SG11201609219QA - Autoinjector with shock reducing elements - Google Patents

Autoinjector with shock reducing elements

Info

Publication number
SG11201609219QA
SG11201609219QA SG11201609219QA SG11201609219QA SG11201609219QA SG 11201609219Q A SG11201609219Q A SG 11201609219QA SG 11201609219Q A SG11201609219Q A SG 11201609219QA SG 11201609219Q A SG11201609219Q A SG 11201609219QA SG 11201609219Q A SG11201609219Q A SG 11201609219QA
Authority
SG
Singapore
Prior art keywords
autoinjector
shock reducing
reducing elements
elements
shock
Prior art date
Application number
SG11201609219QA
Inventor
Christopher R Folk
Scott R Gibson
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11201609219QA publication Critical patent/SG11201609219QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/06—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using both gas and liquid
    • F16F9/08—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using both gas and liquid where gas is in a chamber with a flexible wall
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/10—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using liquid only; using a fluid of which the nature is immaterial
    • F16F9/103—Devices with one or more members moving linearly to and fro in chambers, any throttling effect being immaterial, i.e. damping by viscous shear effect only
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/10—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using liquid only; using a fluid of which the nature is immaterial
    • F16F9/14—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect
    • F16F9/16—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect involving only straight-line movement of the effective parts
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/10—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using liquid only; using a fluid of which the nature is immaterial
    • F16F9/14—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect
    • F16F9/16—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect involving only straight-line movement of the effective parts
    • F16F9/18—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect involving only straight-line movement of the effective parts with a closed cylinder and a piston separating two or more working spaces therein
    • F16F9/20—Devices with one or more members, e.g. pistons, vanes, moving to and fro in chambers and using throttling effect involving only straight-line movement of the effective parts with a closed cylinder and a piston separating two or more working spaces therein with the piston-rod extending through both ends of the cylinder, e.g. constant-volume dampers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/32—Details
    • F16F9/3207—Constructional features
    • F16F9/3228—Constructional features of connections between pistons and piston rods
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/32—Details
    • F16F9/34—Special valve constructions; Shape or construction of throttling passages
    • F16F9/348—Throttling passages in the form of annular discs or other plate-like elements which may or may not have a spring action, operating in opposite directions or singly, e.g. annular discs positioned on top of the valve or piston body
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/32—Details
    • F16F9/34—Special valve constructions; Shape or construction of throttling passages
    • F16F9/348—Throttling passages in the form of annular discs or other plate-like elements which may or may not have a spring action, operating in opposite directions or singly, e.g. annular discs positioned on top of the valve or piston body
    • F16F9/3481—Throttling passages in the form of annular discs or other plate-like elements which may or may not have a spring action, operating in opposite directions or singly, e.g. annular discs positioned on top of the valve or piston body characterised by shape or construction of throttling passages in piston
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/32—Details
    • F16F9/36—Special sealings, including sealings or guides for piston-rods
    • F16F9/361—Sealings of the bellows-type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2086—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
SG11201609219QA 2014-05-07 2015-05-06 Autoinjector with shock reducing elements SG11201609219QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461990063P 2014-05-07 2014-05-07
PCT/US2015/029485 WO2015171777A1 (en) 2014-05-07 2015-05-06 Autoinjector with shock reducing elements

Publications (1)

Publication Number Publication Date
SG11201609219QA true SG11201609219QA (en) 2016-12-29

Family

ID=53200314

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201609219QA SG11201609219QA (en) 2014-05-07 2015-05-06 Autoinjector with shock reducing elements
SG10201811702TA SG10201811702TA (en) 2014-05-07 2015-05-06 Autoinjector with shock reducing elements

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201811702TA SG10201811702TA (en) 2014-05-07 2015-05-06 Autoinjector with shock reducing elements

Country Status (12)

