SG10201802231RA - Methods and compositions for producing hepatocyte-like cells - Google Patents
Methods and compositions for producing hepatocyte-like cellsInfo
- Publication number
- SG10201802231RA SG10201802231RA SG10201802231RA SG10201802231RA SG10201802231RA SG 10201802231R A SG10201802231R A SG 10201802231RA SG 10201802231R A SG10201802231R A SG 10201802231RA SG 10201802231R A SG10201802231R A SG 10201802231RA SG 10201802231R A SG10201802231R A SG 10201802231RA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- cells
- methods
- producing hepatocyte
- hepatocyte
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
- C12N2500/62—DMSO
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/237—Oncostatin M [OSM]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361880056P | 2013-09-19 | 2013-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201802231RA true SG10201802231RA (en) | 2018-05-30 |
Family
ID=52689587
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201707615YA SG11201707615YA (en) | 2013-09-19 | 2014-09-17 | Methods and compositions for producing hepatocyte-like cells |
SG10201802231RA SG10201802231RA (en) | 2013-09-19 | 2014-09-17 | Methods and compositions for producing hepatocyte-like cells |
SG10201914005TA SG10201914005TA (en) | 2013-09-19 | 2014-09-17 | Methods and compositions for producing hepatocyte-like cells |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201707615YA SG11201707615YA (en) | 2013-09-19 | 2014-09-17 | Methods and compositions for producing hepatocyte-like cells |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201914005TA SG10201914005TA (en) | 2013-09-19 | 2014-09-17 | Methods and compositions for producing hepatocyte-like cells |
Country Status (8)
Country | Link |
---|---|
US (3) | US10004767B2 (en) |
EP (2) | EP3046628B1 (en) |
JP (3) | JP6683615B2 (en) |
CA (1) | CA2959117C (en) |
DK (1) | DK3046628T3 (en) |
ES (1) | ES2767062T3 (en) |
SG (3) | SG11201707615YA (en) |
WO (1) | WO2015042125A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
EP3691738A4 (en) * | 2017-10-05 | 2021-06-16 | The Johns Hopkins University | Implantable bioreactor and methods for making and using same |
CN109749981B (en) * | 2017-11-06 | 2023-10-10 | 博品(上海)生物医药科技有限公司 | Hepatocyte-like cells derived from human adipose-derived stem cells, and preparation method and application thereof |
JP2023516484A (en) | 2020-03-11 | 2023-04-19 | ビット バイオ リミテッド | Hepatocyte production method |
WO2023060186A1 (en) | 2021-10-07 | 2023-04-13 | Hepatx Corporation | Methods of tracking donor cells in a recipient |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4491632A (en) | 1979-10-22 | 1985-01-01 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
DE3167442D1 (en) | 1980-07-07 | 1985-01-10 | Nat Res Dev | Improvements in or relating to cell lines |
DE3402927A1 (en) | 1984-01-28 | 1985-08-08 | Pfeifer & Langen, 5000 Köln | CELL CULTURE MICROCARRIERS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR GROWING ANCHOR-DEPENDENT CELLS |
US5026650A (en) | 1988-06-30 | 1991-06-25 | The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration | Horizontally rotated cell culture system with a coaxial tubular oxygenator |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6214618B1 (en) | 1998-04-07 | 2001-04-10 | Solohill Engineering, Inc. | Microcarrier beads having a styrene copolymer core and a covalently linked tri-methylamine exterior |
US6712610B2 (en) | 1999-04-02 | 2004-03-30 | Forsyth Dental Infirmary For Children | Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy and method |
HUP0402158A2 (en) | 2001-10-02 | 2005-01-28 | Novo Nordisk Health Care Ag | Method for production of recombinant proteins in eukaryote cells |
MXPA04009031A (en) * | 2002-03-15 | 2005-12-12 | Incara Cell Technologies Inc | Primitive and proximal hepatic stem cells. |
