SG11201706659WA - Modified von willebrand factor having improved half-life - Google Patents

Modified von willebrand factor having improved half-life

Info

Publication number
SG11201706659WA
SG11201706659WA SG11201706659WA SG11201706659WA SG11201706659WA SG 11201706659W A SG11201706659W A SG 11201706659WA SG 11201706659W A SG11201706659W A SG 11201706659WA SG 11201706659W A SG11201706659W A SG 11201706659WA SG 11201706659W A SG11201706659W A SG 11201706659WA
Authority
SG
Singapore
Prior art keywords
life
von willebrand
willebrand factor
improved half
modified von
Prior art date
Application number
SG11201706659WA
Inventor
Michael Moses
Stefan Schulte
Gerhard Dickneite
Uwe Kalina
Sabine Pestel
Thomas Weimer
Original Assignee
Csl Behring Recombinant Facility Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Csl Behring Recombinant Facility Ag filed Critical Csl Behring Recombinant Facility Ag
Publication of SG11201706659WA publication Critical patent/SG11201706659WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11201706659WA 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life SG11201706659WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15158065 2015-03-06
PCT/EP2016/054647 WO2016142288A1 (en) 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life

Publications (1)

Publication Number Publication Date
SG11201706659WA true SG11201706659WA (en) 2017-09-28

Family

ID=52629450

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201706659WA SG11201706659WA (en) 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life

Country Status (13)

