SG11201505977RA - Methods, systems, and software for identifying bio-molecules using models of multiplicative form - Google Patents
Methods, systems, and software for identifying bio-molecules using models of multiplicative formInfo
- Publication number
- SG11201505977RA SG11201505977RA SG11201505977RA SG11201505977RA SG11201505977RA SG 11201505977R A SG11201505977R A SG 11201505977RA SG 11201505977R A SG11201505977R A SG 11201505977RA SG 11201505977R A SG11201505977R A SG 11201505977RA SG 11201505977R A SG11201505977R A SG 11201505977RA
- Authority
- SG
- Singapore
- Prior art keywords
- models
- molecules
- software
- systems
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/10—Design of libraries
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/20—Screening of libraries
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
- G16B5/20—Probabilistic models
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C10/00—Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/30—Prediction of properties of chemical compounds, compositions or mixtures
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/50—Molecular design, e.g. of drugs
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Genetics & Genomics (AREA)
- Library & Information Science (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Physiology (AREA)
- Computing Systems (AREA)
- Crystallography & Structural Chemistry (AREA)
- Probability & Statistics with Applications (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Ecology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361759276P | 2013-01-31 | 2013-01-31 | |
US201361799377P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/013668 WO2014120821A1 (en) | 2013-01-31 | 2014-01-29 | Methods, systems, and software for identifying bio-molecules using models of multiplicative form |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201505977RA true SG11201505977RA (en) | 2015-08-28 |
Family
ID=51223867
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201505969XA SG11201505969XA (en) | 2013-01-31 | 2014-01-29 | Methods, systems, and software for identifying bio-molecules with interacting components |
SG11201505977RA SG11201505977RA (en) | 2013-01-31 | 2014-01-29 | Methods, systems, and software for identifying bio-molecules using models of multiplicative form |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201505969XA SG11201505969XA (en) | 2013-01-31 | 2014-01-29 | Methods, systems, and software for identifying bio-molecules with interacting components |
Country Status (16)
Country | Link |
---|---|
US (4) | US9684771B2 (en) |
EP (2) | EP2951754B1 (en) |
JP (4) | JP6433028B2 (en) |
KR (3) | KR102215219B1 (en) |
CN (3) | CN109360608B (en) |
AU (2) | AU2014212430B2 (en) |
BR (2) | BR112015018449B1 (en) |
CA (2) | CA2898777C (en) |
DK (2) | DK2951754T3 (en) |
FI (1) | FI2951754T3 (en) |
IL (2) | IL240055A0 (en) |
LT (1) | LT2951754T (en) |
NZ (2) | NZ710323A (en) |
RU (2) | RU2664695C2 (en) |
SG (2) | SG11201505969XA (en) |
WO (2) | WO2014120821A1 (en) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112015018449B1 (en) | 2013-01-31 | 2022-05-31 | Codexis, Inc | Computer-implemented method for identifying biological molecules having a desired activity, computer-readable storage medium, and computing system |
EP2986741B1 (en) | 2013-04-17 | 2019-07-24 | Agency For Science, Technology And Research | Method for generating extended sequence reads |
