SG10201503736XA - Methods for identifying and isolating cells expressing a polypeptide - Google Patents

Methods for identifying and isolating cells expressing a polypeptide

Info

Publication number
SG10201503736XA
SG10201503736XA SG10201503736XA SG10201503736XA SG10201503736XA SG 10201503736X A SG10201503736X A SG 10201503736XA SG 10201503736X A SG10201503736X A SG 10201503736XA SG 10201503736X A SG10201503736X A SG 10201503736XA SG 10201503736X A SG10201503736X A SG 10201503736XA
Authority
SG
Singapore
Prior art keywords
polypeptide
identifying
methods
cells expressing
isolating cells
Prior art date
Application number
SG10201503736XA
Inventor
Austin L Gurney
Alexandra L L Lazetic
Christopher J Bond
Original Assignee
Oncomed Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharm Inc filed Critical Oncomed Pharm Inc
Publication of SG10201503736XA publication Critical patent/SG10201503736XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
SG10201503736XA 2010-02-12 2011-02-11 Methods for identifying and isolating cells expressing a polypeptide SG10201503736XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30425110P 2010-02-12 2010-02-12
US201161437889P 2011-01-31 2011-01-31

Publications (1)

Publication Number Publication Date
SG10201503736XA true SG10201503736XA (en) 2015-06-29

Family

ID=44368462

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201503736XA SG10201503736XA (en) 2010-02-12 2011-02-11 Methods for identifying and isolating cells expressing a polypeptide
SG2012058194A SG183196A1 (en) 2010-02-12 2011-02-11 Methods for identifying and isolating cells expressing a polypeptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2012058194A SG183196A1 (en) 2010-02-12 2011-02-11 Methods for identifying and isolating cells expressing a polypeptide

Country Status (12)

Country Link
US (5) US8551715B2 (en)
EP (1) EP2534257B1 (en)
JP (2) JP6034696B2 (en)
KR (1) KR20120117931A (en)
CN (1) CN102844442B (en)
AU (1) AU2011215685B2 (en)
CA (1) CA2789446A1 (en)
IL (1) IL221349A0 (en)
MX (1) MX2012009175A (en)
NZ (1) NZ601743A (en)
SG (2) SG10201503736XA (en)
WO (1) WO2011100566A2 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2655362A1 (en) 2006-06-13 2007-12-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
EP2562188A3 (en) 2006-09-29 2013-03-06 OncoMed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
JP5618544B2 (en) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド Compositions and methods for diagnosis and treatment of cancer
US8859229B2 (en) * 2007-02-02 2014-10-14 Yale University Transient transfection with RNA
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
NZ590131A (en) 2008-07-08 2012-10-26 Oncomed Pharm Inc Notch-binding agents and antagonists and methods of use thereof
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
ES2575152T3 (en) 2009-10-16 2016-06-24 Oncomed Pharmaceuticals, Inc. Therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
KR20120117931A (en) 2010-02-12 2012-10-24 온코메드 파마슈티칼스, 인크. Methods for identifying and isolating cells expressing a polypeptide
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
CN110042066A (en) * 2010-12-01 2019-07-23 默沙东公司 The FC- bait antibody display system of surface anchoring
US10106598B2 (en) 2010-12-01 2018-10-23 Merck Sharp & Dohme Corp. Surface, anchored Fc-bait antibody display system
CN104023746B (en) 2011-07-15 2016-08-17 昂考梅德药品有限公司 RSPO bonding agent and its application
HUE042192T2 (en) 2011-09-23 2019-06-28 Oncomed Pharm Inc Vegf/dll4 binding agents and uses thereof
EP2858673A4 (en) 2012-06-06 2016-06-22 Oncomed Pharm Inc Binding agents that modulate the hippo pathway and uses thereof
EA032038B1 (en) 2012-07-13 2019-03-29 Онкомед Фармасьютикалс, Инк. Rspo3-binding agents and uses thereof
MX362456B (en) 2012-08-24 2019-01-18 Univ California Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis.
US20150368329A1 (en) * 2012-10-15 2015-12-24 Oncomed Pharmaceuticals, Inc. Methods of Treating Ocular Diseases
US8921055B2 (en) * 2012-10-30 2014-12-30 Berkeley Lights, Inc. Detecting cells secreting a protein of interest
WO2014071018A1 (en) 2012-10-31 2014-05-08 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a dll4 antagonist
ES2948808T3 (en) * 2013-03-11 2023-09-19 Regeneron Pharma Transgenic mice expressing chimeric major histocompatibility complex (MHC) class II molecules
GB201405845D0 (en) 2014-04-01 2014-05-14 Ucl Business Plc Signalling system
GB201407852D0 (en) 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
GB201415347D0 (en) 2014-08-29 2014-10-15 Ucl Business Plc Signalling system
AU2015338974B2 (en) 2014-10-31 2021-08-26 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
WO2016073704A1 (en) * 2014-11-06 2016-05-12 Children's Research Institute, Children's National Medical Center Immunotherapeutics for cancer and autoimmune diseases
IL290459B2 (en) 2014-12-05 2023-11-01 Hope City Cs1 targeted chimeric antigen receptor-modified t cells
TWI715587B (en) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit-binding agents and uses thereof
US11339213B2 (en) 2015-09-23 2022-05-24 Mereo Biopharma 5, Inc. Methods and compositions for treatment of cancer
SG11201811559WA (en) 2016-06-27 2019-01-30 Univ California Cancer treatment combinations
CN110662552A (en) 2016-11-30 2020-01-07 昂科梅德制药有限公司 Methods of cancer treatment comprising TIGIT binding agents
AU2018219226A1 (en) 2017-02-07 2019-08-15 Seattle Children's Hospital (dba Seattle Children's Research Institute) Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
EP3589295A4 (en) 2017-02-28 2020-11-04 Endocyte, Inc. Compositions and methods for car t cell therapy
SG10202110530WA (en) * 2017-03-24 2021-11-29 Lankenau Inst Medical Res Methods and compositions for inducible extracellular membrane capture of monoclonal immunoglobulins secreted by hybridomas
WO2019144095A1 (en) 2018-01-22 2019-07-25 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of use for car t cells
CN112996819A (en) * 2018-08-16 2021-06-18 纪念斯隆-凯特琳癌症中心 Cell sorting system and method of use
CN112969476A (en) * 2018-12-07 2021-06-15 江苏恒瑞医药股份有限公司 Multispecific protein molecules
CN109738506B (en) * 2019-01-10 2021-02-26 青岛大学附属医院 Research method for acetylation sites of autophagy-related proteins in mature adipocytes
US20220177912A1 (en) * 2019-04-12 2022-06-09 The Methodist Hospital Therapeutic particles that enable antigen presenting cells to attack cancer cells
CA3229003A1 (en) 2021-08-25 2023-03-02 Kothai Nachiar Devi PARTHIBAN Preparation of libraries of protein variants expressed in eukaryotic cells

