SG10201808825XA - Defined composition gene modified t-cell products - Google Patents

Defined composition gene modified t-cell products

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Publication number
SG10201808825XA
SG10201808825XA SG10201808825XA SG10201808825XA SG10201808825XA SG 10201808825X A SG10201808825X A SG 10201808825XA SG 10201808825X A SG10201808825X A SG 10201808825XA SG 10201808825X A SG10201808825X A SG 10201808825XA SG 10201808825X A SG10201808825X A SG 10201808825XA
Authority
SG
Singapore
Prior art keywords
cells
cell
defined composition
modified
cell products
Prior art date
Application number
SG10201808825XA
Inventor
Michael C Jensen
Original Assignee
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54288361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201808825X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Childrens Hospital Dba Seattle Childrens Res Inst filed Critical Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Publication of SG10201808825XA publication Critical patent/SG10201808825XA/en

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Abstract

DEFINED COMPOSITION GENE MODIFIED T-CELL PRODUCTS Aspects of the invention described herein, concern approaches to make genetically modified T-cells comprising a chimeric antigen receptor for human therapy. In some alternatives, the methods utilize a selection and/or isolation of CD+ and/or CD8+ T- cells from a mixed T-cell population, such as, peripheral blood or apheresis derived mononuclear cells. Once selected/isolated, the CD4+ and/or CD8+ T-cells are then activated, genetically modified, and propagated, preferably, in separate or isolated cultures in the presence of one or more cytokines, which support survival, engraftment and/or proliferation of the cells, as well as, preferably promoting or inducing the retention of cell surface receptors, such as CD62L, CD28, and/or CD27. Included herein are also methods of treatment, inhibition, amelioration, or elimination of a cancer by administering to a subject in need thereof, one or more types of the genetically engineered T-cells or compositions that comprise the genetically engineered T-cell prepared as described herein. FIG. 11A and FIG. 11B -109-
SG10201808825XA 2014-04-10 2015-04-08 Defined composition gene modified t-cell products SG10201808825XA (en)

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US201461977751P 2014-04-10 2014-04-10
US201461986479P 2014-04-30 2014-04-30
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US201462088363P 2014-12-05 2014-12-05
US201462089730P 2014-12-09 2014-12-09
US201462090845P 2014-12-11 2014-12-11

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