SG10202100951SA - Chemical compositions and methods of using same - Google Patents

Chemical compositions and methods of using same

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Publication number
SG10202100951SA
SG10202100951SA SG10202100951SA SG10202100951SA SG10202100951SA SG 10202100951S A SG10202100951S A SG 10202100951SA SG 10202100951S A SG10202100951S A SG 10202100951SA SG 10202100951S A SG10202100951S A SG 10202100951SA SG 10202100951S A SG10202100951S A SG 10202100951SA
Authority
SG
Singapore
Prior art keywords
methods
same
chemical compositions
compositions
chemical
Prior art date
Application number
SG10202100951SA
Inventor
Margaret Hoang
Mark Gregory
Dae Kim
Dwayne L Dunaway
Elizabeth A Manrao
Joseph M Beechem
Rustem Khafizov
Sanghamithra Korukonda
Yi Deng
Original Assignee
Nanostring Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanostring Technologies Inc filed Critical Nanostring Technologies Inc
Publication of SG10202100951SA publication Critical patent/SG10202100951SA/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/179Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10Detection mode being characterised by the assay principle
    • C12Q2565/101Interaction between at least two labels
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50Detection characterised by immobilisation to a surface
    • C12Q2565/518Detection characterised by immobilisation to a surface characterised by the immobilisation of the nucleic acid sample or target

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SG10202100951SA 2016-11-21 2017-11-21 Chemical compositions and methods of using same SG10202100951SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662424887P 2016-11-21 2016-11-21
US201762457237P 2017-02-10 2017-02-10
US201762536147P 2017-07-24 2017-07-24

Publications (1)

Publication Number Publication Date
SG10202100951SA true SG10202100951SA (en) 2021-03-30

Family

ID=60655103

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10202100951SA SG10202100951SA (en) 2016-11-21 2017-11-21 Chemical compositions and methods of using same

Country Status (9)

Country Link
US (5) US10415080B2 (en)
EP (1) EP3541957A1 (en)
JP (3) JP6730525B2 (en)
KR (4) KR102187291B1 (en)
CN (2) CN110225980B (en)
AU (3) AU2017361521B2 (en)
CA (1) CA3043489A1 (en)
SG (1) SG10202100951SA (en)
WO (1) WO2018094385A1 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
EP3175023A4 (en) 2014-07-30 2018-03-07 President and Fellows of Harvard College Systems and methods for determining nucleic acids
EP3221469B1 (en) * 2014-11-21 2020-01-15 Nanostring Technologies, Inc Enzyme- and amplification-free sequencing
EP3530752B1 (en) 2015-04-10 2021-03-24 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
SG10202107055SA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
JP6971218B2 (en) 2015-07-17 2021-11-24 ナノストリング テクノロジーズ,インコーポレイティド Simultaneous quantification of gene expression in user-defined regions of cross-tissue sections
CA3210120C (en) 2016-04-25 2024-04-09 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
WO2017216270A1 (en) 2016-06-15 2017-12-21 Grabmayr Heinrich Single molecule detection or quantification using dna nanotechnology
EP3472359B1 (en) 2016-06-21 2022-03-16 10X Genomics, Inc. Nucleic acid sequencing
CN110225980B (en) 2016-11-21 2023-01-06 纳米线科技公司 Chemical compositions and methods of use thereof
KR20230166141A (en) * 2016-12-09 2023-12-06 얼티뷰, 인크. Improved methods for multiplex imaging using labeled nucleic acid imaging agents
WO2018218150A1 (en) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
CN111263819A (en) 2017-10-06 2020-06-09 卡特阿纳公司 RNA templated ligation
AU2019216973A1 (en) 2018-02-12 2020-08-27 Nanostring Technologies, Inc Biomolecular probes and methods of detecting gene and protein expression
CA3099909A1 (en) 2018-05-14 2019-11-21 Nanostring Technologies, Inc. Chemical compositions and methods of using same
EP3894585A2 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Generating capture probes for spatial analysis
AU2019398322A1 (en) * 2018-12-13 2021-06-24 President And Fellows Of Harvard College Amplification methods and systems for MERFISH and other applications
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP3976817A1 (en) * 2019-05-31 2022-04-06 10X Genomics, Inc. Method of detecting target nucleic acid molecules
