SG11201600028YA - Substituted aminopyrimidine compounds and methods of use - Google Patents

Substituted aminopyrimidine compounds and methods of use

Info

Publication number
SG11201600028YA
SG11201600028YA SG11201600028YA SG11201600028YA SG11201600028YA SG 11201600028Y A SG11201600028Y A SG 11201600028YA SG 11201600028Y A SG11201600028Y A SG 11201600028YA SG 11201600028Y A SG11201600028Y A SG 11201600028YA SG 11201600028Y A SG11201600028Y A SG 11201600028YA
Authority
SG
Singapore
Prior art keywords
methods
aminopyrimidine compounds
substituted aminopyrimidine
substituted
compounds
Prior art date
Application number
SG11201600028YA
Inventor
Ning Xi
Liang Wang
Zuping Wu
Xuejin Feng
Yanjun Wu
Original Assignee
Calitor Sciences Llc
Sunshine Lake Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calitor Sciences Llc, Sunshine Lake Pharma Co Ltd filed Critical Calitor Sciences Llc
Publication of SG11201600028YA publication Critical patent/SG11201600028YA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Immunology (AREA)
  • Pulmonology (AREA)
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  • Cardiology (AREA)
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  • Neurosurgery (AREA)
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  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
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  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
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SG11201600028YA 2013-09-22 2014-09-17 Substituted aminopyrimidine compounds and methods of use SG11201600028YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361880974P 2013-09-22 2013-09-22
US201461983444P 2014-04-23 2014-04-23
PCT/US2014/055966 WO2015042077A1 (en) 2013-09-22 2014-09-17 Substituted aminopyrimidine compounds and methods of use

Publications (1)

Publication Number Publication Date
SG11201600028YA true SG11201600028YA (en) 2016-02-26

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Country Status (12)

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US (4) US9670194B2 (en)
EP (2) EP3046563B1 (en)
JP (2) JP6494634B2 (en)
KR (2) KR20160060100A (en)
AU (2) AU2014321419B2 (en)
BR (1) BR112016003229A8 (en)
CA (2) CA2920059A1 (en)
MX (2) MX2016003457A (en)
MY (2) MY176421A (en)
RU (2) RU2675105C9 (en)
SG (2) SG11201600028YA (en)
WO (3) WO2015042078A2 (en)

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JP6383810B2 (en) 2014-06-13 2018-08-29 ギリアード サイエンシーズ， インコーポレイテッド Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
MX2016016530A (en) * 2014-06-13 2017-03-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors.
EA201692267A1 (en) 2014-06-13 2017-06-30 Джилид Сайэнс, Инк. PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS
SG11201610095SA (en) 2014-06-13 2016-12-29 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
CR20160600A (en) 2014-07-04 2017-03-07 Lupin Ltd QUINOLIZIONE DERIVATIVES AS PI3K INHIBITORS
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CN106146502B (en) * 2015-04-09 2019-01-04 上海医药工业研究院 End for Larry this synthetic method and prepare intermediate
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CN106146411A (en) * 2015-04-16 2016-11-23 上海医药工业研究院 (S) preparation method of-2-(1-amino-propyl)-5-fluoro-3-phenyl-3H-quinazoline-4-one
CN106279171A (en) * 2015-06-09 2017-01-04 南京安源生物医药科技有限公司 A kind of preparation method of Idelalisib
WO2017044434A1 (en) 2015-09-11 2017-03-16 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use
MX2018005461A (en) * 2015-11-04 2018-08-01 Merck Patent Gmbh Methods for treating cancer using pyrimidine and pyridine compounds with btk inhibitory activity.
US10716788B2 (en) * 2015-11-17 2020-07-21 Merck Patent Gmbh Methods for treating MS using pyrimidine and pyridine compounds with BTK inhibitory activity
SG11201804901WA (en) 2015-12-22 2018-07-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
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