SG11201808552XA - T-cell modulatory multimeric polypeptides and methods of use thereof - Google Patents
T-cell modulatory multimeric polypeptides and methods of use thereofInfo
- Publication number
- SG11201808552XA SG11201808552XA SG11201808552XA SG11201808552XA SG11201808552XA SG 11201808552X A SG11201808552X A SG 11201808552XA SG 11201808552X A SG11201808552X A SG 11201808552XA SG 11201808552X A SG11201808552X A SG 11201808552XA SG 11201808552X A SG11201808552X A SG 11201808552XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- cell modulatory
- cell
- present disclosure
- modulatory multimeric
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/77—Ovalbumin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111 0111011110111110101111111 011111111111011 1 111111101110 III 1111 III1 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/201210 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: (74) Agent: BORDEN, Paula A.; 201 Redwood Shores Park- A61K 39/395 (2006.01) CO7K 14/47 (2006.01) way, Suite 200, Redwood City, California 94065 (US). A61K 48/00 (2006.01) Cl 2N 15/63 (2006.01) CO7K 14/00 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/US2017/033187 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (22) International Filing Date: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 17 May 2017 (17.05.2017) HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (25) Filing Language: English MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (26) Publication Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (30) Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/338,410 18 May 2016 (18.05.2016) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: CUE BIOPHARMA, INC. [US/US]; 675 kind of regional protection available): ARIPO (BW, GH, West Kendall Street, Cambridge, Massachusetts 02142 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (US). UG, TM), ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: SEIDEL III, Ronald D.; 675 West Kendall EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — ge,ass Street, Cambridge, Massachusetts 02142 (US). CHAPAR- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, RO, Rodolfo; 675 West Kendall Street, Cambridge, Mass- achusetts 02142 (US). = Title: T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND (54) METHODS OF USE THEREOF = T Cell Modulatory = Domain Targeting Epitope = = = = = = = — _ C it = B2M = = = = T Cell Modulatory Domain — 1-1 Fc FIG. IC 0 1-1 ei 1-1 (57) : The present disclosure provides T-cell modulatory multimeric polypeptides comprising two different immunomodula- 0 el tory polypeptides, at least one of which is a variant immunomodulatory polypeptide. The present disclosure provides nucleic acids ----- comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. IN ,-1 The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T- 0 cell modulatory multimeric polypeptide of the present disclosure. ei C [Continued on next page] WO 2017/201210 Al MIDEDIMOMMIDIROFIEHIMIIMIHOMERVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662338410P | 2016-05-18 | 2016-05-18 | |
PCT/US2017/033187 WO2017201210A1 (en) | 2016-05-18 | 2017-05-17 | T-cell modulatory multimeric polypeptides and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808552XA true SG11201808552XA (en) | 2018-10-30 |
Family
ID=60326131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808552XA SG11201808552XA (en) | 2016-05-18 | 2017-05-17 | T-cell modulatory multimeric polypeptides and methods of use thereof |
Country Status (11)
Country | Link |
---|---|
US (2) | US11505591B2 (en) |
EP (1) | EP3458096A4 (en) |
JP (1) | JP7071288B2 (en) |
KR (1) | KR20190019068A (en) |
CN (1) | CN109475628A (en) |
AU (1) | AU2017268348A1 (en) |
BR (1) | BR112018073606A2 (en) |
CA (1) | CA3019005A1 (en) |
IL (1) | IL262403A (en) |
SG (1) | SG11201808552XA (en) |
WO (1) | WO2017201210A1 (en) |
Families Citing this family (22)
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TW201722985A (en) | 2015-11-02 | 2017-07-01 | 戊瑞治療有限公司 | CD80 extracellular domain polypeptides and their use in cancer treatment |
SG11201808783XA (en) | 2016-04-15 | 2018-11-29 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
KR20190019068A (en) | 2016-05-18 | 2019-02-26 | 큐 바이오파마, 인크. | T-cell modulated multimeric polypeptides and methods for their use |
IL303806B1 (en) | 2016-12-22 | 2024-01-01 | Cue Biopharma Inc | T-cell modulatory multimeric polypeptides and methods of use thereof |
WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
AU2018234628B2 (en) * | 2017-03-15 | 2023-07-20 | Cue Biopharma, Inc. | Methods for modulating an immune response |
AU2018235838B2 (en) | 2017-03-16 | 2023-12-14 | Alpine Immune Sciences, Inc. | CD80 variant immunomodulatory proteins and uses thereof |
MX2019012849A (en) | 2017-04-28 | 2019-11-28 | Five Prime Therapeutics Inc | Methods of treatment with cd80 extracellular domain polypeptides. |
AU2018327224A1 (en) * | 2017-09-07 | 2020-04-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptide with conjugation sites and methods of use thereof |
CN109879969B (en) * | 2017-12-06 | 2024-04-09 | 天士力生物医药股份有限公司 | HM-3 fusion protein and application thereof |
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TW202039542A (en) * | 2018-12-19 | 2020-11-01 | 美商庫爾生物製藥有限公司 | Multimeric t-cell modulatory polypeptides and methods of use thereof |
KR20210104700A (en) * | 2018-12-19 | 2021-08-25 | 큐 바이오파마, 인크. | Multimeric T-cell regulatory polypeptides and methods of use thereof |
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-
2017
- 2017-05-17 KR KR1020187035419A patent/KR20190019068A/en not_active Application Discontinuation
- 2017-05-17 CA CA3019005A patent/CA3019005A1/en not_active Abandoned
- 2017-05-17 JP JP2018560480A patent/JP7071288B2/en active Active
- 2017-05-17 US US16/089,335 patent/US11505591B2/en active Active
- 2017-05-17 AU AU2017268348A patent/AU2017268348A1/en not_active Abandoned
- 2017-05-17 WO PCT/US2017/033187 patent/WO2017201210A1/en active Application Filing
- 2017-05-17 EP EP17800124.4A patent/EP3458096A4/en active Pending
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2018
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EP3458096A1 (en) | 2019-03-27 |
JP2019522465A (en) | 2019-08-15 |
AU2017268348A1 (en) | 2018-10-25 |
US20230279075A1 (en) | 2023-09-07 |
EP3458096A4 (en) | 2019-11-27 |
US11505591B2 (en) | 2022-11-22 |
KR20190019068A (en) | 2019-02-26 |
IL262403A (en) | 2018-12-31 |
CN109475628A (en) | 2019-03-15 |
BR112018073606A2 (en) | 2019-02-26 |
WO2017201210A1 (en) | 2017-11-23 |
CA3019005A1 (en) | 2017-11-23 |
JP7071288B2 (en) | 2022-05-18 |
US20190106476A1 (en) | 2019-04-11 |
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