SG10201506782XA - Notum protein modulators and methods of use - Google Patents
Notum protein modulators and methods of useInfo
- Publication number
- SG10201506782XA SG10201506782XA SG10201506782XA SG10201506782XA SG10201506782XA SG 10201506782X A SG10201506782X A SG 10201506782XA SG 10201506782X A SG10201506782X A SG 10201506782XA SG 10201506782X A SG10201506782X A SG 10201506782XA SG 10201506782X A SG10201506782X A SG 10201506782XA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- protein modulators
- notum protein
- notum
- modulators
- Prior art date
Links
- 101150025249 Notum gene Proteins 0.000 title 1
- 229940076155 protein modulator Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37788210P | 2010-08-27 | 2010-08-27 | |
US38018110P | 2010-09-03 | 2010-09-03 | |
US38855210P | 2010-09-30 | 2010-09-30 | |
US201161510413P | 2011-07-21 | 2011-07-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201506782XA true SG10201506782XA (en) | 2015-10-29 |
Family
ID=44741704
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201506782XA SG10201506782XA (en) | 2010-08-27 | 2011-08-26 | Notum protein modulators and methods of use |
SG2013014261A SG187965A1 (en) | 2010-08-27 | 2011-08-26 | Notum protein modulators and methods of use |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013014261A SG187965A1 (en) | 2010-08-27 | 2011-08-26 | Notum protein modulators and methods of use |
Country Status (14)
Country | Link |
---|---|
US (2) | US20130224191A1 (en) |
EP (1) | EP2608807A1 (en) |
JP (2) | JP2013539468A (en) |
KR (1) | KR20140018837A (en) |
CN (1) | CN103260646B (en) |
AU (2) | AU2011293127B2 (en) |
BR (1) | BR112013004776A2 (en) |
CA (1) | CA2809369A1 (en) |
CO (1) | CO6700829A2 (en) |
MX (1) | MX2013002255A (en) |
PE (1) | PE20140190A1 (en) |
RU (1) | RU2013113638A (en) |
SG (2) | SG10201506782XA (en) |
WO (1) | WO2012027723A1 (en) |
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WO2010138621A2 (en) | 2009-05-26 | 2010-12-02 | The Uab Research Foundation | Diagnosing and treating iga nephropathy |
MX2013002255A (en) * | 2010-08-27 | 2013-07-03 | Stem Centrx Inc | Notum protein modulators and methods of use. |
US9945842B2 (en) * | 2010-09-03 | 2018-04-17 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
JP6033229B2 (en) | 2010-11-24 | 2016-11-30 | レクシコン ファーマシューティカルズ インコーポレイテッド | Antibody binding to NOTUM pectin acetylesterase |
US8802365B2 (en) * | 2011-03-22 | 2014-08-12 | Whitehead Institute For Biomedical Research | Methods for identifying candidate modulators of NOTUM activity |
US10323081B2 (en) * | 2011-07-06 | 2019-06-18 | Genmag A/S | Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains |
CN105143470B (en) * | 2013-02-28 | 2020-06-09 | 德克萨斯大学系统董事会 | Methods for classifying cancer as susceptible to TMEPAI-directed therapy and treating the cancer |
EP3054973B1 (en) | 2013-10-10 | 2020-12-02 | Beth Israel Deaconess Medical Center, Inc. | Tm4sf1 binding proteins and methods of using same |
MX2016005834A (en) * | 2013-11-06 | 2016-11-17 | Astute Medical Inc | Assays for igfbp7 having improved performance in biological samples. |
WO2015120364A1 (en) * | 2014-02-10 | 2015-08-13 | Merck Sharp & Dohme Corp. | Antibodies that bind to human tau and assay for quantifying human tau using the antibodies |
KR20150105505A (en) * | 2014-03-06 | 2015-09-17 | (주)노바셀테크놀로지 | Novel bio-maker for colorectal cancer and anticancer agent targeting the same |
