SG10201503304RA - Cell culture processes - Google Patents

Cell culture processes

Info

Publication number
SG10201503304RA
SG10201503304RA SG10201503304RA SG10201503304RA SG10201503304RA SG 10201503304R A SG10201503304R A SG 10201503304RA SG 10201503304R A SG10201503304R A SG 10201503304RA SG 10201503304R A SG10201503304R A SG 10201503304RA SG 10201503304R A SG10201503304R A SG 10201503304RA
Authority
SG
Singapore
Prior art keywords
cell culture
culture processes
processes
cell
culture
Prior art date
Application number
SG10201503304RA
Inventor
Andre Giovagnoli
Sylvain Roy
Veronique Ducros
Virginie Charlot
Yves-Olivier Stauffer
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of SG10201503304RA publication Critical patent/SG10201503304RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6437Coagulation factor VIIa (3.4.21.21)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6454Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489Metalloendopeptidases (3.4.24)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21021Coagulation factor VIIa (3.4.21.21)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21075Furin (3.4.21.75)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SG10201503304RA 2007-12-27 2008-12-22 Cell culture processes SG10201503304RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US932807P 2007-12-27 2007-12-27

Publications (1)

Publication Number Publication Date
SG10201503304RA true SG10201503304RA (en) 2015-06-29

Family

ID=40350258

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012095329A SG187397A1 (en) 2007-12-27 2008-12-22 Cell culture processes
SG10201503304RA SG10201503304RA (en) 2007-12-27 2008-12-22 Cell culture processes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012095329A SG187397A1 (en) 2007-12-27 2008-12-22 Cell culture processes

Country Status (21)

Country Link
US (2) US9359629B2 (en)
EP (4) EP2574677B1 (en)
JP (3) JP5727790B2 (en)
KR (4) KR101818411B1 (en)
CN (2) CN101910408A (en)
AR (2) AR069956A1 (en)
AU (1) AU2008345231B2 (en)
BR (1) BR122019022434B8 (en)
CA (1) CA2709890A1 (en)
DK (3) DK2235197T3 (en)
ES (3) ES2649094T3 (en)
HK (1) HK1246827A1 (en)
HR (3) HRP20171375T1 (en)
HU (2) HUE036712T2 (en)
MX (2) MX343271B (en)
NZ (1) NZ586250A (en)
PL (3) PL2574677T3 (en)
PT (3) PT2235197T (en)
SG (2) SG187397A1 (en)
SI (3) SI2235197T1 (en)
WO (1) WO2009086309A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
MY185872A (en) 2006-09-13 2021-06-14 Abbvie Inc Cell culture improvements
TW201028433A (en) 2008-10-20 2010-08-01 Abbott Lab Viral inactivation during purification of antibodies
WO2010141039A1 (en) 2008-10-20 2010-12-09 Abbott Laboratories Isolation and purification of antibodies using protein a affinity chromatography
US8580554B2 (en) * 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
KR101808496B1 (en) 2009-07-31 2017-12-12 백스터 인터내셔널 인코포레이티드 Cell culture medium for adamts protein expression
HUE038193T2 (en) 2010-07-08 2018-09-28 Baxalta GmbH METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT vWF IN CELL CULTURE
WO2012122611A1 (en) * 2011-03-11 2012-09-20 Universidade De São Paulo - Usp Method for the production of recombinant human factor viii
EP2511293A1 (en) 2011-04-13 2012-10-17 LEK Pharmaceuticals d.d. A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9206390B2 (en) 2012-09-02 2015-12-08 Abbvie, Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
KR20150026024A (en) * 2013-08-30 2015-03-11 한미약품 주식회사 Method for mass production of factor vii analog
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
AU2015236008B2 (en) * 2014-03-25 2018-12-20 Genentech, Inc. Methods of preparing a poloxamer for use in cell culture medium
CA2945390A1 (en) * 2014-04-10 2015-10-15 Bayer Healthcare Llc Compounded media powder formulation and method of preparation of liquid medium for cell culture
AU2015270137A1 (en) * 2014-06-03 2016-12-22 Lupin Limited Cell culture process for producing a protein
KR102598799B1 (en) 2014-06-04 2023-11-07 암젠 인크 Methods for harvesting mammalian cell cultures
JP6651548B2 (en) 2015-05-22 2020-02-19 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト Method for producing a modified von Willebrand factor
WO2018073365A1 (en) * 2016-10-19 2018-04-26 F. Hoffmann-La Roche Ag Method for producing an immunoconjugate
CN114657118B (en) * 2021-12-31 2023-12-01 广州齐志生物工程设备有限公司 Multiple amplification method of 2BS cells in bioreactor

