SG11201401716XA - Novel purine derivatives and their use in the treatment of disease - Google Patents
Novel purine derivatives and their use in the treatment of diseaseInfo
- Publication number
- SG11201401716XA SG11201401716XA SG11201401716XA SG11201401716XA SG11201401716XA SG 11201401716X A SG11201401716X A SG 11201401716XA SG 11201401716X A SG11201401716X A SG 11201401716XA SG 11201401716X A SG11201401716X A SG 11201401716XA SG 11201401716X A SG11201401716X A SG 11201401716XA
- Authority
- SG
- Singapore
- Prior art keywords
- disease
- treatment
- purine derivatives
- novel purine
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161552746P | 2011-10-28 | 2011-10-28 | |
PCT/IB2012/055929 WO2013061305A1 (en) | 2011-10-28 | 2012-10-26 | Novel purine derivatives and their use in the treatment of disease |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201401716XA true SG11201401716XA (en) | 2014-05-29 |
Family
ID=47326252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201401716XA SG11201401716XA (en) | 2011-10-28 | 2012-10-26 | Novel purine derivatives and their use in the treatment of disease |
Country Status (21)
Country | Link |
---|---|
US (1) | US9334271B2 (en) |
EP (1) | EP2771342B1 (en) |
JP (1) | JP6059731B2 (en) |
KR (1) | KR20140090218A (en) |
CN (1) | CN104039790B (en) |
AP (1) | AP2014007601A0 (en) |
AU (1) | AU2012327954B2 (en) |
BR (1) | BR112014009890A2 (en) |
CA (1) | CA2853256C (en) |
CL (1) | CL2014001049A1 (en) |
CO (1) | CO6950473A2 (en) |
CU (1) | CU20140048A7 (en) |
EA (1) | EA023935B1 (en) |
ES (1) | ES2587533T3 (en) |
IL (1) | IL232256A0 (en) |
MX (1) | MX340452B (en) |
PL (1) | PL2771342T3 (en) |
PT (1) | PT2771342T (en) |
SG (1) | SG11201401716XA (en) |
TN (1) | TN2014000175A1 (en) |
WO (1) | WO2013061305A1 (en) |
Families Citing this family (23)
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GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
CA2825605C (en) | 2011-01-31 | 2019-05-07 | Novartis Ag | Heterocyclic derivatives |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
KR102479696B1 (en) | 2014-03-26 | 2022-12-22 | 아스텍스 테라퓨틱스 리미티드 | Combinations of an fgfr inhibitor and an igf1r inhibitor |
AU2015238301B2 (en) | 2014-03-26 | 2020-06-25 | Astex Therapeutics Ltd | Combinations |
JO3512B1 (en) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | Quinoxaline derivatives useful as fgfr kinase modulators |
US10144737B2 (en) * | 2014-05-19 | 2018-12-04 | Jiangsu Hengrui Medicine Co., Ltd. | Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors |
KR102618947B1 (en) | 2014-12-30 | 2023-12-27 | 유니버시티 오브 아이오와 리써치 파운데이션 | Methods and compositions for treating brain diseases |
JOP20200201A1 (en) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | Pharmaceutical compositions comprising n-(3,5-dimethoxyphenyl)-n'-(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
CA2996989C (en) | 2015-09-23 | 2023-10-03 | Janssen Pharmaceutica Nv | Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer |
HUE050567T2 (en) | 2015-09-23 | 2020-12-28 | Janssen Pharmaceutica Nv | Tricyclic heterocycles for the treatment of cancer |
EP3241830A1 (en) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Condensed bicyclic heterocyclic derivatives as pesticides |
US10660334B2 (en) | 2016-08-15 | 2020-05-26 | Bayer Cropscience Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
MA54952A (en) * | 2019-02-06 | 2022-05-11 | Synthorx Inc | IL-2 CONJUGATES AND METHODS OF USING THE SAME |
CZ308800B6 (en) * | 2019-02-12 | 2021-05-26 | Univerzita Palackého v Olomouci | Heterocyclic nitrogenous derivatives of purine, pharmaceutical preparations containing these derivatives and their use in neuroprotection |
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2012
- 2012-10-26 WO PCT/IB2012/055929 patent/WO2013061305A1/en active Application Filing
- 2012-10-26 ES ES12798854.1T patent/ES2587533T3/en active Active
- 2012-10-26 PT PT127988541T patent/PT2771342T/en unknown
- 2012-10-26 PL PL12798854.1T patent/PL2771342T3/en unknown
- 2012-10-26 BR BR112014009890-5A patent/BR112014009890A2/en not_active Application Discontinuation
- 2012-10-26 CA CA2853256A patent/CA2853256C/en not_active Expired - Fee Related
- 2012-10-26 AU AU2012327954A patent/AU2012327954B2/en not_active Ceased
- 2012-10-26 KR KR1020147013841A patent/KR20140090218A/en active IP Right Grant
- 2012-10-26 JP JP2014537802A patent/JP6059731B2/en not_active Expired - Fee Related
- 2012-10-26 EP EP12798854.1A patent/EP2771342B1/en not_active Not-in-force
- 2012-10-26 CN CN201280064734.5A patent/CN104039790B/en not_active Expired - Fee Related
- 2012-10-26 US US14/353,950 patent/US9334271B2/en active Active
- 2012-10-26 AP AP2014007601A patent/AP2014007601A0/en unknown
- 2012-10-26 SG SG11201401716XA patent/SG11201401716XA/en unknown
- 2012-10-26 EA EA201490888A patent/EA023935B1/en not_active IP Right Cessation
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2014
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- 2014-04-24 CL CL2014001049A patent/CL2014001049A1/en unknown
- 2014-04-28 CU CU2014000048A patent/CU20140048A7/en unknown
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WO2013061305A1 (en) | 2013-05-02 |
AU2012327954B2 (en) | 2015-11-26 |
MX340452B (en) | 2016-07-08 |
IL232256A0 (en) | 2014-06-30 |
AU2012327954A1 (en) | 2014-06-19 |
US20140336166A1 (en) | 2014-11-13 |
EA023935B1 (en) | 2016-07-29 |
JP2014530903A (en) | 2014-11-20 |
US9334271B2 (en) | 2016-05-10 |
CL2014001049A1 (en) | 2014-10-24 |
ES2587533T3 (en) | 2016-10-25 |
EP2771342A1 (en) | 2014-09-03 |
BR112014009890A2 (en) | 2020-10-27 |
CA2853256C (en) | 2019-05-14 |
EA201490888A1 (en) | 2014-09-30 |
EP2771342B1 (en) | 2016-05-18 |
JP6059731B2 (en) | 2017-01-11 |
TN2014000175A1 (en) | 2015-09-30 |
CN104039790B (en) | 2016-04-13 |
CA2853256A1 (en) | 2013-05-02 |
CN104039790A (en) | 2014-09-10 |
KR20140090218A (en) | 2014-07-16 |
PL2771342T3 (en) | 2016-11-30 |
NZ624366A (en) | 2015-12-24 |
PT2771342T (en) | 2016-08-17 |
AP2014007601A0 (en) | 2014-04-30 |
MX2014005132A (en) | 2014-10-06 |
CU20140048A7 (en) | 2014-12-26 |
CO6950473A2 (en) | 2014-05-20 |
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