SG11201808705XA - Particle manipulation - Google Patents

Particle manipulation

Info

Publication number
SG11201808705XA
SG11201808705XA SG11201808705XA SG11201808705XA SG11201808705XA SG 11201808705X A SG11201808705X A SG 11201808705XA SG 11201808705X A SG11201808705X A SG 11201808705XA SG 11201808705X A SG11201808705X A SG 11201808705XA SG 11201808705X A SG11201808705X A SG 11201808705XA
Authority
SG
Singapore
Prior art keywords
singapore
international
substrate
pillar
sorting
Prior art date
Application number
SG11201808705XA
Inventor
Ye Ai
Zhichao Ma
Original Assignee
Univ Singapore Technology & Design
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Singapore Technology & Design filed Critical Univ Singapore Technology & Design
Publication of SG11201808705XA publication Critical patent/SG11201808705XA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • G01N15/149—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G01N2015/142—Acoustic or ultrasonic focussing

Abstract

IDT Micro-pillar 25 LiNb0 3 Substrate 10 15 Pressure Y-displacement (kPa) (nm) 40 0.2 20 0.1 0 0 -20 -40 -0.2 • LiNbO, Substrate TSAW W O 20 1717 / 6 211 Al PDMS (b) Fluid Figure 2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/176211 Al 12 October 2017 (12.10.2017) WIPO I PCT 1111111111111101110111111111110101111101110101111111101110111011111111111110111111 (51) International Patent Classification: G01N 29/02 (2006.01) BOIL 3/00 (2006.01) (21) International Application Number: PCT/SG2017/050192 (22) International Filing Date: 4 April 2017 (04.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201602719V 6 April 2016 (06.04.2016) SG (71) Applicant: SINGAPORE UNIVERSITY OF TECHNO- LOGY AND DESIGN [SG/SG]; 8 Somapah Road #05- 302, Singapore University Of Technology And Design, Singapore 487372 (SG). (72) Inventors: AI, Ye; Block 53, Changi South Avenue 1, #10-10, Singapore 485996 (SG). MA, Zhichao; Block 57 Changi South Avenue 1, #04-71, Singapore 485998 (SG). (74) Agent: AMICA LAW LLC; 30 Raffles Place, #14-01 Chevron House, Singapore 048622 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: PARTICLE MANIPULATION (57) : The present invention relates to the manipulation and, more particularly, to the sorting of particles. Still more particularly, the present in- vention relates to the use of acoustic waves, in- cluding surface acoustic waves, for the manipula- tion and sorting of particles. In an example, the present invention may be used for the sorting of cells. In an aspect of the invention, there is provided a device for manipulating a particle in a fluid suspension, the device comprising: (a) a sub- strate having a surface; (b) an acoustic source con- figured to generate and deliver an acoustic wave within a region of the substrate surface; and (c) a pillar disposed on the surface of the substrate and the pillar is configured to receive a channel, the channel configured to receive the fluid suspension, wherein the acoustic wave delivered within the re- gion of the substrate surface is delivered to the flu- id suspension in the channel through the pillar. A method using the device of the invention is also disclosed.
SG11201808705XA 2016-04-06 2017-04-04 Particle manipulation SG11201808705XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201602719V 2016-04-06
PCT/SG2017/050192 WO2017176211A1 (en) 2016-04-06 2017-04-04 Particle manipulation

Publications (1)

Publication Number Publication Date
SG11201808705XA true SG11201808705XA (en) 2018-11-29

Family

ID=60001415

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808705XA SG11201808705XA (en) 2016-04-06 2017-04-04 Particle manipulation

Country Status (3)

Country Link
US (1) US20190160463A1 (en)
SG (1) SG11201808705XA (en)
WO (1) WO2017176211A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
EP3092049A1 (en) 2014-01-08 2016-11-16 Flodesign Sonics Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
ES2841528T3 (en) * 2016-03-15 2021-07-08 Centre Nat Rech Scient Acoustic Tweezers
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CN110431743B (en) * 2017-03-09 2023-06-23 株式会社村田制作所 Elastic wave device and elastic wave device package
BR112020009889A2 (en) 2017-12-14 2020-11-03 Flodesign Sonics, Inc. acoustic transducer driver and controller
CN108285869B (en) * 2018-03-14 2023-07-04 吉林大学 Surface acoustic wave sorting chip optimized by special wettability
US11577241B2 (en) 2018-12-03 2023-02-14 Duke University Acoustofluidic systems including acoustic wave generators for manipulating fluids, droplets, and micro/nano objects within a fluid suspension and related methods
EP4045187A1 (en) * 2019-10-18 2022-08-24 Aenitis Technologies Device for particles handling, washing, transfection through acoustophoretic induced migration
KR102253404B1 (en) * 2019-12-26 2021-05-18 연세대학교 산학협력단 Particle counter
CN113976196A (en) * 2021-10-21 2022-01-28 清华大学 Particle separation device based on micro-fluidic

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012027366A2 (en) * 2010-08-23 2012-03-01 President And Fellows Of Harvard College Acoustic waves in microfluidics

Also Published As

Publication number Publication date
WO2017176211A1 (en) 2017-10-12
US20190160463A1 (en) 2019-05-30

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