SG10201808063PA - Compositions for modulating ataxin 2 expression - Google Patents

Compositions for modulating ataxin 2 expression

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Publication number
SG10201808063PA
SG10201808063PA SG10201808063PA SG10201808063PA SG10201808063PA SG 10201808063P A SG10201808063P A SG 10201808063PA SG 10201808063P A SG10201808063P A SG 10201808063PA SG 10201808063P A SG10201808063P A SG 10201808063PA SG 10201808063P A SG10201808063P A SG 10201808063PA
Authority
SG
Singapore
Prior art keywords
ataxin
compositions
expression
modulating
methods
Prior art date
Application number
SG10201808063PA
Inventor
Susan Freier
Gene Hung
C Bennett
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54145357&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201808063P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of SG10201808063PA publication Critical patent/SG10201808063PA/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPOSITIONS FOR MODULATING ATAXIN 2 EXPRESSION Disclosed herein are antisense compounds and methods for decreasing Ataxin 2 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or Ataxin associated disorders, conditions. Ataxin associated diseases include spinocerebellar ataxia type 2 (SCA2), amyotropic sclerosis (ALS), and parkinsonism. No suitable figure.
SG10201808063PA 2014-03-19 2015-03-19 Compositions for modulating ataxin 2 expression SG10201808063PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461955705P 2014-03-19 2014-03-19
US201461982131P 2014-04-21 2014-04-21

Publications (1)

Publication Number Publication Date
SG10201808063PA true SG10201808063PA (en) 2018-10-30

Family

ID=54145357

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201808063PA SG10201808063PA (en) 2014-03-19 2015-03-19 Compositions for modulating ataxin 2 expression
SG11201607761UA SG11201607761UA (en) 2014-03-19 2015-03-19 Compositions for modulating ataxin 2 expression

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201607761UA SG11201607761UA (en) 2014-03-19 2015-03-19 Compositions for modulating ataxin 2 expression

Country Status (25)

Country Link
US (3) US10308934B2 (en)
EP (2) EP3119888B1 (en)
JP (3) JP6902869B2 (en)
KR (1) KR102352589B1 (en)
CN (2) CN116970607A (en)
AU (2) AU2015231130C1 (en)
BR (1) BR112016020472B1 (en)
CA (1) CA2942340A1 (en)
CL (1) CL2016002346A1 (en)
CY (1) CY1124526T1 (en)
DK (1) DK3119888T3 (en)
ES (1) ES2890677T3 (en)
HK (1) HK1232251A1 (en)
HR (1) HRP20211397T1 (en)
HU (1) HUE055877T2 (en)
IL (1) IL247600B (en)
LT (1) LT3119888T (en)
MX (1) MX2016012123A (en)
PL (1) PL3119888T3 (en)
PT (1) PT3119888T (en)
RS (1) RS62526B1 (en)
RU (2) RU2019130898A (en)
SG (2) SG10201808063PA (en)
SI (1) SI3119888T1 (en)
WO (1) WO2015143246A1 (en)

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US10006027B2 (en) 2014-03-19 2018-06-26 Ionis Pharmaceuticals, Inc. Methods for modulating Ataxin 2 expression
IL247600B (en) 2014-03-19 2022-06-01 Ionis Pharmaceuticals Inc Compositions for modulating ataxin 2 expression
EP3353303B1 (en) 2015-09-25 2023-08-02 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating ataxin 3 expression
US9840710B2 (en) 2015-11-18 2017-12-12 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
WO2017117496A1 (en) * 2015-12-31 2017-07-06 Ionis Pharmaceuticals, Inc. Methods for reducing ataxin-2 expression
JOP20190104A1 (en) * 2016-11-10 2019-05-07 Ionis Pharmaceuticals Inc Compounds and methods for reducing atxn3 expression
US20210261981A1 (en) * 2017-10-23 2021-08-26 Prevail Therapeutics, Inc. Gene therapies for neurodegenerative diseases
CN112189053B (en) 2018-05-09 2024-05-14 Ionis制药公司 Compounds and methods for reducing ATXN3 expression
WO2019233921A1 (en) 2018-06-05 2019-12-12 F. Hoffmann-La Roche Ag Oligonucleotides for modulating atxn2 expression
EP3826645A4 (en) * 2018-07-25 2023-05-17 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing atxn2 expression
BR112021010660A2 (en) 2018-12-06 2021-08-24 Biogen Ma Inc. Neurofilament protein to guide therapeutic intervention in amyotrophic lateral sclerosis
TW202035694A (en) * 2018-12-14 2020-10-01 美商百健Ｍａ公司 Compositions and methods for treating and preventing amyotrophic lateral sclerosis
CN109529018B (en) * 2019-01-10 2021-11-30 南方医科大学南方医院 Application of ATXN2L in preparation of drug for reversing oxaliplatin resistance of gastric cancer
US11286485B2 (en) 2019-04-04 2022-03-29 Hoffmann-La Roche Inc. Oligonucleotides for modulating ATXN2 expression
CN113785060A (en) 2019-04-04 2021-12-10 豪夫迈·罗氏有限公司 Oligonucleotides for modulating expression of ATXN2
EP4188390A1 (en) * 2020-07-29 2023-06-07 Alnylam Pharmaceuticals, Inc. Atxn2 irna compositions and methods of use thereof for treating or preventing atxn2-associated neurodegenerative diseases
WO2023250368A2 (en) * 2022-06-24 2023-12-28 Eli Lilly And Company Atxn2 rna interference agents

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