EP2911075A1 (en) * | 2014-02-25 | 2015-08-26 | LTS LOHMANN Therapie-Systeme AG | System for determining a suitability of an agent for transdermal or transmucosal application and corresponding method |
JP6719463B2 (en) | 2014-11-25 | 2020-07-15 | コデクシス, インコーポレイテッド | Engineered imine reductase and method for reductive amination of ketone and amine compounds |
PT3237621T (en) | 2014-12-22 | 2023-07-20 | Codexis Inc | Human alpha-galactosidase variants |
WO2016105579A1 (en) * | 2014-12-22 | 2016-06-30 | Board Of Regents Of The University Of Texas System | Systems and methods for processing sequence data for variant detection and analysis |
US11515004B2 (en) | 2015-05-22 | 2022-11-29 | Csts Health Care Inc. | Thermodynamic measures on protein-protein interaction networks for cancer therapy |
FR3047013A1 (en) * | 2016-01-22 | 2017-07-28 | Univ Montpellier | METHOD FOR CLASSIFYING A BIOLOGICAL SAMPLE |
EP3452940A4 (en) | 2016-05-04 | 2020-01-01 | Deep Genomics Incorporated | Methods and systems for producing an expanded training set for machine learning using biological sequences |
CN109715817B (en) | 2016-06-09 | 2022-12-09 | 科德克希思公司 | Biocatalysts and methods for hydroxylation of chemical compounds |
SG11201810998WA (en) | 2016-06-15 | 2019-01-30 | Codexis Inc | Engineered beta-glucosidases and glucosylation methods |
JP7316662B2 (en) | 2016-08-26 | 2023-07-28 | コデクシス, インコーポレイテッド | Engineered imine reductases and methods for reductive amination of ketone and amine compounds |
US10118610B2 (en) * | 2016-08-31 | 2018-11-06 | Ford Global Technologies, Llc | Autonomous vehicle using path prediction |
CA3051262A1 (en) | 2017-02-13 | 2018-08-16 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
CN108693787A (en) * | 2017-03-29 | 2018-10-23 | 株式会社东芝 | Model construction system and model building method |
JP2020530266A (en) | 2017-06-30 | 2020-10-22 | コデクシス, インコーポレイテッド | T7 RNA polymerase variant |
US10738286B2 (en) | 2017-06-30 | 2020-08-11 | Codexis, Inc. | T7 RNA polymerase variants |
CN107677997B (en) * | 2017-09-28 | 2021-06-29 | 杭州电子科技大学 | Extended target tracking method based on GLMB filtering and Gibbs sampling |
CN111164701A (en) * | 2017-10-06 | 2020-05-15 | 格瑞尔公司 | Fixed-point noise model for target sequencing |
MX2020003709A (en) * | 2017-10-17 | 2020-07-22 | Invitae Corp | Molecular evidence platform for auditable, continuous optimization of variant interpretation in genetic and genomic testing and analysis. |
JP2021506252A (en) | 2017-12-13 | 2021-02-22 | コデクシス, インコーポレイテッド | Carboxylesterase polypeptide for amide coupling |
CN108281192B (en) * | 2017-12-29 | 2022-03-22 | 一诺仪器(中国)有限公司 | Human body component prediction method and system based on ensemble learning algorithm |
KR20210040408A (en) | 2018-07-30 | 2021-04-13 | 코덱시스, 인코포레이티드 | Engineered glycosyltransferase and steviol glycoside glucosylation method |
JP2022512637A (en) * | 2018-10-11 | 2022-02-07 | バークレー ライツ,インコーポレイテッド | Systems and methods for identifying optimized protein production and kits for them |
US11398297B2 (en) * | 2018-10-11 | 2022-07-26 | Chun-Chieh Chang | Systems and methods for using machine learning and DNA sequencing to extract latent information for DNA, RNA and protein sequences |
SG11202103639SA (en) | 2018-10-29 | 2021-05-28 | Codexis Inc | Engineered dna polymerase variants |
SG11202105668PA (en) | 2018-12-14 | 2021-06-29 | Codexis Inc | Engineered tyrosine ammonia lyase |
