SG11201808085WA - Protease-activated t cell bispecific molecules - Google Patents
Protease-activated t cell bispecific moleculesInfo
- Publication number
- SG11201808085WA SG11201808085WA SG11201808085WA SG11201808085WA SG11201808085WA SG 11201808085W A SG11201808085W A SG 11201808085WA SG 11201808085W A SG11201808085W A SG 11201808085WA SG 11201808085W A SG11201808085W A SG 11201808085WA SG 11201808085W A SG11201808085W A SG 11201808085WA
- Authority
- SG
- Singapore
- Prior art keywords
- protease
- international
- idiotype
- activatable
- roche
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
FcKnob) PG LALA Fc(Hole) P329G LALA = (54) Title: PROTEASE-ACTIVATED T CELL BISPECIFIC MOLECULES FIG. 1A Protease site with GS linker Anti CD3 scFv 4.15.64 anti-CD3 V CH1 Common Light Chain 7859 W O 20 17 / 16 25 87 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/162587 Al 28 September 2017 (28.09.2017) WIPO I PCT IIIII111111110111011111111111$111110 011IIIIII0111111111110111111111111111 (51) International Patent Classification: C07K 16/46 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/32 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/EP2017/056556 (22) International Filing Date: 20 March 2017 (20.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16161740.2 22 March 2016 (22.03.2016) EP 62/433,327 13 December 2016 (13.12.2016) US (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jersey 07424 (US). (72) Inventors: BRUENKER, Peter; Burgwiesenstrasse 3c, 8335 Hittnau (CH). CROASDALE-WOOD, Rebecca; 39 college close, Longridge, Preston Lancashire PR3 3AX (GB). KLEIN, Christian; Chapfstrasse 26B, 8906 Bon- stetten (CH). SCHANZER, Juergen Michael; Metzstr. 26, 81667 Mlinchen (DE). STUBENRAUCH, Kay-Gun- nar; Parkstrasse la, 82377 Penzberg (DE). UMANA, Pablo; Felsenrainstrasse 28, 8832 Wollerau (CH). GEI- GER, Martina; Muehlestrasse 4a, 8912 Obfelden (CH). SULLIVAN, Eric; c/o Roche Sequencing Solutions, Inc., 4300 Hacienda Drive, Pleasanton, California 94588 (US). PATEL, Jigar; c/o Roche Sequencing Solutions, Inc., 4300 Hacienda Drive, Pleasanton, California 94588 (US). (74) Agent: BRODBECK, Michel; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, [Continued on next page] (57) : The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific poly- peptides acting as masking moieties. The present in- vention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific mo- lecules and idiotype-specific polypeptides, and vec- tors and host cells comprising such polynucleotides. The invention further relates to methods for produ- cing the protease-activatable T cell activating bispe- cific molecules and idiotype-specific polypeptides of the invention, and to methods of using these pro- tease-activatable T cell activating bispecific mo- lecules and idiotype-specific polypeptides in the treatment of disease. WO 2017/162587 Al MIDEDIMOMOIDEIRMEMOMOHEIHIONDERVOIMIE DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16161740 | 2016-03-22 | ||
US201662433327P | 2016-12-13 | 2016-12-13 | |
PCT/EP2017/056556 WO2017162587A1 (en) | 2016-03-22 | 2017-03-20 | Protease-activated t cell bispecific molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808085WA true SG11201808085WA (en) | 2018-10-30 |
Family
ID=55646332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808085WA SG11201808085WA (en) | 2016-03-22 | 2017-03-20 | Protease-activated t cell bispecific molecules |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP3433280B1 (en) |
KR (1) | KR102444614B1 (en) |
CN (1) | CN108884170A (en) |
AR (2) | AR107946A1 (en) |
AU (1) | AU2017237376B2 (en) |
BR (1) | BR112018016281A2 (en) |
CA (1) | CA3012422A1 (en) |
CO (1) | CO2018007556A2 (en) |