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456591A (en) * 1981-06-25 1984-06-26 Baxter Travenol Laboratories, Inc. Therapeutic method for activating factor VII
SE8501050D0 (en) 1985-03-05 1985-03-05 Kabivitrum Ab BIOLOGICALLY ACTIVE FRAGMENTS OF HUMAN ANTIHEMOPHILIC FACTOR AND METHOD FOR PREPARATION THEREOF
ES8801674A1 (en) 1985-04-12 1988-02-16 Genetics Inst Novel procoagulant proteins.
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US5250421A (en) * 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
US5422260A (en) 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
US5171844A (en) 1987-06-12 1992-12-15 Gist-Brocades N.W. Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
US5200510A (en) 1987-06-16 1993-04-06 Zymogenetics, Inc. Method for purifying factor viii:c, von willebrand factor and complexes thereof
US4921792A (en) * 1987-11-27 1990-05-01 Miles Inc. Continuous cell dispersion, cultivation and substance recovery process
JPH0787799B2 (en) * 1988-03-30 1995-09-27 森永製菓株式会社 Monoclonal antibody production enhancement method
US6100050A (en) 1989-08-17 2000-08-08 Dade Behring Ag Factor VIII:Ca chromogenic assay
NL9000917A (en) 1989-10-25 1991-05-16 Holland Biotechnology PHARMACEUTICAL PREPARATION WITH ENDOPROTEOLYTIC ACTIVITY; PROCESS FOR ENDOPROTEOLYTIC PROCESSING OF (PRECURSOR) PROTEINS AND FOR (MICRO) ORGANIC PREPARATION OF PROTEINS.
US5580560A (en) 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
SE465222C5 (en) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab A recombinant human factor VIII derivative and process for its preparation
AT393356B (en) * 1989-12-22 1991-10-10 Immuno Ag METHOD FOR PRODUCING TBE VIRUS ANTIGES
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
EP0574402B2 (en) 1990-11-26 2012-08-01 Genetics Institute, LLC Expression of pace in host cells and methods of use thereof
CA2103546C (en) 1991-02-28 2002-10-01 Kathleen L. Berkner Modified factor vii
US5997864A (en) 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII
US5661008A (en) 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
CA2124690C (en) 1992-10-02 2007-09-11 Thomas Osterberg Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
AT403167B (en) 1994-11-14 1997-11-25 Immuno Ag SELECTION AND EXPRESSION OF FOREIGN PROTEINS BY MEANS OF A SELECTION-AMPLIFICATION SYSTEM
EP0871753A2 (en) * 1995-12-15 1998-10-21 Systemix, Inc. Method for obtaining retroviral vector supernatant having high transduction efficiency
AT403765B (en) 1996-04-12 1998-05-25 Immuno Ag METHOD FOR PRODUCING A PREPARATION CONTAINING A HIGHLY CLEANED COMPLEX
WO1998000521A1 (en) * 1996-06-28 1998-01-08 The Green Cross Corporation Serum-free media, method for culturing animal cells, and process for producing physiologically active substances
US5854021A (en) 1997-02-28 1998-12-29 Bayer Corporation Enhance protein production method
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AT407255B (en) 1997-06-20 2001-02-26 Immuno Ag RECOMBINANT CELL CLONE WITH INCREASED STABILITY IN SERUM- AND PROTEIN-FREE MEDIUM AND METHOD FOR OBTAINING THE STABLE CELL CLONE