EP3754028A1 (en) 2019-06-18 2020-12-23 Apollo Life Sciences GmbH Method of signal encoding of analytes in a sample
WO2020254672A1 (en) 2019-06-19 2020-12-24 Therycell Gmbh Spatial characterisation of target structures in a sample
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
SG11202106899SA (en) 2019-12-23 2021-09-29 10X Genomics Inc Methods for spatial analysis using rna-templated ligation
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
EP4242325A3 (en) 2020-04-22 2023-10-04 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
EP4153776A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
AU2021294334A1 (en) 2020-06-25 2023-02-02 10X Genomics, Inc. Spatial analysis of DNA methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
EP4092414A1 (en) * 2021-05-19 2022-11-23 Leica Microsystems CMS GmbH Connector, marker and method for analysing biological samples
EP4341671A1 (en) * 2021-05-19 2024-03-27 Leica Microsystems CMS GmbH Method for analyzing a biological sample or a chemical compound or a chemical element
WO2022250774A1 (en) * 2021-05-24 2022-12-01 California Institute Of Technology Linked amplification tethered with exponential radiance
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
EP4216220A1 (en) * 2022-01-25 2023-07-26 Leica Microsystems CMS GmbH Data storage device and method for storing data
WO2023235836A2 (en) * 2022-06-03 2023-12-07 Nanostring Technologies, Inc. Spatial biology informatics integration portal with programmable machine learning pipeline orchestrator
WO2024041749A1 (en) * 2022-08-23 2024-02-29 Leica Microsystems Cms Gmbh Sequencing scaffold and method

Family Cites Families (280)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US327876A (en) * 1885-10-06 Automatic fire-extinguishing apparatus
US4230558A (en) 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4318846A (en) 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5985549A (en) 1985-10-22 1999-11-16 University Of Massachusetts Non-isotopic in-situ hybridization method for detection of nucleic acids
US5091519A (en) 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
US4811218A (en) 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US5151507A (en) 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5066580A (en) 1988-08-31 1991-11-19 Becton Dickinson And Company Xanthene dyes that emit to the red of fluorescein
US6242184B1 (en) 1988-10-18 2001-06-05 University Of Massachusetts In-situ hybridization of single-copy and multiple-copy nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5491224A (en) 1990-09-20 1996-02-13 Bittner; Michael L. Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
US6277569B1 (en) 1990-09-20 2001-08-21 Vysis, Inc. Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US6140496A (en) 1990-10-09 2000-10-31 Benner; Steven Albert Precursors for deoxyribonucleotides containing non-standard nucleosides
US6037120A (en) 1995-10-12 2000-03-14 Benner; Steven Albert Recognition of oligonucleotides containing non-standard base pairs
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
JPH07504087A (en) 1992-02-12 1995-05-11 クロマジェン インク Applications of fluorescent N-nucleosides and fluorescent N-nucleoside structural analogs
WO1993021345A1 (en) 1992-04-21 1993-10-28 The Regents Of The University Of California Multicolor in situ hybridization methods for genetic testing
US5386024A (en) 1993-02-10 1995-01-31 Gen-Probe Incorporated Method to prepare nucleic acids from a biological sample using low pH and acid protease
US5543838A (en) 1993-08-31 1996-08-06 Xerox Corporation Signal multiplexing system for an image sensor array
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5783387A (en) 1995-02-06 1998-07-21 The Regents Of The University Of California Method for identifying and quantifying nucleic acid sequence aberrations
US5780227A (en) 1995-06-07 1998-07-14 Sheridan; Patrick J. Oligonucleotide probe conjugated to a purified hydrophilic alkaline phosphatase and uses thereof
US5945515A (en) 1995-07-31 1999-08-31 Chomczynski; Piotr Product and process for isolating DNA, RNA and proteins
WO1997007245A1 (en) 1995-08-14 1997-02-27 Ely Michael Rabani Methods and devices for parallel multiplex polynucleotide sequencing