Country Link
US (2) US10722655B2 (en)
EP (2) EP3785749A1 (en)
JP (3) JP6640113B2 (en)
KR (1) KR102496507B1 (en)
CN (1) CN106413779B (en)
AU (1) AU2015256082C1 (en)
BR (1) BR112016025852B1 (en)
CA (2) CA3193070A1 (en)
IL (1) IL247935B (en)
MX (1) MX2016014561A (en)
SG (2) SG11201609219QA (en)
WO (1) WO2015171777A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016163642A (en) * 2015-03-06 2016-09-08 大成化工株式会社 Barrel with needle and syringe having the same
FR3036966B1 (en) * 2015-06-05 2021-10-01 Aptar France Sas AUTOINJECTOR
US10653844B2 (en) * 2015-11-27 2020-05-19 Sanofi-Aventis Deutschland Gmbh Auto-injector
JOP20170042B1 (en) 2016-02-12 2022-09-15 Amgen Inc Drug Delivery Device, Method of Manufacture and Method of Use
EP3429663B1 (en) * 2016-03-15 2020-07-15 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
EP3834864A1 (en) 2016-04-08 2021-06-16 Amgen Inc. Drug delivery device, method of manufacture, and method of use
US10549044B2 (en) * 2016-06-09 2020-02-04 Becton, Dickinson And Company Spacer assembly for drug delivery system
US20180015224A1 (en) * 2016-07-13 2018-01-18 California Institute Of Technology Dampers and Methods for Performing Measurements in an Autoinjector
GB2553770A (en) * 2016-09-09 2018-03-21 Owen Mumford Ltd Injection device
CN109890436B (en) * 2016-11-01 2022-12-02 赛诺菲-安万特德国有限公司 Feedback mechanism for an injection device
EP3348294A1 (en) * 2017-01-13 2018-07-18 Carebay Europe Ltd. Medicament delivery device
AU2018210301A1 (en) * 2017-01-17 2019-08-01 Amgen Inc. Injection devices and related methods of use and assembly
US11541183B2 (en) 2017-06-22 2023-01-03 Amgen Inc. Device activation impact/shock reduction
WO2019202130A1 (en) * 2018-04-19 2019-10-24 Sanofi Shock absorber for injection devices
CN112292167B (en) * 2018-04-19 2023-01-20 赛诺菲 Force reduction in an injection device
CN112805048B (en) * 2018-10-02 2023-09-22 安进公司 Injection system for drug delivery with internal force transfer
TWI831847B (en) * 2018-11-01 2024-02-11 美商安進公司 Drug delivery devices with partial needle retraction and methods for operating the same
WO2020091956A1 (en) 2018-11-01 2020-05-07 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
MX2022003703A (en) * 2019-09-30 2022-04-26 Amgen Inc Drug delivery device.
JP7075977B2 (en) 2020-10-09 2022-05-26 成田空港給油施設株式会社 Syringe
US11872369B1 (en) 2021-02-18 2024-01-16 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with leakage and skin contact sensing and method of use thereof
US11311666B1 (en) 2021-02-18 2022-04-26 Fresenius Kabi Deutschland Gmbh Modular wearable medicament delivery device and method of use thereof
US11464902B1 (en) 2021-02-18 2022-10-11 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with compressible reservoir and method of use thereof
US11413394B1 (en) 2021-02-19 2022-08-16 Fresenius Kabi Deutschland Gmbh Display for wearable drug delivery device
US11607505B1 (en) 2021-02-19 2023-03-21 Fresenius Kabi Deutschland Gmbh Wearable injector with sterility sensors
US11344682B1 (en) 2021-02-19 2022-05-31 Fresenius Kabi Deutschland Gmbh Drug supply cartridge with visual use indicator and delivery devices that use the same
US11426523B1 (en) 2021-02-19 2022-08-30 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a removable cartridge
US11406755B1 (en) 2021-02-19 2022-08-09 Fresenius Kabi Deutschland Gmbh Sensing fluid flow irregularities in an on-body injector
US11633537B1 (en) 2021-02-19 2023-04-25 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a pre-filled cartridge
US11497847B1 (en) 2021-02-19 2022-11-15 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive substrate
JPWO2022191136A1 (en) * 2021-03-12 2022-09-15
JP2024510668A (en) * 2021-03-25 2024-03-08 アムジエン・インコーポレーテツド drug delivery device
US11529459B1 (en) 2021-04-30 2022-12-20 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive module
US11351300B1 (en) 2021-04-30 2022-06-07 Fresenius Kabl Deutschland GmbH Drug dispensing system with replaceable drug supply cartridges
US11419976B1 (en) 2021-04-30 2022-08-23 Fresenius Kabi Deutschland Gmbh Wearable drug delivery device with pressurized fluid dispensing
US11504470B1 (en) 2021-04-30 2022-11-22 Fresenius Kabi Deutschland Gmbh Deformable drug reservoir for wearable drug delivery device
US11717608B1 (en) 2021-05-03 2023-08-08 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including an adhesive pad
US11484646B1 (en) 2021-05-04 2022-11-01 Fresenius Kabi Deutschland Gmbh Sealing systems for a reservoir of an on-body injector
JP2023165377A (en) * 2022-05-02 2023-11-15 コスメディ製薬株式会社 Microneedle applicator

