SG10201406063XA - Drug fusions and conjugates with extended half life - Google Patents
Drug fusions and conjugates with extended half lifeInfo
- Publication number
- SG10201406063XA SG10201406063XA SG10201406063XA SG10201406063XA SG10201406063XA SG 10201406063X A SG10201406063X A SG 10201406063XA SG 10201406063X A SG10201406063X A SG 10201406063XA SG 10201406063X A SG10201406063X A SG 10201406063XA SG 10201406063X A SG10201406063X A SG 10201406063XA
- Authority
- SG
- Singapore
- Prior art keywords
- conjugates
- half life
- extended half
- drug fusions
- fusions
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000004927 fusion Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24734609P | 2009-09-30 | 2009-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201406063XA true SG10201406063XA (en) | 2014-11-27 |
Family
ID=43130084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201406063XA SG10201406063XA (en) | 2009-09-30 | 2010-09-23 | Drug fusions and conjugates with extended half life |
Country Status (13)
Country | Link |
---|---|
US (2) | US20120276098A1 (en) |
EP (1) | EP2483308A1 (en) |
JP (1) | JP2013506628A (en) |
KR (1) | KR20120092611A (en) |
CN (2) | CN104147611A (en) |
AU (1) | AU2010303112A1 (en) |
BR (1) | BR112012007374A2 (en) |
CA (1) | CA2774552A1 (en) |
EA (1) | EA201290123A1 (en) |
IL (1) | IL218651A0 (en) |
MX (1) | MX2012003939A (en) |
SG (1) | SG10201406063XA (en) |
WO (1) | WO2011039096A1 (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR075505A1 (en) | 2009-02-19 | 2011-04-06 | Glaxo Group Ltd | VARIATIONS FROM UNION TO ANTI- IMPROVED SERUM ALBUMIN |
EA021146B1 (en) * | 2009-03-27 | 2015-04-30 | Глаксо Груп Лимитед | Drug fusions and conjugates |
NZ603267A (en) * | 2010-04-27 | 2014-12-24 | Chr Hansen As | Method for inoculating yeast into fruit juice |
AU2011254559B2 (en) * | 2010-05-20 | 2014-09-04 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
JP2013538566A (en) * | 2010-08-13 | 2013-10-17 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Improved antiserum albumin binding variants |
CN102718868A (en) * | 2011-03-30 | 2012-10-10 | 上海华谊生物技术有限公司 | Fixed point mono-substituted pegylation of Exendin analogue and preparation method thereof |
WO2012136792A2 (en) * | 2011-04-07 | 2012-10-11 | Glaxo Group Limited | Cck compositions |
US9382304B2 (en) | 2011-07-08 | 2016-07-05 | Amylin Pharmaceuticals, Llc | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
CN102382191A (en) * | 2011-09-23 | 2012-03-21 | 江南大学 | Preparation method and application of novel braingutpeptide stimulant molecule |
UA116217C2 (en) | 2012-10-09 | 2018-02-26 | Санофі | Exendin-4 derivatives as dual glp1/glucagon agonists |
UY35144A (en) * | 2012-11-20 | 2014-06-30 | Novartis Ag | APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT |
AR094181A1 (en) | 2012-12-21 | 2015-07-15 | Sanofi Sa | GLP1 / GIP OR TRIGONAL DUAL AGONISTS OF GLP1 / GIP / GLUCAGON |
WO2014118220A1 (en) * | 2013-01-31 | 2014-08-07 | Glaxo Group Limited | Method of producing a protein |
US20160108098A1 (en) | 2013-05-02 | 2016-04-21 | Glaxosmithkline Intellectual Property Development Limited | Therapeutic peptides |
BR112016004355A2 (en) * | 2013-08-30 | 2017-10-17 | Aprilbio Co Ltd | fab antiserumbumin effector fusion construct and method of preparation thereof |
EP3043824B1 (en) | 2013-09-13 | 2022-07-06 | The Scripps Research Institute | Modified therapeutic agents and compositions thereof |
EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
US10039809B2 (en) | 2013-12-18 | 2018-08-07 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
TW201625670A (en) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | Dual GLP-1/glucagon receptor agonists derived from EXENDIN-4 |
TW201625669A (en) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4 |
TW201625668A (en) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists |
US20170327577A1 (en) * | 2014-06-06 | 2017-11-16 | The California Institute For Biomedical Research | Methods of constructing amino terminal immunoglobulin fusion proteins and compositions thereof |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
CN111388680B (en) * | 2015-01-28 | 2024-01-05 | 中国科学院天津工业生物技术研究所 | Application of polypeptide complex as polypeptide or protein drug carrier, method and fusion protein complex thereof |
