11201808909WA SG11201808909WA SG11201808909WA SG11201808909WA SG 11201808909W A SG11201808909W A SG 11201808909WA SG 11201808909W A SG11201808909W A SG 11201808909WA SG 11201808909W A SG11201808909W A SG 11201808909WA SG 11201808909W A SG11201808909W A SG 11201808909WA
- Authority
- SG
- Singapore
- Prior art keywords
- madrid
- calle
- parque
- santiago
- pcm
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000022534 cell killing Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000002865 immune cell Anatomy 0.000 abstract 2
- 239000012642 immune effector Substances 0.000 abstract 2
- 229940121354 immunomodulator Drugs 0.000 abstract 2
- 241000585705 Alicia <angiosperm> Species 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002489 hematologic effect Effects 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000004043 responsiveness Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A61K39/0011—Cancer antigens
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- G—PHYSICS
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12N2501/505—CD4; CD8
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
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- Analytical Chemistry (AREA)
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Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111 010111110111010111 ME1001111101111111011110111111 International Bureau ... ..... ..Yi j (10) International Publication Number ..... .....!;,,, (43) International Publication Date WO 2017/178572 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: BIOTECH, S.L, Parque Cientifico Madrid (PCM), 1, Calle A61K 39/00 (2006.01) Santiago Grisolia, Suite 205, 28760 Madrid (ES). (21) International Application Number: (74) Agent: ILLESCAS TABOADA, Manuel; C/ Principe de PCT/EP2017/058891 Vergara, 197, Oficina 1° A, 28002 Madrid (ES). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 12 April 2017 (12.04.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (25) Filing Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (26) Publication Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (30) Priority Data: 62/321,964 13 April 2016 (13.04.2016) US KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (71) Applicant: V1VIA BIOTECH, S.L [ES/ES]; Parque Cien- tifico Madrid (PCM), 1, Calle Santiago Grisolia, Suite 205, 28760 Madrid (ES). NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: BALLESTEROS NOBELL, Juan Antonio; VWIA BIOTECH, S.L, Parque Cientifico Madrid (PCM), 1, Calle Santiago Grisolia, Suite 205, 28760 Madrid (ES). BENNET, Teresa Ann; VWIA BIOTECH, S.L, Parque Cientifico Madrid (PCM), 1, Calle Santiago Grisolia, Suite 205, 28760 Madrid (ES). HERNANDEZ CAMPO, Pilar; VWIA BIOTECH, S.L, Parque Cientifico Madrid (PCM), 1, Calle Santiago Grisolia, Suite 205, 28760 Madrid (ES). GOMEZ GONZALEZ, Cristina; VWIA BIOTECH, S.L, Parque Cientifico Madrid (PCM), 1, Calle Santiago Griso- (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — _ = = lia, Suite 205, 28760 Madrid (ES). GORROCHATEGUI Published: GUILLEN, Julian; VWIA BIOTECH, S.L, Parque Cien- — tifico Madrid (PCM), 1, Calle Santiago Grisolia, Suite 205, — with international search report (Art. 21(3)) = = 28760 Madrid (ES). MARTINEZ LOPEZ, Joaquin; — before the expiration of the time limit for amending the Calle Melilla num. 6 6°B, 28005 Madrid (ES). ROBLES claims and to be republished in the event of receipt of — MATEOS, Alicia; VWIA BIOTECH, S.L, Parque Cienti- fico Madrid (PCM), 1, Calle Santiago Grisolia, Suite 205, 28760 Madrid (ES). PRIMO RAMOS, Daniel; VWIA amendments (Rule 48.2(h)) = = = = = = = = 1-1 ei IN kin cc IN 1-1 (54) Title: EX VIVO BITE-ACTIVATED T CELLS I r ----- (57) : Generation and identification of highly effective immune effector cell in terms of target cell-killing activity can be en- 1-1 hanced by optimizing the proximity between a target cell and the immune effector cell. The cancer-killing T cells described herein ei can provide highly effective therapies for diverse cancer types, e.g., solid cancers, hematological cancers, and metastatic forms there - tom.) of. Provided herein are ex-vivo methods of generating cancer-killing T cells, compositions comprising such immune cells; methods ,7 1 1 . 9 of using the cells, methods of selecting optimal agents for enhancing the target cell killing activity, methods of selecting an optim- ized immune cell and methods of using this approach to evaluate patient responsiveness to other cancer therapies.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662321964P | 2016-04-13 | 2016-04-13 | |
PCT/EP2017/058891 WO2017178572A1 (en) | 2016-04-13 | 2017-04-12 | Ex vivo bite-activated t cells |
Publications (1)
Publication Number | Publication Date |
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SG11201808909WA true SG11201808909WA (en) | 2018-11-29 |
Family
ID=58669776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808909WA SG11201808909WA (en) | 2016-04-13 | 2017-04-12 | Ex vivo bite-activated t cells |
Country Status (11)
Country | Link |
---|---|
US (1) | US20190218515A1 (en) |
EP (1) | EP3445391A1 (en) |
JP (2) | JP7038353B2 (en) |
KR (1) | KR20180133442A (en) |
CN (2) | CN117327650A (en) |
AU (2) | AU2017249698B2 (en) |
CA (1) | CA3020830A1 (en) |
IL (2) | IL295538B2 (en) |
MX (2) | MX2018012488A (en) |
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KR20180133442A (en) | 2018-12-14 |
CA3020830A1 (en) | 2017-10-19 |
WO2017178572A1 (en) | 2017-10-19 |
US20190218515A1 (en) | 2019-07-18 |
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