Family Cites Families (218)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE537349A (en)
KR850004274A (en) 1983-12-13 1985-07-11 원본미기재 Method for preparing erythropoietin
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
AU646822B2 (en) 1989-10-13 1994-03-10 Kirin-Amgen Inc. Erythropoietin isoforms
US7217689B1 (en) 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
US5856298A (en) 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
US5318156A (en) * 1992-12-15 1994-06-07 Honeywell Inc. Rigid volume viscous damper
IL192290A0 (en) 1993-08-17 2008-12-29 Kirin Amgen Inc Erythropoietin analogs
US6562596B1 (en) 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
US5773569A (en) 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5830851A (en) 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5885574A (en) 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
IL114909A (en) 1994-08-12 1999-10-28 Immunomedics Inc Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
GB9504878D0 (en) 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5767078A (en) 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
WO1999003887A1 (en) 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
KR100641969B1 (en) 1997-07-23 2006-11-06 로셰 디아그노스틱스 게엠베하 Production of erythropoietin by endogenous gene activation
US6030086A (en) 1998-03-02 2000-02-29 Becton, Dickinson And Company Flash tube reflector with arc guide
US6310078B1 (en) 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
DE19821933C1 (en) 1998-05-15 1999-11-11 Disetronic Licensing Ag Device for administering an injectable product
US20050181482A1 (en) 2004-02-12 2005-08-18 Meade Harry M. Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
DK1088084T3 (en) 1998-06-15 2007-01-29 Gtc Biotherapeutics Inc Erythropoietin analog-human serum albumin fusion protein
US7798993B2 (en) * 1998-07-29 2010-09-21 Becton, Dickinson And Company Single use syringe
DK1123313T3 (en) 1998-10-23 2007-06-18 Amgen Inc Methods and compositions for the prevention and treatment of anemia
AU773891C (en) 1998-10-23 2005-02-17 Kirin-Amgen Inc. Dimeric thrombopoietin peptide mimetics binding to MP1 receptor and having thrombopoietic activity
SE9803662D0 (en) 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab autoinjector
PT2261335T (en) 1998-11-27 2017-09-08 Ucb Pharma Sa Compositions and methods for increasing bone mineralisation
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
EP1169352A4 (en) 1999-04-14 2005-05-04 Smithkline Beecham Corp Erythropoietin receptor antibodies
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
JP4326704B2 (en) 1999-04-16 2009-09-09 ベクトン・ディキンソン・アンド・カンパニー Pen-type syringe with automatic compounding function
US6171286B1 (en) * 1999-04-20 2001-01-09 James R. Gross Self-aligning syringe plunger
CZ299516B6 (en) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof
WO2001031007A2 (en) 1999-10-22 2001-05-03 Millennium Pharmaceuticals, Inc. Nucleic acid molecules derived from rat brain and programmed cell death models
US20050202538A1 (en) 1999-11-12 2005-09-15 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
EP1228214A2 (en) 1999-11-12 2002-08-07 MERCK PATENT GmbH Erythropoietin forms with improved properties
ES2254359T3 (en) 2000-01-21 2006-06-16 Biovex Limited VIRAL CEPA FOR THE ONCOLITIC TREATMENT OF CANCERES.
AUPQ599700A0 (en) 2000-03-03 2000-03-23 Super Internet Site System Pty Ltd On-line geographical directory
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
EP1961425B1 (en) 2000-04-21 2017-07-19 Amgen Inc. Methods and erythropoeitin analogs for the prevention and treatment of anemia
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US7078376B1 (en) 2000-08-11 2006-07-18 Baxter Healthcare S.A. Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
GB2366705B (en) 2000-08-29 2004-07-14 Motorola Inc Communications system, communications unit and method of operation
US20030191291A1 (en) 2000-09-08 2003-10-09 Kochendoerfer Gerd G. Synthetic erythropoiesis stimulating proteins
US7271689B1 (en) 2000-11-22 2007-09-18 Fonar Corporation Magnet structure
WO2002049673A2 (en) 2000-12-20 2002-06-27 F. Hoffmann-La Roche Ag Conjugates of erythropoietin (pep) with polyethylene glycol (peg)
EP1399483B1 (en) 2001-01-05 2010-04-14 Pfizer Inc. Antibodies to insulin-like growth factor i receptor