CN107743494B (en) * | 2015-06-02 | 2022-04-29 | 诺和诺德股份有限公司 | Insulin with polar recombinant extensions |
AR105319A1 (en) | 2015-06-05 | 2017-09-27 | Sanofi Sa | PROPHARMS THAT INCLUDE A DUAL AGONIST GLU-1 / GLUCAGON CONJUGATE HIALURONIC ACID CONNECTOR |
AR105284A1 (en) | 2015-07-10 | 2017-09-20 | Sanofi Sa | DERIVATIVES OF EXENDINA-4 AS SPECIFIC DUAL PEPTIDE AGONISTS OF GLP-1 / GLUCAGÓN RECEPTORS |
MA43348A (en) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | PROTEIN CONJUGATES |
US11414480B2 (en) | 2016-12-07 | 2022-08-16 | Ablynx N.V. | Serum albumin binding immunoglobulin single variable domains |
EP3554546A4 (en) * | 2016-12-14 | 2021-04-14 | Ligandal, Inc. | Methods and compositions for nucleic acid and protein payload delivery |
SG10202108972RA (en) | 2017-01-17 | 2021-09-29 | Ablynx Nv | Improved serum albumin binders |
JP7300385B2 (en) | 2017-01-17 | 2023-06-29 | アブリンクス エン.ヴェー. | improved serum albumin binder |
WO2018140456A1 (en) * | 2017-01-24 | 2018-08-02 | Northwestern University | Active low molecular weight variants of angiotensin converting enzyme 2 (ace2) |
CN108440668A (en) * | 2017-02-16 | 2018-08-24 | 瑞阳(苏州)生物科技有限公司 | The fusion protein of FGF21 and IGF-1 and its application |
JP2020513019A (en) | 2017-04-05 | 2020-04-30 | ノヴォ ノルディスク アー/エス | Oligomer-extended insulin-Fc conjugate |
EP3684816A1 (en) | 2017-09-22 | 2020-07-29 | Kite Pharma, Inc. | Chimeric polypeptides and uses thereof |
CN108426995A (en) * | 2018-02-26 | 2018-08-21 | 徐州医科大学 | A kind of cell elution process based on the drug target residence time |
US11780900B2 (en) | 2018-04-25 | 2023-10-10 | Janssen Sciences Ireland Unlimited Company | Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof |
TW202014433A (en) * | 2018-04-25 | 2020-04-16 | 比利時商健生藥品公司 | Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof |
US11753455B2 (en) | 2018-06-21 | 2023-09-12 | Novo Nordisk A/S | Compounds for treatment of obesity |
CN111234015B (en) * | 2020-02-12 | 2021-04-06 | 康维众和(中山)生物药业有限公司 | Antibody for prolonging half life of medicine, fusion protein and application thereof |
WO2024038067A1 (en) | 2022-08-18 | 2024-02-22 | Boehringer Ingelheim International Gmbh | Combination therapy comprising long acting glp-1/glucagon and npy2 receptor agonists |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ222907A (en) | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
DE768377T1 (en) | 1988-09-02 | 1998-01-02 | Dyax Corp | Production and selection of recombinant proteins with different binding sites |
EP0464022B1 (en) | 1989-03-20 | 2000-05-31 | The General Hospital Corporation | Insulinotropic hormone |
ES2113879T3 (en) | 1990-01-24 | 1998-05-16 | Douglas I Buckley | GLP-1 ANALOGS USEFUL FOR THE TREATMENT OF DIABETES. |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
KR100272077B1 (en) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | Transgenic non-human animals capable of producing heterologous antibodies |
DK36492D0 (en) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | PREPARATION |
ATE417622T1 (en) | 1996-08-08 | 2009-01-15 | Amylin Pharmaceuticals Inc | REGULATION OF GASTROINTESTINAL MOBILITY |
DE69838521T2 (en) | 1997-07-07 | 2008-05-21 | Medical Research Council | Method for increasing the concentration of nucleic acid molecules |
EP1019077B2 (en) | 1997-08-08 | 2010-12-22 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
BR9814189A (en) | 1997-11-14 | 2000-10-03 | Amylin Pharmaceuticals Inc | "exendin agonist compounds" |
EP1066314B1 (en) | 1997-11-14 | 2007-12-26 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
AU759058C (en) | 1998-02-13 | 2005-09-15 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
KR100942864B1 (en) | 2000-12-07 | 2010-02-17 | 일라이 릴리 앤드 캄파니 | GLP-1 Fusion Proteins |
US20030119734A1 (en) | 2001-06-28 | 2003-06-26 | Flink James M. | Stable formulation of modified GLP-1 |
JP5424521B2 (en) | 2001-12-21 | 2014-02-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | Albumin fusion protein |
WO2003059934A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2005003296A2 (en) | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
SI2932981T1 (en) | 2003-09-19 | 2021-11-30 | Novo Nordisk A/S | Albumin-binding derivatives of GLP-1 |
