SG11201706029VA - Anti-senescence compounds and uses thereof - Google Patents

Anti-senescence compounds and uses thereof

Info

Publication number
SG11201706029VA
SG11201706029VA SG11201706029VA SG11201706029VA SG11201706029VA SG 11201706029V A SG11201706029V A SG 11201706029VA SG 11201706029V A SG11201706029V A SG 11201706029VA SG 11201706029V A SG11201706029V A SG 11201706029VA SG 11201706029V A SG11201706029V A SG 11201706029VA
Authority
SG
Singapore
Prior art keywords
senescence compounds
senescence
compounds
Prior art date
Application number
SG11201706029VA
Inventor
Keizer Peterus Leonardus Josephus De
Original Assignee
Univ Erasmus Med Ct Rotterdam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus Med Ct Rotterdam filed Critical Univ Erasmus Med Ct Rotterdam
Publication of SG11201706029VA publication Critical patent/SG11201706029VA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
SG11201706029VA 2015-01-23 2016-01-25 Anti-senescence compounds and uses thereof SG11201706029VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2014183 2015-01-23
EP15193041 2015-11-04
PCT/NL2016/050057 WO2016118014A2 (en) 2015-01-23 2016-01-25 Anti-senescence compounds and uses thereof

Publications (1)

Publication Number Publication Date
SG11201706029VA true SG11201706029VA (en) 2017-08-30

Family

ID=55642804

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201706029VA SG11201706029VA (en) 2015-01-23 2016-01-25 Anti-senescence compounds and uses thereof

Country Status (13)

Country Link
US (1) US11723947B2 (en)
EP (2) EP3247375B1 (en)
JP (1) JP6707549B2 (en)
CN (1) CN107531768A (en)
AU (1) AU2016209737A1 (en)
BR (1) BR112017015833A2 (en)
CA (1) CA2974623A1 (en)
CL (1) CL2017001883A1 (en)
MX (1) MX2017009595A (en)
PE (1) PE20180128A1 (en)
RU (1) RU2017128116A (en)
SG (1) SG11201706029VA (en)
WO (1) WO2016118014A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020511951A (en) * 2017-01-03 2020-04-23 バイオアトラ、エルエルシー Protein therapy for the treatment of senescent cells
AU2018209164B2 (en) 2017-01-17 2021-11-04 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
US20200255489A1 (en) * 2017-10-02 2020-08-13 Eternans Ltd Novel Senolytic Peptides
EP3705109A1 (en) 2019-03-05 2020-09-09 Greenaltech, S.L. Carotenoids in the treatment of senescence-related diseases
WO2020201444A1 (en) * 2019-04-02 2020-10-08 Eternans Ltd Repurposing small molecules for senescence-related diseases and disorders
CN111346101B (en) * 2019-04-16 2023-01-24 中山大学 Application of TAMATINIB in preparation of medicine for treating glioma
JP2022541845A (en) * 2019-07-22 2022-09-27 ワンスキン，インク． Polypeptide with anti-aging effect and use thereof
CN114981298A (en) 2019-12-12 2022-08-30 听治疗有限责任公司 Compositions and methods for preventing and treating hearing loss
CN113144192A (en) * 2020-01-22 2021-07-23 中国科学院上海营养与健康研究所 Application of MAPK/ERK pathway inhibitor in antagonizing skin aging and radiation-induced skin premature aging
WO2021165538A1 (en) 2020-02-21 2021-08-26 Cleara Biotech B.v. Improved anti-senescence compounds and uses thereof
AU2021421391A1 (en) 2021-01-24 2023-07-20 Michael David FORREST Inhibitors of atp synthase - cosmetic and therapeutic uses
EP4249912A1 (en) 2022-03-24 2023-09-27 Cleara Biotech B.V. Phosphorylation of p53 as a prognostic or diagnostic marker for the treatment of senescent cells in a mammal
CN115466321B (en) * 2022-09-23 2024-03-22 南方医科大学珠江医院 FOXO3a-DRI peptide fragment, pharmaceutical composition and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8227455B2 (en) * 2005-04-18 2012-07-24 Rigel Pharmaceuticals, Inc. Methods of treating cell proliferative disorders
CA2745376A1 (en) * 2008-12-01 2010-06-10 Lifespan Extension Llc Methods and compositions for altering health, wellbeing, and lifespan
CA2761489C (en) * 2009-05-08 2021-07-20 Lina Xu High penetration prodrug compositions of peptides and peptide-related compounds
US20130288981A1 (en) * 2012-04-02 2013-10-31 Buck Institute For Research On Aging Targeting senescent cells and cancer cells by interference with jnk and/or foxo4
US20130288980A1 (en) * 2012-04-02 2013-10-31 Buck Institute For Research On Aging Targeting senescent and cancer cells for selective killing by interference with foxo4
CN105307670A (en) * 2013-06-26 2016-02-03 埃克西金炎症有限公司 New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases
JP2020511951A (en) 2017-01-03 2020-04-23 バイオアトラ、エルエルシー Protein therapy for the treatment of senescent cells

Also Published As

Publication number Publication date
PE20180128A1 (en) 2018-01-18
US20180015137A1 (en) 2018-01-18
EP3936141A3 (en) 2022-03-23
MX2017009595A (en) 2018-04-20
RU2017128116A (en) 2019-02-26
CA2974623A1 (en) 2016-07-28
JP2018508196A (en) 2018-03-29
WO2016118014A3 (en) 2016-11-17
JP6707549B2 (en) 2020-06-10
EP3936141A2 (en) 2022-01-12
BR112017015833A2 (en) 2018-03-27
EP3247375B1 (en) 2021-08-04
WO2016118014A2 (en) 2016-07-28
US11723947B2 (en) 2023-08-15
AU2016209737A1 (en) 2017-08-17
RU2017128116A3 (en) 2019-08-21
EP3247375A2 (en) 2017-11-29
CL2017001883A1 (en) 2018-02-02
CN107531768A (en) 2018-01-02

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