EP1383927B1 (en) 2001-04-04 2009-07-08 GenOdyssee New polynucleotides and polypeptides of the erythropoietin gene
EA010435B1 (en) 2001-05-11 2008-08-29 Амген, Инк. Binding to tall-1 molecules and use thereof
KR20040023630A (en) 2001-06-26 2004-03-18 아브게닉스, 인크. Antibodies to opgl
US6900292B2 (en) 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
BR0212136A (en) 2001-08-23 2004-12-07 Genmab As Isolated human monoclonal antibody, methods for inhibiting tnfa production in t cells or monocytes and t cell proliferation, hybridoma, transfectoma, transgenic non-human animal, method for producing a human monoclonal antibody, pharmaceutical composition, methods for treating or preventing a human il-15 mediated disorder, psoriasis and rheumatoid arthritis, method for diagnosing a disease, nucleic acid, and expression vector
US6930086B2 (en) 2001-09-25 2005-08-16 Hoffmann-La Roche Inc. Diglycosylated erythropoietin
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
GB0125506D0 (en) 2001-10-24 2001-12-12 Weston Medical Ltd Needle free injection method and apparatus
WO2003055526A2 (en) 2001-12-21 2003-07-10 Maxygen Aps Erythropoietin conjugates
JP4606739B2 (en) 2002-01-18 2011-01-05 ピエール、ファーブル、メディカマン Novel anti-IGF-IR antibodies and uses thereof
US7241444B2 (en) 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
GB0202252D0 (en) 2002-01-31 2002-03-20 Oxford Biomedica Ltd Anemia
EP1470232A1 (en) 2002-01-31 2004-10-27 Oxford Biomedica (UK) Limited Physiologically regulated erythropoietin-expressing vector for the treatment of anaemia
US20050153879A1 (en) 2002-03-26 2005-07-14 Monica Svetina Process for the preparation of a desired erythropoietin glyco-isoform profile
BRPI0308946B1 (en) 2002-03-29 2016-08-30 Kumiai Chemical Industry Co nucleic acid, protein, recombinant vector, bacterium, processes for cultivating plant presenting said nucleic acid, for cultivating plant presenting said protein, for selecting transformant cell presenting said nucleic acid and for selecting transformant cell presenting said nucleic acid protein
WO2003084477A2 (en) 2002-03-29 2003-10-16 Centocor, Inc. Mammalian cdr mimetibodies, compositions, methods and uses
US20040009902A1 (en) 2002-05-13 2004-01-15 Irving Boime CTP extended erythropoietin
GB0211294D0 (en) * 2002-05-17 2002-06-26 Owen Mumford Ltd Improvements relating to injection devices
US7217796B2 (en) 2002-05-24 2007-05-15 Schering Corporation Neutralizing human anti-IGFR antibody
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
US8034904B2 (en) 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
DE10226537A1 (en) 2002-06-14 2004-01-08 Peter Eichhorst pre-injection device
AU2003256336A1 (en) 2002-06-28 2004-01-19 Centocor, Inc. Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses
WO2004002417A2 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian ch1 deleted mimetibodies, compositions, methods and uses
AU2003246486A1 (en) 2002-07-19 2004-02-09 Cangene Corporation Pegylated erythropoietic compounds
WO2004011065A1 (en) * 2002-07-31 2004-02-05 Alza Corporation Injection device providing automatic needle retraction
JP4406607B2 (en) 2002-08-26 2010-02-03 オンコセラピー・サイエンス株式会社 Peptide and pharmaceutical containing the same
TWI347951B (en) 2002-09-06 2011-09-01 Amgen Inc Therapeutic human anti-il-1r1 monoclonal antibody
US9486581B2 (en) 2002-09-11 2016-11-08 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
JP2006516534A (en) 2002-09-11 2006-07-06 フレセニウス・カビ・ドイッチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング HAS polypeptide, in particular HAS erythropoietin
US6919426B2 (en) 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
US20040071694A1 (en) 2002-10-14 2004-04-15 Devries Peter J. Erythropoietin receptor binding antibodies
US7396913B2 (en) 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
TWI320716B (en) 2002-10-14 2010-02-21 Abbott Lab Erythropoietin receptor binding antibodies
AU2003285874A1 (en) 2002-10-16 2004-05-04 Amgen Inc. HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS
US20040091961A1 (en) 2002-11-08 2004-05-13 Evans Glen A. Enhanced variants of erythropoietin and methods of use
US6939319B1 (en) 2002-11-20 2005-09-06 Conrad Anstead Process and device for single use, needle-free intradermal, subcutaneous, or intramuscular injections
MEP57508A (en) 2002-12-20 2011-05-10 Amgen Inc Binding agents which inhibit myostatin
AU2003299795A1 (en) * 2002-12-20 2004-07-22 Xeris Pharmaceuticals, Inc. Intracutaneous injection
