SG11201703258PA - Engineered imine reductases and methods for the reductive amination of ketone and amine compounds - Google Patents

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Info

Publication number
SG11201703258PA
SG11201703258PA SG11201703258PA SG11201703258PA SG11201703258PA SG 11201703258P A SG11201703258P A SG 11201703258PA SG 11201703258P A SG11201703258P A SG 11201703258PA SG 11201703258P A SG11201703258P A SG 11201703258PA SG 11201703258P A SG11201703258P A SG 11201703258PA
Authority
SG
Singapore
Prior art keywords
ketone
methods
amine compounds
reductive amination
engineered imine
Prior art date
Application number
SG11201703258PA
Inventor
Oscar Alvizo
Melissa Ann Mayo
Jeffrey C Moore
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG11201703258PA publication Critical patent/SG11201703258PA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201703258PA 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds SG11201703258PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462084037P 2014-11-25 2014-11-25
PCT/US2015/062300 WO2016085916A1 (en) 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Publications (1)

Publication Number Publication Date
SG11201703258PA true SG11201703258PA (en) 2017-05-30

Family

ID=56074943

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202012428PA SG10202012428PA (en) 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
SG11201703258PA SG11201703258PA (en) 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202012428PA SG10202012428PA (en) 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Country Status (10)

Country Link
US (4) US10370648B2 (en)
EP (1) EP3224354B1 (en)
JP (1) JP6719463B2 (en)
CN (1) CN107002050A (en)
CA (1) CA2968275C (en)
DK (1) DK3224354T3 (en)
HU (1) HUE053363T2 (en)
IL (1) IL251928B (en)
SG (2) SG10202012428PA (en)
WO (1) WO2016085916A1 (en)

Families Citing this family (9)

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HUE053363T2 (en) 2014-11-25 2021-06-28 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US11046936B2 (en) 2016-08-26 2021-06-29 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
WO2020223102A1 (en) * 2019-05-01 2020-11-05 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN110951705B (en) * 2019-12-20 2020-09-25 中国科学院苏州生物医学工程技术研究所 Amine dehydrogenase mutant, enzyme preparation, recombinant vector, recombinant cell and preparation method and application thereof
CN112852771B (en) * 2020-04-17 2022-04-08 中国科学院天津工业生物技术研究所 Enzymatic synthesis of chiral amino alcohol compounds
CN112779300B (en) * 2020-12-15 2022-10-21 上海合全药物研发有限公司 Method for preparing (S) -3-butyn-2-amine by biocatalysis
CN116286700A (en) * 2021-10-18 2023-06-23 迪嘉药业集团股份有限公司 Imine reductase mutant and application thereof
CN114717211B (en) * 2022-03-23 2023-06-02 江苏集萃分子工程研究院有限公司 Imine reductase mutant M5 and application thereof in synthesis of nitrogen heterocycle chiral amine
CN114807071B (en) * 2022-05-11 2023-10-20 中国科学院天津工业生物技术研究所 Enzymatic preparation method of tofacitinib key intermediate

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Also Published As

Publication number Publication date
EP3224354A1 (en) 2017-10-04
DK3224354T3 (en) 2021-03-01
US10370648B2 (en) 2019-08-06
US20200399616A1 (en) 2020-12-24
JP2018500887A (en) 2018-01-18
JP6719463B2 (en) 2020-07-15
HUE053363T2 (en) 2021-06-28
US10793836B2 (en) 2020-10-06
US11352609B2 (en) 2022-06-07
EP3224354B1 (en) 2021-01-13
IL251928B (en) 2019-12-31
WO2016085916A1 (en) 2016-06-02
CA2968275A1 (en) 2016-06-02
IL251928A0 (en) 2017-06-29
CA2968275C (en) 2023-09-12
US20170355966A1 (en) 2017-12-14
US20190300865A1 (en) 2019-10-03
SG10202012428PA (en) 2021-01-28
EP3224354A4 (en) 2018-05-16
US11802274B2 (en) 2023-10-31
CN107002050A (en) 2017-08-01
US20220275349A1 (en) 2022-09-01

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