BR112021011750A2 (en) | 2018-12-20 | 2021-08-31 | Codexis, Inc. | RECOMBINANT ALPHA-GALACTOSIDASE AND/OR RECOMBINANT ALPHA-GALACTOSIDASE A FRAGMENT, COMPOSITION, RECOMBINANT POLYNUCLEOTIDE SEQUENCE, EXPRESSION VECTOR, HOST CELL, METHODS FOR PRODUCING A VARIANT OF ALPHA-GALACTOSIDASE AE TO TREAT AND/OR PREVENT THE SYMPTOMS OF THE DISEASE DE FABRY, PHARMACEUTICAL COMPOSITION, AND, USE OF COMPOSITIONS |
GB2595106B (en) * | 2019-01-22 | 2022-10-12 | Emulate Inc | High-content imaging of microfluidic devices |
WO2020168286A1 (en) * | 2019-02-14 | 2020-08-20 | University Of Washington | Systems and methods for improved nanopore-based analysis of nucleic acids |
CN109902389B (en) * | 2019-03-01 | 2021-01-01 | 厦门大学 | Uncertainty finite element model correction method based on improved general likelihood estimation |
CN109979539B (en) * | 2019-04-10 | 2020-10-02 | 电子科技大学 | Gene sequence optimization method and device and data processing terminal |
EP3962932A4 (en) | 2019-05-02 | 2023-05-10 | Board of Regents, The University of Texas System | System and method for increasing synthesized protein stability |
JP7298284B2 (en) * | 2019-05-09 | 2023-06-27 | 富士通株式会社 | Arithmetic processing device, arithmetic processing program, and arithmetic processing method |
EP3980901A1 (en) * | 2019-06-07 | 2022-04-13 | Leica Microsystems CMS GmbH | A system and method for processing biology-related data, a system and method for controlling a microscope and a microscope |
KR20220019778A (en) * | 2019-06-12 | 2022-02-17 | 퀀텀-에스아이 인코포레이티드 | Techniques and related systems and methods for protein identification using machine learning |
KR20220106738A (en) | 2019-08-30 | 2022-07-29 | 코덱시스, 인코포레이티드 | engineered lipase variants |
JP7438693B2 (en) * | 2019-09-02 | 2024-02-27 | キヤノンメディカルシステムズ株式会社 | Medical support equipment |
US20210174909A1 (en) * | 2019-12-10 | 2021-06-10 | Homodeus, Inc. | Generative machine learning models for predicting functional protein sequences |
BR112022011760A2 (en) | 2019-12-20 | 2022-08-30 | Codexis Inc | RECOMBINANT ACID ALPHA GLICOSIDASE AND/OR BIOLOGICALLY ACTIVE RECOMBINANT ACID ALPHA GLICOSIDASE FRAGMENT, RECOMBINANT ACID ALPHA GLICOSIDASE, COMPOSITION, RECOMBINANT POLYNUCLEOTIDE SEQUENCE, EXPRESSION VECTOR, PDH EXPRESSION VECTOR, HOST CELL, METHOD FOR PRODUCING A RECOMBINANT VARICOLIDASE ALCOHOLIDASE , RECOMBINANT ACID ALPHA GLUCOSIDASE VARIANT, PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF POMPE DISEASE, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT AND/OR PREVENTION OF THE SYMPTOMS OF POMPE DISEASE IN AN INDIVIDUAL, AND, USE OF THE COMPOSITIONS |
US11188778B1 (en) | 2020-05-05 | 2021-11-30 | Illumina, Inc. | Equalization-based image processing and spatial crosstalk attenuator |
EP4204554A1 (en) | 2020-08-28 | 2023-07-05 | Codexis, Inc. | Engineered protease variants |
US11767519B2 (en) | 2020-08-28 | 2023-09-26 | Codexis, Inc. | Engineered amylase variants |
US11361194B2 (en) | 2020-10-27 | 2022-06-14 | Illumina, Inc. | Systems and methods for per-cluster intensity correction and base calling |
WO2022133289A2 (en) | 2020-12-18 | 2022-06-23 | Codexis, Inc. | Engineered uridine phosphorylase variant enzymes |
US11439159B2 (en) | 2021-03-22 | 2022-09-13 | Shiru, Inc. | System for identifying and developing individual naturally-occurring proteins as food ingredients by machine learning and database mining combined with empirical testing for a target food function |
IL305928A (en) | 2021-04-02 | 2023-11-01 | Codexis Inc | Engineered acetate kinase variant enzymes |
EP4314263A1 (en) | 2021-04-02 | 2024-02-07 | Codexis, Inc. | Engineered adenylate kinase variant enzymes |