EP1603948A1 (en) 2003-03-14 2005-12-14 Pharmacia Corporation Antibodies to igf-i receptor for the treatment of cancers
CA2519113C (en) 2003-04-02 2012-06-05 F. Hoffmann-La Roche Ag Antibodies against insulin-like growth factor i receptor and uses thereof
US7220410B2 (en) 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
US7638605B2 (en) 2003-05-01 2009-12-29 ImClone, LLC Fully human antibodies directed against the human insulin-like growth factor-1 receptor
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
JP2007530440A (en) 2003-05-12 2007-11-01 アフィーマックス・インコーポレイテッド Novel poly (ethylene glycol) modified compounds and uses thereof
WO2004101611A2 (en) 2003-05-12 2004-11-25 Affymax, Inc. Peptides that bind to the erythropoietin receptor
MXPA05012316A (en) 2003-05-12 2006-04-18 Affymax Inc Novel peptides that bind to the erythropoietin receptor.
US7074755B2 (en) 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
US6995245B2 (en) 2003-05-30 2006-02-07 Centocor, Inc. Formation of novel erythropoietin conjugates using transglutaminase
US20050037390A1 (en) 2003-06-04 2005-02-17 Irm Llc, A Delaware Limited Liability Company Methods and compositions for modulating erythropoietin expression
AR046071A1 (en) 2003-07-10 2005-11-23 Hoffmann La Roche ANTIBODIES AGAINST RECEIVER I OF THE INSULINAL TYPE GROWTH FACTOR AND THE USES OF THE SAME
ME02785B (en) 2003-07-15 2012-12-31 Amgen Inc Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
NZ544797A (en) 2003-07-18 2011-04-29 Amgen Fremont Inc Specific antibodies that bind HGF and neutralise binding of HGF to met
US20050019914A1 (en) 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
JP2007512001A (en) 2003-08-28 2007-05-17 バイオレクシス ファーマシューティカル コーポレイション EPO mimetic peptides and fusion proteins
CN1882355A (en) 2003-09-09 2006-12-20 沃伦药品公司 Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin
IL157981A (en) 2003-09-17 2014-01-30 Elcam Medical Agricultural Cooperative Ass Ltd Auto-injector
CN1890383A (en) 2003-09-30 2007-01-03 森托科尔公司 Hinge core mimetibodies, compositions, methods and uses
UA89481C2 (en) 2003-09-30 2010-02-10 Центокор, Инк. Human epo mimetic hinge core mimetibodies, compositions, methods and uses
UA93653C2 (en) 2003-11-07 2011-03-10 Иммунекс Корпорейшн Antibody that specifically binds to human interleukin-4 receptor (il-4r)
PE20050928A1 (en) 2003-11-21 2005-11-08 Schering Corp THERAPEUTIC COMBINATIONS OF ANTI-IGFR1 ANTIBODY
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US7405198B2 (en) 2003-11-24 2008-07-29 Neose Technologies, Inc. Glycopegylated erythropoietin
WO2005058967A2 (en) 2003-12-16 2005-06-30 Pierre Fabre Medicament Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof
EP1548031A1 (en) 2003-12-22 2005-06-29 Dubai Genetics FZ-LLC Nature-identical erythropoietin
US20050170457A1 (en) 2003-12-31 2005-08-04 Chadler Pool Novel recombinant proteins with N-terminal free thiol
WO2005063808A1 (en) 2003-12-31 2005-07-14 Merck Patent Gmbh Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS
US7967772B2 (en) 2004-01-12 2011-06-28 Iscience Interventional Corporation Injector for viscous materials
US7423139B2 (en) 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
WO2005070451A1 (en) 2004-01-22 2005-08-04 Zafena Aktiebolag Pharmaceutical composition comprising non-glycosylated erythropoietin
WO2005084711A1 (en) 2004-03-02 2005-09-15 Chengdu Institute Of Biological Products A pegylated recombinant erythropoietin that has in vivo activity
AR048918A1 (en) 2004-03-11 2006-06-14 Fresenius Kabi De Gmbh CONJUGADOS DE ALMIDON DE HIDROXIETILO Y ERITROPOYETINA
JP2007530045A (en) 2004-03-23 2007-11-01 アムジエン・インコーポレーテツド Human OX40L (CD134L) specific monoclonal antibody
US20050227289A1 (en) 2004-04-09 2005-10-13 Reilly Edward B Antibodies to erythropoietin receptor and uses thereof
WO2005103076A2 (en) 2004-04-23 2005-11-03 Cambridge Antibody Technology Limited Erythropoietin protein variants
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
GB2414404B (en) 2004-05-28 2009-06-03 Cilag Ag Int Injection device
ATE429444T1 (en) 2004-07-07 2009-05-15 Lundbeck & Co As H NEW CARBAMYLATED EPO AND METHOD FOR THE PRODUCTION THEREOF
FR2873699B1 (en) 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa NOVEL ANTI-IGF ANTIBODIES IR RT USES THEREOF
US20060073563A1 (en) 2004-09-02 2006-04-06 Xencor, Inc. Erythropoietin derivatives with altered immunogenicity