CR (1) | CR20180453A (en) |
MA (1) | MA43724B1 (en) |
PE (1) | PE20181891A1 (en) |
PT (1) | PT3433280T (en) |
SG (1) | SG11201808085WA (en) |
WO (1) | WO2017162587A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE051661T2 (en) | 2015-05-18 | 2021-03-29 | Tcr2 Therapeutics Inc | Compositions and medical uses for tcr reprogramming using fusion proteins |
TW202323287A (en) | 2016-11-28 | 2023-06-16 | 日商中外製藥股份有限公司 | Antigen-binding domain, and polypeptide including conveying section |
AU2018225164A1 (en) * | 2017-02-22 | 2019-09-19 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
US10927180B2 (en) | 2017-10-13 | 2021-02-23 | Harpoon Therapeutics, Inc. | B cell maturation antigen binding proteins |
KR20200064096A (en) | 2017-10-14 | 2020-06-05 | 싸이톰스 테라퓨틱스, 인크. | Antibodies, activatable antibodies, bispecific antibodies and bispecific activatable antibodies and methods of using them |
WO2019107380A1 (en) * | 2017-11-28 | 2019-06-06 | 中外製薬株式会社 | Polypeptide including antigen-binding domain and carrying section |
CA3083346A1 (en) * | 2017-11-28 | 2019-06-06 | Chugai Seiyaku Kabushiki Kaisha | Ligand-binding molecule having adjustable ligand-binding activity |
WO2019113386A1 (en) * | 2017-12-07 | 2019-06-13 | Janux Therapeutics, Inc. | Modified bispecific t cell receptors |
CA3089287A1 (en) * | 2018-02-08 | 2019-08-15 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
KR20210020903A (en) * | 2018-05-14 | 2021-02-24 | 하푼 테라퓨틱스, 인크. | Binding moieties for conditional activation of immunoglobulin molecules |
WO2019222275A2 (en) * | 2018-05-14 | 2019-11-21 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using inducible fusion proteins |
JP7477885B2 (en) | 2018-06-22 | 2024-05-02 | キュージーン インコーポレイテッド | Cytokine-based bioactive agents and methods of use thereof |
WO2020020210A1 (en) * | 2018-07-24 | 2020-01-30 | 科济生物医药(上海)有限公司 | Method for treating tumor using immune effector cell |
KR20210086623A (en) | 2018-09-25 | 2021-07-08 | 하푼 테라퓨틱스, 인크. | DDL3 Binding Proteins and Methods of Use |
CN113260379B (en) * | 2018-12-21 | 2022-09-02 | 浙江时迈药业有限公司 | Protease cleavable bispecific antibodies and uses thereof |
WO2020204305A1 (en) * | 2019-03-29 | 2020-10-08 | 주식회사 녹십자 | Fusion protein comprising anti-mesothelin antibody, anti-cd3 antibody or anti-egfr antibody, bispecific or trispecific antibody comprising same, and uses thereof |
GB201906685D0 (en) * | 2019-05-13 | 2019-06-26 | Ultrahuman Six Ltd | Activatable protein constructs and uses thereof |
JPWO2020246563A1 (en) * | 2019-06-05 | 2020-12-10 | ||
CN114341189A (en) * | 2019-06-12 | 2022-04-12 | 奥美药业有限公司 | Novel IL-15 prodrug and application thereof |
CN114127117B (en) * | 2019-07-19 | 2024-03-15 | 上海药明合联生物技术有限公司 | Polypeptide complex for coupling and application thereof |
CA3174665A1 (en) | 2020-04-09 | 2021-10-14 | Cytomx Therapeutics, Inc. | Compositions containing activatable antibodies |
US20230312753A1 (en) | 2020-05-04 | 2023-10-05 | Immunorizon Ltd. | Precursor tri-specific antibody constructs and methods of use thereof |
BR112022024469A2 (en) * | 2020-06-19 | 2023-01-17 | Hoffmann La Roche | Bespecific molecule of proteam -activable cell activation, specific idioty polypeptide, pharmaceutical composition, isolated polynucleotide, vector, host cell, a method for producing a bespecific molecule of tatable tatable cell activation, tativable cell activation molecule BY PROTEASE, USE OF THE BISPECIFIC PROTEASE-ACTIVABABLE T CELL ACTIVATION MOLECULE AND METHOD FOR TREAT A DISEASE IN A SUBJECT |
WO2022170619A1 (en) * | 2021-02-11 | 2022-08-18 | Adagene Pte. Ltd. | Anti-cd3 antibodies and methods of use thereof |
US20230183382A1 (en) * | 2021-10-15 | 2023-06-15 | Cytomx Therapeutics, Inc. | Activatable polypeptide complex |