Country Link
US (1) US11155601B2 (en)
EP (1) EP3265483B1 (en)
JP (1) JP2018510212A (en)
KR (1) KR20170125941A (en)
CN (1) CN107406493B (en)
AU (1) AU2016231327B2 (en)
BR (1) BR112017018468A2 (en)
CA (1) CA2978374A1 (en)
DK (1) DK3265483T3 (en)
ES (1) ES2772933T3 (en)
HK (1) HK1244292A1 (en)
SG (1) SG11201706659WA (en)
WO (1) WO2016142288A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202010767SA (en) 2018-05-18 2020-11-27 Bioverativ Therapeutics Inc Methods of treating hemophilia a
CN113645993A (en) * 2019-02-01 2021-11-12 武田药品工业株式会社 Methods of prophylactic treatment using recombinant VWF (rVWF)
WO2021001522A1 (en) * 2019-07-04 2021-01-07 CSL Behring Lengnau AG A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4970300A (en) 1985-02-01 1990-11-13 New York University Modified factor VIII
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
SG48759A1 (en) 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
EP0546073B1 (en) 1990-08-29 1997-09-10 GenPharm International, Inc. production and use of transgenic non-human animals capable of producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
DE69233482T2 (en) 1991-05-17 2006-01-12 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
DE69233782D1 (en) 1991-12-02 2010-05-20 Medical Res Council Preparation of Autoantibodies on Phage Surfaces Starting from Antibody Segment Libraries
SG42861A1 (en) 1992-04-10 1997-10-17 Sprintpak Pty Ltd Postage stamps
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
AU6029594A (en) 1993-01-15 1994-08-15 Enzon, Inc. Factor viii - polymeric conjugates
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1997003193A1 (en) 1995-07-11 1997-01-30 Chiron Corporation Novel factor viii:c polypeptide analogs with altered metal-binding properties
SE9503380D0 (en) 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
JP3987114B2 (en) 1996-04-24 2007-10-03 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン Inactivation resistance factor (8)
US20040092442A1 (en) 1996-04-24 2004-05-13 University Of Michigan Inactivation resistant factor VIII
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
ES2301183T3 (en) 1996-12-03 2008-06-16 Amgen Fremont Inc. COMPLETELY HUMAN ANTIBODY THAT JOINS THE EGFR RECEIVER.
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
RU2224766C2 (en) 1997-04-14 2004-02-27 Микромет Аг Method for preparing receptors for human antigens and their application
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
PT1079805E (en) 1998-04-27 2005-03-31 Opperbas Holding Bv PHARMACEUTICAL COMPOSITION UNDERSTANDING FACTOR VIII AND NEUTRAL LIPOSOMES
ATE384792T1 (en) 1998-11-18 2008-02-15 Genentech Inc ANTIBODY VARIANTS WITH HIGHER BINDING AFFINITIES COMPARED TO PARENTAL ANTIBODIES
EP1351986A2 (en) 2001-01-12 2003-10-15 The American National Red Cross Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor viii
JP4361786B2 (en) 2001-06-14 2009-11-11 ザ スクリプス リサーチ インスティチュート Stabilized proteins with engineered disulfide bonds
ES2516041T3 (en) 2001-10-10 2014-10-30 Ratiopharm Gmbh Remodeling and glycoconjugation of human growth hormone (hGH)
AU2003227687B2 (en) 2002-04-29 2009-10-15 Stichting Sanquin Bloedvoorziening Antagonists of factor VIII interaction with low-density lipoprotein receptor-related protein
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7365168B2 (en) 2002-10-15 2008-04-29 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7217798B2 (en) 2003-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of Fc-fusion protein serum half-lives by mutagenesis
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7041635B2 (en) 2003-01-28 2006-05-09 In2Gen Co., Ltd. Factor VIII polypeptide
EP1596887B1 (en) 2003-02-26 2022-03-23 Nektar Therapeutics Polymer-factor viii moiety conjugates
ES2558102T3 (en) 2003-05-06 2016-02-02 Biogen Hemophilia Inc. Chimeric coagulation factor proteins for the treatment of a hemostatic disorder
WO2005123780A2 (en) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
LT3130601T (en) 2004-11-12 2020-09-10 Bayer Healthcare Llc Site-directed modification of fviii
PT1835938E (en) 2004-12-27 2013-11-06 Baxter Int Polymer-von willebrand factor-conjugates
AU2006233638A1 (en) 2005-04-14 2006-10-19 Csl Behring Gmbh Modified coagulation Factor VIII with enhanced stability and its derivates
US7645860B2 (en) 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
US7985839B2 (en) 2006-03-31 2011-07-26 Baxter International Inc. Factor VIII polymer conjugates
US7982010B2 (en) 2006-03-31 2011-07-19 Baxter International Inc. Factor VIII polymer conjugates
AU2007245190B2 (en) 2006-03-31 2011-07-21 Takeda Pharmaceutical Company Limited Pegylated factor VIII
JP5448839B2 (en) 2006-12-22 2014-03-19 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー Modified clotting factor with long half-life in vivo
CN101678119B (en) 2006-12-27 2014-02-12 尼克塔治疗公司 Von willebrand factor- and factor VIII-polymer conjugates having releasable linkage
EP1988101A1 (en) 2007-05-04 2008-11-05 Novo Nordisk A/S Improvement of factor VIII polypeptide titers in cell cultures
ES2392569T3 (en) * 2007-06-13 2012-12-11 Csl Behring Gmbh Use of VWF stabilized FVIII preparations for extravascular administration in the therapy and prophylactic treatment of bleeding disorders
DE602008005885D1 (en) 2007-07-11 2011-05-12 Novo Nordisk As PURIFICATION OF FACTOR VIII USING ONE
KR20100095441A (en) 2007-11-09 2010-08-30 백스터 인터내셔널 인코포레이티드 Modified recombinant factor viii and von willebrand factor and methods of use
EP2257311B1 (en) 2008-02-27 2014-04-16 Novo Nordisk A/S Conjugated factor viii molecules
CN102076855A (en) 2008-06-24 2011-05-25 Csl百灵有限公司 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life
ES2692172T3 (en) 2008-10-17 2018-11-30 Baxalta GmbH Modified blood factors comprising a low degree of water-soluble polymer
CN102333788A (en) 2009-02-19 2012-01-25 诺沃—诺迪斯克有限公司 Modification of factor viii
US20120093840A1 (en) 2009-04-06 2012-04-19 Novo Nordisk A/S Targeted delivery of factor viii proteins to platelets
KR101808751B1 (en) * 2009-11-13 2017-12-13 그리폴스 테라퓨틱스 인코포레이티드 VON WILLEBRAND FACTOR (vWF)-CONTAINING PREPARATIONS, AND METHODS, KITS, AND USES RELATED THERETO
US9493543B2 (en) 2010-02-16 2016-11-15 Novo Nordisk A/S Factor VIII fusion protein
WO2011101277A1 (en) 2010-02-16 2011-08-25 Novo Nordisk A/S Conjugated proteins
WO2011101242A1 (en) 2010-02-16 2011-08-25 Novo Nordisk A/S Factor viii molecules with reduced vwf binding
US8859731B2 (en) 2010-04-21 2014-10-14 Novo Nordisk A/S Selective modification of proteins
EP2593130A2 (en) 2010-07-15 2013-05-22 Novo Nordisk A/S Stabilized factor viii variants
CN102161692B (en) * 2011-03-08 2013-10-02 中国人民解放军第三军医大学 Improved hemostatic polypeptide and application thereof
WO2013083858A1 (en) 2012-04-24 2013-06-13 Novo Nordisk A/S Compounds suitable for treatment of haemophilia
EP2662083A1 (en) * 2012-05-08 2013-11-13 CSL Behring GmbH Sugar compositions for treating hemophilia a and/or von willebrand disease
ES2657291T3 (en) * 2013-04-22 2018-03-02 Csl Ltd. A covalent complex of von Willebrand factor and factor VIII associated by a disulfide bridge
WO2014198699A2 (en) * 2013-06-12 2014-12-18 Novo Nordisk A/S Compounds suitable for treatment of haemophilia