EP1814616A1 (en) 2004-11-04 2007-08-08 Sid Technologies Llc Automatic injector
AU2005303887A1 (en) 2004-11-10 2006-05-18 Aplagen Gmbh Molecules which promote hematopoiesis
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
EP1850892B2 (en) 2005-01-24 2023-04-19 Antares Pharma, Inc. Prefilled needle assisted syringe jet injector
EP1841455A1 (en) 2005-01-24 2007-10-10 Amgen Inc. Humanized anti-amyloid antibody
GB2424838B (en) * 2005-04-06 2011-02-23 Cilag Ag Int Injection device (adaptable drive)
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
DE102005025424A1 (en) 2005-06-02 2006-12-07 Tecpharma Licensing Ag Injection device, especially automatic injector or injection pen, has drive-off member propelled by surrounding torsional spring, for efficient delivery of product to patient
RU2502523C2 (en) 2005-06-17 2013-12-27 Имклоун Элэлси PDGFRα ANTIBODIES FOR TREATING SECONDARY BONE TUMOUR
WO2007000328A1 (en) 2005-06-27 2007-01-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof
WO2007011941A2 (en) 2005-07-18 2007-01-25 Amgen Inc. Human anti-b7rp1 neutralizing antibodies
FR2888850B1 (en) 2005-07-22 2013-01-11 Pf Medicament NOVEL ANTI-IGF-IR ANTIBODIES AND THEIR APPLICATIONS
PE20071101A1 (en) 2005-08-31 2007-12-21 Amgen Inc POLYPEPTIDES AND ANTIBODIES
GB0603683D0 (en) 2006-02-23 2006-04-05 Novartis Ag Organic compounds
TWI395754B (en) 2006-04-24 2013-05-11 Amgen Inc Humanized c-kit antibody
MX2008014744A (en) 2006-05-19 2009-02-10 Glycofi Inc Erythropoietin compositions.
FR2905273B1 (en) 2006-09-06 2009-04-03 Becton Dickinson France Soc Pa AUTOMATIC INJECTION DEVICE WITH TIMING MEANS.
CL2007002567A1 (en) 2006-09-08 2008-02-01 Amgen Inc ISOLATED PROTEINS FROM LINK TO ACTIVINE TO HUMAN.
DE102007022791A1 (en) 2006-09-15 2008-03-27 Tecpharma Licensing Ag Injection device with improved attachment of the product container
WO2008057458A2 (en) 2006-11-07 2008-05-15 Merck & Co., Inc. Antagonists of pcsk9
WO2008133647A2 (en) 2006-11-07 2008-11-06 Merck & Co., Inc. Antagonists of pcsk9
EP2083859A4 (en) 2006-11-07 2010-11-24 Merck Sharp & Dohme Antagonists of pcsk9
EP2083864A4 (en) 2006-11-07 2010-12-08 Merck Sharp & Dohme Antagonists of pcsk9
CN101605814B (en) 2006-12-14 2014-02-19 默沙东公司 Engineered anti-TSLP antibody
EP2134391B1 (en) * 2007-03-09 2017-12-13 Eli Lilly and Company Delay mechanism for automatic injection device
CA2681428A1 (en) 2007-04-13 2008-10-23 Novartis Ag Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9)
KR20100034015A (en) 2007-06-20 2010-03-31 아이알엠 엘엘씨 Methods and compositions for treating allergic diseases
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
WO2009055783A2 (en) 2007-10-26 2009-04-30 Schering Corporation Anti-pcsk9 and methods for treating lipid and cholesterol disorders
AR070316A1 (en) 2008-02-07 2010-03-31 Merck & Co Inc PCSK9 ANTAGONISTS (SUBTILISINE-KEXINA TYPE 9 PROPROTEIN)
AR070315A1 (en) 2008-02-07 2010-03-31 Merck & Co Inc ANTIBODIES 1B20 ANTAGONISTS OF PCSK9
GB0802351D0 (en) 2008-02-08 2008-03-12 Owen Mumford Ltd Injection devices
WO2009141219A1 (en) * 2008-05-20 2009-11-26 Shl Group Ab Device for a medicament delivery device
KR101382346B1 (en) 2008-05-23 2014-04-08 현대자동차 주식회사 Shock absorber for vehicle
DE102008044852A1 (en) 2008-08-28 2010-03-04 Schaeffler Kg Damping device, particularly for clamping devices of traction drives at or in internal combustion engines, comprises radially extending panel, which is arranged or formed at surface of piston or at inner wall of cylinder
TWI516501B (en) 2008-09-12 2016-01-11 禮納特神經系統科學公司 Pcsk9 antagonists
CN102264417B (en) 2008-10-29 2014-01-01 Shl集团有限责任公司 Injection device
DK2355867T3 (en) 2008-12-12 2014-09-08 Shl Group Ab DEVICE FOR MEDICINE DELIVERY
JO3672B1 (en) 2008-12-15 2020-08-27 Regeneron Pharma High Affinity Human Antibodies to PCSK9
JO3382B1 (en) 2008-12-23 2019-03-13 Amgen Inc Human cgrp receptor binding antibodies
ATE520432T1 (en) 2009-02-11 2011-09-15 Nils Leuzinger INJECTION DEVICE WITH PRESSURE DAMPING FOR THE INJECTION OF A FLUID
DE202009001836U1 (en) 2009-02-13 2009-05-20 Dieter Hölzle Technik-Projekte GmbH Electromechanical injection device
GB0913136D0 (en) 2009-07-28 2009-09-02 Ucb Pharma Sa Auto-injector
WO2011037791A1 (en) 2009-09-25 2011-03-31 Merck Sharp & Dohme Corp. Antagonists of pcsk9
US8802827B2 (en) 2009-10-30 2014-08-12 Merck Sharp & Dohme Corp. AX1 PCSK9 antagonists