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
KR100272077B1 (en) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 Transgenic non-human animals capable of producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
PT1696031E (en) 1991-12-02 2010-06-25 Medical Res Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
US7166423B1 (en) 1992-10-21 2007-01-23 Miltenyi Biotec Gmbh Direct selection of cells by secretion product
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US7264963B1 (en) 1995-08-18 2007-09-04 Morphosys Ag Protein(poly)peptide libraries
PT859841E (en) 1995-08-18 2002-11-29 Morphosys Ag PROTEIN LIBRARIES / (POLY) PEPTIDES
WO1998018809A1 (en) 1996-10-25 1998-05-07 Cell Genesys, Inc. Targeted cytolysis of cancer cells
AU6537798A (en) * 1997-03-14 1998-10-12 Denise Casentini-Borocz Targeted cytolysis of cancer cells
CN1192109C (en) * 1997-03-26 2005-03-09 帝国学院创新有限公司 Anticoagulant fusion protein anchored to cell membrane
US5837994C1 (en) 1997-04-02 2001-10-16 Gentex Corp Control system to automatically dim vehicle head lamps
US7176179B1 (en) * 1997-05-30 2007-02-13 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
JP3614866B2 (en) 1997-06-12 2005-01-26 リサーチ コーポレイション テクノロジーズ，インコーポレイティド Artificial antibody polypeptide
US6180343B1 (en) 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
US6197294B1 (en) * 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation
DE19900635A1 (en) * 1999-01-11 2000-07-13 Deutsches Krebsforsch Selection of monoclonal antibodies
CA2339889C (en) 1999-07-02 2012-01-31 Morphosys Ag Identification of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US7094571B2 (en) 2000-10-27 2006-08-22 The Board Of Regents Of The University Of Texas System Combinatorial protein library screening by periplasmic expression
CN1306272C (en) * 2000-11-17 2007-03-21 罗切斯特大学 In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
EP1392859B1 (en) 2001-01-16 2006-05-10 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
EP1392818A4 (en) * 2001-04-30 2005-01-05 Hope City Chimeric immunoreceptor useful in treating human cancers
AU2003240005B2 (en) 2002-06-14 2010-08-12 Takeda Pharmaceutical Company Limited Recombination of nucleic acid library members
JP4748984B2 (en) * 2002-06-16 2011-08-17 ダイアックス、コープ Recombination of nucleic acid library members
DE60336023D1 (en) * 2002-07-15 2011-03-24 Univ Texas SCREENING OF COMBINATORY PROTEIN LIBRARIES BY PERIPLASMATIC EXPRESSION
FR2849039B1 (en) * 2002-12-24 2010-10-01 Centre Nat Rech Scient NOVEL PROTEIN ASSOCIATED WITH CENTROSOMES AND ITS APPLICATIONS
US20070048740A1 (en) 2003-02-14 2007-03-01 Research Association For Biotechnology Full-length cDNA
EP1447413A3 (en) * 2003-02-14 2006-01-04 Research Association for Biotechnology Full-length human cDNA
US7479538B2 (en) * 2004-11-12 2009-01-20 The Zhabilov Trust Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing, and treating HIV
CA2625619A1 (en) * 2005-10-14 2007-04-26 Medimmune, Inc. Cell display of antibody libraries
US20110038854A1 (en) * 2006-03-30 2011-02-17 University Of Medicine And Dentistry Of New Jersey Strategy for homo- or hetero-dimerization of various proteins in solution and in cell
US20110076752A1 (en) * 2007-02-09 2011-03-31 Medimmune, Llc Antibody library display by yeast cell plasma membrane
US8067339B2 (en) * 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
KR20120117931A (en) 2010-02-12 2012-10-24 온코메드 파마슈티칼스, 인크. Methods for identifying and isolating cells expressing a polypeptide
CN110042066A (en) * 2010-12-01 2019-07-23 默沙东公司 The FC- bait antibody display system of surface anchoring