WO1997014028A2 (en) 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6007994A (en) 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US7144119B2 (en) 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5853993A (en) 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US20020034737A1 (en) 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US6180415B1 (en) 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US5888778A (en) 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US20050037397A1 (en) 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
AU1080999A (en) 1997-10-14 1999-05-03 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
AU760560B2 (en) 1998-02-12 2003-05-15 Board Of Regents, The University Of Texas System Methods and reagents for the rapid and efficient isolation of circulating cancer cells
US6225285B1 (en) 1998-03-11 2001-05-01 Exelixis Pharmaceuticals, Inc. Semaphorin K1
EP2045334A1 (en) 1998-06-24 2009-04-08 Illumina, Inc. Decoding of array sensors with microspheres
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6426513B1 (en) 1998-09-18 2002-07-30 Massachusetts Institute Of Technology Water-soluble thiol-capped nanocrystals
EP1271154A3 (en) 1998-09-18 2005-08-17 Massachusetts Institute Of Technology Biological applications of semiconductor nanocrystals
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6465193B2 (en) 1998-12-11 2002-10-15 The Regents Of The University Of California Targeted molecular bar codes and methods for using the same
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
DK1159453T3 (en) 1999-03-10 2008-10-06 Asm Scient Inc Method of Direct Nucleic Acid Sequencing
US6511824B1 (en) 1999-03-17 2003-01-28 Exelixis, Inc. Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use
JP2003523935A (en) 1999-03-31 2003-08-12 ユナイテッド セラピューティクス コーポレイション Prostaglandin compounds, compositions and methods for treating peripheral vascular disease and pulmonary hypertension
ATE307901T1 (en) 1999-04-08 2005-11-15 Gen Probe Inc AMPLIFICATION AND SEQUENCING OF PRIMER PAIRS AND THEIR USE
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
JP2002542793A (en) 1999-04-22 2002-12-17 ザ アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ Assay of gene expression pattern by multi-fluorescent FISH
ATE439452T1 (en) 1999-05-07 2009-08-15 Life Technologies Corp METHOD FOR DETECTING ANALYTES USING SEMICONDUCTOR NANOCRYSTALS
US20020051971A1 (en) 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6316200B1 (en) 2000-06-08 2001-11-13 Becton, Dickinson And Company Probes and methods for detection of nucleic acids
WO2001000875A2 (en) 1999-06-25 2001-01-04 Motorola, Inc. Novel methods and products for arrayed microsphere analysis
US6942968B1 (en) 1999-08-30 2005-09-13 Illumina, Inc. Array compositions for improved signal detection
US6379888B1 (en) 1999-09-27 2002-04-30 Becton, Dickinson And Company Universal probes and methods for detection of nucleic acids
US6428957B1 (en) 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
WO2001059432A2 (en) 2000-02-10 2001-08-16 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
EP1257668B1 (en) 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
US20020028457A1 (en) 2000-02-16 2002-03-07 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
WO2001062378A2 (en) 2000-02-22 2001-08-30 Genospectra, Inc. Microarray fabrication techniques and apparatus
US20030186426A1 (en) 2000-03-15 2003-10-02 The Regents Of The University Of California Multichannel flow cell for interacting single optically trapped, DNA molecules with different chemical species
US6734420B2 (en) 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
JP2004523201A (en) 2000-05-16 2004-08-05 ザ チルドレンズ マーシー ホスピタル Single copy genome hybridization probe and method for producing the same
US7033758B2 (en) 2000-06-02 2006-04-25 Bayer Corporation Highly sensitive gene detection and localization using in situ branched-DNA hybridization
US7763421B2 (en) 2000-06-05 2010-07-27 Ventana Medical Systems, Inc. Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation
WO2002009836A2 (en) 2000-08-01 2002-02-07 Surromed, Inc. Methods for solid phase nanoextraction and desorption
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US6777244B2 (en) 2000-12-06 2004-08-17 Hrl Laboratories, Llc Compact sensor using microcavity structures
US6576291B2 (en) 2000-12-08 2003-06-10 Massachusetts Institute Of Technology Preparation of nanocrystallites