EP1784427A2 (en) | 2004-06-01 | 2007-05-16 | Domantis Limited | Bispecific fusion antibodies with enhanced serum half-life |
NZ555464A (en) * | 2004-12-02 | 2010-03-26 | Domantis Ltd | Bispecific domain antibodies targeting serum albumin and glp-1 or pyy |
GB0724331D0 (en) * | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
AU2008334605B2 (en) * | 2007-12-13 | 2013-07-18 | Glaxo Group Limited | Polypeptides, antibody variable domains & antagonists |
WO2009121804A1 (en) * | 2008-03-31 | 2009-10-08 | Glaxo Group Limited | Drug fusions and conjugates |
UY32452A (en) * | 2009-02-19 | 2010-09-30 | Glaxo Group Ltd | IMPROVED SERUM ANTI-ALBUMIN VARIANTS IMPROVED |
AR075505A1 (en) * | 2009-02-19 | 2011-04-06 | Glaxo Group Ltd | VARIATIONS FROM UNION TO ANTI- IMPROVED SERUM ALBUMIN |
EA021146B1 (en) * | 2009-03-27 | 2015-04-30 | Глаксо Груп Лимитед | Drug fusions and conjugates |
-
2010
- 2010-09-23 US US13/498,924 patent/US20120276098A1/en not_active Abandoned
- 2010-09-23 MX MX2012003939A patent/MX2012003939A/en not_active Application Discontinuation
- 2010-09-23 AU AU2010303112A patent/AU2010303112A1/en not_active Abandoned
- 2010-09-23 CN CN201410386267.9A patent/CN104147611A/en active Pending
- 2010-09-23 BR BR112012007374A patent/BR112012007374A2/en not_active IP Right Cessation
- 2010-09-23 JP JP2012531329A patent/JP2013506628A/en active Pending
- 2010-09-23 SG SG10201406063XA patent/SG10201406063XA/en unknown
- 2010-09-23 WO PCT/EP2010/064020 patent/WO2011039096A1/en active Application Filing
- 2010-09-23 CA CA2774552A patent/CA2774552A1/en not_active Abandoned
- 2010-09-23 KR KR1020127011105A patent/KR20120092611A/en not_active Application Discontinuation
- 2010-09-23 CN CN2010800538921A patent/CN102666586A/en active Pending
- 2010-09-23 EP EP10762634A patent/EP2483308A1/en not_active Withdrawn
- 2010-09-23 EA EA201290123A patent/EA201290123A1/en unknown
-
2012
- 2012-03-15 IL IL218651A patent/IL218651A0/en unknown
-
2013
- 2013-11-18 US US14/082,888 patent/US20140227264A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2774552A1 (en) | 2011-04-07 |
MX2012003939A (en) | 2012-07-30 |
US20120276098A1 (en) | 2012-11-01 |
JP2013506628A (en) | 2013-02-28 |
AU2010303112A1 (en) | 2012-04-26 |
CN102666586A (en) | 2012-09-12 |
IL218651A0 (en) | 2012-05-31 |
BR112012007374A2 (en) | 2019-09-24 |
CN104147611A (en) | 2014-11-19 |
EP2483308A1 (en) | 2012-08-08 |
WO2011039096A1 (en) | 2011-04-07 |
KR20120092611A (en) | 2012-08-21 |
EA201290123A1 (en) | 2012-10-30 |
US20140227264A1 (en) | 2014-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL218651A0 (en) | Drug fusions and conjugates with extended half life | |
ZA201107022B (en) | Drug fusions and conjugates | |
HRP20181493T1 (en) | Epsilon-polylysine conjugates and use thereof | |
ZA201006763B (en) | Drug fusions and conjugates | |
ZA201204480B (en) | Conjugate with target-finding ligand and use thereof | |
SG2014012918A (en) | Albumin variants and conjugates | |
EP2486918A4 (en) | Pharmaceutical composition with both immediate and extended release characteristics | |
ZA201308703B (en) | Novel maytansinoid derivatives with peptide linker and conjugates thereof | |
ZA201105623B (en) | Aminopyrazine derivative and medicine | |
IL213848A0 (en) | Fgf21 derivatives with albumin binder a-b-c-d-e-and their use | |
ZA201109034B (en) | Aminopyrrolidinone derivatives and uses thereof | |
IL213974A0 (en) | Isoxazole-isoxazole and isoxazole-isothiazole derivatives | |
EP2575887A4 (en) | Optimized drug conjugates | |
EP2391217A4 (en) | Synthetic conjugates and uses thereof | |
HK1178526A1 (en) | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof 8--7- | |
GB0906195D0 (en) | Needle and syringe | |
IL219768A0 (en) | Drug combination with thebromine and its use in therapy | |
IL219769A0 (en) | Drug combination with theromine and its use in therapy | |
ZA201202203B (en) | Drug fusions and conjugates with extended half life | |
ZA201108276B (en) | Redox drug derivatives | |
EP2408808A4 (en) | Terminally-functionalized conjugates and uses thereof | |
HK1218538A1 (en) | Piperazine derivatives and their pharmaceutical use | |
TWM371940U (en) | Exhibiting body with advertisement feature | |
GB0908338D0 (en) | Redox drug derivatives | |
GB0900539D0 (en) | Modified linkers |