EP2493507A4 (en) 2009-10-30 2013-11-20 Merck Sharp & Dohme Ax213 and ax132 pcsk9 antagonists and variants
AR079336A1 (en) 2009-12-11 2012-01-18 Irm Llc ANTAGONISTS OF THE PRO-PROTEIN CONVERTASE-SUBTILISINE / TYPE 9 QUEXINE (PCSK9)
WO2011096907A1 (en) 2010-02-08 2011-08-11 Insu Teknik Makina Sanayi Ve Ticaret Anonim Sirketi Easy to produce, single piece valve body and piston body for shock absorbers
JP5791637B2 (en) * 2010-02-18 2015-10-07 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Finger protection for injection devices
EP2364740A1 (en) * 2010-03-09 2011-09-14 Sanofi-Aventis Deutschland GmbH Arrangement for transferring a translation of a drive means to a plunger
EP2364741A1 (en) 2010-03-09 2011-09-14 Sanofi-Aventis Deutschland GmbH Interlock mechanism for defining an operation sequence of an auto-injector
EP2364739A1 (en) 2010-03-09 2011-09-14 Sanofi-Aventis Deutschland GmbH Re-usable autoinjector
SG10201507722QA (en) 2010-03-11 2015-10-29 Rinat Neuroscience Corp ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING
EP2399627A1 (en) 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2399631A1 (en) 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Auto-injector with injection damper
WO2012025639A1 (en) * 2010-08-27 2012-03-01 Novo Nordisk A/S Medical injection device
EP2438939A1 (en) 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Arrangement for coupling a plunger to either a syringe or a stopper
WO2012054438A1 (en) 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
EP2468341A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2468337A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Back-end device for an auto-injector and auto-injector
EP2655419A1 (en) 2010-12-22 2013-10-30 F.Hoffmann-La Roche Ag Anti-pcsk9 antibodies and methods of use
GB2487235A (en) 2011-01-17 2012-07-18 Owen Mumford Ltd Injection device with pneumatic damping of the drive mechanism
AU2012210480B2 (en) 2011-01-28 2017-05-18 Sanofi Biotechnology Human antibodies to PCSK9 for use in methods of treating particular groups of subjects
JP2014511378A (en) 2011-02-11 2014-05-15 アイアールエム・リミテッド・ライアビリティ・カンパニー PCSK9 antagonist
AU2012245211B2 (en) 2011-04-21 2016-03-10 Abbvie Inc. Wearable automatic injection device
JOP20200043A1 (en) 2011-05-10 2017-06-16 Amgen Inc Methods of treating or preventing cholesterol related disorders
IN2014KN02883A (en) 2012-05-31 2015-05-08 Carebay Europe Ltd
EP2716316A1 (en) * 2012-10-04 2014-04-09 Sanofi-Aventis Deutschland GmbH Medicament delivery device with damping mechanism
US20140114248A1 (en) * 2012-10-24 2014-04-24 Nuance Designs, LLC Power pack for an autoinjector
EP3907237A1 (en) 2012-12-20 2021-11-10 Amgen Inc. Apj receptor agonists and uses thereof
US8591463B1 (en) * 2013-03-08 2013-11-26 Teva Pharmaceutical Industries Ltd. Re-useable injector device for syringe
WO2014159017A1 (en) 2013-03-14 2014-10-02 Eli Lilly And Company Delay mechanism suitable for compact automatic injection device
JP2016513666A (en) 2013-03-14 2016-05-16 アムジエン・インコーポレーテツド Tissue metalloproteinase inhibitor type 3 (TIMP-3) variants, compositions and methods
US20140274874A1 (en) 2013-03-14 2014-09-18 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
EP2781230B1 (en) 2013-03-22 2019-08-21 TecPharma Licensing AG Substance dispensing device with a signaling device
US9802001B2 (en) 2013-04-10 2017-10-31 Sanofi Dispensing speed control mechanism and injection device
WO2014174519A1 (en) 2013-04-23 2014-10-30 Elcam Medical Agricultural Cooperative Association Ltd. Automatic injection device for administration of high viscosity medication
US20140350517A1 (en) * 2013-05-23 2014-11-27 Allergan, Inc. Injection device with stress protection
EP3003433A1 (en) 2013-06-03 2016-04-13 Novo Nordisk A/S Medical injection device
EP3057629B1 (en) 2013-10-16 2021-12-08 Novo Nordisk A/S Drug delivery device with brake mechanism
EP3068475B1 (en) * 2013-11-13 2021-12-15 F. Hoffmann-La Roche AG Assisted manual injector devices and methods
US20180015224A1 (en) * 2016-07-13 2018-01-18 California Institute Of Technology Dampers and Methods for Performing Measurements in an Autoinjector
US11541183B2 (en) * 2017-06-22 2023-01-03 Amgen Inc. Device activation impact/shock reduction
US11504485B1 (en) * 2021-08-18 2022-11-22 Cellular Vehicles, Inc. Cellular therapy infusion devices, systems, and methods for use

