SE9803518D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE9803518D0
SE9803518D0 SE9803518A SE9803518A SE9803518D0 SE 9803518 D0 SE9803518 D0 SE 9803518D0 SE 9803518 A SE9803518 A SE 9803518A SE 9803518 A SE9803518 A SE 9803518A SE 9803518 D0 SE9803518 D0 SE 9803518D0
Authority
SE
Sweden
Prior art keywords
novel compounds
compounds
tautomers
prophylaxis
enantiomers
Prior art date
Application number
SE9803518A
Other languages
Swedish (sv)
Inventor
Stephen Connolly
David Cox
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9803518A priority Critical patent/SE9803518D0/en
Publication of SE9803518D0 publication Critical patent/SE9803518D0/en
Priority to PCT/SE1999/001829 priority patent/WO2000021934A1/en
Priority to AU14242/00A priority patent/AU1424200A/en

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There are provided novel compounds of formula (I), wherein R<1>, R<2>, R<3>, R<4>, R<5>, A, Q, X, Y and Z are defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment of prophylaxis of inflammatory disease and pain.
SE9803518A 1998-10-15 1998-10-15 Novel compounds SE9803518D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9803518A SE9803518D0 (en) 1998-10-15 1998-10-15 Novel compounds
PCT/SE1999/001829 WO2000021934A1 (en) 1998-10-15 1999-10-11 Compounds
AU14242/00A AU1424200A (en) 1998-10-15 1999-10-11 Compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9803518A SE9803518D0 (en) 1998-10-15 1998-10-15 Novel compounds

Publications (1)

Publication Number Publication Date
SE9803518D0 true SE9803518D0 (en) 1998-10-15

Family

ID=20412958

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9803518A SE9803518D0 (en) 1998-10-15 1998-10-15 Novel compounds

Country Status (3)

Country Link
AU (1) AU1424200A (en)
SE (1) SE9803518D0 (en)
WO (1) WO2000021934A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199135B2 (en) 2001-07-05 2007-04-03 H. Lundbeck A/S Substituted alkyl amido piperidines
US7105544B2 (en) 2001-07-05 2006-09-12 Synaptic Pharmaceutical Corporation Substituted alkyl amido piperidines
EP1449841A1 (en) * 2003-02-19 2004-08-25 Bayer CropScience SA New fungicidal compounds
EP1771439A1 (en) * 2004-07-23 2007-04-11 Bayer CropScience S.A. 4-pyridinylethylcarboxamide derivatives useful as fungicides
EP1741709A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
AR059898A1 (en) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
BRPI0816767B8 (en) 2007-09-14 2021-05-25 Addex Pharmaceuticals Sa compound 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-disubstituted 1',3'-ones, pharmaceutical composition and use of same
ES2439291T3 (en) 2008-09-02 2014-01-22 Janssen Pharmaceuticals, Inc. 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
NZ596053A (en) 2009-05-12 2013-05-31 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (en) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
ES2536433T3 (en) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
DK3096790T3 (en) 2014-01-21 2019-10-07 Janssen Pharmaceutica Nv COMBINATIONS INCLUDING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROP GLUTAMATERG SUBTYPE 2 RECEPTOR AND APPLICATION OF THESE
DK3431106T3 (en) 2014-01-21 2021-03-15 Janssen Pharmaceutica Nv COMBINATIONS INCLUDING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROP GLUTAMATERG SUBTYPE 2 RECEPTOR AND USE OF THESE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024122A1 (en) * 1995-12-29 1997-07-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
JP2000502354A (en) * 1995-12-29 2000-02-29 スミスクライン・ビーチャム・コーポレイション Vitronectin receptor antagonist
EP1471055A1 (en) * 1996-03-29 2004-10-27 Pfizer Inc. 6-phenylpyridyl-2-amine derivatives

Also Published As

Publication number Publication date
AU1424200A (en) 2000-05-01
WO2000021934A1 (en) 2000-04-20

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