JP4334358B2 (en) | 2002-03-25 | 2009-09-30 | 財団法人 ひろしま産業振興機構 | Antibodies that recognize proliferating human hepatocytes, proliferating human hepatocytes, and functional human hepatocytes |
WO2004056976A2 (en) | 2002-12-23 | 2004-07-08 | Fuji Photo Film B.V. | Process for coating cell-culture support |
US7813977B2 (en) | 2003-09-11 | 2010-10-12 | Bgc Partners, Inc. | Graphical user interface related to non-standard trading of financial instruments |
US7361493B1 (en) | 2004-05-26 | 2008-04-22 | The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs | Production of urokinase in a three-dimensional cell culture |
GB2464652B (en) | 2004-09-29 | 2010-06-30 | Cellartis Ab | Improved methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hBS) |
JP2009525044A (en) | 2006-01-30 | 2009-07-09 | ユニバーシティ オブ バージニア パテント ファウンデーション | Methods for preparing and characterizing mesenchymal stem cell aggregates and their use |
WO2007127698A2 (en) | 2006-04-25 | 2007-11-08 | Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College | Adipose derived adult stem cells in hepatic regeneration |
ES2618787T5 (en) | 2006-04-25 | 2022-10-21 | Univ California | Administration of growth factors for the treatment of CNS disorders |
WO2007127454A2 (en) * | 2006-04-28 | 2007-11-08 | Cythera, Inc. | Hepatocyte lineage cells |
CN101448527B (en) * | 2006-05-19 | 2013-12-18 | 香港大学 | Cell-matrix microspheres, methods for preparation and applications |
US8158108B2 (en) | 2006-06-28 | 2012-04-17 | S.C. Johnson & Son, Inc. | VOC-free compressed gas aerosol compositions |
WO2008060360A2 (en) | 2006-09-28 | 2008-05-22 | Surmodics, Inc. | Implantable medical device with apertures for delivery of bioactive agents |
US20110020239A1 (en) * | 2007-05-14 | 2011-01-27 | The Johns Hopkins University | Methods for in vivo imaging of cells |
EP2179034A1 (en) * | 2007-07-20 | 2010-04-28 | Cellartis AB | A novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts stem cells |
CN101978047A (en) | 2008-01-18 | 2011-02-16 | 明尼苏达大学董事会 | Stem cell aggregates and methods for making and using |
WO2009097468A2 (en) | 2008-01-29 | 2009-08-06 | Kliman Gilbert H | Drug delivery devices, kits and methods therefor |
US20100112031A1 (en) | 2008-10-17 | 2010-05-06 | University Of Virginia Patent Foundation | Compositions And Methods For Regulating Extracellular Matrix Production In Adipose Derived Cells |
US20100098739A1 (en) | 2008-10-20 | 2010-04-22 | University Of Virginia Patent Foundation | Compositions and methods for modular soft tissue repair |
WO2010049752A1 (en) | 2008-10-31 | 2010-05-06 | Katholieke Universiteit Leuven | Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells |
US8895300B2 (en) * | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
WO2010059775A1 (en) * | 2008-11-20 | 2010-05-27 | Centocor Ortho Biotech Inc. | Pluripotent stem cell culture on micro-carriers |
KR101017710B1 (en) * | 2009-02-05 | 2011-02-25 | 한양대학교 산학협력단 | Adult stem cell population of cell spheroid form for transplantation and method for producing the same |
WO2010108126A2 (en) * | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
EP2435489A1 (en) | 2009-05-28 | 2012-04-04 | Corning Incorporated | Synthetic microcarriers for culturing cells |
JP2011013535A (en) | 2009-07-03 | 2011-01-20 | Olympus Corp | Light controlling apparatus and optical system |
US20120282228A1 (en) * | 2009-07-15 | 2012-11-08 | Vishal Bhasin | Method of producing progenitor cells from differentiated cells |
CN101914495A (en) | 2010-07-22 | 2010-12-15 | 吉林大学 | Culture method for largely amplifying hair follicle stem cells in vitro |
ITMI20111096A1 (en) * | 2011-06-17 | 2012-12-18 | Filosa Stefania | ENDODERMA CELLS FROM MULTI-TOTAL CELLS |
US9215088B2 (en) | 2011-06-29 | 2015-12-15 | Broadcom Corporation | Identification of application sessions |
