SG10201610247QA - Antibody variants having modifications in the constant region - Google Patents
Antibody variants having modifications in the constant regionInfo
- Publication number
- SG10201610247QA SG10201610247QA SG10201610247QA SG10201610247QA SG10201610247QA SG 10201610247Q A SG10201610247Q A SG 10201610247QA SG 10201610247Q A SG10201610247Q A SG 10201610247QA SG 10201610247Q A SG10201610247Q A SG 10201610247QA SG 10201610247Q A SG10201610247Q A SG 10201610247QA
- Authority
- SG
- Singapore
- Prior art keywords
- modifications
- constant region
- antibody variants
- variants
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
- A61K51/103—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against receptors for growth factors or receptors for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Optics & Photonics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200801709 | 2008-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201610247QA true SG10201610247QA (en) | 2017-02-27 |
Family
ID=41692881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201610247QA SG10201610247QA (en) | 2008-12-03 | 2009-12-03 | Antibody variants having modifications in the constant region |
Country Status (7)
Country | Link |
---|---|
US (5) | US9085625B2 (en) |
EP (2) | EP2373687B1 (en) |
JP (2) | JP5746040B2 (en) |
AU (3) | AU2009324092A1 (en) |
CA (2) | CA3053156A1 (en) |
SG (1) | SG10201610247QA (en) |
WO (1) | WO2010063785A2 (en) |
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CA3053156A1 (en) * | 2008-12-03 | 2010-06-10 | Genmab A/S | Antibody variants having modifications in the constant region |
MX2011013455A (en) | 2009-07-08 | 2012-02-13 | Amgen Inc | Design of stable and aggregation free antibody fc molecules through ch3 domain interface engineering. |
US9150663B2 (en) | 2010-04-20 | 2015-10-06 | Genmab A/S | Heterodimeric antibody Fc-containing proteins and methods for production thereof |
JP2013537416A (en) * | 2010-08-13 | 2013-10-03 | メディミューン リミテッド | Monomer polypeptide containing mutant Fc region and method of use |
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US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
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US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
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MX2019004259A (en) | 2016-10-12 | 2019-09-27 | Bioverativ Usa Inc | Anti-c1s antibodies and methods of use thereof. |
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CN112646041B (en) * | 2019-10-12 | 2023-11-10 | 上海睿智化学研究有限公司 | Heterodimer comprising antibody CH3 domain and antibody and fusion protein comprising same |
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WO2008145141A1 (en) * | 2007-05-31 | 2008-12-04 | Genmab A/S | Method for extending the half-life of exogenous or endogenous soluble molecules |
AU2008255350B2 (en) | 2007-05-31 | 2014-07-10 | Genmab A/S | Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals |
JP6071165B2 (en) | 2007-05-31 | 2017-02-01 | ゲンマブ エー/エス | Stable IgG4 antibody |
US20100255012A1 (en) * | 2007-05-31 | 2010-10-07 | Genmab A/S | Recombinant fucose modified monovalent half-antibodies obtained by molecular engineering |
CA3053156A1 (en) * | 2008-12-03 | 2010-06-10 | Genmab A/S | Antibody variants having modifications in the constant region |
UA109633C2 (en) * | 2008-12-09 | 2015-09-25 | HUMAN ANTIBODY AGAINST TISSUE FACTOR | |
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-
2009
- 2009-12-03 CA CA3053156A patent/CA3053156A1/en active Pending
- 2009-12-03 CA CA2745439A patent/CA2745439C/en active Active
- 2009-12-03 US US13/132,423 patent/US9085625B2/en active Active
- 2009-12-03 EP EP09771325.9A patent/EP2373687B1/en active Active
- 2009-12-03 AU AU2009324092A patent/AU2009324092A1/en not_active Abandoned
- 2009-12-03 EP EP16185985.5A patent/EP3153524A1/en active Pending
- 2009-12-03 SG SG10201610247QA patent/SG10201610247QA/en unknown
- 2009-12-03 WO PCT/EP2009/066290 patent/WO2010063785A2/en active Application Filing
- 2009-12-03 JP JP2011539023A patent/JP5746040B2/en active Active
-
2015
- 2015-05-07 JP JP2015094864A patent/JP6489924B2/en active Active
- 2015-06-15 US US14/739,771 patent/US20150368345A1/en not_active Abandoned
- 2015-06-15 US US14/739,768 patent/US10000570B2/en active Active
-
2016
- 2016-02-03 AU AU2016200663A patent/AU2016200663B2/en active Active
-
2018
- 2018-02-26 AU AU2018201377A patent/AU2018201377B2/en active Active
- 2018-05-11 US US15/977,725 patent/US20180319888A1/en not_active Abandoned
-
2020
- 2020-11-16 US US17/099,328 patent/US20210155699A1/en not_active Abandoned
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US20150376282A1 (en) | 2015-12-31 |
EP2373687A2 (en) | 2011-10-12 |
JP6489924B2 (en) | 2019-03-27 |
AU2018201377B2 (en) | 2020-05-21 |
AU2018201377A1 (en) | 2018-03-15 |
WO2010063785A3 (en) | 2010-07-29 |
CA3053156A1 (en) | 2010-06-10 |
US20110293607A1 (en) | 2011-12-01 |
US20180319888A1 (en) | 2018-11-08 |
JP5746040B2 (en) | 2015-07-08 |
CA2745439C (en) | 2019-10-15 |
US20210155699A1 (en) | 2021-05-27 |
JP2012510282A (en) | 2012-05-10 |
EP2373687B1 (en) | 2016-10-26 |
CA2745439A1 (en) | 2010-06-10 |
WO2010063785A2 (en) | 2010-06-10 |
US10000570B2 (en) | 2018-06-19 |
AU2009324092A1 (en) | 2011-06-23 |
EP3153524A1 (en) | 2017-04-12 |
US9085625B2 (en) | 2015-07-21 |
AU2016200663B2 (en) | 2017-11-30 |
JP2015180648A (en) | 2015-10-15 |
US20150368345A1 (en) | 2015-12-24 |
AU2016200663A1 (en) | 2016-02-18 |
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