SG10201903630UA - Iminosugars useful for the treatment of viral diseases - Google Patents
Iminosugars useful for the treatment of viral diseasesInfo
- Publication number
- SG10201903630UA SG10201903630UA SG10201903630UA SG10201903630UA SG10201903630UA SG 10201903630U A SG10201903630U A SG 10201903630UA SG 10201903630U A SG10201903630U A SG 10201903630UA SG 10201903630U A SG10201903630U A SG 10201903630UA SG 10201903630U A SG10201903630U A SG 10201903630UA
- Authority
- SG
- Singapore
- Prior art keywords
- iminosugars
- useful
- treatment
- viral diseases
- viral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES Formula IA, and their use for treating viral infections.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462075505P | 2014-11-05 | 2014-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201903630UA true SG10201903630UA (en) | 2019-05-30 |
Family
ID=54542590
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201903630UA SG10201903630UA (en) | 2014-11-05 | 2015-11-04 | Iminosugars useful for the treatment of viral diseases |
SG11201703330YA SG11201703330YA (en) | 2014-11-05 | 2015-11-04 | Iminosugars useful for the treatment of viral diseases |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201703330YA SG11201703330YA (en) | 2014-11-05 | 2015-11-04 | Iminosugars useful for the treatment of viral diseases |
Country Status (8)
Country | Link |
---|---|
US (1) | US10428022B2 (en) |
EP (1) | EP3215499B1 (en) |
JP (1) | JP6826986B2 (en) |
CN (1) | CN107207477B (en) |
BR (1) | BR112017008898B1 (en) |
CA (1) | CA2966893C (en) |
SG (2) | SG10201903630UA (en) |
WO (1) | WO2016073652A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017201052A1 (en) * | 2016-05-16 | 2017-11-23 | Emergent Virology Llc | Methods of treating zika virus infection |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2834122A1 (en) | 1978-08-03 | 1980-02-14 | Bayer Ag | METHOD FOR PRODUCING 6-AMINO-6-DESOXY-L-SORBOSE |
DE2853573A1 (en) | 1978-12-12 | 1980-07-03 | Bayer Ag | PREPARATION OF N-SUBSTITUTED DERIVATIVES OF L-DESOXYNOJIRIMYCIN |
DE3038901A1 (en) | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING N-SUBSTITUTED DERIVATIVES OF 1-DESOXYNOJIRIMYCIN |
DE3611841A1 (en) | 1986-04-09 | 1987-10-15 | Bayer Ag | METHOD FOR PRODUCING 1-DESOXYNOJIRIMYCIN AND ITS N-DERIVATIVES |
DE3737523A1 (en) | 1987-11-05 | 1989-05-18 | Bayer Ag | USE OF SUBSTITUTED HYDROXYPIPERIDINES AS ANTIVIRAL AGENTS |
US5043273A (en) | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
US5103008A (en) | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
US4994572A (en) | 1989-10-12 | 1991-02-19 | Monsanto Company | Synthesis of nojirimycin derivatives |
US5200523A (en) | 1990-10-10 | 1993-04-06 | Monsanto Company | Synthesis of nojirimycin derivatives |
AU1876095A (en) | 1994-02-25 | 1995-09-11 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
CN1290168A (en) | 1997-12-11 | 2001-04-04 | 牛津大学院长校长专家委员会 | Inhibition of membrane-associated viral replication |
US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
MY122185A (en) | 1998-02-12 | 2006-03-31 | Searle & Co | Use of n-substituted-1, 5-dideoxy-1, 5-imino-d-glucitol compounds for treating hepatitis virus infections |
GB9828474D0 (en) | 1998-12-24 | 1999-02-17 | British Aerospace | Surface topology inspection |