US20130071931A1 (en) * | 2011-08-02 | 2013-03-21 | National Cancer Center | Process for hepatic differentiation from induced hepatic stem cells, and induced hepatic progenitor cells differentiated thereby |
EP2554176B1 (en) | 2011-08-04 | 2016-07-27 | ETHIANUM Betriebsgesellschaft mbH & Co. KG | Means for liver regeneration |
-
2014
- 2014-09-17 WO PCT/US2014/056049 patent/WO2015042125A2/en active Application Filing
- 2014-09-17 SG SG11201707615YA patent/SG11201707615YA/en unknown
- 2014-09-17 CA CA2959117A patent/CA2959117C/en active Active
- 2014-09-17 EP EP14846200.5A patent/EP3046628B1/en active Active
- 2014-09-17 ES ES14846200T patent/ES2767062T3/en active Active
- 2014-09-17 DK DK14846200.5T patent/DK3046628T3/en active
- 2014-09-17 SG SG10201802231RA patent/SG10201802231RA/en unknown
- 2014-09-17 EP EP19191062.9A patent/EP3685884A1/en active Pending
- 2014-09-17 US US14/917,558 patent/US10004767B2/en active Active
- 2014-09-17 SG SG10201914005TA patent/SG10201914005TA/en unknown
- 2014-09-17 JP JP2016543968A patent/JP6683615B2/en active Active
-
2018
- 2018-05-08 US US15/974,377 patent/US11291691B2/en active Active
-
2020
- 2020-03-26 JP JP2020055548A patent/JP7057797B2/en active Active
-
2022
- 2022-02-15 US US17/672,528 patent/US20220168359A1/en active Pending
- 2022-04-08 JP JP2022064376A patent/JP2022088668A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2767062T3 (en) | 2020-06-16 |
EP3046628B1 (en) | 2019-11-06 |
JP2022088668A (en) | 2022-06-14 |
SG11201707615YA (en) | 2017-10-30 |
EP3046628A4 (en) | 2017-03-08 |
WO2015042125A2 (en) | 2015-03-26 |
EP3046628A2 (en) | 2016-07-27 |
US11291691B2 (en) | 2022-04-05 |
SG10201914005TA (en) | 2020-03-30 |
JP2020114237A (en) | 2020-07-30 |
JP7057797B2 (en) | 2022-04-20 |
JP6683615B2 (en) | 2020-04-22 |
CA2959117C (en) | 2023-08-22 |
US20190083545A1 (en) | 2019-03-21 |
WO2015042125A3 (en) | 2015-11-05 |
US20160256499A1 (en) | 2016-09-08 |
JP2016529920A (en) | 2016-09-29 |
DK3046628T3 (en) | 2020-02-10 |
US10004767B2 (en) | 2018-06-26 |
US20220168359A1 (en) | 2022-06-02 |
EP3685884A1 (en) | 2020-07-29 |
CA2959117A1 (en) | 2015-03-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL273205A (en) | Compositions and methods | |
HK1218837A1 (en) | Compositions and methods | |
HK1218560A1 (en) | Compositions and methods | |
HK1220387A1 (en) | Compositions and methods for immunotherapy | |
HK1219976A1 (en) | Compositions and methods for immunotherapy | |
GB2527241B (en) | Compositions and methods | |
SG11201510176VA (en) | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME | |
SG10201706858XA (en) | Methods and compositions for mobilizing stem cells | |
HK1206755A1 (en) | Low acidic species compositions and methods for producing and using the same | |
GB201308072D0 (en) | Compositions and methods | |
HK1214772A1 (en) | Methods for producing diketopiperazines and compositions containing diketopiperazines | |
EP2986710A4 (en) | Age-modified cells and methods for making age-modified cells | |
EP2943591A4 (en) | Methods and compositions for single cell expression profiling | |
ZA201506874B (en) | Binder compositions and methods for making and using same | |
GB201305813D0 (en) | Compositions and methods | |
ZA201506873B (en) | Binder compositions and methods for making and using same | |
GB201322456D0 (en) | Radiotracer compositions and methods | |
EP2964610A4 (en) | Vinylsulfone-based 18f-labeling compositions and methods and uses thereof | |
SG10201802231RA (en) | Methods and compositions for producing hepatocyte-like cells | |
GB201322617D0 (en) | Methods and compositions | |
GB201312393D0 (en) | Compositions and Methods | |
GB201319917D0 (en) | Accelerator Compositions and Methods | |
GB201308949D0 (en) | Compositions and methods for reducing methane production |