EP4314262A1 (en) | 2021-04-02 | 2024-02-07 | Codexis, Inc. | Engineered guanylate kinase variant enzymes |
IL305924A (en) | 2021-04-02 | 2023-11-01 | Codexis Inc | Engineered cyclic gmp-amp synthase (cgas) variant enzymes |
US11455487B1 (en) | 2021-10-26 | 2022-09-27 | Illumina Software, Inc. | Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling |
CN114913939B (en) * | 2022-07-19 | 2022-11-15 | 北京科技大学 | Drug combination design method and device for high-throughput platform and machine learning optimization |
CN116884503B (en) * | 2023-09-06 | 2023-12-26 | 北京齐碳科技有限公司 | Processing method, device and computing equipment of sequence and posterior matrix |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US20060257890A1 (en) | 1996-05-20 | 2006-11-16 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US6171820B1 (en) * | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
US6153410A (en) | 1997-03-25 | 2000-11-28 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
DK1036198T3 (en) | 1997-12-08 | 2013-01-02 | California Inst Of Techn | Method for Preparation of Polynucleotide and Polypeptide Sequences |
US7315786B2 (en) | 1998-10-16 | 2008-01-01 | Xencor | Protein design automation for protein libraries |
US20020048772A1 (en) | 2000-02-10 | 2002-04-25 | Dahiyat Bassil I. | Protein design automation for protein libraries |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
DE60044223D1 (en) | 1999-01-19 | 2010-06-02 | Maxygen Inc | BY OLIGONUCLEOTIDE-MEDIATED NUCLEIC ACID RECOMBINATION |
US20070065838A1 (en) | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
JP2003524831A (en) * | 1999-11-22 | 2003-08-19 | イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム | System and method for exploring combinatorial space |
US20010051855A1 (en) * | 2000-02-17 | 2001-12-13 | California Institute Of Technology | Computationally targeted evolutionary design |
WO2001064864A2 (en) | 2000-02-28 | 2001-09-07 | Maxygen, Inc. | Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation |
EP1272967A2 (en) | 2000-03-30 | 2003-01-08 | Maxygen, Inc. | In silico cross-over site selection |
US20030032059A1 (en) | 2000-05-23 | 2003-02-13 | Zhen-Gang Wang | Gene recombination and hybrid protein development |
AU2001263411A1 (en) | 2000-05-23 | 2001-12-03 | California Institute Of Technology | Gene recombination and hybrid protein development |
EP1325457A4 (en) | 2000-10-10 | 2007-10-24 | Genencor Int | Information rich libraries |
JP2005506957A (en) * | 2001-06-11 | 2005-03-10 | トランジション・セラピューティックス・インコーポレーテッド | Combined treatment with vitamin B12 and interferon for the treatment of viral, proliferative and inflammatory diseases |
US7747391B2 (en) | 2002-03-01 | 2010-06-29 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
DK2315145T3 (en) | 2002-03-01 | 2016-01-25 | Codexis Mayflower Holdings Llc | Methods, systems, and software for identifying the functional biomolecules |
US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
WO2003085548A1 (en) | 2002-04-04 | 2003-10-16 | Ishihara Sangyo Kaisha, Ltd. | Apparatus and method for analyzing data |
CN1672160B (en) * | 2002-05-20 | 2010-06-09 | 埃博马可西斯公司 | Method for constructing antibody library based on precursor antibody structure |
JP4042492B2 (en) | 2002-08-07 | 2008-02-06 | トヨタ自動車株式会社 | Method and system for adapting engine control parameters |
JP2004355174A (en) * | 2003-05-28 | 2004-12-16 | Ishihara Sangyo Kaisha Ltd | Data analysis method and system |