ATE402701T1 (en) | 1999-02-12 | 2008-08-15 | United Therapeutics Corp | N-(8,8,8-TRIFLUOROOCTYL)-1,5-DIDEOXY-1,5-IMINO- - GLUCITOL FOR THE TREATMENT OF HEPATITIS VIRUS INFECTIONS |
WO2004007453A1 (en) * | 2002-07-17 | 2004-01-22 | Oxford Glycosciences (Uk) Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
KR20080025373A (en) * | 2005-05-17 | 2008-03-20 | 아미쿠스 세라퓨틱스, 인코포레이티드 | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
CN101355971A (en) * | 2005-05-17 | 2009-01-28 | 阿米库斯治疗学公司 | Method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
CN104876855A (en) | 2006-05-24 | 2015-09-02 | 联合治疗公司 | Deoxynojirimycin And D-arabinitol Analogs And Methods Of Using |
CN102727437A (en) | 2006-08-02 | 2012-10-17 | 牛津大学院长校长专家委员会 | Liposome treatment of viral infections |
WO2009118658A2 (en) | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
JP5600329B2 (en) | 2009-02-23 | 2014-10-01 | ユナイテッド セラピューティクス コーポレーション | Methods for treating iminosugars and viral diseases |
WO2010109330A2 (en) | 2009-03-27 | 2010-09-30 | University Of Oxford | Cholesterol level lowering liposomes |
ES2524361T3 (en) * | 2009-06-12 | 2014-12-05 | United Therapeutics Corporation | Iminoazúcares for use in the treatment of bunyavirus and togavirus diseases |
JP5653438B2 (en) | 2009-09-04 | 2015-01-14 | ユナイテッド セラピューティクス コーポレイション | Treatment of orthomyxovirus infection |
US20110065753A1 (en) | 2009-09-04 | 2011-03-17 | United Therapeutics Corporation | Methods of treating poxviral infections |
WO2011028779A1 (en) | 2009-09-04 | 2011-03-10 | United Therapeutics Corporation | Iminosugars and methods of treating filoviral diseases |
KR20150128899A (en) | 2013-03-15 | 2015-11-18 | 유니터 바이롤로지, 엘엘씨 | Antibacterial compounds |
US20160075651A1 (en) | 2013-05-02 | 2016-03-17 | Unither Virology, Llc | Glycolipid inhibition using iminosugars |
EP2991657A4 (en) | 2013-05-02 | 2017-02-22 | The Chancellor, Masters and Scholars of The University of Oxford | Lipidomic biomarkers |
SG11201601646YA (en) | 2013-09-16 | 2016-04-28 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
-
2015
- 2015-11-04 EP EP15794766.4A patent/EP3215499B1/en active Active
- 2015-11-04 BR BR112017008898-3A patent/BR112017008898B1/en active IP Right Grant
- 2015-11-04 JP JP2017543307A patent/JP6826986B2/en active Active
- 2015-11-04 CN CN201580071166.5A patent/CN107207477B/en active Active
- 2015-11-04 WO PCT/US2015/059110 patent/WO2016073652A1/en active Application Filing
- 2015-11-04 SG SG10201903630UA patent/SG10201903630UA/en unknown
- 2015-11-04 CA CA2966893A patent/CA2966893C/en active Active
- 2015-11-04 US US15/524,535 patent/US10428022B2/en active Active
- 2015-11-04 SG SG11201703330YA patent/SG11201703330YA/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3215499A1 (en) | 2017-09-13 |
US10428022B2 (en) | 2019-10-01 |
CN107207477A (en) | 2017-09-26 |
JP6826986B2 (en) | 2021-02-10 |
SG11201703330YA (en) | 2017-05-30 |
WO2016073652A1 (en) | 2016-05-12 |
CN107207477B (en) | 2022-11-01 |
US20180273473A1 (en) | 2018-09-27 |
JP2017533962A (en) | 2017-11-16 |
BR112017008898B1 (en) | 2022-11-29 |
BR112017008898A2 (en) | 2017-12-19 |
CA2966893C (en) | 2023-10-24 |
CA2966893A1 (en) | 2016-05-12 |
WO2016073652A8 (en) | 2017-05-04 |
EP3215499B1 (en) | 2021-01-20 |
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