WO2023064929A1 (en) * | 2021-10-15 | 2023-04-20 | Cytomx Therapeutics, Inc. | Activatable polypeptide complex |
WO2023186760A1 (en) * | 2022-03-28 | 2023-10-05 | F. Hoffmann-La Roche Ag | Improved folr1 protease-activatable t cell bispecific antibodies |
WO2023192973A1 (en) * | 2022-04-01 | 2023-10-05 | Cytomx Therapeutics, Inc. | Activatable multispecific molecules and methods of use thereof |
WO2023220647A1 (en) | 2022-05-11 | 2023-11-16 | Regeneron Pharmaceuticals, Inc. | Multispecific binding molecule proproteins and uses thereof |
WO2023222580A1 (en) | 2022-05-16 | 2023-11-23 | Byondis B.V. | Novel masked antibodies |
CN116462768B (en) * | 2023-06-13 | 2023-09-22 | 浙江时迈药业有限公司 | Bispecific antibodies against FOLR1 and uses thereof |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR7801185A (en) | 1977-04-18 | 1978-11-28 | Hitachi Metals Ltd | ORNATO ADAPTED TO BE FIXED BY AT LEAST ONE PERMANENT IMA |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
JP2919890B2 (en) | 1988-11-11 | 1999-07-19 | メディカル リサーチ カウンスル | Single domain ligand, receptor consisting of the ligand, method for producing the same, and use of the ligand and the receptor |
DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
EP0625200B1 (en) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
WO1999029888A1 (en) | 1997-12-05 | 1999-06-17 | The Scripps Research Institute | Humanization of murine antibody |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
BR0014480A (en) | 1999-10-04 | 2002-06-11 | Medicago Inc | Method for regulating the transcription of foreign genes |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
NZ550217A (en) | 2004-03-31 | 2009-11-27 | Genentech Inc | Humanized anti-TGF-beta antibodies |
EP2374817B1 (en) | 2004-04-13 | 2017-09-06 | F. Hoffmann-La Roche AG | Anti-P-selectin antibodies |
TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
KR101569300B1 (en) | 2005-02-07 | 2015-11-13 | 로슈 글리카트 아게 | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
WO2006099141A2 (en) * | 2005-03-10 | 2006-09-21 | Morphotek, Inc. | Anti-mesothelin antibodies |
PT2235064E (en) | 2008-01-07 | 2016-03-01 | Amgen Inc | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
SG193554A1 (en) | 2011-03-29 | 2013-11-29 | Roche Glycart Ag | Antibody fc variants |
GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
WO2014004549A2 (en) * | 2012-06-27 | 2014-01-03 | Amgen Inc. | Anti-mesothelin binding proteins |
US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
US20140308285A1 (en) * | 2013-03-15 | 2014-10-16 | Amgen Inc. | Heterodimeric bispecific antibodies |
AU2014236769B2 (en) * | 2013-03-15 | 2018-09-27 | Amgen Inc. | Heterodimeric bispecific antibodies |
KR102531517B1 (en) * | 2013-07-05 | 2023-05-12 | 젠맵 에이/에스 | Humanized or chimeric cd3 antibodies |
CN105722859B (en) * | 2013-07-25 | 2021-05-07 | 西托姆克斯治疗公司 | Multispecific antibodies, multispecific activatable antibodies, and methods of use thereof |
EP3049440B1 (en) * | 2013-09-25 | 2020-03-25 | Amgen Inc. | V-c-fc-v-c antibody |
WO2016014974A2 (en) * | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
EP2982692A1 (en) * | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
WO2016077505A2 (en) * | 2014-11-11 | 2016-05-19 | Amunix Operating Inc. | Targeted xten conjugate compositions and methods of making same |
CN107207609B (en) * | 2014-11-20 | 2022-07-19 | 豪夫迈·罗氏有限公司 | Common light chains and methods of use |
SG11201707541WA (en) * | 2015-03-17 | 2017-10-30 | Tilt Biotherapeutics Oy | Oncolytic adenoviruses coding for bi-specific antibodies and methods and uses related thereto |
-
2017
- 2017-03-20 WO PCT/EP2017/056556 patent/WO2017162587A1/en active Application Filing