US6803200B2 (en) 2000-12-12 2004-10-12 Invitrogen Corporation Compositions and methods for the release of nucleic acid molecules from solid matrices
EP2801624B1 (en) 2001-03-16 2019-03-06 Singular Bio, Inc Arrays and methods of use
PL373962A1 (en) 2001-05-21 2005-09-19 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US6815064B2 (en) 2001-07-20 2004-11-09 Quantum Dot Corporation Luminescent nanoparticles and methods for their preparation
US7189509B2 (en) 2001-08-16 2007-03-13 Zhifeng Shao Analysis of gene expression profiles using sequential hybridization
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
CN1571634A (en) 2001-08-23 2005-01-26 免疫公司 Stabilization of cells and biological specimens for analysis
CA2459320C (en) 2001-09-06 2016-07-05 Genomic Profiling Systems, Inc. Rapid detection of replicating cells
AU2002360272A1 (en) 2001-10-10 2003-04-22 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
US20110151438A9 (en) * 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
WO2003054214A2 (en) * 2001-12-10 2003-07-03 Denton Richard V Tsunami chain reaction - geometric dna amplification
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US8394944B2 (en) 2002-09-20 2013-03-12 Siemens Healthcare Diagnostics Inc. Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation
US20090246879A1 (en) 2002-12-20 2009-10-01 Callida Genomics Materials and Methods Relating to Nano-Tags and Nano-Brands
US20060210982A1 (en) 2003-01-31 2006-09-21 Hiroshi Yanagawa Cleavable assigned molecules and screening method using the same
JP4283578B2 (en) 2003-03-31 2009-06-24 学校法人片柳学園 Target sequence detection method using probe nucleic acid containing mismatch amplification substance, probe nucleic acid and target sequence detection assay kit
ATE418621T1 (en) 2003-04-24 2009-01-15 Afshin Ahmadian METHOD FOR DETECTING ALLEL-SPECIFIC MUTATIONS
US7385043B1 (en) 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
US7250371B2 (en) 2003-08-26 2007-07-31 Lam Research Corporation Reduction of feature critical dimensions
US20050048498A1 (en) 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
US20050064435A1 (en) 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
EP1681983A4 (en) 2003-10-14 2008-12-10 Monogram Biosciences Inc Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
WO2005054516A2 (en) 2003-11-26 2005-06-16 Advandx, Inc. Peptide nucleic acid probes for analysis of certain staphylococcus species
US7381529B2 (en) 2003-12-31 2008-06-03 Intel Corporation Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes
US7462475B2 (en) 2004-05-20 2008-12-09 Dna Poleymerase Technology, Inc. Use of whole blood in PCR reactions
CN100583434C (en) 2004-06-07 2010-01-20 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
US20070154889A1 (en) 2004-06-25 2007-07-05 Veridex, Llc Methods and reagents for the detection of melanoma
WO2006016978A1 (en) 2004-06-30 2006-02-16 Applera Corporation Analog probe complexes
EP1802772A4 (en) 2004-09-10 2008-12-31 Sequenom Inc Methods for long-range sequence analysis of nucleic acids
DE602005018316D1 (en) 2004-10-08 2010-01-28 Sysmex Corp A method of detecting a target substance using a nucleic acid probe
JP4839051B2 (en) 2004-10-08 2011-12-14 シスメックス株式会社 Method for detecting a test substance using a nucleic acid probe
US7829278B2 (en) 2004-10-28 2010-11-09 Board Of Trustees Of The University Of Illinois Polynucleotide barcoding
US20060134917A1 (en) 2004-12-16 2006-06-22 Lam Research Corporation Reduction of etch mask feature critical dimensions
US8063196B2 (en) 2005-02-01 2011-11-22 Siemens Healthcare Diagnostics Inc. Highly orthogonal universal sequences for use in nucleic acid assays
EP2272983A1 (en) 2005-02-01 2011-01-12 AB Advanced Genetic Analysis Corporation Reagents, methods and libraries for bead-based sequencing
US7524631B2 (en) 2005-02-02 2009-04-28 Patterson Bruce K HPV E6, E7 mRNA assay and methods of use thereof
CA2606723A1 (en) 2005-05-09 2006-11-16 Panomics, Inc. Multiplex capture of nucleic acids
EP1880025B1 (en) 2005-05-12 2011-03-16 Affymetrix, Inc. Multiplex branched-chain dna assays
US20070048759A1 (en) 2005-06-10 2007-03-01 Dan Luo Detection of target molecules with labeled nucleic acid detection molecules
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
