SG11201702895SA - Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof - Google Patents

Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof

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Publication number
SG11201702895SA
SG11201702895SA SG11201702895SA SG11201702895SA SG11201702895SA SG 11201702895S A SG11201702895S A SG 11201702895SA SG 11201702895S A SG11201702895S A SG 11201702895SA SG 11201702895S A SG11201702895S A SG 11201702895SA SG 11201702895S A SG11201702895S A SG 11201702895SA
Authority
SG
Singapore
Prior art keywords
antigen receptor
chimeric antigen
receptor therapy
therapeutic responsiveness
biomarkers predictive
Prior art date
Application number
SG11201702895SA
Inventor
Felipe Bedoya
Hans Bitter
Jennifer Brogdon
Corin Dorfmeier
Abhishek Garg
David Glass
Joan Mannick
Jan J Melenhorst
Michael C Milone
Leon Murphy
Elena Orlando
Nicholas Wilcox
Original Assignee
Novartis Ag
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pennsylvania filed Critical Novartis Ag
Publication of SG11201702895SA publication Critical patent/SG11201702895SA/en

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/4613—Natural-killer cells [NK or NK-T]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4636—Immune checkpoint inhibitors
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/54—Determining the risk of relapse

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SG11201702895SA 2014-10-08 2015-10-07 Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof SG11201702895SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462061553P 2014-10-08 2014-10-08
US201562144682P 2015-04-08 2015-04-08
PCT/US2015/054542 WO2016057705A1 (en) 2014-10-08 2015-10-07 Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof

Publications (1)

Publication Number Publication Date
SG11201702895SA true SG11201702895SA (en) 2017-05-30

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US (2) US10774388B2 (en)
EP (1) EP3204777A1 (en)
JP (2) JP6815992B2 (en)
KR (1) KR20170068504A (en)
CN (2) CN114107424A (en)
AU (2) AU2015330898B2 (en)
CA (1) CA2963935A1 (en)
IL (2) IL279420B1 (en)
RU (1) RU2743657C2 (en)
SG (1) SG11201702895SA (en)
WO (1) WO2016057705A1 (en)

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