WO2005035721A2 (en) * | 2003-10-08 | 2005-04-21 | Ebioscience | Native immunoglobulin binding reagents and methods for making and using same |
US7529714B2 (en) * | 2004-12-14 | 2009-05-05 | International Business Machines Corporation | Cost management of software application portfolio |
CN1763227A (en) * | 2005-09-01 | 2006-04-26 | 南京工业大学 | Method for improving biological functions of protein |
EP3753947A1 (en) | 2007-09-14 | 2020-12-23 | Adimab, LLC | Rationally designed, synthetic antibody libraries and uses therefor |
AU2008308457A1 (en) | 2007-10-04 | 2009-04-09 | Halcyon Molecular | Sequencing nucleic acid polymers with electron microscopy |
US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
US8383346B2 (en) | 2008-06-13 | 2013-02-26 | Codexis, Inc. | Combined automated parallel synthesis of polynucleotide variants |
CN101353372A (en) * | 2008-08-04 | 2009-01-28 | 林峻 | Novel protein molecular orientation evolvement method |
AU2009325069B2 (en) * | 2008-12-11 | 2015-03-19 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
US8551096B2 (en) * | 2009-05-13 | 2013-10-08 | Boston Scientific Scimed, Inc. | Directional delivery of energy and bioactives |
CN101792934A (en) * | 2009-08-26 | 2010-08-04 | 青岛科技大学 | Novel method for building ultra-high capacity gene library based on combination principle and PCR |
JP5649424B2 (en) * | 2010-02-03 | 2015-01-07 | 大和ハウス工業株式会社 | Waterproof sheet diagnostic method and diagnostic device |
US20120115734A1 (en) * | 2010-11-04 | 2012-05-10 | Laura Potter | In silico prediction of high expression gene combinations and other combinations of biological components |
JP4839416B1 (en) | 2011-01-06 | 2011-12-21 | アクアエンタープライズ株式会社 | Movement process prediction system, movement process prediction method, movement process prediction apparatus, and computer program |
US20120231447A1 (en) * | 2011-02-15 | 2012-09-13 | Howard Hughes Medical Institute | Surface Passivation Methods for Single Molecule Imaging of Biochemical Reactions |
CN102206625A (en) * | 2011-03-04 | 2011-10-05 | 东华大学 | Orthogenesis of protein introns through error-prone PCR/kanamycin screening system |
US20130017540A1 (en) * | 2011-06-07 | 2013-01-17 | Yun Yen | Identification of mutation types associated with acquired resistance and methods for using same |
BR112015018449B1 (en) | 2013-01-31 | 2022-05-31 | Codexis, Inc | Computer-implemented method for identifying biological molecules having a desired activity, computer-readable storage medium, and computing system |
-
2014
- 2014-01-29 BR BR112015018449-9A patent/BR112015018449B1/en active IP Right Grant
- 2014-01-29 JP JP2015556114A patent/JP6433028B2/en active Active
- 2014-01-29 US US14/167,713 patent/US9684771B2/en active Active
- 2014-01-29 WO PCT/US2014/013668 patent/WO2014120821A1/en active Application Filing
- 2014-01-29 CN CN201811237910.6A patent/CN109360608B/en active Active
- 2014-01-29 CN CN201480019389.2A patent/CN105074463B/en active Active
- 2014-01-29 RU RU2015136780A patent/RU2664695C2/en active
- 2014-01-29 SG SG11201505969XA patent/SG11201505969XA/en unknown
- 2014-01-29 CN CN201480018421.5A patent/CN105144190B/en active Active
- 2014-01-29 NZ NZ710323A patent/NZ710323A/en unknown
- 2014-01-29 FI FIEP14746677.5T patent/FI2951754T3/en active
- 2014-01-29 US US14/167,709 patent/US9665694B2/en active Active
- 2014-01-29 LT LTEPPCT/US2014/013666T patent/LT2951754T/en unknown
- 2014-01-29 AU AU2014212430A patent/AU2014212430B2/en active Active