Also Published As

Publication number Publication date
JP2022101692A (en) 2022-07-06
CA2945026A1 (en) 2015-11-12
US10722655B2 (en) 2020-07-28
US20200316303A1 (en) 2020-10-08
CN106413779A (en) 2017-02-15
EP3139977B1 (en) 2021-02-17
JP7487257B2 (en) 2024-05-20
JP2020072938A (en) 2020-05-14
MX2016014561A (en) 2017-06-21
KR102496507B1 (en) 2023-02-03
JP7123898B2 (en) 2022-08-23
WO2015171777A1 (en) 2015-11-12
AU2015256082B2 (en) 2020-02-27
EP3785749A1 (en) 2021-03-03
JP6640113B2 (en) 2020-02-05
JP2017518791A (en) 2017-07-13
US20170182253A1 (en) 2017-06-29
BR112016025852A2 (en) 2017-10-17
SG10201811702TA (en) 2019-01-30
AU2015256082C1 (en) 2020-09-10
AU2015256082A1 (en) 2016-10-06
CA2945026C (en) 2023-10-10
BR112016025852B1 (en) 2022-11-01
KR20160149198A (en) 2016-12-27
CA3193070A1 (en) 2015-11-12
IL247935A0 (en) 2016-11-30
CN106413779B (en) 2020-06-05
IL247935B (en) 2020-08-31
EP3139977A1 (en) 2017-03-15

Similar Documents

Publication Publication Date Title
IL247935B (en) Autoinjector with shock reducing elements
IL286448A (en) Auto-injector
IL256063A (en) Autoinjector
HK1254132A1 (en) Auto-injector
GB201520799D0 (en) None
GB201413050D0 (en) None
GB201516266D0 (en) None
PL3188641T3 (en) Holding assembly
SG11201608972WA (en) Auto-injector with indicator
GB201412161D0 (en) Structure
GB201516146D0 (en) None
GB2528078B (en) Structure
PL3207273T3 (en) Damper assembly
GB2522522B (en) Structure
DK3177838T3 (en) Fluid-redirecting structure
GB201402423D0 (en) Auto-injector assembly
GB201517285D0 (en) Stabilizer arrangement
PL2929790T3 (en) Shoe equipped with shock absorber
GB2547614B (en) Stabilizer
PL3377148T3 (en) Autoinjector
PL3000955T3 (en) Glazing arrangement
GB2529396B (en) Anti-ballistic Structure
GB201513233D0 (en) Sling with steering strips
GB201411356D0 (en) Storage assembly
GB201409138D0 (en) None