Also Published As

Publication number Publication date
US20170002054A1 (en) 2017-01-05
US8945878B2 (en) 2015-02-03
AU2011215685A1 (en) 2012-08-30
EP2534257B1 (en) 2017-09-27
CN102844442A (en) 2012-12-26
WO2011100566A3 (en) 2011-10-06
JP2013519379A (en) 2013-05-30
US20110287979A1 (en) 2011-11-24
US9023621B2 (en) 2015-05-05
SG183196A1 (en) 2012-09-27
IL221349A0 (en) 2012-10-31
CA2789446A1 (en) 2011-08-18
MX2012009175A (en) 2012-12-17
KR20120117931A (en) 2012-10-24
JP2017014220A (en) 2017-01-19
US8551715B2 (en) 2013-10-08
AU2011215685B2 (en) 2015-08-20
NZ601743A (en) 2014-11-28
CN102844442B (en) 2016-09-07
US9873726B2 (en) 2018-01-23
EP2534257A4 (en) 2013-11-20
JP6034696B2 (en) 2016-11-30
US20150315565A1 (en) 2015-11-05
US9422546B2 (en) 2016-08-23
EP2534257A2 (en) 2012-12-19
US20140005077A1 (en) 2014-01-02
WO2011100566A2 (en) 2011-08-18
US20140005076A1 (en) 2014-01-02

Similar Documents

Publication Publication Date Title
IL221349A0 (en) Methods for identifying and isolating cells expressing a polypeptide
HK1220809A1 (en) Structure and method for extending battery life
EP2629350A4 (en) Battery case lid and manufacturing method for battery case lid
PT2725840E (en) Method and device for handling cell outage
SG10201509185UA (en) System for identifying and sorting living cells
EP2659448A4 (en) Matching techniques for cross-platform monitoring and information
IL226156B (en) Electrochemical separation system and a method of assembling the same
EP2648261A4 (en) Method for manufacturing battery cell and battery cell produced using same
GB201000375D0 (en) T Cell clonotypes
EP2542888A4 (en) Method and kit for isolating target cell
EP2660892A4 (en) Film covered battery and method for screening same
EP2555371A4 (en) Battery pack and battery control system
EP2646283A4 (en) Loading analysis system and method
EP2584635A4 (en) Fuel cell and method for manufacturing fuel cell
PL2548247T3 (en) Battery recycling method
GB201118180D0 (en) Method of identifying a material
EP2562246A4 (en) Cell observation device and cell observation method
EP2533348A4 (en) Charging system and charging method
EP2655220A4 (en) Automated case order sequencing method and system
GB201222753D0 (en) Fuelling arrangement and method
EP2597716A4 (en) Fuel cell system and operating method thereof
EP2521789A4 (en) Vectors and methods for transducing b cells
EP2533347A4 (en) Charging method
EP2541661A4 (en) Electrochemical device and method for manufacturing electrochemical device
SG10201405455UA (en) Cells and methods for obtaining them