ES2565670T3 (en) 2005-06-20 2016-04-06 Advanced Cell Diagnostics, Inc. Nucleic acid detection methods in individual cells and identification of rare cells in large populations of heterogeneous cells
DE602006020577D1 (en) 2005-07-01 2011-04-21 Dako Denmark As MONOMERS AND POLYMERS LEFT FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES
WO2007044427A2 (en) 2005-10-05 2007-04-19 Panomics, Inc. Detection of nucleic acids from whole blood
ATE553211T1 (en) 2005-11-10 2012-04-15 Affymetrix Inc DETECTION OF NUCLEIC ACIDS VIA AMPLIFICATION OF DEPUTY NUCLEIC ACIDS
US20090299640A1 (en) 2005-11-23 2009-12-03 University Of Utah Research Foundation Methods and Compositions Involving Intrinsic Genes
EP1963851A4 (en) 2005-12-16 2009-07-29 Applera Corp Method and system for phase-locked sequencing
ATE525482T1 (en) 2005-12-23 2011-10-15 Nanostring Technologies Inc NANOREPORTERS AND METHOD FOR THE PRODUCTION AND USE THEREOF
US8986926B2 (en) 2005-12-23 2015-03-24 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
CN101495654A (en) 2006-04-19 2009-07-29 阿普里拉股份有限公司 Reagents, methods, and libraries for gel-free bead-based sequencing
ES2620398T3 (en) 2006-05-22 2017-06-28 Nanostring Technologies, Inc. Systems and methods to analyze nanoindicators
US7745129B1 (en) 2006-07-12 2010-06-29 Kenneth David Schatz Methods for sequencing of a necleic acid
JP2008043332A (en) 2006-08-17 2008-02-28 Panomics Inc Quantitative determination of nucleic acid from tissue slide
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
WO2008039998A2 (en) 2006-09-28 2008-04-03 President And Fellows Of Harvard College Methods for sequencing dna
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US7615351B2 (en) 2006-12-01 2009-11-10 Panomics, Inc. Two stage nucleic acid amplification using an amplification oligomer
US7883869B2 (en) 2006-12-01 2011-02-08 The Trustees Of Columbia University In The City Of New York Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US8415102B2 (en) 2007-04-10 2013-04-09 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
PL2036989T3 (en) 2007-09-12 2012-12-31 Pasteur Institut Polynucleotide suitable for single cell based reporter assay to monitor gene expression patterns with high spatio-temporal resolution
JP2010539982A (en) 2007-10-01 2010-12-24 アプライド バイオシステムズ, エルエルシー Chase ligation sequencing
JP2010539991A (en) 2007-10-04 2010-12-24 ハルシオン モレキュラー Sequencing of nucleic acid polymers using electron microscopy
EP2511708B1 (en) 2007-10-05 2016-09-14 Affymetrix, Inc. Highly multiplexed particle-based assays
CN101932729B (en) 2007-12-05 2013-03-27 考利达基因组股份有限公司 Efficient base determination in sequencing reactions
CN101586150B (en) 2008-05-23 2016-09-28 陕西佰美基因股份有限公司 Detection probe, general oligonucleotide chip and nucleic acid detection method and application thereof
US20090298709A1 (en) 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
AU2009262894B2 (en) 2008-05-30 2014-01-30 British Columbia Cancer Agency Branch Gene expression profiles to predict breast cancer outcomes
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
ES2684317T3 (en) 2008-08-14 2018-10-02 Nanostring Technologies, Inc Stable nanoinformers
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
JP5850746B2 (en) 2008-11-17 2016-02-03 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
US8715926B2 (en) 2008-11-24 2014-05-06 Loma Linda University Biomarkers for the detection of head and neck tumors
WO2010080566A1 (en) 2008-12-18 2010-07-15 Siemens Healthcare Diagnostics Inc. Methods and reagents for shortening incubation times in hybridization assays
EP3150724A1 (en) 2008-12-19 2017-04-05 President and Fellows of Harvard College Particle-assisted nucleic acid sequencing
US20110275077A1 (en) 2009-01-12 2011-11-10 William James Oligonucleotide-Coated Affinity Membranes and Uses Thereof
US8404444B2 (en) 2009-02-25 2013-03-26 Diacarta Llc Method for predicting the level of damage to cells by measuring free circulating Alu nucleic acid
SG10201402770YA (en) 2009-04-02 2014-08-28 Fluidigm Corp Multi-primer amplification method for barcoding of target nucleic acids
US10072287B2 (en) 2009-09-10 2018-09-11 Centrillion Technology Holdings Corporation Methods of targeted sequencing
US20130023433A1 (en) 2009-09-28 2013-01-24 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
AU2010306862B2 (en) 2009-10-13 2015-08-27 Nanostring Technologies, Inc. Protein detection via nanoreporters