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US6017882A (en) 1997-10-23 2000-01-25 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6358703B1 (en) 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
CA2634664C (en) 1999-02-22 2011-08-09 University Of Connecticut Novel albumin-free factor viii formulations
DK1194161T3 (en) * 1999-07-13 2006-02-13 Biovitrum Ab Stable factor VIII compositions
JP4451514B2 (en) 1999-08-24 2010-04-14 財団法人化学及血清療法研究所 Blood coagulation factor VII variant
JP2001120262A (en) * 1999-10-26 2001-05-08 Welfide Corp Method for enhancing production of physiologically active substance
SE518174C2 (en) * 1999-11-16 2002-09-03 Appliedsensor Sweden Ab Detection method of unwanted microbial infection in animal cell culture
EP1257295B1 (en) 2000-02-11 2009-04-15 Bayer HealthCare LLC Factor vii or viia-like molecules
US6168941B1 (en) * 2000-04-07 2001-01-02 Genvec, Inc. Method of producing adenoviral vector stocks
AU2001254624A1 (en) 2000-05-03 2001-11-12 Novo-Nordisk A/S Human coagulation factor vii variants
EP2226385B1 (en) 2000-09-13 2013-07-10 Novo Nordisk Health Care AG Human Coagulation Factor VII Variants
US20040185535A1 (en) * 2003-03-21 2004-09-23 Giles Wilson Industrial-scale serum-free production of recombinant FVII in mammalian cells
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
US6926894B2 (en) * 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
US20030040095A1 (en) * 2001-03-16 2003-02-27 Achille Arini Method for the production of pharmaceutically active recombinant proteins
RU2338752C2 (en) 2001-03-22 2008-11-20 Ново Нордиск Хелт Кэр Аг Derivatives of factor of vii blood coagulation
JP2003047461A (en) * 2001-07-31 2003-02-18 Astec:Kk Method for carrying out high-density cell culture of cell by using apatite sheet, culturing device and cell culture module
CA2458980C (en) * 2001-08-31 2012-10-30 Bayer Healthcare Ag A unit and a process for carrying out high cell density fermentation
UA82177C2 (en) 2001-09-27 2008-03-25 Ново Нордиск Хэлс Кеа Аг Polypeptides of human coagulation factor vii
BR0212780A (en) * 2001-10-02 2004-10-13 Novo Nordisk Healthcare Ag Methods for producing eukaryotic cell polypeptides, for cultivating eukaryotic cells and for harvesting polypeptides produced by eukaryotic cells
AU2002336919A1 (en) 2001-11-02 2003-05-12 Novo Nordisk Health Care Ag Human coagulation factor vii polypeptides
US20030119723A1 (en) 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and PAI-1 polypeptides
ES2394085T3 (en) * 2002-07-09 2013-01-17 Baxter International Inc. Animal protein free medium for cell culture
WO2004092218A1 (en) * 2003-04-17 2004-10-28 Mitsubishi Pharma Corporation Process for producing recombinant antithrombin
CN104593277A (en) * 2004-03-05 2015-05-06 帝斯曼知识产权资产管理有限公司 Process for cell culturing by continuous perfusion and alternating tangential flow
JP5523674B2 (en) * 2005-02-11 2014-06-18 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Production of polypeptides in serum-free cell culture media containing plant protein hydrolysates
WO2007077217A2 (en) 2006-01-04 2007-07-12 Baxter International Inc. Oligopeptide-free cell culture media
EP2157177B1 (en) 2007-05-22 2013-04-10 Baxter International Inc. Preparative purification process for human furin