- 2014-01-29 RU RU2015136776A patent/RU2695146C2/en active
- 2014-01-29 EP EP14746677.5A patent/EP2951754B1/en active Active
- 2014-01-29 KR KR1020157023739A patent/KR102215219B1/en active IP Right Grant
- 2014-01-29 CA CA2898777A patent/CA2898777C/en active Active
- 2014-01-29 EP EP14746406.9A patent/EP2951579B1/en active Active
- 2014-01-29 AU AU2014212432A patent/AU2014212432B2/en active Active
- 2014-01-29 DK DK14746677.5T patent/DK2951754T3/en active
- 2014-01-29 CA CA2899859A patent/CA2899859C/en active Active
- 2014-01-29 BR BR112015018454-5A patent/BR112015018454B1/en active IP Right Grant
- 2014-01-29 SG SG11201505977RA patent/SG11201505977RA/en unknown
- 2014-01-29 KR KR1020157023727A patent/KR20150113166A/en active Application Filing
- 2014-01-29 KR KR1020217000247A patent/KR102490720B1/en active IP Right Grant
- 2014-01-29 JP JP2015556112A patent/JP6377078B2/en active Active
- 2014-01-29 NZ NZ710299A patent/NZ710299A/en unknown
- 2014-01-29 DK DK14746406.9T patent/DK2951579T3/en active
- 2014-01-29 WO PCT/US2014/013666 patent/WO2014120819A1/en active Application Filing
-
2015
- 2015-07-21 IL IL240055A patent/IL240055A0/en active IP Right Grant
- 2015-07-21 IL IL240056A patent/IL240056A0/en active IP Right Grant
-
2017
- 2017-04-04 US US15/479,220 patent/US20170211206A1/en not_active Abandoned
- 2017-04-04 US US15/479,222 patent/US20170204405A1/en not_active Abandoned
- 2017-07-20 JP JP2017140863A patent/JP2017189176A/en not_active Withdrawn
-
2018
- 2018-07-13 JP JP2018133041A patent/JP6655670B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL240056A0 (en) | Methods, systems, and software for identifying bio-molecules using models of multiplicative form | |
IL279077B (en) | A location determination method and system | |
GB2518458B (en) | Method for pre-testing software compatibility and system thereof. | |
IL246391B (en) | System and method for a nail manipulation | |
HK1221908A1 (en) | Polyspecificity reagents, methods for their preparation and use (polyspecificity) | |
EP3047282A4 (en) | Biomolecule sequencing devices, systems and methods | |
GB2533520B (en) | Gaze-controlled interface method and system | |
EP3080782A4 (en) | Method and system for comparing 3d models | |
EP3016002A4 (en) | Non-factoid question-and-answer system and method | |
GB201610930D0 (en) | Systems and methods for sales execution environment | |
HK1225941A1 (en) | Estimation device, program, estimation method, and estimation system | |
SG11201509812PA (en) | Removable wall decoration kits, systems and methods | |
EP3035642A4 (en) | Software updating method, system, and device | |
EP2946205A4 (en) | Systems and methods for identifying explosives | |
GB201300923D0 (en) | Verification method and system | |
SG11201506422YA (en) | Systems and methods for multi-flux color matching | |
EP3037973A4 (en) | Correlation display system, correlation display method, and correlation display program | |
EP2979181A4 (en) | Systems and methods for providing an emulator | |
EP3006952A4 (en) | Positioning system, positioning method, and positioning program | |
IL227627A0 (en) | Georefenrencing method and system | |
HK1205580A1 (en) | Method for identifying account and system thereof | |
GB2518676B (en) | Telematics system and associated method | |
SG11201508409UA (en) | Workflow execution system and method for cloud environment | |
EP2969157A4 (en) | System and method for sidestream mixing | |
AU2013902703A0 (en) | A location determination method and system |