- 2017-03-20 CR CR20180453A patent/CR20180453A/en unknown
- 2017-03-20 CN CN201780018328.8A patent/CN108884170A/en active Pending
- 2017-03-20 CA CA3012422A patent/CA3012422A1/en active Pending
- 2017-03-20 PE PE2018001324A patent/PE20181891A1/en unknown
- 2017-03-20 MA MA43724A patent/MA43724B1/en unknown
- 2017-03-20 KR KR1020187027293A patent/KR102444614B1/en active IP Right Grant
- 2017-03-20 BR BR112018016281A patent/BR112018016281A2/en unknown
- 2017-03-20 PT PT177112232T patent/PT3433280T/en unknown
- 2017-03-20 SG SG11201808085WA patent/SG11201808085WA/en unknown
- 2017-03-20 EP EP17711223.2A patent/EP3433280B1/en active Active
- 2017-03-20 AU AU2017237376A patent/AU2017237376B2/en active Active
- 2017-03-22 AR ARP170100708A patent/AR107946A1/en unknown
-
2018
- 2018-07-18 CO CONC2018/0007556A patent/CO2018007556A2/en unknown
-
2020
- 2020-11-24 AR ARP200103258A patent/AR120543A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20180128407A (en) | 2018-12-03 |
CA3012422A1 (en) | 2017-09-28 |
AU2017237376A1 (en) | 2018-08-02 |
CN108884170A (en) | 2018-11-23 |
WO2017162587A1 (en) | 2017-09-28 |
CR20180453A (en) | 2018-12-05 |
BR112018016281A2 (en) | 2019-01-02 |
AU2017237376B2 (en) | 2024-03-07 |
KR102444614B1 (en) | 2022-09-21 |
EP3433280A1 (en) | 2019-01-30 |
MA43724A (en) | 2018-11-28 |
AR107946A1 (en) | 2018-06-28 |
CO2018007556A2 (en) | 2018-07-31 |
PT3433280T (en) | 2023-06-15 |
MA43724B1 (en) | 2023-06-28 |
AR120543A2 (en) | 2022-02-23 |
PE20181891A1 (en) | 2018-12-11 |
EP3433280B1 (en) | 2023-04-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201808085WA (en) | Protease-activated t cell bispecific molecules | |
SG11201908787WA (en) | Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap | |
SG11201909154SA (en) | Bispecific antibodies specifically binding to pd1 and lag3 | |
SG11201908719QA (en) | Biomarkers and car t cell therapies with enhanced efficacy | |
SG11201810777WA (en) | Purification of multispecific antibodies | |
SG11201908088RA (en) | Antibodies against pd-l1 | |
SG11201805784PA (en) | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases | |
SG11201909205YA (en) | Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15 | |
SG11201907753TA (en) | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof | |
SG11201810076WA (en) | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety | |
SG11201900885VA (en) | Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule | |
SG11201908784TA (en) | Improved antigen binding receptor formats | |
SG11201808261RA (en) | Genetic variant-phenotype analysis system and methods of use | |
SG11201908796XA (en) | Improved antigen binding receptors | |
SG11201809522WA (en) | Method of nucleic acid sequence determination | |
SG11201908489XA (en) | De novo synthesized combinatorial nucleic acid libraries | |
SG11201901528RA (en) | Proteolytically cleavable chimeric polypeptides and methods of use thereof | |
SG11201811025VA (en) | Systems and methods for automated annotation and screening of biological sequences | |
SG11201906192SA (en) | Methods of treating cancer with anti-pd-1 antibodies | |
SG11201806282XA (en) | High-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies | |
SG11201807176XA (en) | TGFß1-BINDING IMMUNOGLOBULINS AND USE THEREOF | |
SG11201909618TA (en) | Compositions and methods for library construction and sequence analysis | |
SG11201909656YA (en) | Intracellular kinase associated with resistance against anti-tumour immune responses, and uses thereof | |
SG11201407669QA (en) | Methods for improving safety of blood-brain barrier transport | |
SG11201907364WA (en) | Anti-tryptase antibodies, compositions thereof, and uses thereof |