WO2011084168A1 (en) 2010-01-08 2011-07-14 The Regents Of The University Of California Bioassays based on polymeric sequence probes
ES2719502T3 (en) 2010-01-29 2019-07-10 Advanced Cell Diagnostics Inc Nucleic acid in situ detection methods
CA2785529C (en) 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
US20130065780A1 (en) 2010-02-15 2013-03-14 North Carolina State University Office Of Technology Transfer Label-Free Multiplexing Bioassays Using Fluorescent Conjugated Polymers and Barcoded Nanoparticles
CA2787487C (en) 2010-02-26 2018-07-24 Ventana Medical Systems, Inc. Polytag probes
WO2011116088A2 (en) 2010-03-16 2011-09-22 Nanostring Technologies, Inc. Compositions and methods for the detection of genomic features
EP2576830B1 (en) 2010-06-03 2014-08-27 Cellay, Inc. Methods for in situ detection of nucleotide sequences
EP2577300B1 (en) 2010-06-07 2016-09-28 Firefly Bioworks, Inc. Scanning multifunctional particles
US20120003648A1 (en) 2010-07-01 2012-01-05 Affymetrix, Inc. Signal Multiplexing and Signal Amplification
US20120052498A1 (en) 2010-07-01 2012-03-01 Affymetrix, Inc. Detection of Nucleic Acids
US20120004132A1 (en) 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
EP2591363B1 (en) 2010-07-07 2017-09-20 The Regents Of The University Of Michigan Diagnosis and treatment of breast cancer
WO2012040168A2 (en) 2010-09-20 2012-03-29 Advanced Cell Diagnostics, Inc. Biomarkers for differentiating melanoma from benign nevus in the skin
CN102445964A (en) 2010-10-06 2012-05-09 鸿富锦精密工业(深圳)有限公司 Computer case and hard disk module thereof
GB2512213B (en) 2010-10-08 2015-02-11 Harvard College High-throughput single cell barcoding
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
CN104849472A (en) 2010-10-21 2015-08-19 领先细胞医疗诊断有限公司 Ultra sensitive method for in situ detection of nucleic acids
US10024796B2 (en) 2010-10-29 2018-07-17 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
US8865404B2 (en) 2010-11-05 2014-10-21 President And Fellows Of Harvard College Methods for sequencing nucleic acid molecules
EP2640849B1 (en) 2010-11-16 2016-04-06 Nabsys 2.0 LLC Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
US20120178081A1 (en) 2010-12-31 2012-07-12 Affymetrix. Inc. Methods of Labeling Cells, Labeled Cells, and uses Thereof
US20120172246A1 (en) 2010-12-31 2012-07-05 Affymetrix, Inc. Detection of Nucleic Acids
DK2668290T3 (en) 2011-01-28 2017-09-18 Advanced Cell Diagnostics Inc RNASCOPE® HPV ASSAY FOR DETERMINING HPV STATUS OF CANCER AND HEALTH CANCER AND LESSIONS
US20120295801A1 (en) 2011-02-17 2012-11-22 President And Fellows Of Harvard College High-Throughput In Situ Hybridization
JP5971769B2 (en) 2011-03-15 2016-08-17 ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル Methods of treating breast cancer using anthracycline therapy
WO2012135340A2 (en) 2011-03-28 2012-10-04 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US20150086981A1 (en) 2011-05-04 2015-03-26 Genovoxx Gmbh Nucleoside-triphosphate conjugate and methods for the use thereof
WO2012157684A1 (en) 2011-05-16 2012-11-22 地方独立行政法人 大阪府立病院機構 Method for assessing progression of clinical state of malignant neoplasm by quantitative detection of dna in blood
JP6144623B2 (en) 2011-06-16 2017-06-07 日鉄住金環境株式会社 Nucleic acid probe for nucleic acid measurement
EP2723897A4 (en) 2011-06-24 2015-03-18 Nanostring Technologies Inc Multivariate diagnostic assays and methods for using same
US20140302042A1 (en) 2011-07-01 2014-10-09 Dana-Farber Cancer Institute, Inc. Methods of predicting prognosis in cancer
ITPD20110324A1 (en) 2011-10-12 2013-04-13 Innovation Factory S C A R L METHOD FOR DETECTION OF GALFA15 AS A TUMOR MARKER IN PANCREATIC CARCINOMA
WO2013055995A2 (en) 2011-10-14 2013-04-18 President And Fellows Of Harvard College Sequencing by structure assembly
US9670549B2 (en) 2011-11-10 2017-06-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene expression signatures of neoplasm responsiveness to therapy
WO2013082440A2 (en) 2011-11-30 2013-06-06 The University Of North Carolina At Chapel Hill Methods of treating breast cancer with taxane therapy
ES2953308T3 (en) 2011-12-22 2023-11-10 Harvard College Compositions and methods for the detection of analytes
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
US10385392B2 (en) 2011-12-30 2019-08-20 Abbott Molecular Inc. Nucleic acid hybridization probes