Also Published As

Publication number Publication date
BR112017018468A2 (en) 2018-04-17
WO2016142288A1 (en) 2016-09-15
DK3265483T3 (en) 2020-03-02
ES2772933T3 (en) 2020-07-08
AU2016231327B2 (en) 2018-08-09
HK1244292A1 (en) 2018-08-03
EP3265483B1 (en) 2019-12-11
CN107406493A (en) 2017-11-28
US11155601B2 (en) 2021-10-26
KR20170125941A (en) 2017-11-15
CA2978374A1 (en) 2016-09-15
EP3265483A1 (en) 2018-01-10
AU2016231327A1 (en) 2017-10-26
CN107406493B (en) 2021-08-13
JP2018510212A (en) 2018-04-12
US20180051067A1 (en) 2018-02-22

Similar Documents

Publication Publication Date Title
GB201506871D0 (en) Novel compounds
GB201506872D0 (en) Novel compounds
GB201501462D0 (en) Novel compounds
HK1256525A1 (en) Mutated truncated von willebrand factor
EP3164150A4 (en) Modified von willebrand factor
HK1250724A1 (en) Methods for preparing modified von willebrand factor
SG10201912857XA (en) Mutated von willebrand factor
GB201515745D0 (en) Proteins
GB201511787D0 (en) Proteins
HK1250625A1 (en) Truncated von willebrand factor polypeptides for treating hemophilia
GB201504565D0 (en) Novel compounds
GB201505799D0 (en) Stabilisers
IL253635A0 (en) Novel cyclopropabenzofuranyl pyridopyrazinediones
HK1244292A1 (en) Modified von willebrand factor having improved half-life
HK1252269A1 (en) Case made from dissimilar materials
GB201502675D0 (en) Novel compounds
EP3365485C0 (en) Sewing unit
GB201513033D0 (en) Proteins
GB201506092D0 (en) Novel material
SG11201706657PA (en) Compounds for improving the half-life of von willebrand factor
GB201614462D0 (en) Clotting factor
AU2014902532A0 (en) Modified von willebrand factor
GB201521142D0 (en) Chalk
GB201614041D0 (en) Not present
AU2015264V (en) ValleyLights Trachelospermum jasminoides