US20170158753A1 (en) * | 2014-06-25 | 2017-06-08 | Integrated Biotherapeutics, Inc. | Monoclonal antibodies directed against envelope glycoproteins from multiple filovirus species |
WO2017196819A2 (en) * | 2016-05-09 | 2017-11-16 | Icahn School Of Medicine At Mount Sinai | Broadly neutralizing anti-human cytomegalovirus (hcmv) antibodies and methods of use thereof |
EP3585403A4 (en) | 2017-02-22 | 2020-12-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tim3-binding chimeric antigen receptors |
US11274146B2 (en) * | 2017-03-23 | 2022-03-15 | The Trustees Of The University Of Pennsylvania | Anti-C5a antibodies and uses thereof |
WO2019018538A1 (en) * | 2017-07-20 | 2019-01-24 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Recombinant cd123-binding antibodies |
CN114729040A (en) * | 2019-06-21 | 2022-07-08 | 单细胞技术股份有限公司 | anti-TIGIT antibodies |
CN110950960B (en) * | 2019-11-26 | 2021-05-14 | 中国农业大学 | Preparation method of small molecule compound antibody based on high-throughput sequencing and hybrid hybridoma technology |
WO2021242757A1 (en) * | 2020-05-26 | 2021-12-02 | The Trustees Of The University Of Pennsylvania | Monocolonal antibodies against pathological tau, and methods using same |
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-
2011
- 2011-08-26 MX MX2013002255A patent/MX2013002255A/en unknown
- 2011-08-26 BR BR112013004776A patent/BR112013004776A2/en not_active Application Discontinuation
- 2011-08-26 RU RU2013113638/10A patent/RU2013113638A/en not_active Application Discontinuation
- 2011-08-26 CN CN201180052205.9A patent/CN103260646B/en not_active Expired - Fee Related
- 2011-08-26 KR KR1020137007609A patent/KR20140018837A/en active Search and Examination
- 2011-08-26 SG SG10201506782XA patent/SG10201506782XA/en unknown
- 2011-08-26 PE PE2013000347A patent/PE20140190A1/en not_active Application Discontinuation
- 2011-08-26 AU AU2011293127A patent/AU2011293127B2/en not_active Ceased
- 2011-08-26 WO PCT/US2011/049458 patent/WO2012027723A1/en active Application Filing
- 2011-08-26 US US13/819,208 patent/US20130224191A1/en not_active Abandoned
- 2011-08-26 SG SG2013014261A patent/SG187965A1/en unknown
- 2011-08-26 CA CA2809369A patent/CA2809369A1/en not_active Abandoned
- 2011-08-26 JP JP2013526189A patent/JP2013539468A/en not_active Ceased
- 2011-08-26 EP EP11752429.8A patent/EP2608807A1/en not_active Withdrawn
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2013
- 2013-03-15 CO CO13052190A patent/CO6700829A2/en unknown
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2015
- 2015-05-06 US US14/705,842 patent/US20150322166A1/en not_active Abandoned
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2016
- 2016-02-22 JP JP2016030708A patent/JP2016119906A/en active Pending
- 2016-04-14 AU AU2016202380A patent/AU2016202380A1/en not_active Abandoned
Also Published As
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AU2011293127B2 (en) | 2016-05-12 |
BR112013004776A2 (en) | 2017-09-19 |
AU2016202380A1 (en) | 2016-05-05 |
CN103260646B (en) | 2016-01-13 |
AU2011293127A1 (en) | 2013-03-14 |
SG187965A1 (en) | 2013-04-30 |
CA2809369A1 (en) | 2012-03-01 |
WO2012027723A1 (en) | 2012-03-01 |
US20130224191A1 (en) | 2013-08-29 |
CO6700829A2 (en) | 2013-06-28 |
KR20140018837A (en) | 2014-02-13 |
JP2016119906A (en) | 2016-07-07 |
EP2608807A1 (en) | 2013-07-03 |
US20150322166A1 (en) | 2015-11-12 |
JP2013539468A (en) | 2013-10-24 |
CN103260646A (en) | 2013-08-21 |
MX2013002255A (en) | 2013-07-03 |
PE20140190A1 (en) | 2014-02-10 |
RU2013113638A (en) | 2014-10-10 |
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