Also Published As

Publication number Publication date
KR101798813B1 (en) 2017-11-16
JP2014100148A (en) 2014-06-05
AR069956A1 (en) 2010-03-03
PT2574677T (en) 2017-10-19
HUE036496T2 (en) 2018-07-30
JP2016013140A (en) 2016-01-28
SI2574676T1 (en) 2017-10-30
PL2574676T3 (en) 2017-12-29
BR122019022434B8 (en) 2021-07-27
ES2647294T3 (en) 2017-12-20
EP2574677A1 (en) 2013-04-03
ES2644089T3 (en) 2017-11-27
US20090176269A1 (en) 2009-07-09
SI2235197T1 (en) 2017-10-30
BRPI0821481A2 (en) 2014-11-04
ES2649094T3 (en) 2018-01-10
PT2235197T (en) 2017-10-11
PL2235197T3 (en) 2018-01-31
CA2709890A1 (en) 2009-07-09
JP2011507551A (en) 2011-03-10
KR20100097752A (en) 2010-09-03
KR20180005287A (en) 2018-01-15
SI2574677T1 (en) 2017-11-30
EP2574677B1 (en) 2017-09-13
HUE036712T2 (en) 2018-07-30
SG187397A1 (en) 2013-02-28
US9359629B2 (en) 2016-06-07
KR101659458B1 (en) 2016-09-23
BR122019022434B1 (en) 2020-11-03
PT2574676T (en) 2017-10-11
PL2574677T3 (en) 2017-12-29
EP2235197B1 (en) 2017-07-26
EP2574676B1 (en) 2017-08-30
DK2574676T3 (en) 2017-10-09
AU2008345231A1 (en) 2009-07-09
HRP20171374T1 (en) 2017-12-29
HRP20171495T1 (en) 2018-01-26
EP2235197A2 (en) 2010-10-06
EP2574676A1 (en) 2013-04-03
KR101818411B1 (en) 2018-01-12
EP3255152A1 (en) 2017-12-13
AR110864A2 (en) 2019-05-08
JP5727790B2 (en) 2015-06-03
HRP20171375T1 (en) 2017-12-15
CN106222220A (en) 2016-12-14
WO2009086309A2 (en) 2009-07-09
CN101910408A (en) 2010-12-08
DK2574677T3 (en) 2017-11-06
WO2009086309A3 (en) 2009-10-01
MX343269B (en) 2016-10-31
HK1246827A1 (en) 2018-09-14
AU2008345231B2 (en) 2014-09-11
KR20160112025A (en) 2016-09-27
US20160244506A1 (en) 2016-08-25
JP5890854B2 (en) 2016-03-22
KR20170126514A (en) 2017-11-17
NZ586250A (en) 2012-11-30
DK2235197T3 (en) 2017-10-09
MX343271B (en) 2016-10-31

Similar Documents

Publication Publication Date Title
HK1246827A1 (en) Cell culture processes
IL197444A0 (en) Cell culture improvements
HK1216883A1 (en) Stem cell cultures
GB0720484D0 (en) Cells
GB0605450D0 (en) Cell co-culture
EP1997877A4 (en) Cell culture substrate
EP2028264A4 (en) Cell incubator
EP2128242A4 (en) Cell culture module
GB0517382D0 (en) Cell culture
GB0800524D0 (en) Cell culture system
GB0817990D0 (en) Cell culture vessel
IL194524A0 (en) Three dimensional cell culture
EP2271739A4 (en) Product for cell culture
GB0606671D0 (en) Cell Culture
GB0817240D0 (en) Modified bacterial cell
GB0808778D0 (en) Cell culture technique
GB0718014D0 (en) Cell culture apparatus
GB0922428D0 (en) Cell culture
GB0915268D0 (en) Cell culture
GB0700936D0 (en) Cells
GB0810505D0 (en) M cell
GB0806524D0 (en) Cell differentiation
GB0724655D0 (en) Recipient for cell cultivation
GB0806640D0 (en) Culture
GB0806637D0 (en) Culture