US9096902B2 (en) 2012-03-22 2015-08-04 The Regents Of The University Of California Genetic barcodes
US20140178869A1 (en) 2012-04-05 2014-06-26 Advanced Cell Diagnostics, Inc. Detection of immunoglobulin light chain restriction by rna in situ hybridization
CN104704128A (en) 2012-05-22 2015-06-10 纳米线科技公司 NANO46 genes and methods to predict breast cancer outcome
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
CA2877378A1 (en) 2012-06-29 2014-01-03 Nanostring Technologies, Inc. Methods of treating breast cancer with gemcitabine therapy
US9347106B2 (en) 2012-07-18 2016-05-24 The Regents Of The University Of California Multiplex assay for the detection of citrus pathogens
US20140120083A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
US20150283142A1 (en) 2013-03-15 2015-10-08 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
WO2014075067A1 (en) 2012-11-12 2014-05-15 Nanostring Technologies, Inc. Methods to predict breast cancer outcome
CA2905830C (en) 2013-03-12 2022-01-18 Curegenix Inc. Quinazoline and naphthyridine derivatives useful in the treatment of cancer
EP3578666A1 (en) 2013-03-12 2019-12-11 President and Fellows of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
KR20210122917A (en) 2013-03-14 2021-10-12 샤이어 휴먼 지네틱 테라피즈 인크. Cftr mrna compositions and related methods and uses
AU2014239954B2 (en) 2013-03-15 2020-07-16 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
CN105247077A (en) 2013-03-28 2016-01-13 领先细胞医疗诊断有限公司 Differentiation between transient and persistent high risk HPV infection by in situ hybridization
EP2992115B1 (en) 2013-04-30 2020-03-04 California Institute of Technology Multiplex labeling of molecules by sequential hybridization barcoding
WO2014182598A1 (en) 2013-05-06 2014-11-13 Physicians Choice Laboratory Services, Llc Diagnostic assay combining cellular and cell free nucleic acid
EP3574970A1 (en) 2013-05-17 2019-12-04 Siemens Healthcare Diagnostics Inc. Particle release and collection
EP3811974A1 (en) 2013-05-30 2021-04-28 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
CA2914816A1 (en) 2013-06-14 2014-12-18 Nanostring Technologies, Inc. Multiplexable tag-based reporter system
US10697005B2 (en) 2013-06-26 2020-06-30 Ramesh Vallabhaneni Method and system for tracking specific in situ hybridizations in biological samples using molecular barcodes
US20150051117A1 (en) 2013-08-16 2015-02-19 President And Fellows Of Harvard College Assembly of Nucleic Acid Sequences in Emulsions
WO2015031541A1 (en) 2013-08-28 2015-03-05 Stem Centrx, Inc. Novel sez6 modulators and methods of use
US20150105298A1 (en) 2013-10-10 2015-04-16 The Research Foundation For The State University Of New York Multi-oligomer in situ hybridization probes
PE20161242A1 (en) 2013-10-22 2016-12-11 Massachusetts Inst Technology LIPID FORMULATIONS FOR THE ADMINISTRATION OF MESSENGER RNA
US20150110857A1 (en) 2013-10-22 2015-04-23 Shire Human Genetic Therapies, Inc. Cns delivery of mrna and uses thereof
WO2015084726A1 (en) 2013-12-02 2015-06-11 Qbase, LLC Event detection through text analysis template models
WO2015089449A2 (en) 2013-12-12 2015-06-18 Stem Centrx, Inc. Novel anti-dpep3 antibodies and methods of use
WO2015095766A2 (en) 2013-12-20 2015-06-25 Stem Centrx, Inc. Novel anti-lingo1 antibodies and methods of use
EP3087394A2 (en) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
EP3094751A4 (en) 2014-01-14 2017-06-07 Santa Maria Biotherapeutics, Inc. Activin inhibitor response prediction and uses for treatment
US20150247204A1 (en) 2014-02-07 2015-09-03 The General Hopital Corporation Differential diagnosis of hepatic neoplasms
WO2015123565A1 (en) 2014-02-14 2015-08-20 The General Hospital Corporation Methods for diagnosing igg4-related disease
JP2017514143A (en) 2014-02-21 2017-06-01 アッヴィ・ステムセントルクス・エル・エル・シー Anti-DLL3 antibodies and drug conjugates for use in melanoma
EP3617322A1 (en) 2014-02-24 2020-03-04 Ventana Medical Systems, Inc. Automated rna detection using labeled 2 -o-methyl rna oligonucleotide probes and signal amplification systems
US20150247205A1 (en) 2014-02-28 2015-09-03 The General Hospital Corporation Diagnosis of multiple myeloma and lymphoma
WO2015136509A2 (en) 2014-03-14 2015-09-17 Genesis Theranostix Korlatolt Felelossegu Tarsasag Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy
WO2015143078A1 (en) 2014-03-18 2015-09-24 University Of Massachusetts Raav-based compositions and methods for treating amyotrophic lateral sclerosis
BR112016021383A2 (en) 2014-03-24 2017-10-03 Genentech Inc METHOD TO IDENTIFY A PATIENT WITH CANCER WHO IS LIKE OR LESS LIKELY TO RESPOND TO TREATMENT WITH A CMET ANTAGONIST, METHOD TO IDENTIFY A PATIENT WITH PREVIOUSLY TREATED CANCER, METHOD TO DETERMINE THE EXPRESSION OF THE HGF BIOMARKER, ANTI-C-MET ANTAGONIST AND ITS USE, DIAGNOSTIC KIT AND ITS PREPARATION METHOD
WO2015148606A2 (en) 2014-03-25 2015-10-01 President And Fellows Of Harvard College Barcoded protein array for multiplex single-molecule interaction profiling
EP3175023A4 (en) 2014-07-30 2018-03-07 President and Fellows of Harvard College Systems and methods for determining nucleic acids
US9933431B2 (en) 2014-08-22 2018-04-03 Arizona Board Of Regents On Behalf Of Arizona State University System and method for iterative detection of biological molecules
EP3221469B1 (en) 2014-11-21 2020-01-15 Nanostring Technologies, Inc Enzyme- and amplification-free sequencing
WO2016152936A1 (en) 2015-03-24 2016-09-29 国立大学法人 群馬大学 Simple method for detecting rna sequences
EP3283629A4 (en) * 2015-04-17 2018-08-29 President and Fellows of Harvard College Barcoding systems and methods for gene sequencing and other applications
WO2017079406A1 (en) 2015-11-03 2017-05-11 President And Fellows Of Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
WO2017147483A1 (en) 2016-02-26 2017-08-31 The Board Of Trustees Of The Leland Stanford Junior University Multiplexed single molecule rna visualization with a two-probe proximity ligation system
WO2017161251A1 (en) 2016-03-17 2017-09-21 President And Fellows Of Harvard College Methods for detecting and identifying genomic nucleic acids
WO2017177017A1 (en) 2016-04-07 2017-10-12 Omniome, Inc. Methods of quantifying target nucleic acids and identifying sequence variants
EP4324929A1 (en) 2016-05-16 2024-02-21 Nanostring Technologies, Inc. Methods for detecting target nucleic acids in a sample
EP3472359B1 (en) 2016-06-21 2022-03-16 10X Genomics, Inc. Nucleic acid sequencing
CN110225980B (en) 2016-11-21 2023-01-06 纳米线科技公司 Chemical compositions and methods of use thereof
CA3053384A1 (en) 2017-03-01 2018-09-07 The Board Of Trustees Of The Leland Stanford Junior University Highly specific circular proximity ligation assay
KR20200143420A (en) 2018-04-09 2020-12-23 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 Method of in situ gene sequencing
CA3099909A1 (en) 2018-05-14 2019-11-21 Nanostring Technologies, Inc. Chemical compositions and methods of using same
EP3836967A4 (en) 2018-07-30 2022-06-15 ReadCoor, LLC Methods and systems for sample processing or analysis
EP4034675A4 (en) 2019-09-26 2023-10-04 Jumpcode Genomics, Inc. Method and system for targeted nucleic acid sequencing
CA3163623A1 (en) 2020-01-03 2021-07-08 Harry LARMAN In situ rna analysis using probe pair ligation
US20210403992A1 (en) 2020-06-29 2021-12-30 Miltenyi Biotec B.V. & Co. KG METHOD COMBINING SINGLE CELL GENE EXPRESSION MAPPING AND TARGETED RNA OR c-DNA SEQUENCING USING PADLOCK OLIGONUCLEOTIDES COMPRISING A BARCODE REGION
US20220040346A1 (en) 2020-08-10 2022-02-10 Sterilization Station, LLC System and method for shopping cart disinfection and sterilization using ultraviolet light
EP4001432A1 (en) 2020-11-13 2022-05-25 Miltenyi Biotec B.V. & Co. KG Algorithmic method for efficient indexing of genetic sequences using associative arrays
CN114854838A (en) 2021-02-04 2022-08-05 美天施生物科技有限两合公司 Method for combining in-vitro sequencing and in-situ sequencing of target RNA or cDNA
WO2022197801A1 (en) 2021-03-17 2022-09-22 Yale University Systems and methods for determining barcodes and screening in situ
US20220356519A1 (en) 2021-05-10 2022-11-10 Pacific Biosciences Of California, Inc. Single-molecule seeding and amplification on a surface
EP4337787A1 (en) 2021-05-14 2024-03-20 Akoya Biosciences, Inc. Amplification of rna detection signals in biological samples
US20220403462A1 (en) 2021-06-18 2022-12-22 Miltenyi Biotec B.V. & Co. KG Method of spatial sequencing of genes from tissue using padlocks with gaps on substrate
EP4108783B1 (en) 2021-06-24 2024-02-21 Miltenyi Biotec B.V. & Co. KG Spatial sequencing with mictag

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